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9 documents found
1: Title: SAMMSON fosters cancer cell fitness by concertedly enhancing mitochondrial and cytosolic translation.
Authors: Vendramin, Roberto, et.al. .
Journal: Nature structural & molecular biology (Nat Struct Mol Biol), Vol. 25 (11): 1035-1046, 2018 .
Snippet: SAMMSON interferes with XRN2 binding to CARF in the nucleus by favoring the formation of an aberrant cytoplasmic RNA-protein complex containing CARF and p32, a mitochondrial protein required for the processing of the mitochondrial rRNAs.
Affiliation: Laboratory for RNA Cancer Biology, Department of Oncology, LKI, KU Leuven, Leuven, Belgium. Laboratory for Molecular Cancer Biology, Department of Oncology, LKI, KU Leuven, Leuven, Belgium. Laboratory For Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium. Department of Applied Biological Science, Global Innovation Research Organizations, Tokyo University of Agriculture and Technology, Tokyo, Japan. RNA Molecular Biology, Center for Microscopy and Molecular Imaging, Université Libre de Bruxelles, Charleroi, Belgium. Centre for Genomic Regulation, University Pompeu Fabra and Catalan Institution for Research and Advanced Studies, Barcelona, Spain. Center for Medical Genetics, Gent University, Gent, Belgium. Cancer Research Institute Gent, Gent University, Gent, Belgium. Laboratory for RNA Cancer Biology, Department of Oncology, LKI, KU Leuven, Leuven, Belgium. eleonora.leucci@kuleuven.be. .
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2: Title: A comprehensive genome-wide analysis of the long noncoding RNA expression profile in metastatic lymph nodes of oral mucosal melanoma.
Authors: Ju, Houyu, et.al. .
Journal: Gene, 2018 .
Snippet: Gene Ontology (GO) and pathway analyses indicated that they play an important role in the melanin biosynthetic process, new growing cell tip and lysosomes in metastatic OMM.
Affiliation: Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China. Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China. Electronic address: doctorruanmin@hotmail.com. Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China. Electronic address: huyayi@shsmu.edu.cn. Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, China. Electronic address: renguoxincn@sina.com. .
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3: Title: Long non-coding RNAs in melanoma.
Authors: Yu, Xin, et.al. .
Journal: Cell proliferation (Cell Prolif), 2018 .
Snippet: In the melanoma, deregulation of a number of lncRNAs, such as HOTAIR, MALAT1, BANCR, ANRIL, SPRY-IT1 and SAMMSON, have been reported.
Affiliation: Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Sha Tin, Hong Kong. Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Sha Tin, Hong Kong. State Key Laboratory of Digestive Disease and LKS Institute of Health Sciences, The Chinese University of Hong Kong, Sha Tin, Hong Kong. .
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4: Title: SAMMSON drives the self-renewal of liver tumor initiating cells through EZH2-dependent Wnt/β-catenin activation.
Authors: Li, Xiaopeng, et.al. .
Journal: Oncotarget, Vol. 8 (61): 103785-103796, 2017 .
Snippet: Here we found long noncoding RNA SAMMSON is highly expressed in liver cancer and liver TICs.
Affiliation: Department of Infectious Disease, The First Affiliated Hospital of Nanchang University, Nanchang, JiangXi 330006, China. Department of Function, JiangXi Children's Hospital, Nanchang, JiangXi 330006, China. Department of Pathology, The First Affiliated Hospital of Nanchang University, Nanchang, JiangXi 330006, China. .
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5: Title: How long noncoding RNAs enforce their will on mitochondrial activity: regulation of mitochondrial respiration, reactive oxygen species production, apoptosis, and metabolic reprogramming in cancer.
Authors: De Paepe, Boel, et.al. .
Journal: Current genetics (Curr Genet), 2017 .
Snippet: From the nonexhaustive list of lncRNAS described in this review, ANRIL, AScmtRNA, H19, HOTAIR, LincRNA-p21, MALAT1, RMRP, SAMMSON, and VL30 have emerged as potent regulators of mitochondrial metabolism.
Affiliation: Laboratory for Mitochondrial Investigations & Neuromuscular Reference Center, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium. boel.depaepe@ugent.be. Center for Medical Genetics, Cancer Research Institute Ghent, Ghent University, Ghent, Belgium. .
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6: Title: Discovery of Cancer Driver Long Noncoding RNAs across 1112 Tumour Genomes: New Candidates and Distinguishing Features.
Authors: Lanzós, Andrés, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7, 2017 .
Snippet: Using a stratified approach, we identify 15 high-confidence candidates: 9 novel and 6 known cancer-related genes, including MALAT1, NEAT1 and SAMMSON.
Affiliation: Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain. Universitat Pompeu Fabra (UPF), Barcelona, Spain. Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), 08003 Barcelona, Spain. Research Unit on Biomedical Informatics, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Dr. Aiguader 88, Barcelona, Spain. .
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7: Title: Targeting the lncRNA SAMMSON Reveals Metabolic Vulnerability in Melanoma.
Journal: Cancer cell, Vol. 29 (5): 619-21, 2016 .
Snippet: report a role for the long non-coding RNA SAMMSON in driving mitochondrial function in melanoma.
Affiliation: Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Headington, Oxford OX3 7DQ, UK. Electronic address: colin.goding@ludwig.ox.ac.uk. .
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8: Title: SAMMSON Long Noncoding RNA Is Essential for Melanoma Cell Viability.
Journal: Cancer discovery (Cancer Discov), Vol. 6 (5): 470, 2016 .
Snippet: SAMMSON is expressed in the majority of human melanomas and promotes cell growth and survival.
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9: Title: Melanoma addiction to the long non-coding RNA SAMMSON.
Authors: Leucci, Eleonora, et.al. .
Journal: Nature, Vol. 531 (7595): 518-22, 2016 .
Snippet: Mechanistically, SAMMSON interacts with p32, a master regulator of mitochondrial homeostasis and metabolism, to increase its mitochondrial targeting and pro-oncogenic function.
Affiliation: Laboratory For Molecular Cancer Biology, Center for Human Genetics, KULeuven, Herestraat 49, 3000 Leuven, Belgium. Center for the Biology of Disease, VIB, Herestraat 49, 3000 Leuven, Belgium. Institut de Génétique et de Biologie Moleculaire et Cellulaire (IGBMC), Rue Laurent Fries 1, 67404 Illkirch, France. Laboratory of Translational Cell and Tissue Research, Department of Pathology, KULeuven and UZ Leuven, Herestraat 49, 3000 Leuven, Belgium. Mouse Histopathology Core Facility, Center for the Biology of Disease, VIB-KULeuven, Herestraat 49, 3000 Leuven, Belgium. Medical Biotechnology Center, VIB, Albert Baertsoenkaai 3, 9000 Gent, Belgium. Department of Biochemistry, Gent University, Albert Baertsoenkaai 3, 9000 Gent, Belgium. Center for Medical Genetics, Gent University, De Pintelaan 185, 9000 Gent, Belgium. Cancer Research Institute Gent, Gent University, De Pintelaan 185, 9000 Gent, Belgium. Gynaecologische Oncologie, KU Leuven, Herestraat 49, 3000 Leuven, Belgium. Laboratory of Computational Biology, Center for Human Genetics, KULeuven, Herestraat 49, 3000 Leuven, Belgium. Department of Applied Mathematics, Computer Science and Statistics, Gent University, De Pintelaan 185, 9000 Gent, Belgium. Department of Mathematics, KU Leuven, Celestijnenlann 200B, 3001 Leuven, Belgium. RNA Molecular Biology, Center for Microscopy and Molecular Imaging, Université Libre de Bruxelles (ULB), rue des Professeurs Jeener et Brachet 12, 6041 Charleroi, Belgium. .
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