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24 documents found
1: Title: The effect of QTL-rich region polymorphisms identified by targeted DNA-seq on pig production traits.
Authors: Stuczyńska, Anna, et.al. .
Journal: Molecular biology reports (Mol Biol Rep), 2018 .
Snippet: The aim of the present study was to analyse the effect of PLCD4, PECR, FN1 and PNKD mutations on pig productive traits and tested the usefulness of targeted enrichment DNA sequencing method as tool for preselection of genetic markers.
Affiliation: University of Huddersfield, School of Applied Science, CeBioR, Queensgate, HD1 3DH, Huddersfield, Great Britain. Department of Animal Molecular Biology, National Research Institute of Animal Production, 32-083, Balice, Poland. katarzyna.piorkowska@izoo.krakow.pl. Department of Pig Breeding, National Research Institute of Animal Production, 32-083, Balice, Poland. Department of Cattle Breeding, National Research Institute of Animal Production, 32-083, Balice, Poland. .
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2: Title: Exome analysis in an Estonian multiplex family with neural tube defects-a case report.
Authors: Pappa, Liina, et.al. .
Journal: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (Childs Nerv Syst), 2017 .
Snippet: All affected individuals had a variable set of additional low frequency deleterious variants in PTK7, PLCD4, IL4I1 or RASSF4 as likely causal loci contributing to the disease development.
Affiliation: Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia. liinapappa@hotmail.com. Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia. Tallinn Children's Hospital, Tallinn, Estonia. .
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3: Title: Complementary Critical Functions of Zfy1 and Zfy2 in Mouse Spermatogenesis and Reproduction.
Authors: Nakasuji, Takashi, et.al. .
Journal: PLoS genetics (Plos Genet), Vol. 13 (1): e1006578, 2017 .
Snippet: Mass spectrometric screening, followed by confirmation with western blot analysis, showed that PLCZ1, PLCD4, PRSS21, and HTT protein expression were significantly deceased in spermatozoa of Zfy1/2-DKO mice compared with those of wild-type mice.
Affiliation: Comprehensive Reproductive Medicine, Regulation of Internal Environment and Reproduction, Systemic Organ Regulation, Graduate School, Tokyo Medical and Dental University (TMDU), Bunkyo, Tokyo, Japan. Department of Systems BioMedicine, Tokyo Medical and Dental University (TMDU), Bunkyo, Tokyo, Japan. RIKEN BioResource Center, Tsukuba, Ibaraki, Japan. Division of Rare Cancer Research, National Cancer Center Research Institute, Chuo, Tokyo, Japan. Department of Reproductive Biology, National Center for Child Health and Development, Setagaya, Tokyo, Japan. Molecular Biology Division, Faculty of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Nagasaki, Japan. Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America. .
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4: Title: Virus-encoded microRNA contributes to the molecular profile of EBV-positive Burkitt lymphomas.
Authors: Piccaluga, Pier Paolo, et.al. .
Journal: Oncotarget, Vol. 7 (1): 224-40, 2016 .
Snippet: Among others, we identified LIN28B, CGNL1, GCET2, MRAS, PLCD4, SEL1L, SXX1, and the tyrosine kinases encoding STK10/STK33, all provided with potential pathogenetic significance.
Affiliation: Hematopathology Section, Department of Experimental, Diagnostic, and Experimental Medicine, S. Orsola-Malpighi Hospital, Bologna University School of Medicine, Bologna, Italy. Department of Medical Biotechnology, University of Siena, Siena, Italy. School of Biological and Chemical Sciences, Queen Mary University of London, London, UK. Department of Pathology, University of Nairobi, Nairobi, Kenya. Department of Pathology, Makerere University, Kampala, Uganda. Tumour Immunology Unit, Department of Health Science, Human Pathology Section, Palermo University School of Medicine, Palermo, Italy. Department of Pathology and Diagnostic, University of Verona, Verona, Italy. Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA. Diagnostic Hematopathology Unit, European Institute of Oncology, Milan, Italy. .
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5: Title: Identification of Region-Specific Myocardial Gene Expression Patterns in a Chronic Swine Model of Repaired Tetralogy of Fallot.
Authors: Charron, Sabine, et.al. .
Journal: PloS one, Vol. 10 (8): e0134146, 2015 .
Snippet: Moreover, calcium handling and contractile function genes (SLN, ACTC1, PLCD4, PLCZ), potential arrhythmia-related genes (MYO5B, KCNA5), and cytoskeleton and cellular organization-related genes (XIRP2, COL8A1, KCNA6) were among the most deregulated genes in rTOF ventricles.
Affiliation: L'Institut de Rythmologie et Modélisation Cardiaque LIRYC, Université de Bordeaux, Pessac, France; Inserm U1045 CRCTB, Université de Bordeaux, Bordeaux, France. L'Institut de Rythmologie et Modélisation Cardiaque LIRYC, Université de Bordeaux, Pessac, France; Inserm U1045 CRCTB, Université de Bordeaux, Bordeaux, France; Hôpital cardiologique Haut-Lévêque, CHU de Bordeaux, Pessac, France. L'Institut de Rythmologie et Modélisation Cardiaque LIRYC, Université de Bordeaux, Pessac, France; Inserm U1045 CRCTB, Université de Bordeaux, Bordeaux, France; Max Delbrück Center for Molecular Medicine, Berlin, Germany. Plateforme Technologique d'Innovation Biomédicale, Université de Bordeaux, Pessac, France. L'Institut de Rythmologie et Modélisation Cardiaque LIRYC, Université de Bordeaux, Pessac, France; Inserm U1045 CRCTB, Université de Bordeaux, Bordeaux, France; University of Oxford, Institute of Biomedical Engineering, Oxford, United-Kingdom. L'Institut de Rythmologie et Modélisation Cardiaque LIRYC, Université de Bordeaux, Pessac, France; Hôpital cardiologique Haut-Lévêque, CHU de Bordeaux, Pessac, France; Laboratoire Maladies Rares: Génétique et Métabolisme (MRGM), EA 4576, Université de Bordeaux, Bordeaux, France. .
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6: Title: Gestation Related Gene Expression of the Endocannabinoid Pathway in Rat Placenta.
Authors: Vaswani, Kanchan, et.al. .
Journal: Mediators of inflammation (Mediators Inflamm), Vol. 2015, 2015 .
Snippet: Gene expression of enzymes Faah, Mgll, Plcd4, Pld1, Nat1, Daglα, and Ptgs2 was studied (cohort 1, microarray).
Affiliation: University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital Campus, Herston, QLD 4029, Australia. Department of Anatomy & Developmental Biology, Monash University, Clayton, VIC 3800, Australia ; School of Medicine (Optometry), Deakin University, Pigdons Road, Waurn Ponds, VIC 3800, Australia. .
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7: Title: Altered theta oscillations and aberrant cortical excitatory activity in the 5XFAD model of Alzheimer's disease.
Journal: Neural plasticity (Neural Plast), Vol. 2015, 2015 .
Snippet: Transcriptome analysis of hippocampal probes and subsequent qPCR validation revealed an upregulation of Plcd4 that might be indicative of enhanced muscarinic signalling.
Affiliation: Federal Institute for Drugs and Medical Devices (BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175 Bonn, Germany. Department of Psychiatry and Psychotherapy, University of Cologne, Faculty of Medicine, Kerpener Street 62, 50937 Cologne, Germany. Institute of Molecular Psychiatry, University of Bonn, Sigmund-Freud Street 25, 53125 Bonn, Germany. German Center for Neurodegenerative Diseases (DZNE), Ludwig-Erhard-Allee 2, 53175 Bonn, Germany. .
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8: Title: RNA sequencing identifies upregulated kyphoscoliosis peptidase and phosphatidic acid signaling pathways in muscle hypertrophy generated by transgenic expression of myostatin propeptide.
Authors: Miao, Yuanxin, et.al. .
Journal: International journal of molecular sciences (Int J Mol Sci), Vol. 16 (4): 7976-94, 2015 .
Snippet: Interestingly, a pathway analysis based on grouping the differentially expressed genes uncovered that cardiomyopathy-related pathways and phosphatidic acid (PA) pathways (Dgki, Dgkz, Plcd4) were up-regulated.
Affiliation: Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China. miaoyuanxin19880610@126.com. The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China. miaoyuanxin19880610@126.com. Department of Human Nutrition, Food and Animal Sciences, University of Hawaii at Manoa, Honolulu, HI 96822, USA. jinzeng@hawaii.edu. Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China. xz8907@163.com. The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China. xz8907@163.com. Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China. deer66@126.com. The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China. deer66@126.com. Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China. shzhao@mail.hzau.edu.cn. The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China. shzhao@mail.hzau.edu.cn. Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China. xyli@mail.hzau.edu.cn. The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China. xyli@mail.hzau.edu.cn. .
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9: Title: Recurrent triploidy due to a failure to complete maternal meiosis II: whole-exome sequencing reveals candidate variants.
Authors: Filges, I, et.al. .
Journal: Molecular human reproduction (Mol Hum Reprod), Vol. 21 (4): 339-46, 2015 .
Snippet: These included a novel change in the PLCD4 gene, and a rare variant in the OSBPL5 gene, which have been implicated in oocyte activation upon fertilization and completion of MII.
Affiliation: Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada V6T 1Z3 Child and Family Research Institute, Vancouver, BC, Canada V5Z 4H4 Medical Genetics, Department of Biomedicine, University Hospital Basel, Basel 4031, Switzerland. Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada V6T 1Z3 Child and Family Research Institute, Vancouver, BC, Canada V5Z 4H4. Child and Family Research Institute, Vancouver, BC, Canada V5Z 4H4 Department of Pathology, University of British Columbia, Vancouver, BC, Canada V6T 2B5. Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada V5Z 4H4 Centre for Applied Neurogenetics, University of British Columbia, Vancouver, BC, Canada V6T 1Z3. Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada V6T 1Z3 Child and Family Research Institute, Vancouver, BC, Canada V5Z 4H4 wrobinson@cfri.ca. .
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10: Title: Silencing of phosphoinositide-specific phospholipase C ε remodulates the expression of the phosphoinositide signal transduction pathway in human osteosarcoma cell lines.
Journal: Anticancer research (Anticancer Res), Vol. 34 (8): 4069-75, 2014 .
Snippet: RESULTS: The growth rate of the cells was slowed, and the expression of ezrin, PLCB1, PLCG2 and PLCD4 was significantly modified.
Affiliation: Department of Sense Organs, Sapienza University, Rome, Italy ritalovasco@hotmail.it. Department of Medicine and Surgery Sciences and Biotechnologies, Sapienza University, Rome, Italy. Department of Biochemistry Sciences "A. Rossi Fanelli", Sapienza University, Rome, Italy. .
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11: Title: Ezrin silencing remodulates the expression of Phosphoinositide-specific Phospholipase C enzymes in human osteosarcoma cell lines.
Authors: Lo Vasco, V R, et.al. .
Journal: Journal of cell communication and signaling (J Cell Commun Signal), Vol. 8 (3): 219-29, 2014 .
Snippet: In Hs888, the expression of PLCB1 and of PLCD4 significantly increased, of PLCE moderately increased in a time dependent manner; the expression of PLCG2 was up-regulated.
Affiliation: Sense Organs Department, Policlinico Umberto I Faculty of Medicine and Dentistry, Sapienza University of Rome, viale del Policlinico 155, 00185, Italy, Rome, ritalovasco@hotmail.it. .
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12: Title: Nuclear PLCs affect insulin secretion by targeting PPARγ in pancreatic β cells.
Authors: Fiume, Roberta, et.al. .
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology (Faseb J), Vol. 26 (1): 203-10, 2012 .
Snippet: Studies with inhibitors and agonists established a role for PLC in the regulation of insulin secretion but did not distinguish between effects due to nuclear or cytoplasmic PLC signaling pathways that act in a distinct fashion.
Affiliation: Department of Human Anatomy, University of Bologna, Bologna, Italy. .
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13: Title: Identification and analysis of the promoter region of the human PLC-delta4 gene.
Authors: Chae, Song Wha, et.al. .
Journal: Molecular biology reports (Mol Biol Rep), Vol. 34 (2): 69-77, 2007 .
Snippet: In addition, we also showed that 12-O-tetradecanoylphorbol-1,3-acetate (TPA), a PKC activator and tumor promoter, induced the activity of the PLC-delta4 promoter via the AP-1 binding site.
Affiliation: Neuroscience Genome Research Center, The Catholic University of Korea, Banpo-dong, Socho-ku, Seoul 137-701, Korea. .
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14: Title: Disruption of phospholipase Cdelta4 gene modulates the liver regeneration in cooperation with nuclear protein kinase C.
Authors: Akutagawa, Atsushi, et.al. .
Journal: Journal of biochemistry (J Biochem), Vol. 140 (5): 619-25, 2006 .
Snippet: The specific increases in PLC activity well correlated with the transient increases of protein kinase C (PKC) alpha in chromatin of PLC delta4(+/+).
Affiliation: Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65, Tsurumai-cho, Showa-ku, Nagoya 466-8550. .
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15: Title: Phospholipase Cdelta4 associates with glutamate receptor interacting protein 1 in testis.
Authors: Irino, Yasuhiro, et.al. .
Journal: Journal of biochemistry (J Biochem), Vol. 138 (4): 451-6, 2005 .
Snippet: Here we focused on the function of the C2 domain of PLCdelta4 and report that glutamate receptor-interacting protein1 (GRIP1) was identified as a binding protein of the PLCdelta4-C2 domain on yeast two-hybrid screening.
Affiliation: Laboratory of Genome and Biosignal, School of Life Science, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. .
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16: Title: Phospholipase C delta-type consists of three isozymes: bovine PLCdelta2 is a homologue of human/mouse PLCdelta4.
Authors: Irino, Yasuhiro, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Bioph Res Co), Vol. 320 (2): 537-43, 2004 .
Snippet: To date, 12 phospholipase C (PLC) isozymes have been identified in mammals, and they are divided into five classes, beta-, gamma-, delta-, epsilon-, and zeta-type.
Affiliation: Laboratory of Genome and Biosignal, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, 192-0392 Tokyo, Japan. .
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17: Title: Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells.
Authors: Leung, David W, et.al. .
Journal: Molecular cancer (Mol Cancer), Vol. 3, 2004 .
Snippet: Overexpression of PLCdelta4 selectively activates protein kinase C-phi and upregulates the expression of epidermal growth factor receptors EGFR/erbB1 and HER2/erbB2, leading to constitutive activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathway in MCF-7 cells.
Affiliation: Cell Therapeutics, Inc, 201 Elliott Ave, W, Seattle, WA 98119, USA. dwleung1@msn.com .
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18: Title: Phospholipase Cdelta4 is required for Ca2+ mobilization essential for acrosome reaction in sperm.
Authors: Fukami, Kiyoko, et.al. .
Journal: The Journal of cell biology (J Cell Biol), Vol. 161 (1): 79-88, 2003 .
Snippet: Zona pellucida (ZP)-induced acrosome reaction in sperm is a required step for mammalian fertilization.
Affiliation: Division of Biochemistry, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan. kfukami@ims.u-tokyo.ac.jp .
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19: Title: Membrane targeting of C2 domains of phospholipase C-delta isoforms.
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 277 (5): 3568-75, 2002 .
Snippet: In contrast to PLC-delta1-C2 and PLC-delta3-C2, PLC-delta4-C2 has significant Ca(2+)-independent membrane affinity and no PS selectivity due to the presence of cationic residues in the Ca(2+)-binding loops and the substitution of Ser for the Ca(2+)-coordinating Asp in position 717.
Affiliation: Department of Chemistry, University of Illinois, Chicago 60607, USA. .
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20: Title: Requirement of phospholipase Cdelta4 for the zona pellucida-induced acrosome reaction.
Authors: Fukami, K, et.al. .
Journal: Science (New York, N.Y.) (Science), Vol. 292 (5518): 920-3, 2001 .
Snippet: Several phospholipase C (PLC) isoforms have been found in male and female mammalian gametes, and splicing isoforms of PLCdelta4 are predominantly expressed in testis.
Affiliation: Department of Biochemistry, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8039, Japan. kfukami@ims.u-tokyo.ac.jp .
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