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8 documents found
1: Title: Identification of miRNA biomarkers of pneumonia using RNA-sequencing and bioinformatics analysis.
Authors: Huang, Sai, et.al. .
Journal: Experimental and therapeutic medicine (Exp Ther Med), Vol. 13 (4): 1235-1244, 2017 .
Snippet: KALRN, Ras homolog family member A (RHOA), β-catenin (CTNNB1), RNA polymerase II subunit K (POLR2K) and amyloid precursor protein (APP) were determined to encode crucial proteins in the PPI network constructed.
Affiliation: Department of Hematology, People's Liberation Army General Hospital, Beijing 100853, P.R. China. Department of Emergency, People's Liberation Army General Hospital, Beijing 100853, P.R. China. Department of Ultrasound, People's Liberation Army General Hospital, Beijing 100853, P.R. China. .
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2: Title: The role of tumor metabolism as a driver of prostate cancer progression and lethal disease: results from a nested case-control study.
Authors: Kelly, Rachel S, et.al. .
Journal: Cancer & metabolism (Unknown Journal), Vol. 4, 2016 .
Snippet: RESULTS: Oxidative phosphorylation and pyrimidine metabolism were identified as the most dysregulated pathways in lethal tumors (p < 0.007), and within these pathways, a number of novel differentially expressed genes were identified including POLR2K and APT6V1A.
Affiliation: Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA USA ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA USA ; Channing Division of Network Medicine, 181 Longwood Avenue, Boston, MA 02115 USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA USA ; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA USA ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA USA ; Department of Epidemiology, College of Medicine and College of Public Health and Health Professions, University of Florida, Gainesville, FL USA. Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA USA ; Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden. Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA USA ; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA USA ; Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA USA. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA USA. Department of Radiation Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA USA ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA USA ; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA USA. Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA USA. Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA 02139 USA ; Dana-Farber Cancer Institute, Boston, MA USA ; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02139 USA. .
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3: Title: Chlorogenic acid prevents acetaminophen-induced liver injury: the involvement of CYP450 metabolic enzymes and some antioxidant signals.
Authors: Pang, Chun, et.al. .
Journal: Journal of Zhejiang University. Science. B (J Zhejiang Univ Sci B), Vol. 16 (7): 602-10, 2015 .
Snippet: Further, CGA increased the AP-induced decreased mRNA expression of peroxiredoxin (Prx) 1, 2, 3, 5, 6, epoxide hydrolase (Ephx) 2, and polymerase (RNA) II (DNA directed) polypeptide K (Polr2k), and nuclear factor erythroid-2-related factor 2 (Nrf2).
Affiliation: Shanghai Key Laboratory of Complex Prescription, the MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Center for Traditional Chinese Medicine and Systems Biology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Center for Drug Safety Evaluation and Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. .
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4: Title: An in-depth map of polyadenylation sites in cancer.
Authors: Lin, Yuefeng, et.al. .
Journal: Nucleic acids research (Nucleic Acids Res), Vol. 40 (17): 8460-71, 2012 .
Snippet: Candidate targets of alternative polyadenylation-mediated upregulation of short isoforms include POLR2K, and signaling cascades of cell-cell and cell-extracellular matrix contact, particularly involving regulators of Rho GTPases.
Affiliation: Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA. .
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5: Title: Tiling resolution array CGH and high density expression profiling of urothelial carcinomas delineate genomic amplicons and candidate target genes specific for advanced tumors.
Authors: Heidenblad, Markus, et.al. .
Journal: BMC medical genomics (Bmc Med Genomics), Vol. 1, 2008 .
Snippet: Amplification of the 8q22 segment was primarily associated with YWHAZ (14-3-3-zeta) and POLR2K over expression.
Affiliation: Department of Clinical Genetics, Lund University Hospital, SE-221 85 Lund, Sweden. mah@santaris.com .
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6: Title: Identification of differential expression of genes in hepatocellular carcinoma by suppression subtractive hybridization combined cDNA microarray.
Authors: Liu, Yuefang, et.al. .
Journal: Oncology reports (Oncol Rep), Vol. 18 (4): 943-51, 2007 .
Snippet: In addition to the overexpression of AFP, these genes (increased in the presence of HCC) are involved in many processes, such as transcription and protein biosynthesis (HNRPDL, PABPC1, POLR2K, SRP9, SNRPA, and six ribosomal protein genes including RPL8, RPL14, RPL41, RPS5, RPS17, RPS24), the metabolism of lipids and proteins (FADS1, ApoA-II, ApoM, FTL), cell proliferation (Syndecan-2, and Annexin A2), and signal transduction (LRRC28 and FMR1).
Affiliation: Key Laboratory of Antibody Technique of Ministry of Health, Nanjing Medical University, Nanjing 210029, PR China. .
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7: Title: An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.
Authors: Itoh, K, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Bioph Res Co), Vol. 236 (2): 313-22, 1997 .
Snippet: Nrf2 was found to bind to the ARE with high affinity only as a heterodimer with a small Maf protein, suggesting that Nrf2/small Maf activates gene expression directly through the ARE.
Affiliation: Institute of Basic Medical Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tennoudai, Japan. .
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8: Title: cDNA cloning of a mouse factor that activates transcription from a metal response element of the mouse metallothionein-I gene in yeast.
Authors: Xu, C .
Journal: DNA and cell biology (Dna Cell Biol), Vol. 12 (6): 517-25, 1993 Jul-Aug .
Snippet: The cDNA hybridizes to a 550-base mRNA that is constitutively expressed in mouse tissue culture cells.
Affiliation: Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. .
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