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13 documents found
1: Title: ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield.
Authors: Ou, Juanjuan, et.al. .
Journal: Nature communications (Nat Commun), Vol. 10 (1): 1078, 2019 .
Snippet: We demonstrated that ABHD5 localizes to lysosome and interacts with PDIA5 to prevent PDIA5 from interacting with RNASET2 and inactivating RNASET2.
Affiliation: Department of Oncology and Southwest Cancer Center, Southwest Hospital, Army Medical University, Chongqing, 400038, China. ojj521000@sina.com. Department of Oncology and Southwest Cancer Center, Southwest Hospital, Army Medical University, Chongqing, 400038, China. Biomedical Analysis Center, Army Medical University, Chongqing, 400038, China. Department of Oncology, Fuling Central Hospital, Chongqing, 408099, China. Department of Oncology and Southwest Cancer Center, Southwest Hospital, Army Medical University, Chongqing, 400038, China. leejjun2007@163.com. Department of Oncology and Southwest Cancer Center, Southwest Hospital, Army Medical University, Chongqing, 400038, China. lianghoujie@sina.com. .
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2: Title: Decreased levels of PDI and P5 in oligodendrocytes in Alzheimer's disease.
Authors: Honjo, Yasuyuki, et.al. .
Journal: Neuropathology : official journal of the Japanese Society of Neuropathology (Neuropathology), 2017 .
Snippet: Protein disulfide isomerase (PDI) is a chaperone protein located in the endoplasmic reticulum (ER).
Affiliation: Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Japan. Department of Neurology, Graduate School of Medicine, Kyoto University, Japan. Department of Neuroscience, Osaka City University Graduate School of Medicine, Japan. Department of Neurology, Graduate School of Medicine, Wakayama Medical University, Japan. Department of Clinical Neuroscience, Osaka City University Medical School, Japan. .
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3: Title: Identification of six polymorphisms as novel susceptibility loci for ischemic or hemorrhagic stroke by exome-wide association studies.
Authors: Yamada, Yoshiji, et.al. .
Journal: International journal of molecular medicine (Int J Mol Med), Vol. 39 (6): 1477-1491, 2017 .
Snippet: GABRB3, TMPRSS7, PDIA5 and CYP4F12 may thus be novel susceptibility loci for ischemic stroke, whereas STYK1 and COL17A1 may be such loci for ICH and SAH, respectively.
Affiliation: Department of Human Functional Genomics, Advanced Science Research Promotion Center, Mie University, Tsu 514‑8507, Japan. CREST, Japan Science and Technology Agency, Kawaguchi 332-0012, Japan. Department of Cardiovascular Medicine, Inabe General Hospital, Inabe 511-0428, Japan. Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi 507-8522, Japan. Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 101-0062, Japan. Section of Molecular Pathology, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan. Research Team for Social Participation and Community Health, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan. Research Team for Promoting Support System for Home Care, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan. Research Team for Social Participation and Health Promotion, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan. Center for Promotion of Clinical Investigation, Tokyo Metropolitan Geriatric Hospital, Tokyo 173-0015, Japan. Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo 173-0015, Japan. Department of Clinical Laboratory, Tokyo Metropolitan Geriatric Hospital, Tokyo 173-0015, Japan. .
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4: Title: Gene expression profiling in human precision cut liver slices in response to the FXR agonist obeticholic acid.
Authors: Ijssennagger, Noortje, et.al. .
Journal: Journal of hepatology (J Hepatol), Vol. 64 (5): 1158-66, 2016 .
Snippet: ChIP-sequencing in mouse liver confirmed FXR binding to IR1 sequences of Akap13, Cgnl1, Dyrk3, Pdia5, Ppp1r3b and Tbx6.
Affiliation: Department of Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, 3508 AB Utrecht, The Netherlands. Nutrition, Metabolism & Genomics Group, Division of Human Nutrition, Wageningen University, 6703 HD Wageningen, The Netherlands. Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3508 AB Utrecht, The Netherlands. Department of Surgery, Rijnstate Hospital, 6815 AD Arnhem, The Netherlands. Department of Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, 3508 AB Utrecht, The Netherlands. Electronic address: S.W.C.vanmil@umcutrecht.nl. .
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5: Title: Protein disulfide isomerases: Impact of thapsigargin treatment on their expression in melanoma cell lines.
Authors: Silva, Zélia, et.al. .
Journal: International journal of biological macromolecules (Int J Biol Macromol), Vol. 79, 2015 .
Snippet: While SK-MEL-30 PDIs' expression is not THG dose-dependent, an increase in glucose related protein 78 (GRP78), PDIA5, PDIA6, and thioredoxin-related-transmembrane proteins' (TMX3 and TMX4) expression, in response to higher drug concentrations, was observed in MNT-1.
Affiliation: CEDOC, Chronic Diseases Research Center, NOVA Medical School/Faculdade Ciências Médicas da Universidade Nova de Lisboa, Campo dos Mártires da Pátria, 130, 1169-056 Lisboa, Portugal. CEDOC, Chronic Diseases Research Center, NOVA Medical School/Faculdade Ciências Médicas da Universidade Nova de Lisboa, Campo dos Mártires da Pátria, 130, 1169-056 Lisboa, Portugal; Departamentio das Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal. CEDOC, Chronic Diseases Research Center, NOVA Medical School/Faculdade Ciências Médicas da Universidade Nova de Lisboa, Campo dos Mártires da Pátria, 130, 1169-056 Lisboa, Portugal; UEI Parasitologia Médica, Instituto de Higiene e Medicina Tropical da Universidade NOVA de Lisboa, Rua da Junqueira 100, 1349-008 Lisboa, Portugal. Electronic address: cnovo@ihmt.unl.pt. .
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6: Title: Association of a Polymorphism in the BIRC6 Gene with Pseudoexfoliative Glaucoma.
Authors: Ayub, Humaira, et.al. .
Journal: PloS one, Vol. 9 (8): e105023, 2014 .
Snippet: The goal of the current study is to investigate the role of these two genes, protein disulphide isomerase A member 5 (PDIA5) and baculoviral IAP repeat containing 6 (BIRC6), in different forms of glaucoma.
Affiliation: Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan. Department of Ophthalmology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. Al-Shifa Trust Eye Hospital, Rawalpindi, Pakistan. Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. Department of Ophthalmology, Tufts University School of Medicine, Boston, Massachusetts, United States of America. Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan; Al-Nafees Medical College & Hospital, Isra University, Islamabad, Pakistan. Department of Ophthalmology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. .
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7: Title: Discovery of protein disulfide isomerase P5 inhibitors that reduce the secretion of MICA from cancer cells.
Authors: Horibe, Tomohisa, et.al. .
Journal: Chembiochem : a European journal of chemical biology (Chembiochem), Vol. 15 (11): 1599-606, 2014 .
Snippet: In order to regulate the activity of P5, which is a member of the protein disulfide isomerase family, we screened a chemical compound library for P5-specific inhibitors, and identified two candidate compounds (anacardic acid and NSC74859).
Affiliation: Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, 606-8501 (Japan). .
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8: Title: Endoplasmic reticulum stress-activated transcription factor ATF6α requires the disulfide isomerase PDIA5 to modulate chemoresistance.
Authors: Higa, Arisa, et.al. .
Journal: Molecular and cellular biology (Mol Cell Biol), Vol. 34 (10): 1839-49, 2014 .
Snippet: Here, using a phenotypic small interfering RNA (siRNA) screening, we identified a novel role for ATF6α in chemoresistance and defined the protein disulfide isomerase A5 (PDIA5) as necessary for ATF6α activation upon ER stress.
Affiliation: INSERM U1053, Université Bordeaux Segalen, Bordeaux, France. .
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9: Title: Protein disulfide isomerase P5-immunopositive inclusions in patients with Alzheimer's disease.
Authors: Honjo, Yasuyuki, et.al. .
Journal: Journal of Alzheimer's disease : JAD (J Alzheimers Dis), Vol. 38 (3): 601-9, 2014 .
Snippet: The accumulation of misfolded proteins induces ER stress and may cause apoptosis of neuronal cells through S-nitrosylation and down-regulation of PDI and P5 in AD.
Affiliation: Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. .
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10: Title: Structure of the non-catalytic domain of the protein disulfide isomerase-related protein (PDIR) reveals function in protein binding.
Authors: Vinaik, Roohi, et.al. .
Journal: PloS one, Vol. 8 (4): e62021, 2013 .
Snippet: Protein disulfide isomerase-related (PDIR) protein (also known as PDIA5) is a specialized member that participates in the folding of α1-antitrypsin and N-linked glycoproteins.
Affiliation: Department of Biochemistry, Groupe de Recherche Axé sur la Structure des Protéines, McGill University, Montréal, Québec, Canada. .
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11: Title: Mitochondrial proteomics of nasopharyngeal carcinoma metastasis.
Authors: Liu, Jianping, et.al. .
Journal: BMC medical genomics (Bmc Med Genomics), Vol. 5, 2012 .
Snippet: Ten mitochondrial DEPs including PRDX3, PRDX6, SOD2, ECH1, SERPINB5, COX5A, PDIA5, EIF5A, IDH3B, and PSMC4 were rationalized in the tumor-stroma co-evolution model that mitochondrial oxidative stress directly contributes to tumor metastasis.
Affiliation: Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, PR China. .
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12: Title: Unfolded protein response is not activated in the mucopolysaccharidoses but protein disulfide isomerase 5 is deregulated.
Authors: Villani, Guglielmo R D, et.al. .
Journal: Journal of inherited metabolic disease (J Inherit Metab Dis), Vol. 35 (3): 479-93, 2012 .
Snippet: However, our results show that in most of the analyzed MPS fibroblasts the expression of a poorly known protein belonging to the family of the protein disulfide isomerases, namely Pdia5, is upregulated; here we discuss if its upregulation could be an early event of ER stress possibly related to the severity of the damage induced in the mutant proteins.
Affiliation: Department of Biochemistry and Medical Biotechnologies, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy. villani@dbbm.unina.it .
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13: Title: Genes of the unfolded protein response pathway harbor risk alleles for primary open angle glaucoma.
Authors: Carbone, Mary Anna, et.al. .
Journal: PloS one, Vol. 6 (5): e20649, 2011 .
Snippet: We selected 16 orthologous genes with 62 polymorphic markers and identified in two independent human populations two genes of the UPR that harbor POAG risk alleles, BIRC6 and PDIA5.
Affiliation: Department of Genetics, North Carolina State University, Raleigh, North Carolina, United States of America. .
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