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1: Title: Degradation of AMPK-α1 sensitizes BRAF inhibitor-resistant melanoma cells to arginine deprivation.
Authors: Li, Ying-Ying, et.al. .
Journal: Molecular oncology (Mol Oncol), Vol. 11 (12): 1806-1825, 2017 .
Snippet: High levels of RNF44 corresponding to low levels of AMPK-α1 appeared in BR xenografts and melanoma tumor samples from BR and BRAFi/MEK inhibitor (MEKi)-resistant (BMR) melanoma patients.
Affiliation: Department of Medicine, University of Miami Miller School of Medicine, FL, USA. Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, FL, USA. Division of Hematology and Oncology, Miami Veterans Affairs Healthcare System, FL, USA. Dauer Electron Microscopy Lab, Department of Biology, University of Miami, FL, USA. Department of Neurosurgery, Taipei Medical University-Wan Fang Hospital, Taiwan. Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan. Department of Surgery, University of Miami Miller School of Medicine, FL, USA. Department of Molecular Pathology, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA. Department of Laboratory Medicine, Miami Veterans Affairs Healthcare System, FL, USA. .
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