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12 documents found
1: Title: SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding.
Authors: Xu, Jinxin, et.al. .
Journal: Structure (London, England : 1993) (Structure), Vol. 25 (8): 1251-1263.e5, 2017 .
Snippet: Surprisingly, we showed that the PPII/α2 loop, which is generally regarded as a membrane insertion loop in PX family proteins, is involved in the E-cadherin binding with SNX16.
Affiliation: State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China. CAS Key Laboratory of Regenerative Biology, Guangdong Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Medical University Joint School of Biological Sciences, South China Institute of Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China. High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China. CAS Key Laboratory of Regenerative Biology, Guangdong Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Medical University Joint School of Biological Sciences, South China Institute of Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China. Electronic address: shu_xiaodong@gibh.ac.cn. State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China. Electronic address: liu_jinsong@gibh.ac.cn. .
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2: Title: An investigation of obesity susceptibility genes in Northern Han Chinese by targeted resequencing.
Authors: Wu, Yili, et.al. .
Journal: Medicine (Medicine (baltimore)), Vol. 96 (7): e6117, 2017 .
Snippet: After correcting for multiple testing, 65 SNPs from 25 nearest genes (INSIG1, FABP5, PTPRN2, VIPR2, WDR60, SHH, UBE3C, LMBR1, PAG1, IMPA1, CHMP4, SNX16, BLACE, EN2, CNPY1, LOC100506302, RBM33, LOC389602, LOC285889, LINC01006, NOM1, DNAJB6, LOC101927914, ESYT2, LINC00689) were associated with obesity at significant level q-value ≤ 0.05.
Affiliation: Department of Epidemiology and Health Statistics, Public Health College, Qingdao University, Qingdao, Shandong Province, China. .
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3: Title: ChIP-seq analysis of histone H3K9 trimethylation in peripheral blood mononuclear cells of membranous nephropathy patients.
Authors: Sui, W G, et.al. .
Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] (Braz J Med Biol Res), Vol. 47 (1): 42-9, 2014 .
Snippet: Five positive genes, DiGeorge syndrome critical region gene 6 (DGCR6), sorting nexin 16 (SNX16), contactin 4 (CNTN4), baculoviral IAP repeat containing 3 (BIRC3), and baculoviral IAP repeat containing 2 (BIRC2), were selected and quantified.
Affiliation: 181st Hospital, Nephrology Department, Guangxi Key Laboratory of Metabolic Diseases Research, GuilinGuangxi, China, Guangxi Key Laboratory of Metabolic Diseases Research, Nephrology Department, 181st Hospital, Guilin, Guangxi, China. Guangxi Normal University, The Life Science College, GuilinGuangxi, China, The Life Science College, Guangxi Normal University, Guilin, Guangxi, China. Jinan University, Shenzhen People's Hospital, The Second Clinical Medical College, Clinical Medical Research Center, ShenzhenGuangdong, China, Clinical Medical Research Center, The Second Clinical Medical College, Shenzhen People's Hospital, Jinan University, Shenzhen, Guangdong, China. .
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4: Title: SNX16 negatively regulates the migration and tumorigenesis of MCF-7 cells.
Authors: Zhang, Leilei, et.al. .
Journal: Cell regeneration (London, England) (Cell Regen (lond)), Vol. 2 (1): 3, 2013 .
Snippet: Inhibition of SNX23, polymerization of microtubule filaments as well as the PI3-kinase all disrupt the cell cortex distribution of SNX16.
Affiliation: Key Laboratory of Regenerative Biology, Chinese Academy of Sciences, and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Guangzhou, 510530 China. .
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5: Title: Role of SNX16 in the dynamics of tubulo-cisternal membrane domains of late endosomes.
Authors: Brankatschk, Ben, et.al. .
Journal: PloS one, Vol. 6 (7): e21771, 2011 .
Snippet: In this paper, we report that the PX domain-containing protein SNX16, a member of the sorting nexin family, is associated with late endosome membranes.
Affiliation: Department of Biochemistry, University of Geneva, Geneva, Switzerland. .
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6: Title: A presynaptic endosomal trafficking pathway controls synaptic growth signaling.
Authors: Rodal, Avital A, et.al. .
Journal: The Journal of cell biology (J Cell Biol), Vol. 193 (1): 201-17, 2011 .
Snippet: SNX16 promotes synaptic growth signaling by activated bone morphogenic protein receptors, and live imaging in neurons reveals that SNX16-positive early endosomes undergo transient interactions with Nwk-containing recycling endosomes.
Affiliation: Department of Biology, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. arodal@brandeis.edu .
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7: Title: Evaluation of nine candidate genes in patients with normal tension glaucoma: a case control study.
Authors: Wolf, Christiane, et.al. .
Journal: BMC medical genetics (Bmc Med Genet), Vol. 10, 2009 .
Snippet: METHODS: Ninety-eight SNPs were selected to tag the common genetic variation in nine genes, namely OPTN (optineurin), RDX (radixin), SNX16 (sorting nexin 16), OPA1 (optic atrophy 1), MFN1 (mitofusin 1), MFN2 (mitofusin 2), PARL (presenilin associated, rhomboid-like), SOD2 (superoxide dismutase 2, mitochondrial) and CYP1B1 (cytochrome P450, family 1, subfamily B, polypeptide 1).
Affiliation: Centre for Ophthalmology, Institute for Ophthalmic Research, Molecular Genetics Laboratory, Tuebingen, Germany. cwolf@mpipsykl.mpg.de .
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8: Title: Novel blood biomarkers of human urinary bladder cancer.
Authors: Osman, Iman, et.al. .
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research (Clin Cancer Res), Vol. 12 (11 Pt 1): 3374-80, 2006 .
Snippet: Differential expression of a combined set of seven gene transcripts (insulin-like growth factor-binding protein 7, sorting nexin 16, chondroitin sulfate proteoglycan 6, and cathepsin D, chromodomain helicase DNA-binding protein 2, nell-like 2, and tumor necrosis factor receptor superfamily member 7) was able to discriminate bladder cancer from control samples with a sensitivity of 83% (95% confidence interval, 67-93%) and a specificity of 93% (95% confidence interval, 76-99%).
Affiliation: New York University School of Medicine, New York 10016, USA. Iman.Osmqan@med.nyu.edu .
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9: Title: Endosome-to-cytosol transport of viral nucleocapsids.
Authors: Le Blanc, Isabelle, et.al. .
Journal: Nature cell biology (Nat Cell Biol), Vol. 7 (7): 653-64, 2005 .
Snippet: This last step, which initiates infection, depends on the late endosomal lipid lysobisphosphatidic acid (LBPA) and its putative effector Alix/AIP1, and is regulated by phosphatidylinositol-3-phosphate (PtdIns3P) signalling via the PtdIns3P-binding protein Snx16.
Affiliation: Biochemistry Department, University of Geneva, 30 quai E. Ansermet, 1211 Geneva 4, Switzerland. .
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10: Title: Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Authors: Watahiki, Akira, et.al. .
Journal: Nature methods (Nat Methods), Vol. 1 (3): 233-9, 2004 .
Snippet: Real-time PCR further identified cell line-specific exons for Tmc6, Abi1, Sorbs1, Ndel1 and Snx16.
Affiliation: Genome Science Laboratory, RIKEN, Wako main campus, 2-1 Hirosawa, Wako, Saitama, 351-0198 Japan. .
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11: Title: Sorting nexin 16 regulates EGF receptor trafficking by phosphatidylinositol-3-phosphate interaction with the Phox domain.
Authors: Choi, Jang Hyun, et.al. .
Journal: Journal of cell science (J Cell Sci), Vol. 117 (Pt 18): 4209-18, 2004 .
Snippet: Treatment with wortmannin, a PtdIns 3-kinase inhibitor, abolished the endosomal localization of SNX16, suggesting that the intracellular localization of SNX16 is regulated by PtdIns 3-kinase activity.
Affiliation: Division of Molecular and Life Science, Pohang University of Science and Technology, San 31, Hojadong, Pohang, Kyungbuk 790-784, Republic of Korea. .
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12: Title: Evidence for a role of SNX16 in regulating traffic between the early and later endosomal compartments.
Authors: Hanson, Brendon J, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 278 (36): 34617-30, 2003 .
Snippet: Like other sorting nexins, SNX16 associates with the membrane via the PX domain which interacts with the phospholipid phosphatidylinositol 3-phosphate.
Affiliation: Membrane Biology Laboratory, Institute of Molecular and Cell Biology, Singapore 117609, Singapore. .
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