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16 documents found
1: Title: Combining multi-dimensional data to identify a key signature (gene and miRNA) of cisplatin-resistant gastric cancer.
Authors: Zhou, Danyang, et.al. .
Journal: Journal of cellular biochemistry (J Cell Biochem), 2018 .
Snippet: Six hub genes were identified and verified in the TCGA database, including five up-regulated genes, POLR2L, POLR2C, POLR2F, APRT, and LMAN2, and a down-regulated gene, NFKB2.
Affiliation: Department of Biochemistry and Molecular Biology, Daqing Campus, Harbin Medical University, Daqing, Heilongjiang, P. R. China. Department of Nephrology, Daqing People Hospital, Daqing, P. R. China. Daqing Oilfield General Hospital, Daqing, P. R. China. Department of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, P. R. China. .
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2: Title: POLR2C Mutations Are Associated With Primary Ovarian Insufficiency in Women.
Authors: Moriwaki, Mika, et.al. .
Journal: Journal of the Endocrine Society (J Endocr Soc), Vol. 1 (3): 162-173, 2017 .
Snippet: Results: We identified a heterozygous nonsense mutation in a subunit of RNA polymerase II (POLR2C) that synthesizes messenger RNA.
Affiliation: Division of Endocrinology, Metabolism and Diabetes. UStar Center for Genetic Discovery, Department of Human Genetics. Bioinformatics, Huntsman Cancer Institute, and. Division of Genetic Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84112. .
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3: Title: RNA-Sequencing Analyses Demonstrate the Involvement of Canonical Transient Receptor Potential Channels in Rat Tooth Germ Development.
Authors: Yang, Jun, et.al. .
Journal: Frontiers in physiology (Front Physiol), Vol. 8, 2017 .
Snippet: We found that GNAO1, ENO1, EFNB1, CALM1, SIAH2, ATP6V0A1, KDELR2, GTPBP1, POLR2C, SORT1, and members of the canonical transient receptor potential (TRPC) channel family are involved in tooth germ development.
Affiliation: Department of Stomatology, Huashan Hospital, Fudan UniversityShanghai, China. .
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4: Title: Identification of potential molecular associations between chikungunya virus non-structural protein 2 and human host proteins.
Authors: Rana, J, et.al. .
Journal: Acta virologica (Acta Virol), Vol. 61 (1): 39-47, 2017 .
Snippet: The analysis identified seven host proteins (CCDC130, CPNE6, POLR2C, MAPK9, EIF4A2, EEF1A1 and EIF3I) as putative interactors of CHIKV nsP2 which were selected for further analysis based on their roles in host cellular machinery.
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5: Title: eEF1Bγ binds the Che-1 and TP53 gene promoters and their transcripts.
Authors: Pisani, Cinzia, et.al. .
Journal: Journal of experimental & clinical cancer research : CR (J Exp Clin Cancer Res), Vol. 35 (1): 146, 2016 .
Snippet: BACKGROUND: We have previously shown that the eukaryotic elongation factor subunit 1B gamma (eEF1Bγ) interacts with the RNA polymerase II (pol II) alpha-like subunit "C" (POLR2C), alone or complexed, in the pol II enzyme.
Affiliation: CNR-Institute of Molecular Biology and Pathology, Department of Molecular Medicine, Sapienza University, Viale Regina Elena 291, 00161, Rome, Italy. cinzia.pisani@uniroma1.it. CNR-Institute of Molecular Biology and Pathology, Department of Molecular Medicine, Sapienza University, Viale Regina Elena 291, 00161, Rome, Italy. CNR -Institute of Cell Biology and Neurobiology, Rome, Italy. IRCCS Fondazione Santa Lucia, Rome, Italy. Department of Research, Advanced Diagnostic, and Technological Innovation, SAFU Laboratory, Regina Elena Cancer Institute, Rome, Italy. CNR-Institute of Molecular Biology and Pathology, Department of Molecular Medicine, Sapienza University, Viale Regina Elena 291, 00161, Rome, Italy. nicoletta.corbi@uniroma1.it. .
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6: Title: A network-based approach to identify disease-associated gene modules through integrating DNA methylation and gene expression.
Authors: Zhang, Yuanyuan, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 465 (3): 437-42, 2015 .
Snippet: Importantly, through analyzing the functions and comparing expression and methylation values of these genes between cases and controls, we find some genes, such as VASN, SNRPD3, and gene modules, targeted by POLR2C, CHMP1B and TAF9, which might be novel breast cancer-related biomarkers.
Affiliation: School of Computer Science and Technology, Xidian University, Xi'an 710071, PR China. School of Computer Science and Technology, Xidian University, Xi'an 710071, PR China. Electronic address: jyzhang@mail.xidian.edu.cn. .
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7: Title: Rpb3 promotes hepatocellular carcinoma through its N-terminus.
Authors: Fang, Zhe-Ping, et.al. .
Journal: Oncotarget, Vol. 5 (19): 9256-68, 2014 .
Snippet: In particular, N-terminus of Rpb3 blocked Rpb3 binding to Snail, inhibited Rpb3-high-expression HCC cells proliferation, migration, tumor growth in nude mice, and also inhibited DEN-induced liver tumorigenesis.
Affiliation: Department of Hepatobiliary Surgery, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai 317000, China. Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China. Institute of Cell Biology, Zhejiang University, 866 Yu-Hang-Tang Road, Hangzhou 310058, China. Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA. .
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8: Title: Identification of stably expressed reference genes for RT-qPCR data normalization in defined localizations of cyclic bovine ovaries.
Authors: Schoen, K, et.al. .
Journal: Anatomia, histologia, embryologia (Anat Histol Embryol), Vol. 44 (3): 200-11, 2015 .
Snippet: Expression profiles of twelve potential reference genes (GAPDH, ACTB, YWHAZ, HPRT1, SDHA, UBA52, POLR2C, RPS9, ACTG2, H3F3B, RPS18 and RPL19) were analysed.
Affiliation: Department of Veterinary Medicine, Institute of Veterinary Anatomy, Freie Universität Berlin, Koserstraße 20, 14195, Berlin, Germany. Department of Veterinary Medicine, Institute of Veterinary Biochemistry, Freie Universität Berlin, Oertzenweg 19b, 14163, Berlin, Germany. .
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9: Title: HSP90 and its R2TP/Prefoldin-like cochaperone are involved in the cytoplasmic assembly of RNA polymerase II.
Authors: Boulon, Séverine, et.al. .
Journal: Molecular cell (Mol Cell), Vol. 39 (6): 912-24, 2010 .
Snippet: Data indicate that RNA polymerase II is built in the cytoplasm and reveal quality-control mechanisms that link HSP90 and its cochaperone hSpagh (RPAP3) to the nuclear import of fully assembled enzymes.
Affiliation: Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee, Dundee, UK. .
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10: Title: MGMT -535G>T polymorphism is associated with prognosis for patients with metastatic colorectal cancer treated with oxaliplatin-based chemotherapy.
Authors: Park, Jee Hyun, et.al. .
Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol), Vol. 136 (8): 1135-42, 2010 .
Snippet: In a logistic regression analysis adjusted to age, sex, primary site, disease status, and regimen, the POLR2C rs4937 and MSH2 rs3732183 polymorphisms were statistically associated with the response to the oxaliplatin-based chemotherapy.
Affiliation: Department of Internal Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea. .
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11: Title: Ribonucleic acid polymerase II binding subunit 3 (Rpb3), a potential nuclear target of insulin-like growth factor binding protein-3.
Authors: Oufattole, Mohammed, et.al. .
Journal: Endocrinology, Vol. 147 (5): 2138-46, 2006 .
Snippet: We therefore identified IGFBP-3 interacting proteins by screening a rat L6 myoblast cDNA library using the yeast two-hybrid assay and two N-terminal deletion mutants as bait: BP3/231 (231 residues, L61 to K291) and BP3/111 (K181-K291).
Affiliation: Department of Animal Sciences, Washington State University, Pullman, 99164-6351, USA. .
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12: Title: RNA polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR, the psoriasis vulgaris candidate gene product.
Authors: Corbi, Nicoletta, et.al. .
Journal: Journal of cell science (J Cell Sci), Vol. 118 (Pt 18): 4253-60, 2005 .
Snippet: We have recently demonstrated that the expression of RPB3 is regulated during muscle differentiation and that, inside RNA polymerase II (RNAP II), it is directly involved in contacting regulatory proteins such as the myogenic transcription factor Myogenin and activating transcription factor ATF4.
Affiliation: Istituto di Biologia e Patologia Molecolari CNR, Universita' di Roma La Sapienza, P. le A. Moro, 5, 00185 Roma, Italy. .
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13: Title: Distinct regions of RPB11 are required for heterodimerization with RPB3 in human and yeast RNA polymerase II.
Authors: Benga, Wagane J, et.al. .
Journal: Nucleic acids research (Nucleic Acids Res), Vol. 33 (11): 3582-90, 2005 .
Snippet: In Saccharomyces cerevisiae, RNA polymerase II assembly is probably initiated by the formation of the RPB3-RPB11 heterodimer.
Affiliation: Unité Mixte de Recherche 7100 CNRS-Université Louis Pasteur, Ecole Supérieure de Biotechnologie de Strasbourg Boulevard Sébastien Brandt, BP 10413, 67412 Illkirch Cedex, France. .
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14: Title: The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin.
Authors: Corbi, Nicoletta, et.al. .
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology (Faseb J), Vol. 16 (12): 1639-41, 2002 .
Snippet: RNA polymerase II core subunit 3 (RPB3) is an a-like core subunit of RNA polymerase II (pol II).
Affiliation: Istituto di Tecnologie Biomediche, CNR, 00137 Rome, Italy. .
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15: Title: Archaeal RNA polymerase subunits F and P are bona fide homologs of eukaryotic RPB4 and RPB12.
Authors: Werner, F, et.al. .
Journal: Nucleic acids research (Nucleic Acids Res), Vol. 28 (21): 4299-305, 2000 .
Snippet: The F and P subunits present in archaeal RNA polymerases were only recently identified in a purified archaeal RNA polymerase preparation and, on the basis of localized sequence homologies, tentatively identified as archaeal versions of the eukaryotic RPB4 and RPB12 RNA polymerase subunits, respectively.
Affiliation: Department of Biochemistry, Imperial College of Science, Technology and Medicine, Exhibition Road, London SW7 2AY, UK. .
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16: Title: The interacting RNA polymerase II subunits, hRPB11 and hRPB3, are coordinately expressed in adult human tissues and down-regulated by doxorubicin.
Authors: Fanciulli, M, et.al. .
Journal: FEBS letters (Febs Lett), Vol. 427 (2): 236-40, 1998 .
Snippet: Using hRPB11 as bait in a yeast two-hybrid system, two cDNA variants encoding a second RNA polymerase II subunit, hRPB3, have now been isolated and characterized.
Affiliation: Cell Metabolism and Pharmacokinetics Laboratory, Regina Elena Cancer Institute, Rome, Italy. fanciulli@crs.ifo.it .
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