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7 documents found
1: Title: Altered Expression of Human Smooth Muscle Myosin Phosphatase Targeting (MYPT) Isovariants with Pregnancy and Labor.
Authors: Lartey, Jon, et.al. .
Journal: PloS one, Vol. 11 (10): e0164352, 2016 .
Snippet: OBJECTIVES: We used cross-species genome alignment, to infer putative human sequences not available in the public domain, and isovariant-specific quantitative PCR, to analyse the expression of mRNA encoding putative LZ+ and LZ- forms of PPP1R12A, PPP1R12B and PPP1R12C as well as canonical PPP1R16A and PPP1R16B genes in human uterine smooth muscle from non-pregnant, pregnant and in-labor donors.
Affiliation: Institute of Cellular Medicine, William Leech Building, Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, United Kingdom, NE2 4HH. Institute of Genetic Medicine, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, United Kingdom, NE1 3BZ. .
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2: Title: Amplification of chromosome 8q21-qter associated with the acquired paclitaxel resistance of nasopharyngeal carcinoma cells.
Authors: Li, Wei, et.al. .
Journal: International journal of clinical and experimental pathology (Int J Clin Exp Pathol), Vol. 8 (10): 12346-56, 2015 .
Snippet: 15 genes of 762 transcripts on this chromosome region were consistently up-regulated detected by cDNA microarray in three taxol resistant sub-lines, and functionally clustered into various groups, including genes related to vascular formation vascular formation (ANGPT1), apoptosis (MYC, TOP1MT), cell adhesion and cell cycle (PPP1R16A, SDC2, CA2, ANKRD46), gene regulation (HRSP12, ZNF696, SLC39A4, POP1), metabolism (PYCRL).
Affiliation: Department of Otoalryngology-Head Neck Surgery, Third Xiangya Hospital, Central South University Changsha 410013, Hunan, China. Department of Central laboratory, Third Xiangya Hospital, Central South University Changsha 410013, Hunan, China. Department of Head and Neck Surgery, The Affiliated Cancer Hospital of Xiangya Medical School, Central South University Changsha 410013, Hunan, China. Department of Head and Neck Surgery, Peace Hospital of Changzhi Medical College Changzhi 046000, Shangxi, China. .
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3: Title: Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood.
Authors: Burkhardt, Ralph, et.al. .
Journal: PLoS genetics (Plos Genet), Vol. 11 (9): e1005510, 2015 .
Snippet: Based on an integrative analysis of expression quantitative trait loci in blood mononuclear cells and correlations between gene expressions and metabolite levels, we provide evidence for putative causative genes: SLC22A16 for total acylcarnitines, ARG1 for arginine, HLCS for 2-hydroxyisovalerylcarnitine, JAM3 for stearoylcarnitine via a trans-effect at chromosome 1, and PPP1R16A for aspartic acid traits.
Affiliation: LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig Germany; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany. LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig Germany; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany; Department for Cell Therapy, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany. LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig Germany; Heart Center Leipzig, Leipzig, Germany. LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig Germany; Institute for Laboratory Medicine, Ludwig-Maximilians University Munich, Munich, Germany. LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig Germany; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. Medical Department, Clinic for Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany. LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig Germany; Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany. Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Leipzig Germany. Medical Department, Clinic for Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany; Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Leipzig Germany. .
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4: Title: Ornithine decarboxylase antizyme Oaz3 modulates protein phosphatase activity.
Authors: Ruan, Yibing, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 286 (33): 29417-27, 2011 .
Snippet: We identified myosin phosphatase targeting subunit 3 (MYPT3), a regulator of protein phosphatase PP1β, as a major p12-interacting protein, and show that MYPT3 is present in sperm tails and that its ankyrin repeat binds p12.
Affiliation: Department of Biochemistry & Molecular Biology, University of Calgary, Calgary T2N 4N1, Canada. .
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5: Title: Molecular markers of endometrial carcinoma detected in uterine aspirates.
Authors: Colas, Eva, et.al. .
Journal: International journal of cancer. Journal international du cancer (Int J Cancer), Vol. 129 (10): 2435-44, 2011 .
Snippet: We identified ACAA1, AP1M2, CGN, DDR1, EPS8L2, FASTKD1, GMIP, IKBKE, P2RX4, P4HB, PHKG2, PPFIBP2, PPP1R16A, RASSF7, RNF183, SIRT6, TJP3, EFEMP2, SOCS2 and DCN as differentially expressed in ECs.
Affiliation: Biomedical Research Unit, Research Institute Vall d'Hebron University Hospital, Barcelona, Spain. .
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6: Title: PPP1R16A, the membrane subunit of protein phosphatase 1beta, signals nuclear translocation of the nuclear receptor constitutive active/androstane receptor.
Authors: Sueyoshi, Tatsuya, et.al. .
Journal: Molecular pharmacology (Mol Pharmacol), Vol. 73 (4): 1113-21, 2008 .
Snippet: We have now identified a membrane-associated subunit of protein phosphatase 1 (PPP1R16A, or abbreviated as R16A) as a novel CAR-binding protein.
Affiliation: Pharmacogenetics section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. sueyoshi@niehs.nih.gov .
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7: Title: Phosphorylation of myosin phosphatase targeting subunit 3 (MYPT3) and regulation of protein phosphatase 1 by protein kinase A.
Authors: Yong, Jeffery, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 281 (42): 31202-11, 2006 .
Snippet: Deletion or mutations of this motif resulted in enhancement of the associated PP1c activity, suggesting that phosphorylation of MYPT3 may play an important role in regulating PP1c catalytic activity.
Affiliation: GSK-IMCB Group, Institute of Molecular and Cell Biology, Singapore 138673, Singapore. .
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