refine search
Authors
Locations
Journals
Publication Dates
Find concepts in Knowledge Base
Explore current query
documentsstatisticstop authorclipboard
6 documents found
1: Title: SOCS2 exacerbates myocardial injury induced by ischemia/reperfusion in diabetic mice and H9c2 cells through inhibiting the JAK-STAT-IGF-1 pathway.
Authors: Sheng, Mengting, et.al. .
Journal: Life sciences (Life Sci), Vol. 188, 2017 .
Snippet: KEY FINDINGS: The mRNA levels of selected DEGs, such as Angptl4, Gadd45b, Rnf122 and SOCS2, showed a high degree of correlation with the microarray data.
Affiliation: Department of Intensive Care Unit (ICU), the People's Hospital of Three Gorges University/the First People's Hospital of Yichang, Yichang 443000, China. Department of Cardiology, the People's Hospital of Three Gorges University/the First People's Hospital of Yichang, Yichang 443000, China. Institute of Cardiovascular Diseases, China Three Gorges University, Yichang 443000, China. Department of Cardiology, the First College of Clinical Medical Sciences of Three Gorges University/Central People's Hospital of Yichang, Yichang 443000, China. Department of Geriatrics, the People's Hospital of Three Gorges University/the First People's Hospital of Yichang, Yichang 443000, China. Department of B ultrasound room, the People's Hospital of Three Gorges University/the First People's Hospital of Yichang, Yichang 443000, China. Department of Inspection office, the People's Hospital of Three Gorges University/the First People's Hospital of Yichang, Yichang 443000, China. Department of Cardiology, the People's Hospital of Three Gorges University/the First People's Hospital of Yichang, Yichang 443000, China. Electronic address: lijunming@medmail.com.cn. .
Related Products: order online
2: Title: Gene-wide Association Study Reveals RNF122 Ubiquitin Ligase as a Novel Susceptibility Gene for Attention Deficit Hyperactivity Disorder.
Authors: Garcia-Martínez, Iris, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7 (1): 5407, 2017 .
Snippet: RNF122 encodes for an E3 ubiquitin ligase involved in the proteasome-mediated processing, trafficking, and degradation of proteins that acts as an essential mediator of the substrate specificity of ubiquitin ligation.
Affiliation: Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain. Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Catalonia, Spain. Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain. Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain. ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain. Genomics and Disease Group, Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), Barcelona, Spain. Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Catalonia, Spain. Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain. Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Catalonia, Spain. Institut de Recerca Sant Joan de Déu (IR-SJD), Esplugues, Catalonia, Spain. Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain. marta.ribases@vhir.org. Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Catalonia, Spain. marta.ribases@vhir.org. Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain. marta.ribases@vhir.org. .
Related Products: order online
3: Title: RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation.
Authors: Wang, Wendie, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), Vol. 113 (34): 9581-6, 2016 .
Snippet: The transmembrane domain of RNF122 associates with the caspase activation and recruitment domains (CARDs) of RIG-I; this interaction effectively triggers RING finger domain of RNF122 to deliver the Lys-48-linked ubiquitin to the Lys115 and Lys146 residues of RIG-I CARDs and promotes RIG-I degradation, resulting in a marked inhibition of RIG-I downstream signaling.
Affiliation: National Key Laboratory of Medical Molecular Biology, Department of Immunology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China; Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing 100021, China; Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing 100850, China; caoxt@immunol.org zhangjy@nic.bmi.ac.cn. National Key Laboratory of Medical Molecular Biology, Department of Immunology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China; National Key Laboratory of Medical Immunology, Institute of Immunology, Second Military Medical University, Shanghai 200433, China caoxt@immunol.org zhangjy@nic.bmi.ac.cn. .
Related Products: order online
4: Title: RNF122: a novel ubiquitin ligase associated with calcium-modulating cyclophilin ligand.
Authors: Peng, Zhi, et.al. .
Journal: BMC cell biology (Bmc Cell Biol), Vol. 11, 2010 .
Snippet: RNF122 interacts with CAML, and its E3 ubiquitin ligase activity was noted to be dependent on the RING finger domain.
Affiliation: Chinese National Human Genome Center, #3-707 North YongChang Road BDA, Beijing 100176, PR China. .
Related Products: order online
5: Title: [Cloning, expression and subcellular localization of a novel human gene-RNF122].
Authors: Wang, Li, et.al. .
Journal: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences (Beijing Da Xue Xue Bao), Vol. 38 (3): 239-43, 2006 .
Snippet: RESULTS: A novel human gene-RNF122 was cloned, which was proved to have been expressed in several normal and tumor tissues and many cell lines, and localized in ER and Golgi apparatus.
Affiliation: Department of Immunology, Peking University School of Basic Medical Science Center for Human Disease Genomics, Peking University, Beijing 100083, China. .
Related Products: order online
6: Title: Cell-based screening and validation of human novel genes associated with cell viability.
Authors: Wang, Lan, et.al. .
Journal: Journal of biomolecular screening (J Biomol Screen), Vol. 11 (4): 369-76, 2006 .
Snippet: A subsequent fluorescence-based assay revealed that 4 of the 39 genes (PIP5KL1, OLFM1, RNF122, FAM26B) were associated with cell viability.
Affiliation: Chinese National Human Genome Center, Beijing, China. .
Related Products: order online
Documents per page: 20 | 50 | 100