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7 documents found
1: Title: The Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal Peptidase.
Authors: Estoppey, David, et.al. .
Journal: Cell reports (Cell Rep), Vol. 19 (3): 451-460, 2017 .
Snippet: Flavivirus infections by Zika and dengue virus impose a significant global healthcare threat with no US Food and Drug Administration (FDA)-approved vaccination or specific antiviral treatment available.
Affiliation: Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, 4056 Basel, Switzerland. Novartis Institute for Tropical Diseases, 10 Biopolis Road, Chromos #05-01, 138670 Singapore, Singapore. Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland. Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA. Novartis Institute for Tropical Diseases, 10 Biopolis Road, Chromos #05-01, 138670 Singapore, Singapore. Electronic address: bonamgh1@gmail.com. Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, 4056 Basel, Switzerland; Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland. Electronic address: dominic.hoepfner@novartis.com. .
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2: Title: Clinicopathological significance of SPC18 in colorectal cancer: SPC18 participates in tumor progression.
Authors: Hattori, Takuya, et.al. .
Journal: Cancer science (Cancer Sci), Vol. 108 (1): 143-150, 2017 .
Snippet: In order to identify novel prognostic markers or therapeutic targets for CRC, we searched for candidate genes in our comprehensive gene expression libraries, and focused on SEC11A, which encodes the SPC18 protein.
Affiliation: Department of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan. .
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3: Title: Competitive Inhibition of the Endoplasmic Reticulum Signal Peptidase by Non-cleavable Mutant Preprotein Cargos.
Authors: Cui, Jingqiu, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 290 (47): 28131-40, 2015 .
Snippet: Specifically, we find that a variant preproinsulin, pPI-F25P, is translocated across the ER membrane, where it binds to the catalytic SPase subunit SEC11A, inhibiting SPase activity in a dose-dependent manner.
Affiliation: From the Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin 300052, China, the Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan 48105. the Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan 48105, the Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. the Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan 48105. the Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, and. the Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106 michael.weiss@case.edu. the Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan 48105, parvan@umich.edu. From the Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin 300052, China, the Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan 48105, mingli@umich.edu. .
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4: Title: Archaeal membrane-associated proteases: insights on Haloferax volcanii and other haloarchaea.
Authors: Giménez, María I, et.al. .
Journal: Frontiers in microbiology (Front Microbiol), Vol. 6, 2015 .
Snippet: Interestingly, two different signal peptidase I homologs exist in H. volcanii, Sec11a and Sec11b, which likely play distinct physiological roles.
Affiliation: Instituto de Investigaciones Biológicas, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Consejo Nacional de Investigaciones Científicas y Técnicas Mar del Plata, Argentina. .
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5: Title: [Alternative polyadenylation site analysis of tumor-related genes based on 3'RACE in gastric cancer cells].
Authors: Lai, Dengpan, et.al. .
Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao), Vol. 34 (12): 1738-42, 2014 .
Snippet: METHODS: We used 3'RACE to capture the APA sites of two tumor-related genes (HSP90α and SEC11A) in gastric cancer cell lines MKN45, MKN28 and AGS, and compared the results with annotated poly(A) sites in UCSC database.
Affiliation: Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine of Ministry of Education, Shanghai Jiaotong University, Shanghai 200240, China.E-mail: dengpanlai@gmail.com. .
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6: Title: Signal peptidase complex 18, encoded by SEC11A, contributes to progression via TGF-α secretion in gastric cancer.
Authors: Oue, N, et.al. .
Journal: Oncogene, Vol. 33 (30): 3918-26, 2014 .
Snippet: SEC11A mRNA expression was measured by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) in gastric cancer (GC) tissue samples.
Affiliation: Department of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan. Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan. Pathology Division, and Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan. Division of Translational Research, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan. Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan. .
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7: Title: Cloning, expression, and purification of functional Sec11a and Sec11b, type I signal peptidases of the archaeon Haloferax volcanii.
Authors: Fine, Amir, et.al. .
Journal: Journal of bacteriology (J Bacteriol), Vol. 188 (5): 1911-9, 2006 .
Snippet: By employing an in vitro signal peptidase assay designed for use with high salt concentrations such as those encountered by halophilic archaea such as Haloferax volcanii, the signal peptide-cleaving activities of both isolated membranes and purified Sec11a and Sec11b were addressed.
Affiliation: Dept. of Life Sciences, Ben Gurion University, P.O. Box 653, Beersheva 84105, Israel. .
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