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19 documents found
1: Title: Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth.
Authors: Loveday, Chey, et.al. .
Journal: Human molecular genetics (Hum Mol Genet), 2019 .
No Abstract available.
Affiliation: Division of Genetics and Epidemiology. Medical Genetics Unit, St George's University of London, London, UK. Cancer Genetics Unit, Royal Marsden Hospital, London, UK. Cancer Research UK Cancer Therapeutics Unit and Division of Structural Biology, Institute of Cancer Research, London, UK. Department of Clinical Genetics, Churchill Hospital, Oxford, UK. Institute of Genetic Medicine, International Centre for Life, Newcastle University, Newcastle upon Tyne, UK. West of Scotland Genetic Services, Southern General Hospital, Scotland, UK. Yorkshire Regional Clinical Genetics Service, Chapel Allerton Hospital, Leeds, UK. Genetic Health Service New Zealand, Wellington Hospital, Wellington, NZ. .
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2: Title: Evidence of distinct RELN and TGFB1 genetic associations in familial and non-familial otosclerosis in a British population.
Authors: Mowat, Andrew J, et.al. .
Journal: Human genetics (Hum Genet), 2018 .
Snippet: Other genes in which an association has been reported include BMP2, COL1A1, FGF2, PPP2R5B and TGFB1.
Affiliation: UCL Ear Institute, University College London, London, WC1X 8EE, UK. Department of ENT Surgery, The Princess Margaret Hospital, Windsor, SL4 3SJ, UK. Royal National Throat Nose and Ear Hospital, London, WC1X 8EE, UK. UCL Ear Institute, University College London, London, WC1X 8EE, UK. sally.dawson@ucl.ac.uk. .
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3: Title: MicroRNA-320a Strengthens Intestinal Barrier Function and Follows the Course of Experimental Colitis.
Authors: Cordes, Friederike, et.al. .
Journal: Inflammatory bowel diseases (Inflamm Bowel Dis), Vol. 22 (10): 2341-55, 2016 .
Snippet: RESULTS: MiR-320a transfection of T84 cells reinforced barrier integrity reflected by increased transepithelial resistance (P < 0.01) and inhibited barrier-destructive enteropathogenic Escherichia coli effects resulting in increased tight junction protein JAM-A expression (P = 0.02) and decrease of barrier integrity-destabilizing miR-320a target PPP2R5B (P < 0.001).
Affiliation: *Department of Medicine B, University Hospital Münster, Münster, Germany; †Institute of Palliative Care, University Hospital Münster, Münster, Germany; ‡Center for Molecular Biology of Inflammation, Institute of Infectiology, University of Münster, Münster, Germany; and §Department of Medicine (Gastroenterology, Infectious Diseases, Rheumatology), Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Berlin, Germany. .
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4: Title: Therapeutic relevance of the protein phosphatase 2A in cancer.
Authors: Cunningham, Chelsea E, et.al. .
Journal: Oncotarget, Vol. 7 (38): 61544-61561, 2016 .
Snippet: Interestingly, most mitotic regulators, including PLK1, exhibited SDL interactions with only one class of PP2A subunits (PPP2R1A, PPP2R2D, PPP2R3B, PPP2R5B and PPP2R5D).
Affiliation: Department of Pathology, Cancer Cluster, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E5 Canada. Center for Bioinformatics and Computational Biology, Department of Computer Science, University of Maryland, Maryland, MD 20742, USA. College of Pharmacy, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 2Z4, Canada. Cell Signaling Laboratory, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E5 Canada. Cancer Research, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, S7N 5E5, Canada. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Department of Cell and Regenerative Biology and Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI 53705-2275, USA. VIB Center for the Biology of Disease, VIB, 3000 Leuven, Belgium. .
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5: Title: Protein phosphatase 2A regulatory subunit B56β modulates erythroid differentiation.
Authors: Wu, Jianping, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 478 (3): 1179-84, 2016 .
Snippet: We previously demonstrated that catalytic subunit α of protein phosphatase 2A (PP2Acα) modulates fetal liver erythropoiesis.
Affiliation: Orthopedic Department of the Second Affiliated Hospital of Soochow University, Suzhou 215000, China. Emergency Department of the First Affiliated Hospital of Soochow University, Suzhou 215006, China. Department of Cardiology of the First Affiliated Hospital, Soochow University, Suzhou 215006, China. Institute for Cardiovascular Science & Department of Cardiovascular Surgery of the First Affiliated Hospital, Soochow University, Suzhou 215006, China. Jiangsu Province Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agriculture University, Nanjing 210000, China. Electronic address: huangzan@njau.edu.cn. Institute for Cardiovascular Science & Department of Cardiovascular Surgery of the First Affiliated Hospital, Soochow University, Suzhou 215006, China. Electronic address: chenweiqian@suda.edu.cn. Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou 215006, China. Electronic address: uuzyshen@126.com. .
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6: Title: PPP2R5B, a regulatory subunit of PP2A, contributes to adipocyte insulin resistance.
Authors: Beg, Muheeb, et.al. .
Journal: Molecular and cellular endocrinology (Mol Cell Endocrinol), Vol. 437, 2016 .
Snippet: Thus, we conclude that PPP2R5B, a B subunit of PP2A is a negative regulator of Akt phosphorylation contributing partly to the chronic hyperinsulinemia induced insulin resistance in adipocytes.
Affiliation: Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, 226031, India. Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, 226031, India; Academy of Scientific and Innovative Research, CSIR-CDRI, India. Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, 226031, India; Academy of Scientific and Innovative Research, CSIR-CDRI, India. Electronic address: anil_gaikwad@cdri.res.in. .
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7: Title: Deletion of 11q12.3-11q13.1 in a patient with intellectual disability and childhood facial features resembling Cornelia de Lange syndrome.
Authors: Boyle, Martine Isabel, et.al. .
Journal: Gene, Vol. 572 (1): 130-4, 2015 .
Snippet: The deletion contains several genes including PPP2R5B, which has been associated with intellectual disability and overgrowth; NRXN2, which has been associated with intellectual disability and autism spectrum disorder; and CDCA5, which is part of the cohesin pathway, as are all the five known CdLS genes.
Affiliation: Applied Human Molecular Genetics, Kennedy Center, Department of Clinical Genetics, University of Copenhagen, Rigshospitalet, Glostrup, Denmark. Applied Human Molecular Genetics, Kennedy Center, Department of Clinical Genetics, University of Copenhagen, Rigshospitalet, Glostrup, Denmark. Electronic address: Zeynep.tumer@regionh.dk. .
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8: Title: Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth.
Authors: Loveday, Chey, et.al. .
Journal: Human molecular genetics (Hum Mol Genet), Vol. 24 (17): 4775-9, 2015 .
Snippet: Prioritisation of functionally relevant genes with multiple unique de novo mutations revealed four mutations in protein phosphatase 2A (PP2A) regulatory subunit B family genes protein phosphatase 2, regulatory Subunit B', beta (PPP2R5B); protein phosphatase 2, regulatory Subunit B', gamma (PPP2R5C); and protein phosphatase 2, regulatory Subunit B', delta (PPP2R5D).
Affiliation: Division of Genetics and Epidemiology. Division of Genetics and Epidemiology, Medical Genetics Unit, St George's University of London, London, UK, Cancer Genetics Unit, Royal Marsden Hospital, London, UK. Cancer Research UK Cancer Therapeutics Unit and Division of Structural Biology, Institute of Cancer Research, London, UK. Department of Clinical Genetics, Churchill Hospital, Oxford, UK. Institute of Genetic Medicine, International Centre for Life, Newcastle University, Newcastle upon Tyne, UK. West of Scotland Genetic Services, Southern General Hospital, Scotland, UK, Yorkshire Regional Clinical Genetics Service, Chapel Allerton Hospital, Leeds, UK and. Genetic Health Service New Zealand, Wellington Hospital, Wellington, NZ. Division of Genetics and Epidemiology, Cancer Genetics Unit, Royal Marsden Hospital, London, UK, rahmanlab@icr.ac.uk. .
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9: Title: A de novo 0.57 Mb microdeletion in chromosome 11q13.1 in a patient with speech problems, autistic traits, dysmorphic features and multiple endocrine neoplasia type 1.
Authors: Mohrmann, Inga, et.al. .
Journal: European journal of medical genetics (Eur J Med Genet), Vol. 54 (4): e461-4, 2011 Jul-Aug .
Snippet: The neurodevelopmental phenotype of the patient might be associated with the deletion of the genes NRXN2 and PPP2R5B which have been described to be involved in synaptogenesis and dendritic branching.
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10: Title: Clk2 and B56β mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt.
Authors: Rodgers, Joseph T, et.al. .
Journal: Molecular cell (Mol Cell), Vol. 41 (4): 471-9, 2011 .
Snippet: Clk2 phosphorylates the PP2A regulatory subunit B56β (PPP2R5B, B'β), which is a critical regulatory step in the assembly of the PP2A holoenzyme complex on Akt leading to dephosphorylation of both S473 and T308 Akt sites.
Affiliation: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. .
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11: Title: Differentially expressed genes strongly correlated with femur strength in rats.
Authors: Alam, Imranul, et.al. .
Journal: Genomics, Vol. 94 (4): 257-62, 2009 .
Snippet: Of these, 12 candidate genes were prioritized for further validation, and 8 of these genes (Ifit3, Ppp2r5b, Irf7, Mpeg1, Bloc1s2, Pycard, Sec23ip, and Hps6) were confirmed by quantitative PCR (qPCR).
Affiliation: Department of Biomedical Engineering, Indiana University Purdue University Indianapolis (IUPUI), Indianapolis, IN 46202-5251, USA. .
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12: Title: Internal controls for quantitative polymerase chain reaction of swine mammary glands during pregnancy and lactation.
Authors: Tramontana, S, et.al. .
Journal: Journal of dairy science (J Dairy Sci), Vol. 91 (8): 3057-66, 2008 .
Snippet: Initial analysis revealed TBK1, PCSK2, PTBP1, API5, VAPB, QTRT1, TRIM41, TMEM24, PPP2R5B, and AP1S1 as the most stable genes (sample/reference = 1 +/- 0.2).
Affiliation: Istituto di Zootecnica, Università Cattolica del Sacro Cuore, 29100 Piacenza, Italy. .
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13: Title: B56beta, a regulatory subunit of protein phosphatase 2A, interacts with CALEB/NGC and inhibits CALEB/NGC-mediated dendritic branching.
Authors: Brandt, Nicola, et.al. .
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology (Faseb J), Vol. 22 (7): 2521-33, 2008 .
Snippet: Using affinity chromatography and mass spectrometry, we demonstrate that the whole protein phosphatase 2A trimer, including structural and catalytic subunits, binds to CALEB/NGC via B56beta.
Affiliation: Institute of Cell Biology and Neurobiology, Center for Anatomy, Charité-Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany. .
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14: Title: Mutation analysis of five candidate genes in familial breast cancer.
Authors: Marsh, Anna, et.al. .
Journal: Breast cancer research and treatment (Breast Cancer Res Tr), Vol. 105 (3): 377-89, 2007 .
Snippet: PPP2R1B and PPP2R5B code for subunits of protein phosphatase 2A (PP2A), which regulates autophosphorylation of ATM.
Affiliation: Cancer and Cell Biology, Queensland Institute of Medical Research, c/o RBH Post Office, Herston, Brisbane, QLD , 4029 , Australia. .
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15: Title: The glycine 90 to aspartate alteration in the Abeta subunit of PP2A (PPP2R1B) associates with breast cancer and causes a deficit in protein function.
Authors: Esplin, Edward D, et.al. .
Journal: Genes, chromosomes & cancer (Gene Chromosome Canc), Vol. 45 (2): 182-90, 2006 .
Snippet: The wild-type Abeta subunit interacted with the B56gamma (PPP2R5C), PR72 (PPP2R3A), and PR48 subunits of PP2A but did not interact with the B55alpha (PPP2R2A), B56alpha (PPP2R5A), or B56beta (PPP2R5B) regulatory subunits in an in vitro binding assay.
Affiliation: Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, 75390-9041, USA. edward.esplin@alumni.southwestern.edu .
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16: Title: Unfolding-resistant translocase targeting: a novel mechanism for outer mitochondrial membrane localization exemplified by the Bbeta2 regulatory subunit of protein phosphatase 2A.
Authors: Dagda, Ruben K, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 280 (29): 27375-82, 2005 .
Snippet: The Bbeta regulatory subunit gene is mutated in spinocerebellar ataxia type 12, and one of its splice variants, Bbeta2, targets PP2A to mitochondria to promote apoptosis in PC12 cells (Dagda, R. K., Zaucha, J. A., Wadzinski, B. E., and Strack, S. (2003) J. Biol.
Affiliation: Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA. .
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17: Title: Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1).
Authors: Forbes, S A, et.al. .
Journal: Human genetics (Hum Genet), Vol. 100 (3-4): 481-5, 1997 .
Snippet: In the course of constructing a conting, we have identified the location of the gene encoding the B56 beta subunit of protein phosphatase 2A (PP2A), which is involved in cell signal transduction pathways and thus represents a candidate gene for MEN1.
Affiliation: MRC Molecular Endocrinology Group, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK. .
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18: Title: Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1.
Authors: Lemmens, I, et.al. .
Journal: Genomics, Vol. 44 (1): 94-100, 1997 .
Snippet: The precise locations for 19 genes and three ESTs within this contig have been determined, and three gene clusters consisting of a centromeric group (VRF, FKBP2, PNG, and PLCB3), a middle group (PYGM, ZFM1, SCG1, SCG2 (which proved to be the MEN1 gene), and PPP2R5B), and a telomeric group (H4B, ANG3, ANG2, ANG1, FON, FAU, NOF, NON, and D11S2196E) were observed.
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19: Title: Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1.
Authors: Lemmens, I, et.al. .
Journal: Human molecular genetics (Hum Mol Genet), Vol. 6 (7): 1177-83, 1997 .
Snippet: Two candidate genes, ZFM1 and PPP2R5B, from this region have been previously excluded, and in order to identify additional candidate genes we used a BAC to isolate cDNAs from a bovine parathyroid cDNA library by direct selection.
Affiliation: Laboratory for Molecular Oncology and Flanders Interuniversity Institute for Biotechnology, Center for Human Genetics, KU Leuven, Belgium. .
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