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28 documents found
1: Title: Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort.
Authors: Sharma, Ashok, et.al. .
Journal: PloS one, Vol. 11 (3): e0152476, 2016 .
Snippet: A SNP near PKIA (rs117128341, P = 6.5x10-8,
Affiliation: Center for Biotechnology and Genomic Medicine, Georgia Regents University, Augusta, GA, United States of America. Pediatric Epidemiology Center, Department of Pediatrics, University of South Florida, Tampa, FL, United States of America. Division of Population Health Sciences and Education, St George's University of London, London, United Kingdom. Pacific Northwest Diabetes Research Institute, Seattle, WA, United States of America. Digestive Health Institute, Children's Hospital Colorado, University of Colorado Denver, Aurora, CO, United States of America. Center for Public Health Genomics, University of Virginia, Charlottesville, VA, United States of America. Department of Pediatrics, University of Turku, Turku, Finland. Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, United States of America. Institute of Diabetes Research, Helmholtz Zentrum München, and Klinikum rechts der Isar, Technische Universität München, and Forschergruppe Diabetes e.V., Munich-Neuherberg, Germany. Department of Clinical Sciences, Lund University/CRC, Malmö, Sweden. National Institutes of Diabetes and Digestive and Kidney Disorders, National Institutes of Health, Bethesda, MD, United States of America. Diabetes and Celiac Disease Unit, Lund University, Malmo, Sweden. .
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2: Title: Highly expressed protein kinase A inhibitor α and suppression of protein kinase A may potentiate acetaminophen-induced hepatotoxicity.
Authors: Yun, Jun-Won, et.al. .
Journal: Toxicology letters (Toxicol Lett), Vol. 229 (1): 59-65, 2014 .
Snippet: Among them, protein kinase (cAMP-dependent) inhibitor alpha, Pkia, a member of protein kinase A (PKA) inhibitor family, was found to be most significantly and highly expressed in susceptible animals (~3.5 fold with p<0.01).
Affiliation: Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea. College of Pharmacy, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 120-808, Republic of Korea. Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeon-ju, Republic of Korea. College of Pharmacy, The Catholic University of Korea, Bucheon, Republic of Korea. College of Pharmacy, Institute of Pharmaceutical Sciences, Hanyang University, Ansan, Gyeonggido 426-791, Republic of Korea. Electronic address: onbae@hanyang.ac.kr. College of Pharmacy, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 120-808, Republic of Korea. Electronic address: kmlim@ewha.ac.kr. .
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3: Title: A CALM-derived nuclear export signal is essential for CALM-AF10-mediated leukemogenesis.
Authors: Conway, Amanda E, et.al. .
Journal: Blood, Vol. 121 (23): 4758-68, 2013 .
Snippet: Fusions of the CALM NES (NES(CALM)-AF10) or NES motifs from heterologous proteins (ABL1, Rev, PKIA, APC) in-frame with AF10 are sufficient to immortalize murine hematopoietic progenitors in vitro.
Affiliation: Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA. .
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4: Title: Cardiomyocyte life-death decisions in response to chronic β-adrenergic signaling.
Authors: Whelan, Russell S, et.al. .
Journal: Circulation research (Circ Res), Vol. 112 (3): 408-10, 2013 .
No Abstract available.
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5: Title: Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling.
Authors: Zhang, Xiaoying, et.al. .
Journal: Circulation research (Circ Res), Vol. 112 (3): 498-509, 2013 .
Snippet: PKA inhibition revealed a cardioprotective role of β-adrenergic signaling via cAMP/exchange protein directly activated by cAMP/Rap1/Rac/extracellular signal-regulated kinase pathway.
Affiliation: Cardiovascular Research Center, Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA. .
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6: Title: Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing.
Authors: Piazzon, Nathalie, et.al. .
Journal: Journal of molecular cell biology (J Mol Cell Biol), Vol. 4 (6): 398-408, 2012 .
Snippet: Bicc1 similarly induces silencing of the protein kinase inhibitor PKIα by miR-27a.
Affiliation: Ecole Polytechnique Fédérale de Lausanne (EPFL) SV ISREC, Station 19, CH-1015 Lausanne, Switzerland. .
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7: Title: Anti-mitogenic effects of β-agonists and PGE2 on airway smooth muscle are PKA dependent.
Authors: Yan, Huandong, et.al. .
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology (Faseb J), Vol. 25 (1): 389-97, 2011 .
Snippet: The antimitogenic efficacy of PGE(2) in inhibiting control cultures was associated with greater ability to stimulate sustained PKA activation and greater inhibition of late-phase promitogenic p42/p44 and PI3K activities.
Affiliation: Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201-1075, USA. .
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8: Title: Identification of a nuclear export signal in the catalytic subunit of AMP-activated protein kinase.
Authors: Kazgan, Nevzat, et.al. .
Journal: Molecular biology of the cell (Mol Biol Cell), Vol. 21 (19): 3433-42, 2010 .
Snippet: Cytoplasmic localization can be restored by substituting well-defined snurportin-1 or protein kinase A inhibitor (PKIA) CRM1-binding NESs into AMPKα.
Affiliation: Neuroscience Center, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27599-7250, USA. .
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9: Title: A genome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample.
Authors: Djurovic, Srdjan, et.al. .
Journal: Journal of affective disorders (J Affect Disord), Vol. 126 (1-2): 312-6, 2010 .
Snippet: The most significant markers were located in DLEU2, GUCY1B2, PKIA, CCL2, CNTNAP5, DPP10, and FBN1.
Affiliation: Institute of Psychiatry, University of Oslo, Oslo, Norway. srdjan.djurovic@medisin.uio.no .
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10: Title: A novel expression system for intracellular production and purification of recombinant affinity-tagged proteins in Aspergillus niger.
Authors: Roth, Andreas H F J, et.al. .
Journal: Applied microbiology and biotechnology (Appl Microbiol Biotechnol), Vol. 86 (2): 659-70, 2010 .
Snippet: Target genes can be expressed under the control of the highly efficient, constitutive pkiA promoter or the novel sucrose-inducible promoter of the beta-fructofuranosidase (sucA) gene of A. niger in the presence or absence of alternative carbon sources.
Affiliation: Institute of Microbiology, Technical University Braunschweig, Spielmannstrasse 7, 38106, Braunschweig, Germany. .
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11: Title: Detection and interpretation of expression quantitative trait loci (eQTL).
Authors: Michaelson, Jacob J, et.al. .
Journal: Methods (San Diego, Calif.) (Methods), Vol. 48 (3): 265-76, 2009 .
Snippet: Also, the integration of eQTL with complementary information such as physical protein interaction data may significantly improve statistical power and provide insight into possible molecular mechanisms linking the regulator to its target gene.
Affiliation: Biotechnology Center, Technische Universität Dresden, Tatzberg 47/49, 01307 Dresden, Germany. .
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12: Title: Gene expression profiles of adipose tissue of obese rats after central administration of neuropeptide Y-Y5 receptor antisense oligodeoxynucleotides by cDNA microarrays.
Authors: Qiu, Jie, et.al. .
Journal: Peptides, Vol. 29 (11): 2052-60, 2008 .
Snippet: Different clusters of genes associated with apoptosis, signal transduction, energy metabolism, lipid metabolism, etc., such as FXR1, PHLDA1, MAEA, PIK3R1, ICAM2, PITPN, CALM2, CAMK2D, PKIA, DRD2, SLC25A14, CKB, AADAC, LIPA, ACOX3, FADS1, were concerned.
Affiliation: Department of Pediatrics, Nanjing Maternity and Child Health Hospital of Nanjing Medical University, 210004 Nanjing, China; Institute of Pediatrics of Nanjing Medical University, 210029 Nanjing, China. .
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13: Title: Molecular correlates for maximal oxygen uptake and type 1 fibers.
Authors: Parikh, Hemang, et.al. .
Journal: American journal of physiology. Endocrinology and metabolism (Am J Physiol-endoc M), Vol. 294 (6): E1152-9, 2008 .
Snippet: Eleven genes (NDUFB4, COX5A, UQCRB, ATP5C1, ATP5G3, ETHE1, FABP3, ISCA1, MYST4, C9orf3, and PKIA) were positively correlated with both Vo(2max) and the percentage of type 1 fibers.
Affiliation: Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmö, Malmö, Sweden. hemang.parikh@med.lu.se .
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14: Title: Increased expression of protein kinase A inhibitor alpha (PKI-alpha) and decreased PKA-regulated genes in chronic intermittent alcohol exposure.
Authors: Repunte-Canonigo, Vez, et.al. .
Journal: Brain research (Brain Res), Vol. 1138, 2007 .
Snippet: The protein kinase A inhibitor alpha (PKI-alpha, Pkia), a member of the endogenous PKI family implicated in reducing nuclear PKA activity, was found to be increased in all three regions tested.
Affiliation: Molecular and Integrative Neuroscience Department and San Diego Alcohol, Research Center, The Scripps Research Institute, La Jolla, CA 92103, USA. .
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15: Title: Adenovirus-mediated delivery and expression of a cAMP-dependent protein kinase inhibitor gene to BEAS-2B epithelial cells abolishes the anti-inflammatory effects of rolipram, salbutamol, and prostaglandin E2: a comparison with H-89.
Authors: Meja, Koremu K, et.al. .
Journal: The Journal of pharmacology and experimental therapeutics (J Pharmacol Exp Ther), Vol. 309 (2): 833-44, 2004 .
Snippet: All cAMP-elevating drugs tested promoted the phosphorylation of cAMP response element-binding protein (CREB), activated a cAMP response element (CRE)-driven luciferase reporter gene, and suppressed both granulocyte/macrophage colony-stimulating factor (GM-CSF) generation and [(3)H]arachidonic acid (AA) release in response to interleukin-1beta and monocyte chemotactic protein (MCP)-1, respectively.
Affiliation: Thoracic Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom. .
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16: Title: cAMP-dependent protein kinase A mediation of vasopressin gene expression in the hypothalamus of the osmotically challenged rat.
Authors: Wong, Liang-Fong, et.al. .
Journal: Molecular and cellular neurosciences (Mol Cell Neurosci), Vol. 24 (1): 82-90, 2003 .
Snippet: We have tested the hypothesis that 3', 5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) is involved in the regulation of the vasopressin (VP) gene in the magnocellular neurons of the paraventricular nucleus (PVN) of the osmotically challenged rat.
Affiliation: The University Research Centre for Neuroendocrinology, University of Bristol, Bristol Royal Infirmary, Marlborough Street, Bristol BS2 8HW, England, UK. .
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17: Title: Vascular endothelial cells express isoforms of protein kinase A inhibitor.
Authors: Lum, Hazel, et.al. .
Journal: American journal of physiology. Cell physiology (Am J Physiol-cell Ph), Vol. 282 (1): C59-66, 2002 .
Snippet: The expression and function of the endogenous inhibitor of cAMP-dependent protein kinase (PKI) in endothelial cells are unknown.
Affiliation: Department of Pharmacology, Rush Presbyterian St. Luke's Medical Center, Chicago, Illinois 60612, USA. hlum@rush.edu .
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18: Title: Combined molecular and biochemical approach identifies Aspergillus japonicus and Aspergillus aculeatus as two species.
Authors: Parenicová, L, et.al. .
Journal: Applied and environmental microbiology (Appl Environ Microb), Vol. 67 (2): 521-7, 2001 .
Snippet: Aspergillus niger pyruvate kinase (pkiA) and pectin lyase A (pelA) and Agaricus bisporus 28S rRNA genes, which were used as probes in the RFLP analysis, revealed clear polymorphism between these two taxa.
Affiliation: Section of Molecular Genetics of Industrial Microorganisms, Wageningen University, NL-6703 HA Wageningen, The Netherlands. .
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19: Title: Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA.
Authors: Zheng, L, et.al. .
Journal: The Biochemical journal (Biochem J), Vol. 349 (Pt 2): 403-7, 2000 .
Snippet: Northern-blot analysis of three PKI isoforms, including the PKIA identified previously, revealed significant differences in their expression patterns.
Affiliation: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, People's Republic of China. .
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20: Title: Retroviral inhibition of cAMP-dependent protein kinase inhibits myelination but not Schwann cell mitosis stimulated by interaction with neurons.
Authors: Howe, D G, et.al. .
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci), Vol. 20 (10): 3513-21, 2000 .
Snippet: Many reports suggest that neuronal contact exerts this influence on Schwann cells by elevating Schwann cell cAMP and activating cAMP-dependent protein kinase A (PKA).
Affiliation: The Curriculum in Neurobiology and the Department of Pharmacology, The University of North Carolina, Chapel Hill, North Carolina 27599, USA. .
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