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18 documents found
1: Title: Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors.
Authors: Djurec, Magdolna, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), 2018 .
Snippet: The protumorigenic activity of Saa3 in CAFs is mediated by Mpp6, a member of the palmitoylated membrane protein subfamily of the peripheral membrane-associated guanylate kinases (MAGUK).
Affiliation: Molecular Oncology, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain. Bioinformatics Unit, Structural Biology and Biocomputing Programmes, CNIO, 28029 Madrid, Spain. Department of Systems Biology, Columbia University Medical Center, New York, NY 10032. Divison of Stem Cells and Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany. Department of Biochemistry, School of Medicine, Autonomous University of Madrid, 28018 Madrid, Spain. Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, Spain. Department of Surgery, Clinical University Hospital Virgen Arrixaca, Murcian Institute of Biomedical Investigation (IMIB), 30120 Murcia, Spain. Molecular Oncology, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain; mcguerra@cnio.es mbarbacid@cnio.es. .
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2: Title: The S100A8-serum amyloid A3-LOX-1 cascade in atherosclerotic plaque rupture.
Authors: Wang, Ya-ting, et.al. .
Journal: International journal of cardiology (Int J Cardiol), Vol. 203, 2016 .
No Abstract available.
Affiliation: Department of Cardiology, Internal Medicine, Second Xiangya Hospital of Central South University, Changsha, Hunan, P. R. China. Department of Cardiology, Internal Medicine, Second Xiangya Hospital of Central South University, Changsha, Hunan, P. R. China. Electronic address: xudanyan02@sina.com. .
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3: Title: Long non-coding RNA MALAT1 regulates hyperglycaemia induced inflammatory process in the endothelial cells.
Authors: Puthanveetil, Prasanth, et.al. .
Journal: Journal of cellular and molecular medicine (J Cell Mol Med), Vol. 19 (6): 1418-25, 2015 .
Snippet: This increase was associated with parallel increase in serum amyloid antigen 3 (SAA3), an inflammatory ligand and target of MALAT1 and was further accompanied by increase in mRNAs and proteins of inflammatory mediators, tumour necrosis factor alpha (TNF-α) and interleukin 6 (IL-6).
Affiliation: Department of Pathology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. .
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4: Title: The acute-phase protein SAA3 is present in the preterm human colostrum and breast milk.
Authors: Knee, Olatejumoye, et.al. .
Journal: Archives of disease in childhood. Fetal and neonatal edition (Arch Dis Child Fetal Neonatal Ed), Vol. 100 (4): F369-71, 2015 .
No Abstract available.
Affiliation: Neonatal Intensive Care Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. Neonatal Intensive Care Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK Department of Paediatrics, Basildon University Hospital, Basildon, UK. Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge, UK. .
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5: Title: A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4.
Authors: Hansen, M T, et.al. .
Journal: Oncogene, Vol. 34 (4): 424-35, 2015 .
Snippet: SAA proteins stimulated the transcription of RANTES (regulated upon activation normal T-cell expressed and presumably secreted), G-CSF (granulocyte-colony-stimulating factor) and MMP2 (matrix metalloproteinase 2), MMP3, MMP9 and MMP13.
Affiliation: Danish Cancer Society Research Center, Copenhagen, Denmark. 1] Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany [2] KIT Karlsruhe, Eggenstein-Leopoldshafen, Germany. Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany. 1] Danish Cancer Society Research Center, Copenhagen, Denmark [2] Neuro-Oncology Group, Laboratory of Neural Plasticity, Institute of Neuroscience and Pharmacology, Faculty of Health Sciences, Copenhagen University, Copenhagen, Denmark. Experimental and Clinical Research Center, Charité Universitätsmedizin Berlin, at the Max-Delbrück Center for Molecular Medicine, Berlin, Germany. Air Liquide Danmark A/S, Horsens, Denmark. Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX, USA. .
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6: Title: A novel Saa3-promoter reporter distinguishes inflammatory subtypes in experimental arthritis and human synovial fibroblasts.
Authors: Geurts, Jeroen, et.al. .
Journal: Annals of the rheumatic diseases (Ann Rheum Dis), Vol. 70 (7): 1311-9, 2011 .
Snippet: OBJECTIVE: To evaluate the applicability of a lentiviral (LV) serum amyloid A3 (Saa3)-promoter luciferase (Luc) reporter for assessing inflammation in experimental arthritis, synovial fibroblasts (SF) from osteoarthritis (OA) and rheumatoid arthritis (RA) patients.
Affiliation: Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands. .
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7: Title: Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytes.
Authors: Conde, Javier, et.al. .
Journal: Annals of the rheumatic diseases (Ann Rheum Dis), Vol. 70 (3): 551-9, 2011 .
Snippet: Intracellular signal transducers involved in the IL-1β-mediated upregulation of LCN2 and SAA3 included Janus kinase (JAK) 2, phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein (MAP) kinases.
Affiliation: Correspondence to Dr Oreste Gualillo, Santiago University Clinical Hospital, Research Laboratory 9 (NEIRID LAB, Laboratory of Neuro Endocrine Interactions in Rheumatology and Inflammatory Diseases). Building C, Level 2, Calle Choupana s/n, 15706, Santiago de Compostela, Spain. .
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8: Title: Logical structures extracted from metastasis experiments.
Journal: Cancer science (Cancer Sci), Vol. 100 (11): 2006-13, 2009 .
Snippet: I propose that dysregulation of pro-inflammatory Toll-like receptor 4 signaling, stimulated by its endogenous ligands, establishes pre-metastatic soil.
Affiliation: Department of Pharmacology, Tokyo Womens Medical University, Shinjuku-ku, Tokyo, Japan. ymaru@research.twmu.ac.jp .
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9: Title: Computational design and application of endogenous promoters for transcriptionally targeted gene therapy for rheumatoid arthritis.
Authors: Geurts, Jeroen, et.al. .
Journal: Molecular therapy : the journal of the American Society of Gene Therapy (Mol Ther), Vol. 17 (11): 1877-87, 2009 .
Snippet: Applying a filter based on spacing between TATA box and transcription start site (TSS) combined with the presence of over-represented nuclear factor kappaB (NFkappaB), AP-1, or CCAAT/enhancer-binding protein beta (C/EBPbeta) sites, 382 candidate murine and human promoters were reduced to 66, corresponding to 45 genes.
Affiliation: Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. .
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10: Title: Ah receptor represses acute-phase response gene expression without binding to its cognate response element.
Authors: Patel, Rushang D, et.al. .
Journal: Laboratory investigation; a journal of technical methods and pathology (Lab Invest), Vol. 89 (6): 695-707, 2009 .
Snippet: We investigated the potential of the aryl hydrocarbon receptor (AHR) to suppress NF-kappaB regulated-gene expression, especially acute-phase genes, such as serum amyloid A (Saa).
Affiliation: Department of Veterinary and Biomedical Sciences and Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA. .
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11: Title: Evaluation of colostrum-derived human mammary-associated serum amyloid A3 (M-SAA3) protein and peptide derivatives for the prevention of enteric infection: in vitro and in murine models of intestinal disease.
Authors: Gardiner, Gillian E, et.al. .
Journal: FEMS immunology and medical microbiology (Fems Immunol Med Microbiol), Vol. 55 (3): 404-13, 2009 .
Snippet: In vitro experiments confirmed that a 10-mer peptide derived from human mammary-associated serum amyloid A3 (M-SAA3) protected intestinal epithelial cells from enteropathogenic Escherichia coli (EPEC) adherence.
Affiliation: Teagasc, Moorepark Food Research Center, Fermoy Co, Cork, Ireland. ggardiner@wit.ie .
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12: Title: Induction of human mammary-associated serum amyloid A3 expression by prolactin or lipopolysaccharide.
Authors: Larson, Marilynn A, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Bioph Res Co), Vol. 301 (4): 1030-7, 2003 .
Snippet: Human SAA3 gene expression was detected by RT-PCR after stimulation of mammary gland epithelial cells with either prolactin (PRL) or lipopolysaccharide (LPS).
Affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA. .
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13: Title: The conserved TFLK motif of mammary-associated serum amyloid A3 is responsible for up-regulation of intestinal MUC3 mucin expression in vitro.
Authors: Mack, David R, et.al. .
Journal: Pediatric research (Pediatr Res), Vol. 53 (1): 137-42, 2003 .
Snippet: Peptides derived from the bovine N-terminal amino acid sequence of M-SAA3 were produced and added to cell culture medium of HT29 cells to study the effects on intestinal mucin gene expression.
Affiliation: Department of Pediatrics, Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, Ontario, Canada. dmack@cheo.on.ca .
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14: Title: Human serum amyloid A3 peptide enhances intestinal MUC3 expression and inhibits EPEC adherence.
Authors: Larson, Marilynn A, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Bioph Res Co), Vol. 300 (2): 531-40, 2003 .
Snippet: Furthermore, immunofluorescence and immunoblot analysis using a MUC3-specific monoclonal antibody confirms that the human M-SAA3 peptide stimulates MUC3 protein expression and secretion by the HT29 cells.
Affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA. .
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15: Title: NFkappa B interacts with serum amyloid A3 enhancer factor to synergistically activate mouse serum amyloid A3 gene transcription.
Authors: Bing, Z, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 275 (41): 31616-23, 2000 .
Snippet: When SEF-transfected cells were further stimulated with conditioned medium or interleukin-1, SAA3 promoter activity was dramatically increased, suggesting that SEF may cooperate functionally with other interleukin-1-inducible transcription factors to synergistically up-regulate SAA3 gene transcription.
Affiliation: Department of Biochemistry and Molecular Biology, Program in Genes and Development, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA. .
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16: Title: Synergistic induction of mouse serum amyloid A3 promoter by the inflammatory mediators IL-1 and IL-6.
Authors: Huang, J H, et.al. .
Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research (J Interf Cytok Res), Vol. 19 (12): 1403-11, 1999 .
Snippet: In this study, we show that interleukin-1 (IL-1) is the major cytokine in the conditioned medium responsible for SAA3 induction, and the induction by IL-1 can be effectively blocked by H-7, a protein kinase C inhibitor.
Affiliation: Department of Biochemistry and Molecular Biology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA. .
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17: Title: Purification and characterization of the serum amyloid A3 enhancer factor.
Authors: Bing, Z, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 274 (35): 24649-56, 1999 .
Snippet: Ultraviolet cross-linking and Southwestern experiments indicated that SEF consisted of a single polypeptide with an apparent molecular mass of 65 kDa.
Affiliation: Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA. .
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18: Title: Induction of the mouse serum amyloid A3 gene by cytokines requires both C/EBP family proteins and a novel constitutive nuclear factor.
Authors: Huang, J H, et.al. .
Journal: Molecular and cellular biology (Mol Cell Biol), Vol. 14 (7): 4475-84, 1994 .
Snippet: Our studies thus demonstrate that both C/EBP family proteins and SEF-1 are required to transactivate the SAA3 gene.
Affiliation: Department of Biochemistry and Molecular Biology, University of Texas M. D. Anderson Cancer Center, Houston 77030. .
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