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10 documents found
1: Title: IGF1R signaling drives antiestrogen resistance through PAK2/PIX activation in luminal breast cancer.
Authors: Zhang, Yinghui, .
Journal: Oncogene, 2018 .
Snippet: These include the tamoxifen resistance suppressors BMPR1B, CDK10, CDK5, EIF2AK1, and MAP2K5, and the tamoxifen resistance inducers CHEK1, PAK2, RPS6KC1, TTK, and TXK.
Affiliation: Division of Toxicology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands. Division of Toxicology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands. Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Department of Medical Oncology and Cancer Genomic Netherlands, Rotterdam, The Netherlands. Department of Pathology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands. Division of Toxicology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands. .
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2: Title: Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer.
Authors: Morton, Lindsay M, .
Journal: Journal of the National Cancer Institute (J Natl Cancer Inst), Vol. 109 (11), 2017 .
Snippet: RPS6KC1 , RAF controls = 0.0005, P = 6.68 × 10 -8 ).
Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD; Department of Epidemiology and Cancer Control, Division of Cancer Survivorship, Department of Oncology, Department of Biostatistics, Hartwell Center for Bioinformatics and Biotechnology, and Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN; Cancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD; Departments of Medicine, Pediatrics, and Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY; Section of Hematology, Oncology and Stem Cell Transplantation, Department of Pediatrics, University of Chicago, Chicago, IL; Nationwide Children's Hospital and the Ohio State University School of Medicine, Columbus, OH; Department of Pediatrics, University of Minnesota, Minneapolis, MN; Information Management Services, Inc., Calverton, MD; Cancer Prevention and Clinical Statistics Programs and Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Genetics and Department of Radiation Physics, The University of Texas at MD Anderson Cancer Center, Houston, TX; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL. .
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3: Title: Mutational profiling of kinases in glioblastoma.
Authors: Bleeker, Fonnet E, .
Journal: BMC cancer, Vol. 14, 2014 .
Snippet: Somatic mutations were found in TP53, PTEN, IDH1, PIK3CA, EGFR, BRAF, EPHA3, NRAS, TGFBR2, FLT3 and RPS6KC1.
Affiliation: Department of Oncology, University of Torino, SP 142, Km 3,95, Candiolo, Torino, 10060, Italy; Candiolo Cancer Institute - FPO, IRCCS, Candiolo, Torino, Italy. .
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4: Title: Growth inhibition by bupivacaine is associated with inactivation of ribosomal protein S6 kinase 1.
Authors: Beigh, Mushtaq Ahmad, .
Journal: BioMed research international (Biomed Res Int), Vol. 2014, 2014 .
Snippet: Although inhibition of Erk, Akt, and AMPK seemingly appears to mediate some of the bupivacaine effects, potential downstream targets that mediate its effect remain unknown.
Affiliation: Department of Biotechnology, Science Block, University of Kashmir, Srinagar J&K 190006, India. Department of Biotechnology, Science Block, University of Kashmir, Srinagar J&K 190006, India ; Department of Biotechnology and Bioinformatics, University of Kashmir, Srinagar J&K 190006, India. .
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5: Title: Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer.
Authors: Liang, Han, .
Journal: Genome research (Genome Res), Vol. 22 (11): 2120-9, 2012 .
Snippet: Our results revealed 12 potential driver cancer genes including 10 tumor-suppressor candidates (ARID1A, INHBA, KMO, TTLL5, GRM8, IGFBP3, AKTIP, PHKA2, TRPS1, and WNT11) and two oncogene candidates (ERBB3 and RPS6KC1).
Affiliation: Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. .
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6: Title: Second basic pockets contribute to the localization of PX domains by binding to phosphatidic acid.
Authors: Takeuchi, Hiroshi, .
Journal: Advances in biological regulation (Adv Biol Regul), Vol. 52 (1): 183-94, 2012 .
No Abstract available.
Affiliation: Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science and Station for Collaborative Research, Kyushu University, Fukuoka 812-8582, Japan. .
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7: Title: RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains.
Authors: Liu, Lingling, .
Journal: Molecules and cells (Mol Cells), Vol. 19 (1): 39-45, 2005 .
Snippet: Deletion studies showed that RPK118 interacted with PRDX3 through its pseudokinase domains, and with early endosomes through its PX domain.
Affiliation: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, China. .
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8: Title: Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis.
Authors: Ishida, Seiichi, .
Journal: Biochemical pharmacology (Biochem Pharmacol), Vol. 68 (11): 2177-86, 2004 .
Snippet: Among them, we focused on two components of the PI3-kinase/Akt signal transduction pathway, phosphoinositide-3-kinase, beta-catalytic subunit and ribosomal protein S6 kinase polypeptide 1, which are related to the regulation of cell proliferation and apoptosis.
Affiliation: Division of Pharmacology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. .
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9: Title: Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein.
Authors: Hayashi, Shun, .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 277 (36): 33319-24, 2002 .
Snippet: Sphingosine kinase (SPHK) is a key enzyme catalyzing the formation of sphingosine 1 phosphate (SPP), a lipid messenger that is implicated in the regulation of a wide variety of important cellular events through intracellular as well as extracellular mechanisms.
Affiliation: Division of Biochemistry, Department of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. .
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10: Title: Cloning, characterization, and chromosome mapping of RPS6KC1, a novel putative member of the ribosome protein S6 kinase family, to chromosome 12q12-q13.1.
Authors: Zhang, H, .
Journal: Genomics, Vol. 61 (3): 314-8, 1999 .
Snippet: A catalytic domain containing the conserved residues of the Ser/Thr protein kinase, especially human ribosome protein S6 kinase (RSK), was found to be located in the C-terminal end of the deduced protein.
Affiliation: Institute of Genetics, Fudan University, Shanghai, 200433, People's Republic of China. .
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