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31 documents found
1: Title: Whole-genome DNA methylation characteristics in pediatric precursor B cell acute lymphoblastic leukemia (BCP ALL).
Authors: Chaber, Radosław, et.al. .
Journal: PloS one, Vol. 12 (11): e0187422, 2017 .
Snippet: Amongst these, one was located within the gene body of the MBP gene and another was within the promoter region- PSMF1 gene.
Affiliation: Institute of Nursing and Health Sciences, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland. National Research Institute of Animal Production, Laboratory of Genomics, Balice, Poland. Department of Paediatric Bone Marrow Transplantation, Oncology and Hematology, Medical University of Wroclaw, Wroclaw, Poland. Department of Clinical Genetics, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Bydgoszcz, Nicolaus Copernicus University in Torun, Torun, Poland. Department of Pediatric, Hematology, Oncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin, Poland. Department of Hematology, Medical University, Wroclaw, Poland. Institute of Informatics, University of Warsaw, Warsaw, Poland. Centre for Innovative Research in Medical and Natural Sciences, Laboratory of Molecular Biology, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland. School of Chemistry, University of Bristol, Bristol, United Kingdom. Department of Genetics, Institution of Experimental and Clinical Medicine, University of Rzeszow, Rzeszow, Poland. .
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2: Title: Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage.
Authors: An, Hongli, et.al. .
Journal: Molecular and cellular biology (Mol Cell Biol), Vol. 37 (6), 2017 .
Snippet: Moreover, we found that RAD6 promotes proteasome activity and nuclear translocation by enhancing the degradation of PSMF1 and the lamin B receptor (LBR).
Affiliation: Center for Translational Medicine at The First Affiliated Hospital, School of Forensic Sciences, School of Pharmacy, Xi'an Jiao Tong University Health Science Center, Xi'an, Shaanxi, People's Republic of China. Research Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, Shanghai, People's Republic of China. Department of Transfusion Medicine, Changhai Hospital, Second Military Medical University, Shanghai, Shanghai, People's Republic of China. People's Hospital of Zunhua, School of Life Sciences, North China University of Science and Technology, Tangshan, Hebei, People's Republic of China. Department of Obstetrics and Gynecology, Hsinchu Mackay Memorial Hospital, Hsinchu, Taiwan, Republic of China. Center for Translational Medicine at The First Affiliated Hospital, School of Forensic Sciences, School of Pharmacy, Xi'an Jiao Tong University Health Science Center, Xi'an, Shaanxi, People's Republic of China chensu@xjtu.edu.cn sfl@tongji.edu.cn. Research Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, Shanghai, People's Republic of China chensu@xjtu.edu.cn sfl@tongji.edu.cn. .
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3: Title: [Application of gene microarray to screen differential expression genes of Modic changes at vertebral endplates].
Authors: Xu, Minou, et.al. .
Journal: Zhonghua yi xue za zhi, Vol. 95 (31): 2532-6, 2015 .
Snippet: The qRT-PCR analysis of 2 up-regulated genes (CXCL14, KCNMA1) and 4 under-regulated genes (MARCKS, ZEB2, PSMF1, and CNN2) mRNA expression levels validated the results from the microarray analysis.
Affiliation: Department of Orthopaedics, Zheng Linhai Second People's Hospital, Zhejiang 317016, China. Department of Orthopaedics, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China, Email: rj_spine@163.com. .
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4: Title: MicroRNA-203 Modulates the Radiation Sensitivity of Human Malignant Glioma Cells.
Authors: Chang, Ji Hyun, et.al. .
Journal: International journal of radiation oncology, biology, physics (Int J Radiat Oncol Biol Phys), Vol. 94 (2): 412-20, 2016 .
Snippet: Western blot analysis validated the fact that miR-203 downregulated ATM, RAD51, SRC, PLD2, PI3K-AKT, JAK-STAT3, VEGF, HIF-1α, and MMP2.
Affiliation: Department of Radiation Oncology, Graduate School of Medicine, Seoul National University, Seoul, Republic of Korea. Medical Science Research Institute, Seoul National University Bundang Hospital, Kyeonggido, Republic of Korea. Department of Radiation Oncology, Graduate School of Medicine, Seoul National University, Seoul, Republic of Korea; Medical Science Research Institute, Seoul National University Bundang Hospital, Kyeonggido, Republic of Korea; Cancer Research Institute, Seoul National University, Seoul, Republic of Korea. Electronic address: inah228@snu.ac.kr. .
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5: Title: VCP and PSMF1: Antagonistic regulators of proteasome activity.
Authors: Clemen, Christoph S, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 463 (4): 1210-7, 2015 .
Snippet: We demonstrate here that the evolutionarily highly conserved type II triple-A ATPase VCP and the proteasome inhibitor PSMF1/PI31 interact directly, and antagonistically regulate proteasomal activity.
Affiliation: Institute of Biochemistry I, Medical Faculty, University of Cologne, 50931 Cologne, Germany. Electronic address: christoph.clemen@uni-koeln.de. Institute of Biochemistry I, Medical Faculty, University of Cologne, 50931 Cologne, Germany. Functional Proteomics, SFB815 Core Unit, Medical Faculty, Goethe University, 60590 Frankfurt, Germany. Molecular Cardiology, Department of Internal Medicine II, University Hospital Ulm, 89081 Ulm, Germany. Institute of Neuropathology, University Hospital Erlangen, 91054 Erlangen, Germany. Department of Neurology, University Hospital Erlangen, 91054 Erlangen, Germany. Institute of Genetics, University of Cologne, 50674 Cologne, Germany. Institute of Biochemistry II, Medical Faculty, and Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany. Structural Chemistry Program, Eskitis Institute, Griffith University, Queensland 4111, Australia; Faculty of Veterinary Science, The University of Melbourne, Victoria 3030, Australia. Institute of Neuropathology, University Hospital Erlangen, 91054 Erlangen, Germany. Electronic address: rolf.schroeder@uk-erlangen.de. .
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6: Title: Proteomics analysis of EV71-infected cells reveals the involvement of host protein NEDD4L in EV71 replication.
Authors: Kuo, Rei-Lin, et.al. .
Journal: Journal of proteome research (J Proteome Res), Vol. 14 (4): 1818-30, 2015 .
Snippet: We found that the depletion of NEDD4L significantly reduced the replication of EV71, whereas PSMF1 knockdown enhanced EV71 replication.
Affiliation: †Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan 333, Taiwan. ‡Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Tao-Yuan 333, Taiwan. §Department of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan 333, Taiwan. ∥Molecular Medicine Research Center, Chang Gung University, Tao-Yuan 333, Taiwan. ⊥Clinical Virology Laboratory, Linkou Chang Gung Memorial Hospital, Tao-Yuan 333, Taiwan. .
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7: Title: The FP domains of PI31 and Fbxo7 have the same protein fold but very different modes of protein-protein interaction.
Authors: Shang, Jinsai, et.al. .
Journal: Journal of biomolecular structure & dynamics (J Biomol Struct Dyn), Vol. 33 (7): 1528-38, 2015 .
Snippet: The PI31 FP domain may also interact with the F-box motif in Fbxo7.
Affiliation: a Department of Chemistry and Biochemistry , Southern Illinois University at Carbondale , Carbondale , IL 62901 , USA. .
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8: Title: Molecular and cellular roles of PI31 (PSMF1) protein in regulation of proteasome function.
Authors: Li, Xiaohua, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 289 (25): 17392-405, 2014 .
Snippet: We investigated molecular features and cellular roles of PI31 (PSMF1) on regulation of proteasome function.
Affiliation: From the Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390. From the Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 george.demartino@utsouthwestern.edu. .
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9: Title: Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins.
Authors: Nelson, David E, et.al. .
Journal: Open biology (Open Biol), Vol. 3 (10): 130131, 2013 .
Snippet: F-box proteins (FBPs) are substrate-recruiting subunits of Skp1-cullin1-FBP (SCF)-type E3 ubiquitin ligases.
Affiliation: Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK. .
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10: Title: Fub1p, a novel protein isolated by boundary screening, binds the proteasome complex.
Authors: Hatanaka, Akira, et.al. .
Journal: Genes & genetic systems (Genes Genet Syst), Vol. 86 (5): 305-14, 2011 .
Snippet: Domain analyses of Fub1p identified a minimum functional domain in the C terminus that was essential for boundary establishment and showed a limited sequence homology to the human PSMF1, which is known to inhibit proteasome activity.
Affiliation: Department of Applied Chemistry & Biotechnology, Graduate School of Engineering, University of Fukui, Fukui, Japan. .
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11: Title: Biological effects of the plant-derived polyphenol resveratrol in human articular cartilage and chondrosarcoma cells.
Authors: Im, Hee-Jeong, et.al. .
Journal: Journal of cellular physiology (J Cell Physiol), Vol. 227 (10): 3488-97, 2012 .
Snippet: Protein-DNA interaction arrays suggest that RSV inhibits the activation of transcription factors involved in inflammation and cartilage catabolic signaling pathways, including direct downstream regulators of MAPK (e.g., AP-1, PEA3) and NFκB.
Affiliation: Department of Biochemistry, Rush University Medical Center, Chicago, IL, USA. hee-jeong_sampen@rush.edu .
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12: Title: Knockdown of secreted protein acidic and rich in cysteine (SPARC) expression diminishes radiosensitivity of glioma cells.
Authors: Liu, Haiyan, et.al. .
Journal: Cancer biotherapy & radiopharmaceuticals (Cancer Biother Radiopharm), Vol. 26 (6): 705-15, 2011 .
Snippet: One of the mechanisms for this effect may be associated with the reduced cell apoptosis responding to radiation, which may be contributed by the phosphoinositide 3-kinase/AKT pathway activation.
Affiliation: School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu Province, China. .
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13: Title: A replication study of genome-wide CNV association for hepatic biomarkers identifies nine genes associated with liver function.
Authors: Kim, Hyo-Young, et.al. .
Journal: BMB reports (Bmb Rep), Vol. 44 (9): 578-83, 2011 .
Snippet: Results showed 9 genes (CIDEB, DFFA, PSMA3, PSMC5, PSMC6, PSMD12, PSMF1, SDC4, and SIAH1) were overlapped for AST, but no overlapped genes were found for ALT.
Affiliation: Department of Agricultural Biotechnology and the Research Institute for Agriculture and Life Science, Seoul National University, Seoul 151-742, Korea. .
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14: Title: Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in NAFLD.
Authors: Xu, Dan, et.al. .
Journal: Hepato-gastroenterology (Hepato-gastroenterol), Vol. 58 (110-111): 1703-7, 2011 Sep-Oct .
Snippet: BACKGROUND/AIMS: The aim of this study was to detect the levels of leptin in serum and the expression of leptin, obesity receptor (OB-R), phosphatidylinositol 3-Kinase (p85) (PI3-K p85) and phospho-Akt-kinase (Akt) in non-alcoholic fatty liver disease (NAFLD).
Affiliation: Department of Gastroenterology, The Central Hospital of Wuhan, Wuhan, China. .
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15: Title: AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy.
Authors: Astle, M V, et.al. .
Journal: Oncogene, Vol. 31 (15): 1949-62, 2012 .
Snippet: Here we show that PI3K/AKT pathway activation in response to phosphatase and tensin homolog (PTEN) knockdown, mutant PI3K, catalytic, α polypeptide (PIK3CA) or activated AKT expression, promotes accumulation of p53 and p21, increases cell size and induces senescence-associated β-galactosidase activity.
Affiliation: Growth Control and Differentiation Program, Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. .
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16: Title: [The antagonistic effect of PI3K-gamma inhibitor AS605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats].
Authors: Song, Li-Fang, et.al. .
Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition (Sichuan Da Xue Xue Bao Yi Xue Ban), Vol. 42 (4): 471-4, 2011 .
Snippet: RESULTS: Compared with the control group, the HW/BW of ISO group was increased significantly (P < 0.05) with a increased collagen inter cardiac muscle cells (P < 0. 05).
Affiliation: State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. .
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17: Title: Marsdenia tenacissima extract restored gefitinib sensitivity in resistant non-small cell lung cancer cells.
Authors: Han, Shu-Yan, et.al. .
Journal: Lung cancer (Amsterdam, Netherlands) (Lung Cancer), Vol. 75 (1): 30-7, 2012 .
Snippet: The M→M+G treatment significantly reduced the phosphorylation of EGFR downstream signaling molecules PI3K/Akt/mTOR and ERK, on which MTE and gefitinib alone had no obvious effects on the resistant cells.
Affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Integration of Chinese and Western Medicine, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing 100142, PR China. .
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18: Title: Advanced or metastatic pancreatic cancer: molecular targeted therapies.
Authors: Bayraktar, Soley, et.al. .
Journal: The Mount Sinai journal of medicine, New York (Mt Sinai J Med), Vol. 77 (6): 606-19, 2010 Nov-Dec .
Snippet: Although laboratory results of targeted therapies have been impressive, until now only erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, has demonstrated marginal survival benefit in combination with gemcitabine in phase III clinical trials.
Affiliation: Sylvester Comprehensive Cancer Center, Division of Hematology/Oncology, University of Miami, Miami, FL, USA. .
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19: Title: Proteomic analysis of testis biopsies in men treated with injectable testosterone undecanoate alone or in combination with oral levonorgestrel as potential male contraceptive.
Authors: Cui, Yugui, et.al. .
Journal: Journal of proteome research (J Proteome Res), Vol. 7 (9): 3984-93, 2008 .
Snippet: TU treatment changed the expression of heterogeneous nuclear ribonucleoprotein K (hnRNP K), proteasome inhibitor PI31 subunit (PSMF1), and superoxide dismutase [Mn] mitochondrial precursor (SOD2).
Affiliation: Laboratory of Reproductive Medicine, Department of Histology and Embryology, and Center of Clinical Reproductive Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China. .
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20: Title: Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor.
Authors: Kirk, Rebecca, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 283 (32): 22325-35, 2008 .
Snippet: F-box proteins are the substrate-recognition components of the Skp1-Cul1-F box protein (SCF) E3 ubiquitin ligases.
Affiliation: Structural Biology Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom. .
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