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13 documents found
1: Title: The lncRNA Plscr4 Controls Cardiac Hypertrophy by Regulating miR-214.
Authors: Lv, Lifang, et.al. .
Journal: Molecular therapy. Nucleic acids (Mol Ther Nucleic Acids), Vol. 10, 2018 .
Snippet: Finally, we demonstrated that Plscr4 acted as an endogenous sponge of miR-214 and forced expression of Plscr4 downregulated miR-214 expression to promote Mfn2 and attenuate hypertrophy.
Affiliation: Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang 150081, China. Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang 150081, China; Northern Translational Medicine Research and Cooperation Center, Heilongjiang Academy of Medical Sciences, Harbin Medical University, Harbin, Heilongjiang 150081, China. Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang 150081, China; Northern Translational Medicine Research and Cooperation Center, Heilongjiang Academy of Medical Sciences, Harbin Medical University, Harbin, Heilongjiang 150081, China. Electronic address: shanhongli@ems.hrbmu.edu.cn. Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang 150081, China; Northern Translational Medicine Research and Cooperation Center, Heilongjiang Academy of Medical Sciences, Harbin Medical University, Harbin, Heilongjiang 150081, China. Electronic address: lianghaihai@ems.hrbmu.edu.cn. .
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2: Title: Snail represses the expression of human phospholipid scramblase 4 gene.
Journal: Gene, Vol. 591 (2): 433-41, 2016 .
Snippet: Luciferase assays depicted a dose dependent decrease in hPLSCR4 promoter activity with an increase in amount of Snail.
Affiliation: Applied and Industrial Microbiology Lab, Bhupat and Jyoti Mehta School of Biosciences, Department of Biotechnology, IIT Madras, Chennai 600036, India. Electronic address: manojabiocrat@gmail.com. Applied and Industrial Microbiology Lab, Bhupat and Jyoti Mehta School of Biosciences, Department of Biotechnology, IIT Madras, Chennai 600036, India. Electronic address: gummadi@iitm.ac.in. .
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3: Title: Biochemical and functional characterization of human phospholipid scramblase 4 (hPLSCR4).
Journal: Biological chemistry (Biol Chem), Vol. 393 (10): 1173-81, 2012 .
Snippet: Human phospholipid scramblase 4 (hPLSCR4), an isoform of the scramblase family, is a type II single-pass transmembrane protein whose function remains unknown.
Affiliation: Department of Biotechnology, Applied Industrial Microbiology Laboratory, Indian Institute of Technology-Madras, Chennai 600 036, India. .
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4: Title: Phospholipid scramblase expression in the pregnant mouse uterus in LPS-induced preterm delivery.
Authors: McLean, Kelley C, et.al. .
Journal: Reproductive sciences (Thousand Oaks, Calif.) (Reprod Sci), Vol. 19 (11): 1211-8, 2012 .
Snippet: Lipopolysaccharide treatment resulted in increased expression of PLSCR-1 and a decrease in Plscr4 mRNA, thereby demonstrating modulation of PLSCR-1 and PLSCR-4 in LPS-induced PTB.
Affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont College of Medicine, Burlington, VT, USA. kelley.mclean@vtmednet.org .
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5: Title: A whole-genome association study for pig reproductive traits.
Authors: Onteru, S K, et.al. .
Journal: Animal genetics (Anim Genet), Vol. 43 (1): 18-26, 2012 .
Snippet: PLSCR4) were associated with TNB and NBA in the first two parities.
Affiliation: Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, IA 50011, USA. .
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6: Title: Lipid metabolic effect of Korean red ginseng extract in mice fed on a high-fat diet.
Authors: Song, Yong-Bum, et.al. .
Journal: Journal of the science of food and agriculture (J Sci Food Agric), Vol. 92 (2): 388-96, 2012 .
Snippet: KRGE was found to down-regulate genes associated with lipid metabolism or cholesterol metabolism (Lipa, Cyp7a1, Il1rn, Acot2, Mogat1, Osbpl3, Asah3l, Insig1, Anxa2, Vldlr, Hmgcs1, Sytl4, Plscr4, Pla2g4e, Slc27a3, Enpp6), all of which were up-regulated by HFD.
Affiliation: Korea Ginseng Corporation Ginseng Research Institute, Yuseong-gu, Daejeon, Korea. .
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7: Title: A minimal nuclear localization signal (NLS) in human phospholipid scramblase 4 that binds only the minor NLS-binding site of importin alpha1.
Authors: Lott, Kaylen, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 286 (32): 28160-9, 2011 .
Snippet: In this study, we have characterized the cellular localization of human phospholipid scramblase 4 (hPLSCR4), a member of the phospholipid scramblase protein family.
Affiliation: Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. .
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8: Title: Calcium binding studies of peptides of human phospholipid scramblases 1 to 4 suggest that scramblases are new class of calcium binding proteins in the cell.
Authors: Sahu, Santosh Kumar, et.al. .
Journal: Biochimica et biophysica acta (Biochim Biophys Acta), Vol. 1790 (10): 1274-81, 2009 .
Snippet: RESULTS: The results in this study show that (i) affinities of the peptides are in the order hPLSCR1>hPLSCR3>hPLSCR2>hPLSCR4 for Ca2+ and in the order hPLSCR1>hPLSCR2>hPLSCR3>hPLSCR4 for Mg2+, (ii) binding of ions brings about conformational change in the secondary structure of the peptides.
Affiliation: Department of Biotechnology, Indian Institute of Technology--Madras, Chennai 600 036, India. .
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9: Title: The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane.
Authors: Py, Bénédicte, et.al. .
Journal: PloS one, Vol. 4 (3): e5006, 2009 .
Snippet: At the molecular level, we show that SLPI is a ligand for the phospholipid scramblase 1 (PLSCR1) and PLSCR4, membrane proteins that are involved in the regulation of the movements of phospholipids between the inner and outer leaflets of the plasma membrane.
Affiliation: Institut Cochin, Université Paris-Descartes, CNRS, UMR 8104, Paris, France. .
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10: Title: Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants.
Authors: Shibata, Hideki, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 283 (15): 9623-32, 2008 .
Snippet: ALG-2-interacting proteins were classified into two groups based on binding ability to ALG-2(DeltaGF122): (i) isoform-non-interactive (ABS-1) types, including Alix, annexin A7, annexin A11, and TSG101 and (ii) isoform-interactive (ABS-2) types including PLSCR3, PLSCR4 and Sec31A.
Affiliation: Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Japan. .
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11: Title: Suicide candidate genes associated with bipolar disorder and schizophrenia: an exploratory gene expression profiling analysis of post-mortem prefrontal cortex.
Authors: Kim, Sanghyeon, et.al. .
Journal: BMC genomics, Vol. 8, 2007 .
Snippet: Two genes, PLSCR4 (phospholipid scramblase 4) and EMX2 (empty spiracles homolog 2 (Drosophila)) were differentially expressed in suicide groups of both diagnostic groups by microarray analysis.
Affiliation: Department of Psychiatry, Univ, of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA. Howard.Gershenfeld@UTSouthwestern.edu. .
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12: Title: Phospholipid scramblase isoform expression in pregnant rat uterus.
Authors: Phillippe, Mark, et.al. .
Journal: Journal of the Society for Gynecologic Investigation (J Soc Gynecol Investig), Vol. 13 (7): 497-501, 2006 .
Snippet: A rat spleen cDNA bacteriophage library was used as a template for PCR-based sequencing to determine the cDNA and translated amino acid sequences for the PLSCR3 and PLSCR4 homologs expressed in rats.
Affiliation: Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington, Vermont 05403, USA. Mark.Phillippe@uvm.edu <Mark.Phillippe@uvm.edu> .
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13: Title: Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3).
Authors: Wiedmer, Therese, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (P Natl Acad Sci Usa), Vol. 101 (36): 13296-301, 2004 .
Snippet: The phospholipid scramblases (PLSCR1 to PLSCR4) are a structurally and functionally unique class of proteins, which are products of a tetrad of genes conserved from Caenorhabditis elegans to humans.
Affiliation: Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. .
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