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119 documents found
1: Title: Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling.
Authors: Segala, Gregory, et.al. .
Journal: Nature communications (Nat Commun), Vol. 10 (1): 1833, 2019 .
Snippet: For ERα, we demonstrate that the Vps11/18-mediated ubiquitination of the scaffold protein PELP1 impairs the activation of ERα by c-Src.
Affiliation: Département de Biologie Cellulaire, Université de Genève, Sciences III, 30 quai Ernest-Ansermet, 1211, Genève, Switzerland. Department of Molecular Microbiology, Oslo University Hospital, 0372, Oslo, Norway. Département de Génétique et Évolution, Université de Genève, Sciences III, 30 quai Ernest-Ansermet, 1211, Genève, Switzerland. Département de Biologie Cellulaire, Université de Genève, Sciences III, 30 quai Ernest-Ansermet, 1211, Genève, Switzerland. didier.picard@unige.ch. .
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2: Title: Metformin Induces Human Esophageal Carcinoma Cell Pyroptosis by Targeting the miR-497/PELP1 Axis.
Authors: Wang, Lu, et.al. .
Journal: Cancer letters (Cancer Lett), 2019 .
Snippet: Proline-, glutamic acid- and leucine-rich protein-1 (PELP1) is a scaffolding oncogene and upregulated PELP1 in advanced stages of ESCC is highly associated with cancer progression and patient outcomes.
Affiliation: Department of Gastrointestinal Oncology, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China; Institute of Precision Cancer Medicine and Pathology, Jinan University Medical College, Guangzhou, China; Cancer Research Centre, Shantou University Medical College, Shantou, Guangdong, China. Department of Gastrointestinal Oncology, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China; Cancer Research Centre, Shantou University Medical College, Shantou, Guangdong, China. Cancer Research Centre, Shantou University Medical College, Shantou, Guangdong, China. Department of Thoracic Surgery, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China. Department of Gastrointestinal Oncology, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China. Department of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine, 4170 City Ave, Philadelphia, PA, 19131, USA. Institute of Precision Cancer Medicine and Pathology, And Department of Pathology, Jinan University Medical College, Guangzhou, China; Department of Immunotherapy and Tumor Tissue Bank, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China. Electronic address: haozhang@jnu.edu.cn. .
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3: Title: Targeting steroid receptor co-activators to inhibit breast cancer stem cells.
Authors: Truong, Thu H, et.al. .
Journal: Oncoscience, Vol. 5 (11-12): 281-282, 2018 .
No Abstract available.
Affiliation: Departments of Medicine (Division of Hematology, Oncology, and Transplantation) and Pharmacology, Masonic Cancer Center, University of Minnesota, Minneapolis MN 55455 USA. .
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4: Title: The Clinical Value of PELP1 for Breast Cancer: A Comparison with Multiple Cancers and Analysis in Breast Cancer Subtypes.
Authors: Wang, Xingen, et.al. .
Journal: Cancer research and treatment : official journal of Korean Cancer Association (Cancer Res Treat), Vol. 51 (2): 706-717, 2019 .
Snippet: PELP1 has low expression rate (<20%) in colorectal cancers, gastric cancers and renal cell carcinomas, but higher in lung cancers (49.1%) and ovarian cancers (42.3%).
Affiliation: Department of Pathology, Peking University Shenzhen Hospital, Shenzhen, China. Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong. Department of Pathology, Kwong Wah Hospital, Hong Kong. Department of Pathology, Tuen Mun Hosiptal, Hong Kong. .
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5: Title: Increased expression of PELP1 in human sperm is correlated with decreased semen quality.
Authors: Skibinska, Izabela, et.al. .
Journal: Asian journal of andrology (Asian J Androl), 2018 .
Snippet: Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is a scaffolding protein involved in both genomic and nongenomic estrogen signal transduction pathways.
Affiliation: Department of Cell Biology, Faculty of Health Sciences, Poznan University of Medical Sciences, Rokietnicka 5D, Poznan 60-806, Poland. Division of Infertility and Reproductive Endocrinology, Faculty of Medicine I, Poznan University of Medical Sciences, Polna 33, Poznan 60-535, Poland. .
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6: Title: Cancer Stem Cell Phenotypes in ER+ Breast Cancer Models are Promoted by PELP1/AIB1 Complexes.
Authors: Truong, Thu H, et.al. .
Journal: Molecular cancer research : MCR (Mol Cancer Res), 2018 .
Snippet: Proline, glutamic acid, and leucine rich protein 1 (PELP1) is overexpressed in approximately 80% of invasive breast tumors.
Affiliation: Masonic Cancer Center, University of Minnesota. Department of Medicine, University of Minnesota. Microbiology, Immunology and Cancer Biology, Weill Cornell Medicine. Department of Laboratory Medicine and Pathology, University of Minnesota. Division of Hematology, Oncology, and Transplantation, Departments of Medicine and Pharmacology and The Masonic Cancer Center, University of Minnesota. Masonic Cancer Center, University of Minnesota hans1354@umn.edu. .
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7: Title: Expression of oestrogen receptors (GPER, ESR1, ESR2) in human ductuli efferentes and proximal epididymis.
Authors: Rago, V, et.al. .
Journal: Andrology, Vol. 6 (1): 192-198, 2018 .
Snippet: Furthermore, the presence of PELP1 (proline-glutamic acid-leucine-rich protein 1), a co-regulator of the oestrogen receptors, was also evaluated.
Affiliation: Department of Pharmacy, Health Science and Nutrition, University of Calabria, Arcavacata di Rende, Cosenza, Italy. Pathologic Anatomy Unit, Annunziata Hospital, Cosenza, Italy. .
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8: Title: Role of Scaffold Protein Proline-, Glutamic Acid-, and Leucine-Rich Protein 1 (PELP1) in the Modulation of Adrenocortical Cancer Cell Growth.
Authors: De Luca, Arianna, et.al. .
Journal: Cells, Vol. 6 (4), 2017 .
Snippet: Moreover, treatment of H295R with E2 or IGF-II induced a multiprotein complex formation consisting of PELP1, IGF1R, ERα, and Src that is involved in ERK1/2 rapid activation.
Affiliation: Cell and Applied Biology Laboratory, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy. ariannadl@hotmail.it. Cell and Applied Biology Laboratory, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy. paolaavena@libero.it. Cell and Applied Biology Laboratory, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy. rosa.sirianni@unical.it. Cell and Applied Biology Laboratory, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy. adechimento@libero.it. Clinica Medica 3, Department of Medicine-DIMED, University of Padova, 35128 Padova, Italy. Francesco.fallo@unipd.it. Clinica Medica 3, Department of Medicine-DIMED, University of Padova, 35128 Padova, Italy. catia.pilon@unipd.it. Cell and Applied Biology Laboratory, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy. icasaburi@yahoo.it. Cell and Applied Biology Laboratory, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy. v.pezzi@unical.it. .
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9: Title: Update on Immunohistochemical Analysis in Breast Lesions.
Authors: Peng, Yan, et.al. .
Journal: Archives of pathology & laboratory medicine (Arch Pathol Lab Med), Vol. 141 (8): 1033-1051, 2017 .
Snippet: Studies suggest that androgen receptor, p16, p53, GATA3, and PELP1 may have potential diagnostic, prognostic, and predictive value in triple-negative breast carcinoma cases; these findings may provide insight and a greater understanding of the tumor biology in triple-negative breast carcinomas.
Affiliation: From the Department of Pathology, University of Texas Southwestern Medical Center, Dallas (Drs Peng and Butt); the Department of Pathology, Mayo Clinic and Foundation, Rochester, Minnesota (Dr Chen); the Department of Pathology, Cooper Medical School of Rowan University, Camden, New Jersey (Dr Zhang); and the Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, New York (Dr Tang). .
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10: Title: PELP1 - A Key Mediator of Estrogen Signaling and Actions in the Brain.
Authors: Thakkar, Roshni, et.al. .
Journal: Journal of neuroendocrinology (J Neuroendocrinol), 2017 .
Snippet: As a whole, the findings discussed in this review indicate that PELP1 functions as a critical ER coregulator in the brain to mediate E2 signaling and actions.
Affiliation: Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA. Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, TX. Department of Neurobiology, North China University of Science and Technology, Tangshan, Hebei, China. .
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11: Title: Cytoplasmic Localization of Proline, Glutamic Acid, Leucine-rich Protein 1 (PELP1) Induces Breast Epithelial Cell Migration through Up-regulation of Inhibitor of κB Kinase ϵ and Inflammatory Cross-talk with Macrophages.
Authors: Girard, Brian J, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 292 (1): 339-350, 2017 .
Snippet: Global gene expression analysis was performed on HMEC lines expressing vector control, PELP1-wt, or mutant PELP1 in which the nuclear localization sequence was altered, resulting in cytoplasmic localization of PELP1 (PELP1-cyto).
Affiliation: From the Masonic Cancer Center and. Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455. From the Masonic Cancer Center and hans1354@umn.edu. Departments of Medicine and. .
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12: Title: NLRP3 Inflammasome Activation in the Brain after Global Cerebral Ischemia and Regulation by 17β-Estradiol.
Authors: Thakkar, Roshni, et.al. .
Journal: Oxidative medicine and cellular longevity (Oxid Med Cell Longev), Vol. 2016, 2016 .
Snippet: Intriguingly, the ability of E2 to exert these anti-inflammatory effects was lost in PELP1 forebrain-specific knockout mice, indicating a key role for PELP1 in E2 anti-inflammatory signaling.
Affiliation: Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA. Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, TX, USA. Department of Mathematics, Augusta University, Augusta, GA, USA. .
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13: Title: The AAA ATPase MDN1 Acts as a SUMO-Targeted Regulator in Mammalian Pre-ribosome Remodeling.
Authors: Raman, Nithya, et.al. .
Journal: Molecular cell (Mol Cell), Vol. 64 (3): 607-615, 2016 .
Snippet: We define MDN1 as a SUMO-targeted AAA ATPase, and we propose that a controlled SUMO cycle on PELP1 serves as regulatory point for mammalian 60S maturation through ordered recruitment and release of MDN1.
Affiliation: Institute of Biochemistry II, Goethe University, School of Medicine, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. Elisabeth Weir, Max-Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany. Institute of Biochemistry II, Goethe University, School of Medicine, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. Electronic address: ste.mueller@em.uni-frankfurt.de. .
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14: Title: Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode.
Authors: Wang, Donglai, et.al. .
Journal: Nature, Vol. 538 (7623): 118-122, 2016 .
Snippet: For example, acetylation of p53 also modulates its interactions with similar acidic domains found in other p53 regulators including VPRBP (also known as DCAF1), DAXX and PELP1 (refs.
Affiliation: Institute for Cancer Genetics, Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, College of Physicians &Surgeons, Columbia University, 1130 Nicholas Ave, New York, New York 10032, USA. Department of Biochemistry and Molecular Biophysics and Systems Biology, Center for Computational Biology and Bioinformatics, Howard Hughes Medical Institute, Columbia University, 1130 Nicholas Ave, New York, New York 10032, USA. State Key Laboratory of Proteomics, National Center for Protein Sciences (The PHOENIX Center, Beijing), Beijing, 102206, China. Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, Shenzhen 518060, China. Alkek Center for Molecular Discovery, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA. .
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15: Title: Identification of genes associated with renal cell carcinoma using gene expression profiling analysis.
Authors: Yao, Ting, et.al. .
Journal: Oncology letters (Oncol Lett), Vol. 12 (1): 73-78, 2016 .
Snippet: GATA3, ERG and MYB serve important roles in RCC while FOXC1, ESR1, FOXL1, PATZ1, STAT5A and PELP1 may be potential genes associated with RCC.
Affiliation: Physical Examination Center, Laiwu, Shandong 271100, P.R. China. Department of Chronic Non-Communicable Diseases Control and Prevention, Laiwu Center for Disease Control and Prevention, Laiwu, Shandong 271100, P.R. China. Department of Health Education, Laiwu Center for Disease Control and Prevention, Laiwu, Shandong 271100, P.R. China. Department of Health Inspection, Laiwu Center for Disease Control and Prevention, Laiwu, Shandong 271100, P.R. China. Department of Communicable Diseases Control and Prevention, Laiwu Center for Disease Control and Prevention, Laiwu, Shandong 271100, P.R. China. .
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16: Title: Expression of Estrogen Receptor Coactivator Proline-, Glutamic Acid- and Leucine-Rich Protein 1 within Paraspinal Muscles in Adolescents with Idiopathic Scoliosis.
Authors: Skibinska, Izabela, et.al. .
Journal: PloS one, Vol. 11 (4): e0152286, 2016 .
Snippet: In deep paraspinal back muscles, a significant correlation between the PELP1 expression level on the concave side and the Cobb angle (r = 0.4; p<0.05) was noted as well as between the PELP1 and ESR1 expression level (r = 0.7; p<0.05) while no correlation between PELP1 and ESR2 expression level was found.
Affiliation: Department of Cell Biology, Health Sciences Faculty, University of Medical Sciences, Poznan, Poland. Spine Disorders and Pediatric Orthopedics Department, Faculty of Medicine I, University of Medical Sciences, Poznan, Poland. .
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17: Title: PELP1: Structure, biological function and clinical significance.
Journal: Gene, Vol. 585 (1): 128-34, 2016 .
Snippet: Further, PELP1 plays essential roles in several pathways including hormonal signaling, cell cycle progression, ribosomal biogenesis, and the DNA damage response.
Affiliation: Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, United States. Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, United States. Electronic address: vadlamudi@uthscsa.edu. .
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18: Title: Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer.
Journal: Cancer research (Cancer Res), Vol. 76 (6): 1653-63, 2016 .
Snippet: Mechanistic investigations showed how PELP1 interacted with GR to activate Brk expression and demonstrated that physiologic cell stress, including hypoxia, promoted phosphorylation of GR serine 134, initiating a feed-forward signaling loop that contributed significantly to Brk upregulation.
Affiliation: Division of Hematology, Oncology, and Transplantation, Departments of Medicine and Pharmacology and The Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota. Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas. Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina. Department of Pathology and Laboratory Medicine and Center for Cancer Research, University of Tennessee HSC, Memphis, Tennessee. Division of Hematology, Oncology, and Transplantation, Departments of Medicine and Pharmacology and The Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota. lange047@umn.edu. .
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19: Title: Proline-, glutamic acid-, and leucine-rich protein 1 mediates estrogen rapid signaling and neuroprotection in the brain.
Authors: Sareddy, Gangadhara R, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), Vol. 112 (48): E6673-82, 2015 .
Snippet: In addition, PELP1 FBKO studies revealed that PELP1 is required for E2-mediated neuroprotection and for E2-mediated preservation of cognitive function after GCI.
Affiliation: Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, TX 78229; Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912; Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912; Neurobiology Institute of Medical Research Center, North China University of Science and Technology, Tangshan, People's Republic of China 063000; Department of Epidemiology & Biostatistics, University of Texas Health Science Center, San Antonio, TX 78229; Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229; South Texas Veterans Health System, Audie L. Murphy VA Hospital, San Antonio, TX 78229; Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, TX 78229; dbrann@gru.edu vadlamudi@uthscsa.edu. Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912; Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 30904 dbrann@gru.edu vadlamudi@uthscsa.edu. .
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20: Title: Prognostic significance of proline, glutamic acid, leucine rich protein 1 (PELP1) in triple-negative breast cancer: a retrospective study on 129 cases.
Authors: Zhang, Yanzhi, et.al. .
Journal: BMC cancer, Vol. 15, 2015 .
Snippet: Proline, glutamic acid, leucine rich protein 1 (PELP1) is a novel steroidal receptor co-regulator, functioning as an oncogene and its expression is maintained in estrogen receptor (ER) negative breast cancers.
Affiliation: Department of Pathology, Harbin Medical University-Daqing, No. 39 Xinyang Road, Hi-Tech Zone, Daqing, Heilongjiang, China. yeach_hmu@126.com. Department of Pathology, Harbin Medical University-Daqing, No. 39 Xinyang Road, Hi-Tech Zone, Daqing, Heilongjiang, China. daijiali999@163.com. Department of Pathology, Tohoku University School of Medicine, Sendai, Japan. kmcnamara@patholo2.med.tohoku.ac.jp. Department of Histology and Biology, Harbin Medical University-Daqing, Daqing, China. baib_hmu@126.com. Department of Pathology, Harbin Medical University-Daqing, No. 39 Xinyang Road, Hi-Tech Zone, Daqing, Heilongjiang, China. shimumu2009@139.com. Department of Pathology, Tohoku University School of Medicine, Sendai, Japan. drmonicachan@hotmail.com. Department of Pathology, Harbin Medical University-Daqing, No. 39 Xinyang Road, Hi-Tech Zone, Daqing, Heilongjiang, China. liuming_hmu@126.com. Department of Pathology, The Fifth Affiliated Hospital of Harbin Medical University, Daqing, China. liuming_hmu@126.com. Department of Pathology, Tohoku University School of Medicine, Sendai, Japan. hsasano@patholo2.med.tohoku.ac.jp. Department of Pathology, Harbin Medical University-Daqing, No. 39 Xinyang Road, Hi-Tech Zone, Daqing, Heilongjiang, China. wangxiulinihao@sina.cn. Department of Pathology, Harbin Medical University-Daqing, No. 39 Xinyang Road, Hi-Tech Zone, Daqing, Heilongjiang, China. xiaoleili2004@163.com. Department of Pathology, Harbin Medical University-Daqing, No. 39 Xinyang Road, Hi-Tech Zone, Daqing, Heilongjiang, China. llj19971997@163.com. Department of Pathology, Harbin Medical University-Daqing, No. 39 Xinyang Road, Hi-Tech Zone, Daqing, Heilongjiang, China. haorenmaying@126.com. Department of Pathology, Daqing Oilfield General Hospital, Daqing, China. caosw_dqytzyy@126.com. Department of Pathology, Daqing Longnan Hospital, Daqing, China. xingyc_lnhospital@126.com. Department of Pathology, Harbin Medical University-Daqing, No. 39 Xinyang Road, Hi-Tech Zone, Daqing, Heilongjiang, China. zhaobs_hmu@126.com. Department of Pathology, Harbin Medical University-Daqing, No. 39 Xinyang Road, Hi-Tech Zone, Daqing, Heilongjiang, China. songyl_hmu@126.com. Department of Pathology, Harbin Medical University-Daqing, No. 39 Xinyang Road, Hi-Tech Zone, Daqing, Heilongjiang, China. wangl_cmu@126.com. .
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