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12 documents found
1: Title: Ankyrin-B is a PI3P effector that promotes polarized α5β1-integrin recycling via recruiting RabGAP1L to early endosomes.
Authors: Qu, Fangfei, et.al. .
Journal: eLife, Vol. 5, 2016 .
Snippet: We demonstrate that AnkB binds to Rab GTPase Activating Protein 1-Like (RabGAP1L) and recruits it to PI3P-positive organelles, where RabGAP1L inactivates Rab22A, and promotes polarized trafficking to the leading edge of migrating fibroblasts.
Affiliation: Department of Biochemistry, Duke University Medical Center, Durham, United States. Department of Cell Biology, Duke University Medical Center, Durham, United States. Department of Neurobiology, Duke University Medical Center, Durham, United States. Howard Hughes Medical Institute, Duke University Medical Center, Durham, United States. UNC Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Durham, United States. Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, United States. .
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2: Title: Human carcinoma-associated mesenchymal stem cells promote ovarian cancer chemotherapy resistance via a BMP4/HH signaling loop.
Authors: Coffman, Lan G, et.al. .
Journal: Oncotarget, Vol. 7 (6): 6916-32, 2016 .
Snippet: We previously characterized human ovarian carcinoma-associated mesenchymal stem cells (CA-MSCs).
Affiliation: Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Michigan Medical Center, Ann Arbor, Michigan, USA. Department of Cell and Developmental Biology, University of Michigan Medical Center, Ann Arbor, Michigan, USA. Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA. .
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3: Title: A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity.
Authors: Yao, Yuwei, et.al. .
Journal: eLife, Vol. 4, 2015 .
Snippet: Gpr52 is located within an intron of Rabgap1l, which exhibits epistatic effects on Gpr52-mediated modulation of Htt levels by inhibiting its substrate Rab39B, which co-localizes with Htt and translocates Htt to the endoplasmic reticulum.
Affiliation: State Key Laboratory of Genetic Engineering, Department of Biophysics, School of Life Sciences, Fudan University, Shanghai, China. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States. MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Boston, United States. Developmental Molecular Pathways, Novartis Institutes for Biomedical Research, Cambridge, United States. Department of Neurology and Research Center of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. Department of Anatomy, Histology and Embryology, Shanghai Medical College, Fudan University, Shanghai, China. .
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4: Title: High-resolution 400K oligonucleotide array comparative genomic hybridization analysis of neurofibromatosis type 1-associated cutaneous neurofibromas.
Authors: Asai, Akiko, et.al. .
Journal: Gene, Vol. 558 (2): 220-6, 2015 .
Snippet: Amongst the 6 tumor-related candidate genes (RABGAP1L, ADCY1, SLIT2, GRLF1, UST, and ARC) identified in the regions of recurrent chromosomal imbalances, the gene expression changes of UST (down-regulation) and ARC (up-regulation) were found to be significantly associated with copy number alterations.
Affiliation: Department of Biochemistry, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan; Department of Plastic & Reconstructive Surgery, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan. Department of Biochemistry, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan. Department of Biochemistry, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan. Electronic address: aota@aichi-med-u.ac.jp. Department of Biochemistry, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan; Department of Internal Medicine Division of Hematology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan. Department of Plastic & Reconstructive Surgery, Daiyukai Daiichi Hospital, Ichinomiya, Aichi, Japan. Department of Plastic & Reconstructive Surgery, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan. .
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5: Title: New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing.
Authors: Ross, Jeffrey S, et.al. .
Journal: The oncologist (Oncologist), Vol. 19 (3): 235-42, 2014 .
Snippet: Four (14%) of the ICC cases featured novel gene fusions involving the tyrosine kinases FGFR2 and NTRK1 (FGFR2-KIAA1598, FGFR2-BICC1, FGFR2-TACC3, and RABGAP1L-NTRK1).
Affiliation: Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York, USA; Foundation Medicine, Inc., Cambridge, Massachusetts, USA; University of Chicago, Chicago, Illinois, USA; The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA. .
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6: Title: Deletion variants of RABGAP1L, 10q21.3, and C4 are associated with the risk of systemic lupus erythematosus in Korean women.
Authors: Kim, Ji-Hong, et.al. .
Journal: Arthritis and rheumatism (Arthritis Rheum), Vol. 65 (4): 1055-63, 2013 .
Snippet: In the independent replication, the CNV regions in 1q25.1 (RABGAP1L) and 10q21.3 were successfully replicated (odds ratio [OR] 1.30, P=0.038 and OR 1.90, P=3.6×10(-5), respectively), and the associations were confirmed again by deletion-typing PCR.
Affiliation: Catholic University of Korea, and Department of Rheumatology, Hanyang University Hospital of Rheumatic Diseases, Haengdang-dong, Seongdong-gu, Seoul, Republic of Korea. .
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7: Title: Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.
Authors: Oguri, Mitsutoshi, et.al. .
Journal: American journal of hypertension (Am J Hypertens), Vol. 23 (1): 70-7, 2010 .
Snippet: RESULTS: The chi(2)-test revealed that 10 polymorphisms were significantly (P < 0.05) related to the prevalence of hypertension in subject panel A. To validate the relations, these polymorphisms were examined in subject panel B. The A-->G polymorphism (rs645106) of SDK1 and the C-->G polymorphism (rs12078839) of RABGAP1L were significantly associated with hypertension in subject panel B. Multivariable logistic regression analysis with adjustment for covariates, as well as a stepwise forward selection procedure revealed that the A-->G polymorphism of SDK1 was significantly associated with hypertension in both subject panels A and B, with the G allele protecting against this condition.
Affiliation: Department of Cardiology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan. .
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8: Title: RABGAP1L gene rearrangement resulting from a der(Y)t(Y;1)(q12;q25) in acute myeloid leukemia arising in a child with Klinefelter syndrome.
Journal: Virchows Archiv : an international journal of pathology (Virchows Arch), Vol. 454 (3): 311-6, 2009 .
Snippet: Fluorescence in situ hybridization showed that the breakpoint at 1q25 disrupted RABGAP1L, a strongly expressed gene in CFU-GEMM, erythroid cells, and megakaryocytes, while the Yq12 breakpoint fell within the heterochromatic region.
Affiliation: Cytogenetics and Molecular Genetics, Bambino Gesù Children's Hospital, Piazza S. Onofrio 4, 00165, Rome, Italy. .
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9: Title: Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4.MLL fusion allele.
Authors: Kowarz, E, et.al. .
Journal: Leukemia, Vol. 21 (6): 1232-8, 2007 .
Snippet: Reciprocal MLL fusions with novel translocation partner genes, for example NF-KB1 and RABGAP1L, were identified and actively transcribed in leukemic cells.
Affiliation: Institute of Pharmaceutical Biology, ZAFES, DCAL, JWG-University Frankfurt, Biocenter, Frankfurt, Main, Germany. .
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10: Title: Decreased platelet expression of myosin regulatory light chain polypeptide (MYL9) and other genes with platelet dysfunction and CBFA2/RUNX1 mutation: insights from platelet expression profiling.
Authors: Sun, L, et.al. .
Journal: Journal of thrombosis and haemostasis : JTH (J Thromb Haemost), Vol. 5 (1): 146-54, 2007 .
Snippet: Genes downregulated > or = 5-fold include those involving calcium binding proteins (CABP5), ion transport (sodium/potassium/Ca exchanger, SLC24A3), cytoskeletal/microtubule proteins (erythrocyte membrane protein band 4.1-like 3, EPB41L3; tropomyosin 1, TPM1; tubulin, alpha 1, TUBA1), signaling proteins (RAB GTPase activating protein 1-like, RABGAP1L; beta3-endonexin, ITGB3 BP) and chemokines (platelet factor 4 variant 1, PF4V1; chemokine CXCL5, CXCL5).
Affiliation: Sol Sherry Thrombosis Research Center and Division of Hematology, Temple University School of Medicine, Philadelphia, PA 19140, USA. .
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11: Title: Reduced KIAA0471 mRNA expression in Alzheimer's patients: a new candidate gene product linked to the disease?
Authors: de Yebra, Lluïsa, et.al. .
Journal: Human molecular genetics (Hum Mol Genet), Vol. 13 (21): 2607-12, 2004 .
Snippet: After studying medial septum and hippocampus brain areas, we found an inhibition of the KIAA0471 gene expression in three out of six AD patients, including one with a presenilin 1 gene mutation.
Affiliation: Unitat de Bioquímica, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Facultat de Medicina, Universitat de Barcelona, C/Casanova 143, 08036 Barcelona, Spain. lluisadeyebra@ub.edu .
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12: Title: Gene trapping of two novel genes, Hzf and Hhl, expressed in hematopoietic cells.
Authors: Hidaka, M, et.al. .
Journal: Mechanisms of development (Mech Develop), Vol. 90 (1): 3-15, 2000 .
Snippet: Embryonic stem (ES) cells containing a gene trap vector insertion were cultured on OP9 stromal cells to induce hematopoietic differentiation and screened for lacZ reporter gene expression.
Affiliation: Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Canada. .
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