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3 documents found
1: Title: New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.
Authors: Zhang, Qi, .
Journal: Scientific reports (Sci Rep), Vol. 5, 2015 .
Snippet: We profiled E2 ubiquitin-conjugating enzymes that pair with Roquins and found that RC3H1 and RC3H2 interact with two sets of overlapping but not identical E2 enzymes to drive the assembly of polyubiquitin chains of different linkages.
Affiliation: Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada. Small-Angle X-ray Scattering Core Facility, Center for Cancer Research of the National Cancer Institute, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA. Protein-Nucleic Acid Interaction Section, Structural Biophysics Laboratory, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA. Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5G 1L7, Canada. .
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2: Title: Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses.
Authors: Maruyama, Takeshi, .
Journal: Science signaling (Sci Signal), Vol. 7 (309): ra8, 2014 .
Snippet: Using a functional siRNA (small interfering RNA) screen in HeLa cells, we identified Roquin-2 (also called RC3H2) as an E3 ubiquitin ligase required for ROS-induced ubiquitination and degradation of ASK1.
Affiliation: 1Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. .
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3: Title: Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation.
Authors: Pratama, Alvin, .
Journal: Immunity, Vol. 38 (4): 669-80, 2013 .
Snippet: Here we have analyzed mice with mutations that eliminate the RING domain from Roquin-1 or its paralog, Roquin-2 (Rc3h2).
Affiliation: Department of Pathogens and Immunity, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia. .
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