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4 documents found
1: Title: Novel urokinase-plasminogen activator inhibitor SPINK13 inhibits growth and metastasis of hepatocellular carcinoma in vivo.
Authors: Wei, Ling, et.al. .
Journal: Pharmacological research (Pharmacol Res), Vol. 143, 2019 .
Snippet: The antitumor effect of SPINK13 was examined by transwell assay or the nude mice tumor model.The expression of uPA was much higher in highly aggressive HCC cell lines than in lowly aggressive HCC cell lines or non-tumor hepatic cell lines.
Affiliation: Medical School of Chinese PLA & Department of Clinical Laboratory, Medical Laboratory Center, Chinese PLA General Hospital, Beijing 100853, PR China; Beijing Centre for Physical and Chemical Analysis, Beijing 100089, PR China. Department of Laboratory Medicine, School of Pharmacy and Medical Technology, Putian University, Putian 351100, Fujian Province, PR China. Beijing Centre for Physical and Chemical Analysis, Beijing 100089, PR China. Medical School of Chinese PLA & Department of Clinical Laboratory, Medical Laboratory Center, Chinese PLA General Hospital, Beijing 100853, PR China. Beijing Centre for Physical and Chemical Analysis, Beijing 100089, PR China. Electronic address: baomingli@126.com. Medical School of Chinese PLA & Department of Clinical Laboratory, Medical Laboratory Center, Chinese PLA General Hospital, Beijing 100853, PR China. Electronic address: wangcb301@126.com. .
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2: Title: Downregulation of SPINK13 Promotes Metastasis by Regulating uPA in Ovarian Cancer Cells.
Authors: Cai, Shengyun, et.al. .
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology (Cell Physiol Biochem), Vol. 45 (3): 1061-1071, 2018 .
Snippet: SPINK13 was found to inhibit the expression of urokinase-type plasminogen activator (uPA), while recombinant uPA protein could reverse the inhibitory effect of SPINK13 on OC metastasis.
Affiliation: Department of Gynaecology and Obstetrics, Changhai Hospital, Second Military Medical University, Shanghai, China. Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China. .
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3: Title: Identification of the dopamine transporter SLC6A3 as a biomarker for patients with renal cell carcinoma.
Authors: Schrödter, Sarah, et.al. .
Journal: Molecular cancer (Mol Cancer), Vol. 15, 2016 .
Snippet: RESULTS: Differential expression of fourteen mRNAs, yet not studied in ccRCC in depth, was confirmed using qPCR (upregulation: SLC6A3, NPTX2, TNFAIP6, NDUFA4L2, ENPP3, FABP6, SPINK13; downregulation: FXYD4, SLC12A1, KNG1, NPHS2, SLC13A3, GCGR, PLG).
Affiliation: Department of Urology, University Hospital Bonn, Bonn, Germany. sarah.schroedter@hotmail.de. Section for Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology, University Hospital Bonn, Cologne/Bonn, Germany. martin.braun85@googlemail.com. Department of Urology, University Hospital Bonn, Bonn, Germany. isabella.syring@ukb.uni-bonn.de. Section for Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology, University Hospital Bonn, Cologne/Bonn, Germany. isabella.syring@ukb.uni-bonn.de. Section for Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology, University Hospital Bonn, Cologne/Bonn, Germany. niklaskluemper1992@gmail.com. Section for Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology, University Hospital Bonn, Cologne/Bonn, Germany. mariodeng@googlemail.com. Klinik und Poliklinik für Urologie und Kinderurologie, Universitätsklinikum Bonn, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany. mariodeng@googlemail.com. Department of Urology, University Hospital Bonn, Bonn, Germany. Doris.Schmidt@ukb.uni-bonn.de. Section for Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology, University Hospital Bonn, Cologne/Bonn, Germany. sven.perner1972@googlemail.com. Department of Urology, University Hospital Bonn, Bonn, Germany. Stefan.Mueller@ukb.uni-bonn.de. Department of Urology, University Hospital Bonn, Bonn, Germany. joerg.ellinger@ukb.uni-bonn.de. Klinik und Poliklinik für Urologie und Kinderurologie, Universitätsklinikum Bonn, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany. joerg.ellinger@ukb.uni-bonn.de. .
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4: Title: Spink13, an epididymis-specific gene of the Kazal-type serine protease inhibitor (SPINK) family, is essential for the acrosomal integrity and male fertility.
Authors: Ma, Li, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 288 (14): 10154-65, 2013 .
Snippet: Here we show that the rat (Rattus norvegicus) epididymis-specific gene Spink13, an androgen-responsive serine protease inhibitor, could bind to the sperm acrosome region.
Affiliation: Shanghai Key Laboratory of Molecular Andrology, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200031 Shanghai, China. .
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