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6 documents found
1: Title: Samd7 is a cell type-specific PRC1 component essential for establishing retinal rod photoreceptor identity.
Authors: Omori, Yoshihiro, .
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), Vol. 114 (39): E8264-E8273, 2017 .
Snippet: Samd7 physically interacts with Polyhomeotic homologs (Phc proteins), components of the Polycomb repressive complex 1 (PRC1), and colocalizes with Phc2 and Ring1B in Polycomb bodies.
Affiliation: Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Osaka 565-0871, Japan. Laboratory of Supramolecular Crystallography, Institute for Protein Research, Osaka University, Osaka 565-0871, Japan. Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan. Laboratory of Epigenetics, Institute for Protein Research, Osaka University, Osaka 565-0871, Japan. Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan. Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Osaka 565-0871, Japan; .
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2: Title: Autosomal recessive retinitis pigmentosa with homozygous rhodopsin mutation E150K and non-coding cis-regulatory variants in CRX-binding regions of SAMD7.
Authors: Van Schil, Kristof, .
Journal: Scientific reports (Sci Rep), Vol. 6, 2016 .
Snippet: A homozygous RHO mutation c.448G > A, p.E150K was found in two affected siblings, while no coding SAMD7 mutations were identified.
Affiliation: Center for Medical Genetics, Ghent University and Ghent University Hospital, Ghent, Belgium. Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany. Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan. Al-Nafees Medical College &Hospital, Isra University, Islamabad, Pakistan. Pakistan Academy of Sciences, Islamabad, Pakistan. Department of Ophthalmology, Ghent University Hospital, Ghent, Belgium. Division of Ophthalmology, The Children's Hospital of Philadelphia, Philadelphia, USA. Department of Ophthalmology, Brugmann University Hospital, Brussels, Belgium. .
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3: Title: [Relationship between artesunate influence on the process of TGF-beta1 induced alveolar epithelial cells transform into mesenchymal cells and on idiopathic pulmonary fibrosis].
Authors: Wang, Chang-Ming, .
Journal: Yao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao), Vol. 49 (1): 142-7, 2014 .
Snippet: Meanwhile, incubation with artesunate intervened on RLE-6TN cells could lead to the apparent down-regulation of the expression of Smad3 and up-regulation of Samd7 and the transition of RLE-6TN cells to mesenchymal-like by TGF-beta1 induction, after artesunate intervened on it, RLE-6TN cells to epithelial-like.
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4: Title: Sterile alpha motif containing 7 (samd7) is a novel crx-regulated transcriptional repressor in the retina.
Authors: Hlawatsch, Julia, .
Journal: PloS one, Vol. 8 (4): e60633, 2013 .
Snippet: Samd7 suppressed luciferase activity from a reporter plasmid with five Crx consensus repeats in a dose dependent manner and reduced Crx-mediated transactivation of regulatory sequences in the retinoschisin gene and the Samd7 gene itself.
Affiliation: Institute of Human Genetics, University of Regensburg, Regensburg, Germany. .
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5: Title: Desferrioxamine attenuates doxorubicin-induced acute cardiotoxicity through TFG-β/Smad p53 pathway in rat model.
Authors: Al-Shabanah, Othman A, .
Journal: Oxidative medicine and cellular longevity (Oxid Med Cell Longev), Vol. 2012, 2012 .
Snippet: A single dose of DOX significantly increased mRNA expression of TGF-β, Smad2, Smad4, CDKN2A and p53 and significantly decreased Samd7 and Mdm2 mRNA expression levels.
Affiliation: Department of Pharmacology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. .
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6: Title: Arkadia-Smad7-mediated positive regulation of TGF-beta signaling in a rat model of tubulointerstitial fibrosis.
Authors: Liu, Fu-You, .
Journal: American journal of nephrology (Am J Nephrol), Vol. 27 (2): 176-83, 2007 .
Snippet: RESULTS: The results indicated progressive tubulointerstitial fibrosis, high expression levels of Arkadia, Smurf2, TbetaRI, TGF-beta1 mRNA, type 1 collagen mRNA, and Smad7 mRNA, and low levels of Smad7 protein in the kidneys of rats with unilateral ureteral obstruction, in which Smurf2 interacted with both Smad7 and TbetaRI, and Arkadia only interacted with Samd7 but not with TbetaRI.
Affiliation: Department of Nephrology, Second Xiangya Hospital of the Central South University, Changsha, China. .
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