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22 documents found
1: Title: Identifying Genetic Differences Between Dongxiang Blue-Shelled and White Leghorn Chickens Using Sequencing Data.
Authors: Zhao, Qingbo, et.al. .
Journal: G3 (Bethesda, Md.) (G3 (bethesda)), 2017 .
Snippet: We show that the White Leghorn genes JARID2, RBMS3, GPC3, TRIB2,ROBO1, SAMSN1, OSBP2 and IGFALS are involved in immunity, reproduction, and growth, and thus might represent footprints of the selection process.
Affiliation: Shanghai Jiao Tong University. Institute of Animal Husbandry and Veterinary Research,Shanghai Academy of Agricultural Sciences. Shanghai Academy of Agricultural Sciences. Shanghai Jiao Tong University panyuchun1963@aliyun.com. .
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2: Title: Generation of special autosomal dominant polycystic kidney disease iPSCs with the capability of functional kidney-like cell differentiation.
Authors: Huang, Jiahui, et.al. .
Journal: Stem cell research & therapy (Stem Cell Res Ther), Vol. 8 (1): 196, 2017 .
Snippet: METHODS: Six ADPKD patients and four healthy individuals were recruited as donors of somatic cells from a Chinese ADPKD family without mutations of the PKD genes but carrying SAMSN1 gene deletion.
Affiliation: Institute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China. Institute of Urology First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China. Department of Clinical Laboratory, Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People's Republic of China. State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, People's Republic of China. Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People's Republic of China. Institute of Embryo-Fetal Original Adult Disease Affiliated to Shanghai Jiao Tong, University School of Medicine, Shanghai, People's Republic of China. Institute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China. wangy63cn@126.com. .
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3: Title: A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic.
Authors: Ward-Caviness, Cavin K, et.al. .
Journal: PloS one, Vol. 12 (3): e0173880, 2017 .
Snippet: All three were intergenic; the most significant interaction was in a regulatory region associated with SAMSN1, a gene previously associated with atherosclerosis and B cell activation.
Affiliation: Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, United States of America. Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany. National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Chapel Hill, NC, United States of America. National Center for Geospatial Medicine, Rice University, Houston, TX, United States of America. Division of Cardiology, Duke University School of Medicine, Durham, NC, United States of America. Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, United States of America. Cooperative Studies Program Epidemiology Center-Durham, Veterans Affairs Medical Center, Durham, NC, United States of America. .
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4: Title: Angioimmunoblastic T cell lymphoma: novel molecular insights by mutation profiling.
Authors: Wang, Ming, et.al. .
Journal: Oncotarget, Vol. 8 (11): 17763-17770, 2017 .
Snippet: More importantly, we identified mutations in TNFRSF21 (1/9), CCND3 (1/9) and SAMSN1 (1/9), which are not yet seen or strongly implicated in the pathogenesis of AITL.
Affiliation: Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, UK. Department of Pathology, Health Science Centre, Peking University, China. Department of Pathology, Chi-Mei Medical Center, Tainan, Taiwan. Department of Cellular Pathology, Southampton University Hospitals National Health Service Foundation Trust, Southampton, UK. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. Department of Oncology and Onco-Hematology, University of Milan, Milan, Italy. Department of Hematology and Pediatric Onco-Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. .
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5: Title: Prognostic relevance of SAMSN1 expression in gastric cancer.
Authors: Kanda, Mitsuro, et.al. .
Journal: Oncology letters (Oncol Lett), Vol. 12 (6): 4708-4716, 2016 .
Snippet: A marked decrease in the level of SAMSN1 mRNA was detected in 8/11 GC cell lines as compared with that in a non-transformed intestinal epithelium cell line (FHs 74) without promoter methylation.
Affiliation: Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan. Department of Surgery, Aichi-Gakuin University School of Dentistry, Nagoya, Aichi 464-8651, Japan. .
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6: Title: Whole Genome Sequence of Multiple Myeloma-Prone C57BL/KaLwRij Mouse Strain Suggests the Origin of Disease Involves Multiple Cell Types.
Authors: Amend, Sarah R, et.al. .
Journal: PloS one, Vol. 10 (5): e0127828, 2015 .
Snippet: Using mouse haplotype analysis, human MM SNP array data, and whole exome and whole genome sequencing of KaLwRij mice, we identified novel KaLwRij gene variants, including deletion of Samsn1 and deleterious point mutations in Tnfrsf22 and Tnfrsf23.
Affiliation: Division of Oncology, Washington University School of Medicine, St. Louis, MO, United States of America. Medical College of Wisconsin, Milwaukee, WI, United States of America. Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, MN, United States of America. Department of Physiology, University of Toronto, Toronto, Canada. Department of Surgery, Washington University School of Medicine, St. Louis, MO, United States of America. .
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7: Title: Suppression of SAMSN1 Expression is Associated with the Malignant Phenotype of Hepatocellular Carcinoma.
Authors: Sueoka, Satoshi, et.al. .
Journal: Annals of surgical oncology (Ann Surg Oncol), Vol. 22 Suppl 3, 2015 .
Snippet: METHODS: We focused here on SAM domain, SH3 domain, and nuclear localization signals 1 (SAMSN1) and investigated expression and methylation status of SAMSN1 in HCC cell lines and 144 pairs of surgical specimens.
Affiliation: Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan. Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan. m-kanda@med.nagoya-u.ac.jp. Department of Surgery, Aichi-Gakuin University School of Dentistry, Nagoya, Japan. Department of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan. .
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8: Title: SAMSN1 Is a Tumor Suppressor Gene in Multiple Myeloma.
Authors: Noll, Jacqueline E, et.al. .
Journal: Neoplasia (New York, N.Y.) (Neoplasia), Vol. 16 (7): 572-85, 2014 .
Snippet: We identify promoter methylation as a potential mechanism through which SAMSN1 expression is modulated in human myeloma cell lines.
Affiliation: Myeloma Research Laboratory, School of Medical Sciences, Faculty of Health Science, University of Adelaide, Adelaide, Australia; Department of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia. Acute Myeloid Leukaemia Laboratory, Department of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia. Department of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia. Myeloma Research Laboratory, School of Medical Sciences, Faculty of Health Science, University of Adelaide, Adelaide, Australia; Department of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia. Electronic address: andrew.zannettino@adelaide.edu.au. .
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9: Title: SAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme.
Authors: Yan, Yong, et.al. .
Journal: PloS one, Vol. 8 (11): e81905, 2013 .
Snippet: Multivariate survival analysis with Cox proportional hazards regression models confirmed that high expression of SAMSN1 was a strong risk factor for PFS and OS of GBM patients.
Affiliation: Neurosurgery Research Institution of Shanghai, Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, China. .
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10: Title: Comparison of immunological characteristics of peripheral, splenic and tonsilar naïve B cells by differential gene expression meta-analyses.
Authors: Chokeshai-u-saha, Kaj, et.al. .
Journal: Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand (Asian Pac J Allergy), Vol. 30 (4): 326-30, 2012 .
Snippet: These included enhanced expressions of CD27, CR2, EGR1, GADD45B, ICAM1, ICOSLG, IGHA, IL6, MMP9, SAMSN1, SMAD7, TNFAIP3, but reduced HLA-DOB expression.
Affiliation: Division of Allergy and Clinical Immunology, Department of Medicine, Faculty Medicine, Chulalongkorn University, Bangkok, Thailand. .
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11: Title: Translocation t(11;14) (q13;q32) and genomic imbalances in multi-ethnic multiple myeloma patients: a Malaysian study.
Authors: Ni, Ivyna Bong Pau, et.al. .
Journal: Hematology reports (Hematol Rep), Vol. 4 (3): e19, 2012 .
Snippet: Genes located in the chromosomal aberration regions in our study, such as NAMPT, IVNS1ABP, IRF2BP2, PICALM, STAT1, STK17B, FBXL5, ACSL1, LAMP2, SAMSN1 and ATP8B4 might be potential prognostic markers and therapeutic targets in the treatment and management of multiple myeloma patients positive for BCL1/JH t(11;14) (q13;q32) translocation.
Affiliation: Hematology Unit, Cancer Research Centre, Institute for Medical Research, Kuala Lumpur; .
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12: Title: Predicting ulcerative colitis-associated colorectal cancer using reverse-transcription polymerase chain reaction analysis.
Authors: Watanabe, Toshiaki, et.al. .
Journal: Clinical colorectal cancer (Clin Colorectal Cancer), Vol. 10 (2): 134-41, 2011 .
Snippet: RESULTS: We identified 20 genes showing differential expression in UC-Ca and UC-NonCa patients, including cancer-related genes such as CYP27B1, RUNX3, SAMSN1, EDIL3, NOL3, CXCL9, ITGB2, and LYN.
Affiliation: Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan. toshwatanabe@yahoo.co.jp .
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13: Title: Immunoinhibitory adapter protein Src homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading.
Authors: von Holleben, Max, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 286 (15): 13489-501, 2011 .
Snippet: The Src homology domain 3 (SH3)-containing adapter protein SH3 lymphocyte protein 2 (SLy2, also known as hematopoietic adapter-containing SH3 and sterile α-motif (SAM) domains 1; HACS1) is strongly up-regulated upon B cell activation and functions as an endogenous immunoinhibitor in vivo, but the underlying molecular mechanisms of SLy2 function have been elusive.
Affiliation: Institute of Medical Microbiology and Hospital Hygiene, Heinrich Heine University, 40225 Duesseldorf, Germany. .
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14: Title: SLy2 targets the nuclear SAP30/HDAC1 complex.
Authors: Brandt, Simone, et.al. .
Journal: The international journal of biochemistry & cell biology (Int J Biochem Cell Biol), Vol. 42 (9): 1472-81, 2010 .
Snippet: The adapter protein SLy2 (SH3 protein expressed in lymphocytes 2), also named HACS1, NASH1 or SAMSN1, is expressed in hematopoietic tissues, muscle, heart, brain, lung, pancreas, endothelial cells and myelomas.
Affiliation: Institute of Medical Microbiology and Hospital Hygiene, Heinrich-Heine University Duesseldorf, Germany. .
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15: Title: Molecular profiles of schizophrenia in the CNS at different stages of illness.
Authors: Narayan, Sujatha, et.al. .
Journal: Brain research (Brain Res), Vol. 1239, 2008 .
Snippet: While only four genes, SAMSN1, CDC42BPB, DSC2 and PTPRE, were consistently expressed across all groups, there was dysfunction in overlapping systems among all stages, including cellular signal transduction, lipid metabolism and protein localization.
Affiliation: Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. .
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16: Title: Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer.
Authors: Yamada, Hideki, et.al. .
Journal: Genes, chromosomes & cancer (Genes Chromosomes Cancer), Vol. 47 (9): 810-8, 2008 .
Snippet: We found frequent downregulation of two coding genes, SAMSN1 and USP25, as well as of three miRNA genes, miR-99a, let-7c, and miR-125b-2, which reside in the commonly deleted region in human lung cancer.
Affiliation: Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan. .
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17: Title: Gene dosage change of TPTE and BAGE2 and breakpoint analysis in Robertsonian Down syndrome.
Authors: Shaw, Sheng-Wen, et.al. .
Journal: Journal of human genetics (J Hum Genet), Vol. 53 (2): 136-43, 2008 .
Snippet: We further used real-time PCR to detect the copy number of TPTE and BAGE2 located on 21p11 and SAMSN1 on 21q11.
Affiliation: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, 333, Taiwan. .
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18: Title: The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease.
Authors: Kimura, Ryo, et.al. .
Journal: Human molecular genetics (Hum Mol Genet), Vol. 16 (1): 15-23, 2007 .
Snippet: Logistic regression analysis with age, sex and apolipoprotein E (APOE)-epsilon4 dose supported genetic risk of 17 markers, of which eight markers were linked to the SAMSN1, PRSS7, NCAM2, RUNX1, DYRK1A and KCNJ6 genes.
Affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, 2-2-D3 Yamadaoka, Suita, Osaka 565-0871, Japan. .
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19: Title: The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades.
Authors: Zhu, Yuan Xiao, et.al. .
Journal: The Journal of experimental medicine (J Exp Med), Vol. 200 (6): 737-47, 2004 .
Snippet: Induction of Hacs1 by IL-4 is dependent on Stat6 signaling and can also be impaired by inhibitors of phosphatidylinositol 3-kinase, protein kinase C, and nuclear factor kappaB.
Affiliation: Ontario Cancer Institute, University Health Network, McLaughlin Centre for Molecular Medicine, University of Toronto, Ontario M5G 2C1, Canada. .
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20: Title: Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms.
Authors: Brun, Marie-Elisabeth, et.al. .
Journal: Gene, Vol. 312, 2003 .
Snippet: The 1.5-Mb proximal domain: (i) is a patchwork of chromosome duplications; (ii) shares sequence similarity with several chromosomes; (iii) contains several gene fragments (truncated genes having an intron/exon structure) intermingled with retrotransposed pseudogenes; and (iv) harbours two genes (TPTE and BAGE2) that belong to gene families and have a cancer and/or testis expression profile.
Affiliation: Institut de Génétique Humaine, CNRS UPR 1142, 141, rue de la Cardonille, 34396 Montpellier, France. .
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