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28 documents found
1: Title: PHF20 collaborates with PARP1 to promote stemness and aggressiveness of neuroblastoma cells through activation of SOX2 and OCT4.
Authors: Long, Wenyong, et.al. .
Journal: Journal of molecular cell biology (J Mol Cell Biol), 2018 .
Snippet: Mechanistically, PHF20 interacts with poly (ADP-ribose) polymerase 1 (PARP1) and directly binds to promoter regions of octamer-binding transcription factor 4 (OCT4) and sex determining region Y-box 2 (SOX2) to modulate a histone mark associated with active transcription, trimethylation of lysine 4 on histone H3 protein subunit (H3K4me3).
Affiliation: Department of Neurosurgery in Xiangya Hospital, Central South University, Changsha 410008, China. Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA. Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China. Institute Center for Molecular Design and Biomimetics, The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA. Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA. Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, TX 77030, USA. .
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2: Title: Identification of potential pathogenic genes associated with osteoporosis.
Authors: Xia, B, et.al. .
Journal: Bone & joint research (Bone Joint Res), Vol. 6 (12): 640-648, 2017 .
Snippet: CONCLUSION: Genes such as VPS35, FCGR2A, TBCA, HIRA, TYROBP, JUND, PHF20, NFKB2, RPL35A and BICD2 may be considered to be potential pathogenic genes of osteoporosis and may be useful for further study of the mechanisms underlying osteoporosis.Cite this article: B. Xia, Y. Li, J. Zhou, B. Tian, L. Feng.
Affiliation: Attending Doctor Department of Orthopedics, Jining No. 1 People's Hospital, 272011 Shandong Province, China. Attending Doctor Department of Gynecology, Jining No. 1 People's Hospital, 272011 Shandong Province, China. Attending Doctor Department of Orthopedics, Jining No. 1 People's Hospital, 272011 Shandong Province, China fenglide12@163.com. .
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3: Title: Identification of genes and pathways potentially related to PHF20 by gene expression profile analysis of glioblastoma U87 cell line.
Authors: Liu, Tianlong, et.al. .
Journal: Cancer cell international (Cancer Cell Int), Vol. 17, 2017 .
Snippet: METHODS: Genome wide gene expression analysis was performed to identify differentially expressed genes (DEGs) in U87 cells with PHF20 gene knockdown.
Affiliation: Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Department of Neurosurgery, The First Affiliated Hospital of SooChow University, Suzhou, China. Department of Pharmacy, The First Affiliated Hospital of SooChow University, Suzhou, China. State Key Laboratory of Cancer Biology, Department of Biopharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an, China. Department of Pharmacology, Chungnam National University, Daejon, South Korea. Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. .
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4: Title: PHF20 positively regulates osteoblast differentiation via increasing the expression and activation of Runx2 with enrichment of H3K4me3.
Authors: Yang, Jin-Woo, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7 (1): 8060, 2017 .
Snippet: Mechanistically, PHF20 increased the promoter activity of osteogenic genes including Og2, Alp, and Bsp through direct association with Runx2.
Affiliation: Department of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam National University, Gwangju, 61186, South Korea. Research Center for Biomineralization Disorders, School of Dentistry, Chonnam National University, Gwangju, 61186, South Korea. Department of Pharmacology and Medical Science, College of Medicine, Chungnam National University, Daejeon, 35015, South Korea. Department of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam National University, Gwangju, 61186, South Korea. jtkoh@chonnam.ac.kr. Research Center for Biomineralization Disorders, School of Dentistry, Chonnam National University, Gwangju, 61186, South Korea. jtkoh@chonnam.ac.kr. .
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5: Title: JMJD3 suppresses stem cell-like characteristics in breast cancer cells by downregulation of Oct4 independently of its demethylase activity.
Authors: Xun, Jing, et.al. .
Journal: Oncotarget, Vol. 8 (13): 21918-21929, 2017 .
Snippet: The inhibitory effect of JMJD3 on Oct4 was independent of demethylase activity, but mediated via degradation of PHF20.
Affiliation: College of Medicine, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China. Tianjin Key Laboratory of Modern Drug Delivery and High Efficiency in Tianjin University, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China. .
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6: Title: Sprint-interval but not continuous exercise increases PGC-1α protein content and p53 phosphorylation in nuclear fractions of human skeletal muscle.
Authors: Granata, Cesare, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7, 2017 .
Snippet: We demonstrate an exercise-induced increase in nuclear p53 protein content, an event that may relate to greater p53 stability - as also suggested by increased PHF20 protein content.
Affiliation: Institute of Sport, Exercise and Active Living (ISEAL), College of Sport and Exercise Science, Victoria University, Melbourne, Australia. School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada. Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany. .
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7: Title: Identification of Akt interaction protein PHF20/TZP that transcriptionally regulates p53.
Authors: Park, Sungman, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 291 (43): 22852, 2016 .
No Abstract available.
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8: Title: PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.
Authors: Klein, Brianna J, et.al. .
Journal: Cell reports (Cell Rep), Vol. 17 (4): 1158-1170, 2016 .
Snippet: Together, our findings establish a unique PHF20-mediated link between MOF histone acetyltransferase (HAT), p53, and H3K4me2, and suggest a model for rapid spreading of H4K16ac-enriched open chromatin.
Affiliation: Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Department of Epigenetics and Molecular Carcinogenesis, Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Faculty of Medicine, Ludwig Maximilian University of Munich, Munich 80336, Germany. Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA. Department of Epigenetics and Molecular Carcinogenesis, Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Department of General, Visceral and Tumor Surgery, University Clinic Cologne, Cologne 50931, Germany. Faculty of Medicine, Ludwig Maximilian University of Munich, Munich 80336, Germany; Department of General, Visceral and Tumor Surgery, University Clinic Cologne, Cologne 50931, Germany. Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: mer.georges@mayo.edu. Department of Epigenetics and Molecular Carcinogenesis, Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: xbshi@mdanderson.org. Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: tatiana.kutateladze@ucdenver.edu. .
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9: Title: Mitochondrial adaptations to high-volume exercise training are rapidly reversed after a reduction in training volume in human skeletal muscle.
Authors: Granata, Cesare, et.al. .
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology (Faseb J), Vol. 30 (10): 3413-3423, 2016 .
Snippet: After HVT, mitochondrial respiration and citrate synthase activity (∼40-50%), as well as the protein content of electron transport system (ETS) subunits (∼10-40%), and that of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), NRF1, mitochondrial transcription factor A (TFAM), PHF20, and p53 (∼65-170%) all increased compared to baseline; mitochondrial specific respiration remained unchanged.
Affiliation: Institute of Sport, Exercise, and Active Living, College of Sport and Exercise Science, Victoria University, Melbourne, Victoria, Australia. School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada; and. Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany. Institute of Sport, Exercise, and Active Living, College of Sport and Exercise Science, Victoria University, Melbourne, Victoria, Australia; david.bishop@vu.edu.au. .
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10: Title: [The expression and clinical significance of Bax and PHF20 in laryngeal squamous cell carcinoma].
Authors: Zhang, Chunming, et.al. .
Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery (Lin Chuang Er Bi Yan Hou Ke Za Zhi), Vol. 29 (19): 1701-5, 2015 .
Snippet: OBJECTIVE: To investigate the expression of Bax and PHF20 in laryngeal squamous cell carcinoma (LSCC)and to discuss their relevance and the roles in carcinogenesis and development in LSCC.
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11: Title: G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression.
Authors: Zhang, Xi, et.al. .
Journal: Nature communications (Nat Commun), Vol. 7, 2016 .
Snippet: Along with the PHF20/MOF complex, G9a links the crosstalk between ERα methylation and histone acetylation that governs the epigenetic regulation of hormonal gene expression.
Affiliation: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. Department of Molecular and Cellular Biology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA. Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA. The University of Texas Graduate School of Biomedical Sciences, Houston, Texas 77030, USA. .
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12: Title: SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence.
Authors: Johmura, Yoshikazu, et.al. .
Journal: Nature communications (Nat Commun), Vol. 7, 2016 .
Snippet: Ectopic expression of a catalytic mutant of KDM4A stabilizes p53 and enhances p53 interaction with PHF20 in the presence of Fbxo22.
Affiliation: Department of Cell Biology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601 Nagoya, Japan. Department of Molecular Biology, Hamamatsu University School of Medicine, Higashi-ku, 431-3192 Hamamatsu, Japan. Department of Perinatology, Aichi Human Service Center, Institute for Developmental Research, 713-8 Kamiya-cho, Kasugai, Aichi 489-0392, Japan. Department of Experimental Pathology and Tumor Biology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601 Nagoya, Japan. Department of Comparative and Experimental Medicine and Center for Animal Sciences, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601 Nagoya, Japan. Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, 153-8904 Tokyo, Japan. Zhongshan Hospital of Dalian University, 6 Jiefang St, Zhongshan District, 116001 Dalian, China. .
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13: Title: Expression of PHF20 protein contributes to good prognosis of NSCLC and is associated with Bax expression.
Authors: Tang, Na, et.al. .
Journal: International journal of clinical and experimental pathology (Int J Clin Exp Pathol), Vol. 8 (10): 12198-206, 2015 .
Snippet: BACKGROUND: Recent studies demonstrate that plant homeodomain finger protein 20 (PHF20), which was initially described as an immunogenic antigen in glioblastoma, is a putative transcriptional factor, and exhibits tumor suppressor activity.
Affiliation: Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University Shenyang 110001, China. Department of Pathology, Liaoning Tumor Hospital Shenyang 110042, China. Center for Assisted Reproduction, Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University Shenyang 110004, China. .
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14: Title: Training intensity modulates changes in PGC-1α and p53 protein content and mitochondrial respiration, but not markers of mitochondrial content in human skeletal muscle.
Authors: Granata, Cesare, et.al. .
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology (Faseb J), Vol. 30 (2): 959-70, 2016 .
Snippet: Similarly, the protein content of peroxisome proliferator-activated receptor γ coactivator (PGC)-1α, p53, and plant homeodomain finger-containing protein 20 (PHF20) increased only after SIT (60-90%).
Affiliation: *Institute of Sport, Exercise and Active Living (ISEAL), College of Sport and Exercise Science, Victoria University, Melbourne, Victoria, Australia; School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada; and Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany. *Institute of Sport, Exercise and Active Living (ISEAL), College of Sport and Exercise Science, Victoria University, Melbourne, Victoria, Australia; School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada; and Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany david.bishop@vu.edu.au. .
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15: Title: Altered expression of tumor suppressor PHF20 in myeloproliferative neoplasms.
Authors: Lasho, T L, et.al. .
Journal: Leukemia, Vol. 28 (8): 1762-4, 2014 .
No Abstract available.
Affiliation: Mayo College of Medicine, Mayo Clinic, Rochester, MN, USA. Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. .
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16: Title: PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65.
Authors: Zhang, Tiejun, et.al. .
Journal: Nature communications (Nat Commun), Vol. 4, 2013 .
Snippet: This effect strictly depends on the interaction between PHF20 and methylated lysine residues of p65, which hinders recruitment of PP2A to p65, thereby maintaining p65 in a phosphorylated state.
Affiliation: Department of Pharmacology, Infection Signaling Network Research Center, College of Medicine, Chungnam National University, Daejeon 301 747, South Korea. .
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17: Title: Jmjd3 inhibits reprogramming by upregulating expression of INK4a/Arf and targeting PHF20 for ubiquitination.
Authors: Zhao, Wei, et.al. .
Journal: Cell, Vol. 152 (5): 1037-50, 2013 .
Snippet: The latter pathway involves Jmjd3 targeting of PHF20 for ubiquitination and degradation via recruitment of an E3 ligase, Trim26.
Affiliation: Center for Inflammation and Epigenetics, The Methodist Hospital Research Institute, Houston, TX 77030, USA. .
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18: Title: Whole blood transcriptome correlates with treatment response in nasopharyngeal carcinoma.
Authors: Zaatar, Adel M, et.al. .
Journal: Journal of experimental & clinical cancer research : CR (J Exp Clin Cancer Res), Vol. 31, 2012 .
Snippet: RESULTS: A blood-based gene expression signature composed of three genes - LDLRAP1, PHF20, and LUC7L3 - is able to differentiate NPC from various other diseases and from unaffected controls with significant accuracy (area under the receiver operating characteristic curve of over 0.90).
Affiliation: Mount Miriam Cancer Hospital, 23, Jalan Bulan, Fettes Park, Tanjong Bungah 11200Penang, Malaysia. .
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19: Title: PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage.
Authors: Li, Yuwen, et.al. .
Journal: Cellular signalling (Cell Signal), Vol. 25 (1): 74-84, 2013 .
Snippet: PHF20 appears to be a novel antigen in glioma, and has also termed glioma-expressed antigen 2. PHF20 is thought to contribute to the development of cancers, including glioblastoma, lung cancer, colon cancer and ovarian cancer.
Affiliation: Department of Pharmacology, Metabolic Diseases and Cell Signaling Laboratory, Cancer Research Institute, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon, 301-131, South Korea. .
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20: Title: PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.
Authors: Cui, Gaofeng, et.al. .
Journal: Nature structural & molecular biology (Nat Struct Mol Biol), Vol. 19 (9): 916-24, 2012 .
Snippet: PHF20 is a multidomain protein and subunit of a lysine acetyltransferase complex that acetylates histone H4 and p53 but whose function is unclear.
Affiliation: Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA. .
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