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17 documents found
1: Title: Clinical validation of genetic variants associated with in vitro chemotherapy-related lymphoblastoid cell toxicity.
Authors: Fasching, Peter A, et.al. .
Journal: Oncotarget, Vol. 8 (44): 78133-78143, 2017 .
Snippet: Two SNPs in and close to the PIGB gene significantly improved the prediction of NLEs after FEC, in addition to the factors of age and body surface area.
Affiliation: Department of Gynecology and Obstetrics, Erlangen University Hospital, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany. Department of Medicine, Division of Hematology/Oncology, University of California at Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA. Department of Gynecology and Obstetrics, Biostatistics Unit, Erlangen University Hospital, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany. Department of Gynecology and Obstetrics, Ludwig-Maximilians-University Munich, Munich, Germany. Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Mayo Medical School-Mayo Foundation, Rochester, MN, USA. Department of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Institute of Human Genetics, Erlangen University Hospital, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany. Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, MN, USA. Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA. Department of Biostatistics, University of Kansas Medical Center, Kansas City, KS, USA. Division of Gynecologic Oncology, National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany. Department of Oncology, Onkologie Bethanien, Frankfurt, Germany. Department of Gynecology and Obstetrics, Charité University Hospital, Campus Virchow, Berlin, Germany. Department of Gynecology and Obstetrics, Düsseldorf University Hospital, Heinrich Heine University, Düsseldorf, Germany. Department of Gynecologic Oncology, Schwerpunktpraxis für Gynäkologische Onkologie, Fürstenwalde, Germany. Department of Breast Diseases, Breast Center of Düsseldorf, Luisenkrankenhaus, Düsseldorf, Germany. Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany. .
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2: Title: Antioxidative Metabolites Synthesized by Marine Pigmented Vibrio sp. and Its Protection on Oxidative Deterioration of Membrane Lipids.
Authors: Pawar, Ravindra, et.al. .
Journal: Applied biochemistry and biotechnology (Appl Biochem Biotechnol), Vol. 179 (1): 155-67, 2016 .
Snippet: (PIGB 184) isolated from water samples of the Arabian Sea and identified through 16S rRNA demonstrated the production of pigmentary antioxidants with higher ABTS activities 90.9 ± 0.42 % in comparison with the standard commercial pigmented antioxidant, quercetin 88.8 ± 1.4 %.
Affiliation: Biological Oceanography Division, CSIR-National Institute of Oceanography, Dona Paula, Goa, 403004, India. Biological Oceanography Division, CSIR-National Institute of Oceanography, Dona Paula, Goa, 403004, India. cmohan@nio.org. NCIM - Resource Centre, CSIR-National Chemical Laboratory, Pune, Maharashtra, India. Division of Biochemical Sciences, CSIR-National Chemical Laboratory, Pune, Maharashtra, India. .
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3: Title: Crystal structure of the catalytic domain of PigE: a transaminase involved in the biosynthesis of 2-methyl-3-n-amyl-pyrrole (MAP) from Serratia sp. FS14.
Authors: Lou, Xiangdi, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 447 (1): 178-83, 2014 .
Snippet: MAP is synthesized sequentially by PigD, PigE and PigB.
Affiliation: Key Laboratory of Agricultural and Environmental Microbiology, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, 210095 Nanjing, China. Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China. Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. Key Laboratory of Agricultural and Environmental Microbiology, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, 210095 Nanjing, China. Electronic address: dqxu@njau.edu.cn. Key Laboratory of Agricultural and Environmental Microbiology, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, 210095 Nanjing, China. Electronic address: wwwang@njau.edu.cn. .
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4: Title: Complementation of essential yeast GPI mannosyltransferase mutations suggests a novel specificity for certain Trypanosoma and Plasmodium PigB proteins.
Authors: Cortes, Leslie K, et.al. .
Journal: PloS one, Vol. 9 (1): e87673, 2014 .
Snippet: We used yeast genetics to test the in vivo specificity of Gpi10/PigB proteins from several Plasmodium and Trypanosoma species by examining their ability to restore viability to Saccharomyces cerevisiae strains harboring lethal defects in Man-III (gpi10Δ) or Man-IV (smp3Δ) addition to GPI precursor lipids.
Affiliation: New England Biolabs, Ipswich, Massachusetts, United States of America. .
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5: Title: Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
Authors: Li, Liang, et.al. .
Journal: BMC genomics, Vol. 15, 2014 .
Snippet: Most SNPs regulated gene expression in a trans manner, except 7 SNPs in the PIGB gene that were significantly associated with both the expression of PIGB and gemcitabine cytotoxicity.
Affiliation: Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA. wang.liewei@mayo.edu. .
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6: Title: Mechanism for release of alkaline phosphatase caused by glycosylphosphatidylinositol deficiency in patients with hyperphosphatasia mental retardation syndrome.
Authors: Murakami, Yoshiko, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 287 (9): 6318-25, 2012 .
Snippet: The GPI-anchored protein was secreted substantially into medium from PIGV-, PIGB-, and PIGF-deficient CHO cells, in which incomplete GPI bearing mannose was accumulated.
Affiliation: Department of Immunoregulation, Research Institute for Microbial Diseases, and Laboratory of Immunoglycobiology, WPI Immunology Frontier Research Center, Osaka, Japan 565-0871, Japan. .
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7: Title: Cyclic AMP negatively regulates prodigiosin production by Serratia marcescens.
Authors: Kalivoda, Eric J, et.al. .
Journal: Research in microbiology (Res Microbiol), Vol. 161 (2): 158-67, 2010 .
Snippet: Exogenous cAMP decreased both pigment production and pigA-lacZ transcription in the wild-type (WT) strain, and pigA-lacZ transcription was significantly increased in a crp mutant relative to WT. Suppressor and epistasis analysis indicate that the hyperpigment phenotype was dependent upon pigment biosynthetic genes (pigA, pigB, pigC, pigD and pigM).
Affiliation: Charles T. Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, University of Pittsburgh Eye Center, Pittsburgh, PA 15213, USA. .
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8: Title: siRNA-mediated inhibition of phosphatidylinositol glycan Class B (PIGB) confers resistance to methylmercury in HEK293 cells.
Authors: Hwang, Gi-Wook, et.al. .
Journal: The Journal of toxicological sciences (J Toxicol Sci), Vol. 32 (5): 581-3, 2007 .
Snippet: Screening revealed that downregulation of the gene for phosphatidylinositol glycan class B (PIGB) by siRNA confers resistance to methylmercury in HEK293 cells.
Affiliation: Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan. .
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9: Title: A gene for a dioxygenase-like protein determines the production of the DF signal in Xanthomonas campestris pv. campestris.
Authors: Poplawsky, Alan R, et.al. .
Journal: Molecular plant pathology (Mol Plant Pathol), Vol. 6 (6): 653-7, 2005 .
Snippet: Here, determination and analysis of the pigB DNA sequence reveals the presence of two open reading frames, the first (xanB1) encoding a putative reductase/halogenase, and the second (xanB2) showing the highest level of identity to Streptomyces genes encoding putative pteridine-dependent dioxygenase-like proteins.
Affiliation: Department of Plant, Soil and Entomological Sciences, University of Idaho, Moscow, Idaho 83844-2339, USA. .
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10: Title: Disruption of the copper efflux pump (CopA) of Serratia marcescens ATCC 274 pleiotropically affects copper sensitivity and production of the tripyrrole secondary metabolite, prodigiosin.
Authors: Williamson, N R, et.al. .
Journal: Journal of industrial microbiology & biotechnology (J Ind Microbiol Biot), Vol. 33 (2): 151-8, 2006 .
Snippet: We also demonstrate that the gene products of pigB-pigE of Sma 274 are sufficient for the biosynthesis of 2-methyl-3-n-amyl-pyrrole and condensation with 4-methoxy-2,2'-bipyrrole-5-carboxyaldehyde to form prodigiosin, as we have shown for Serratia sp.
Affiliation: Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, UK. .
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11: Title: Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel 2-methyl-3-n-amyl-pyrrole (MAP) assembly pathway, definition of the terminal condensing enzyme, and implications for undecylprodigiosin biosynthesis in Streptomyces.
Authors: Williamson, Neil R, et.al. .
Journal: Molecular microbiology (Mol Microbiol), Vol. 56 (4): 971-89, 2005 .
Snippet: We report a novel pathway for the biosynthesis of MAP, involving PigD, PigE and PigB.
Affiliation: Department of Biochemistry, University of Cambridge, Cambridge, UK. .
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12: Title: Characterization of the mutS-proximal region of the Salmonella typhimurium SPI-1 identifies a group of pathogenicity island-associated genes.
Authors: Pancetti, A, et.al. .
Journal: FEMS microbiology letters (Fems Microbiol Lett), Vol. 197 (2): 203-8, 2001 .
Snippet: The expression of at least two of these genes, pigA and pigB, is controlled by SprA, a transcription factor encoded within SPI-1 that controls the expression of genes associated with the type III secretion system of this island.
Affiliation: Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale School of Medicine, New Haven, CT 06536-0812, USA. .
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13: Title: Xanthomonas campestris pv. campestris requires a functional pigB for epiphytic survival and host infection.
Authors: Poplawsky, A R, et.al. .
Journal: Molecular plant-microbe interactions : MPMI (Mol Plant Microbe In), Vol. 11 (6): 466-75, 1998 .
Snippet: campestris parent strain B-24, Tn3HoHo1 pigB insertion mutation strain B24-B2, chromosomally restored pigB mutation strain B24-B2R, and strain B24-79 with a Tn3HoHo1 insertion in an unrelated part of the genome were compared for epiphytic survival on, and natural infection of, cauliflower.
Affiliation: Department of Plant, Soil and Entomological Sciences, University of Idaho, Moscow 83844-2339, USA. alpop@uidaho.edu .
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14: Title: Saccharomyces cerevisiae GPI10, the functional homologue of human PIG-B, is required for glycosylphosphatidylinositol-anchor synthesis.
Authors: Sütterlin, C, et.al. .
Journal: The Biochemical journal (Biochem J), Vol. 332 ( Pt 1), 1998 .
Snippet: An increasing number of plasma membrane proteins have been shown to be attached to the membrane via a glycosylphosphatidylinositol (GPI) moiety.
Affiliation: Biozentrum of the University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland. .
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15: Title: Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1.
Authors: Hong, Y, et.al. .
Journal: Genomics, Vol. 44 (3): 347-9, 1997 .
Snippet: Consistent with this notion, three other genes, PIGB, PIGF, and PIGH, are autosomal.
Affiliation: Department of Immunoregulation, Osaka University, Japan. .
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16: Title: pigB determines a diffusible factor needed for extracellular polysaccharide slime and xanthomonadin production in Xanthomonas campestris pv. campestris.
Authors: Poplawsky, A R, et.al. .
Journal: Journal of bacteriology (J Bacteriol), Vol. 179 (2): 439-44, 1997 .
Snippet: pigB mutant strains could also be restored extracellularly by growth adjacent to strains with insertion mutations in any of the other six xanthomonadin transcriptional units, the parent strain (B-24), or strains of five different species of Xanthomonas.
Affiliation: Department of Plant, Soil, and Entomological Sciences, University of Idaho, Moscow 83844-2339, USA. alpop@uidaho.edu .
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17: Title: PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor.
Authors: Takahashi, M, et.al. .
Journal: The EMBO journal (Embo J), Vol. 15 (16): 4254-61, 1996 .
Snippet: Many eukaryotic cell surface proteins are bound to the membrane via the glycosylphosphatidylinositol (GPI) anchor that is covalently linked to their carboxy-terminus.
Affiliation: Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, Suita, Japan. .
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