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23 documents found
1: Title: Identification of biomarkers associated with diagnosis and prognosis of colorectal cancer patients based on integrated bioinformatics analysis.
Authors: Chen, Linbo, et.al. .
Journal: Gene, Vol. 692, 2019 .
Snippet: A prognostic gene signature consisted of 9 genes including SLC4A4, NFE2L3, GLDN, PCOLCE2, TIMP1, CCL28, SCGB2A1, AXIN2, and MMP1 was constructed with a good performance in predicting overall survivals of CRC patients.
Affiliation: Department of Gastroenterology, Ningbo Yinzhou People's Hospital, Ningbo 315040, China. Department of Infectious Diseases, Ningbo Yinzhou People's Hospital, Ningbo 315040, China. Electronic address: 849840290@qq.com. Department of Gastroenterology, Ningbo Yinzhou People's Hospital, Ningbo 315040, China. Electronic address: xufeng200468@126.com. .
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2: Title: A six-mRNA prognostic model to predict survival in head and neck squamous cell carcinoma.
Authors: Tian, Saisai, et.al. .
Journal: Cancer management and research (Cancer Manag Res), Vol. 11, 2019 .
Snippet: Results: We identified six candidate genes, namely, FOXL2NB, PCOLCE2, SPINK6, ULBP2, KCNJ18, and RFPL1, and, using a six-gene model, predicted the risk of death of head and neck squamous cell carcinoma in The Cancer Genome Atlas.
Affiliation: Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China, wdzhangy@hotmail.com. Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China, wdzhangy@hotmail.com. .
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3: Title: A genome-wide association study of red-blood cell fatty acids and ratios incorporating dietary covariates: Framingham Heart Study Offspring Cohort.
Authors: Kalsbeek, Anya, et.al. .
Journal: PloS one, Vol. 13 (4): e0194882, 2018 .
Snippet: Our analysis found nine previously identified loci associated with FA levels (FADS, ELOVL2, PCOLCE2, LPCAT3, AGPAT4, NTAN1/PDXDC1, PKD2L1, HBS1L/MYB and RAB3GAP1/MCM6), while identifying four novel loci.
Affiliation: Department of Mathematics, Statistics and Computer Science, Dordt College, Sioux Center, Iowa, United States of America. Department of Statistics, Baylor University, Waco, TX, United States of America. Department of Statistics, Duke University, Durham, NC, United States of America. Department of Mathematics and Statistics, University of Maryland- Baltimore County, Baltimore, MD, United States of America. Department of Nutritional Sciences, Penn State University, State College, PA, United States of America. OmegaQuant, Sioux Falls, SD, United States of America. .
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4: Title: Whole-genome expression analyses of type 2 diabetes in human skin reveal altered immune function and burden of infection.
Authors: Wu, Chun, et.al. .
Journal: Oncotarget, Vol. 8 (21): 34601-34609, 2017 .
Snippet: Genes in cell adhesion molecules pathway (NCAM1 and L1CAM) and collagen family (PCOLCE2 and COL9A3) are downregulated, suggesting structural changes in the skin of T2DM.
Affiliation: Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL, USA. Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, P.R. China. Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA. .
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5: Title: Interferon signaling in ascites-associated macrophages is linked to a favorable clinical outcome in a subgroup of ovarian carcinoma patients.
Authors: Adhikary, Till, et.al. .
Journal: BMC genomics, Vol. 18 (1): 243, 2017 .
Snippet: A hallmark of subgroup A is a high expression of clinically unfavorable markers, including (i) high CD163 expression, a surface receptor characteristic of an anti-inflammatory activation state, (ii) increased PCOLCE2 expression, indicative of enhanced extracellular matrix organization, and (iii) elevated ascites levels of IL-6 and IL-10, linked to the aggressiveness of ovarian cancer and immune suppression.
Affiliation: Institute of Molecular Biology and Tumor Research (IMT), Center for Tumor Biology and Immunology (ZTI), Philipps University, Marburg, Germany. Genomics Core Facility, Center for Tumor Biology and Immunology (ZTI), Philipps University, Marburg, Germany. Clinic for Gynecology, Gynecological Oncology and Gynecological Endocrinology, Center for Tumor Biology and Immunology (ZTI), Philipps University, Marburg, Germany. Institute of Molecular Biology and Tumor Research (IMT), Center for Tumor Biology and Immunology (ZTI), Philipps University, Marburg, Germany. rmueller@imt.uni-marburg.de. .
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6: Title: Matrix and cell phenotype differences in Dupuytren's disease.
Authors: van Beuge, Marike M, et.al. .
Journal: Fibrogenesis & tissue repair (Unknown Journal), Vol. 9, 2016 .
Snippet: PCOLCE2, an activator of BMP1, the main enzyme cleaving the C-terminal pro-peptide from procollagen, was also reduced in nodule.
Affiliation: Department of Pathology & Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands. Department of Pathology & Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands ; Department of Plastic Surgery, Department of Pathology & Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands. Department of Plastic Surgery, Department of Pathology & Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands. .
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7: Title: Intermittent energy restriction induces changes in breast gene expression and systemic metabolism.
Authors: Harvie, Michelle N, et.al. .
Journal: Breast cancer research : BCR (Breast Cancer Res), Vol. 18 (1): 57, 2016 .
Snippet: Some of these women also had increases in genes associated with breast epithelial cell differentiation (secretoglobulins, milk proteins and mucins) and decreased collagen synthesis (TNMD, PCOLCE2, TIMP4).
Affiliation: Genesis Breast Cancer Prevention Centre, University Hospital of South Manchester NHS Foundation Trust, Southmoor Road, Manchester, M23 9LT, UK. michelle.harvie@manchester.ac.uk. Applied Bioinformatics of Cancer, University of Edinburgh, Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, Carrington Crescent, Edinburgh, EH4 2XR, UK. Genesis Breast Cancer Prevention Centre, University Hospital of South Manchester NHS Foundation Trust, Southmoor Road, Manchester, M23 9LT, UK. Breast Cancer Now Research Unit, Institute of Cancer Sciences, Academic Health Science Centre, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK. Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, Princess St, Manchester, M1 7DN, UK. The Christie NHS Foundation Trust, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK. .
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8: Title: Exome sequencing in one family with gastric- and rectal cancer.
Journal: BMC genetics (Bmc Genet), Vol. 17, 2016 .
Snippet: The mutations were found in 12 different genes; DZIP1L, PCOLCE2, IGSF10, SUCNR1, OR13C8, EPB41L4B, SEC16A, NOTCH1, TAS2R7, SF3A1, GAL3ST1, and TRIOBP.
Affiliation: Karolinska Institutet, Department of Molecular Medicine and Surgery, Stockholm, Sweden. jessada.thutkawkorapin@ki.se. Karolinska Institutet, Department of Molecular Medicine and Surgery, Stockholm, Sweden. simone.picelli@ki.se. Eukaryotic Single Cell Genomics facility, Science for Life Laboratory, Stockholm, Sweden. simone.picelli@ki.se. Karolinska Institutet, Department of Molecular Medicine and Surgery, Stockholm, Sweden. ksvinaykumar@gmail.com. Karolinska Institutet, Department of Molecular Medicine and Surgery, Stockholm, Sweden. Tao.Liu@ki.se. Karolinska Institutet, Department of Molecular Medicine and Surgery, Stockholm, Sweden. Daniel.Nilsson@ki.se. Karolinska Institutet, Department of Molecular Medicine and Surgery, Stockholm, Sweden. Annika.Lindblom@ki.se. .
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9: Title: Genome-wide RNA-Seq analysis of breast muscles of two broiler chicken groups differing in shear force.
Authors: Piórkowska, K, et.al. .
Journal: Animal genetics (Anim Genet), Vol. 47 (1): 68-80, 2016 .
Snippet: In the down-regulated gene group, genes which play a role in lipogenesis (THRSP, PLIN1) and in collagen synthesis (P4HA3, LEPREL4, PCOLCE2, COL16A1, COL20A1, VWA1) were detected.
Affiliation: Department of Animal Genomics and Molecular Biology, National Research Institute of Animal Production, 32-083 Balice, Poland. Department of Animal Genetics and Breeding, National Research Institute of Animal Production, 32-083 Balice, Poland. .
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10: Title: What does procollagen C-endopeptidase enhancer protein 2 have to do with HDL-cholesteryl ester uptake? Or how I learned to stop worrying and love reverse cholesterol transport?
Authors: Sorci-Thomas, Mary G, et.al. .
Journal: Current opinion in lipidology (Curr Opin Lipidol), Vol. 26 (5): 420-5, 2015 .
Snippet: For example, reduced ATP-binding cassette transporter 1-mediated production of nascent HDL lowers plasma HDL concentration, just as an increase in cholesteryl ester uptake by scavenger receptor class B1 reduces HDL levels.
Affiliation: aDepartment of Medicine and Endocrinology bDepartment of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin cformerly of Wake Forest School of Medicine, Department of Molecular Medicine, Winston-Salem, North Carolina, USA. .
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11: Title: Procollagen C-endopeptidase Enhancer Protein 2 (PCPE2) Reduces Atherosclerosis in Mice by Enhancing Scavenger Receptor Class B1 (SR-BI)-mediated High-density Lipoprotein (HDL)-Cholesteryl Ester Uptake.
Authors: Pollard, Ricquita D, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 290 (25): 15496-511, 2015 .
Snippet: PCPE2, a 52-kDa glycoprotein located in the extracellular matrix, enhances the cleavage of C-terminal procollagen by bone morphogenetic protein 1 (BMP1).
Affiliation: the Section of Molecular Medicine, Department of Internal Medicine and the Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27101. the Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut 06268. From the Department of Medicine and the Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226. Shire Human Genetic Therapies, Lexington, Massachusetts 02421, and. the Department of Pediatrics, University of Kentucky, Lexington, Kentucky 40506. From the Department of Medicine and the Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, msthomas@mcw.edu. .
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12: Title: A genome-wide association study of saturated, mono- and polyunsaturated red blood cell fatty acids in the Framingham Heart Offspring Study.
Authors: Tintle, N L, et.al. .
Journal: Prostaglandins, leukotrienes, and essential fatty acids (Prostaglandins Leukot Essent Fatty Acids), Vol. 94, 2015 .
Snippet: Of particular interest were novel associations between (1) arachidonic acid and PCOLCE2 (regulates apoA-I maturation and modulates apoA-I levels), and (2) oleic and linoleic acid and LPCAT3 (mediates the transfer of fatty acids between glycerolipids).
Affiliation: Department of Mathematics, Statistics and Computer Science, Dordt College, Sioux Center, IA 51250, USA. Electronic address: nathan.tintle@dordt.edu. Health Diagnostic Laboratory, Richmond, VA, USA; Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA. Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave., Boston, MA, USA. Framingham Heart Study, 73 Mt. Wayte Ave., Framingham, MA 01702, USA; Boston University School of Medicine, 72 E. Concord St., Boston, MA 02118, USA. Department of Mathematics, Statistics and Computer Science, Dordt College, Sioux Center, IA 51250, USA. Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave., Boston, MA, USA; Boston University School of Medicine, 72 E. Concord St., Boston, MA 02118, USA; Department of Mathematics and Statistics, Boston University, 111 Cummington St., Boston, MA, USA. Health Diagnostic Laboratory, Richmond, VA, USA; Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA; OmegaQuant, Sioux Falls, SD, USA. Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA. .
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13: Title: Human amniotic fluid-derived mesenchymal cells from fetuses with a neural tube defect do not deposit collagen type i protein after TGF-β1 stimulation in vitro.
Authors: Hosper, Nynke A, et.al. .
Journal: Stem cells and development (Stem Cells Dev), Vol. 23 (5): 555-62, 2014 .
Snippet: We found that cells derived from fetuses with a NTD, in contrast to healthy human amniotic fluid cells, did not deposit collagen type I. Furthermore, the NTD cells showed, compared with both healthy amniotic fluid cells and fetal fibroblasts, much lower mRNA expression levels of genes that are involved in collagen biosynthesis [procollagen C-endopeptidase enhancer proteins (PCOLCE), PCOLCE2, ADAM metallopeptidase with thrombospondin type 1 motif, 2 (ADAMTS2), ADAMTS14].
Affiliation: 1 Medical Biology Section, Department of Pathology and Medical Biology, University Medical Centre Groningen , University of Groningen, GZ Groningen, The Netherlands . .
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14: Title: Differences in the degree of cerulein-induced chronic pancreatitis in C57BL/6 mouse substrains lead to new insights in identification of potential risk factors in the development of chronic pancreatitis.
Authors: Ulmasov, Barbara, et.al. .
Journal: The American journal of pathology (Am J Pathol), Vol. 183 (3): 692-708, 2013 .
Snippet: Genes with differentially regulated expression between the two substrains that might be candidates in CP progression included Mmp7, Pcolce2, Itih4, Wdfy1, and Vtn.
Affiliation: Department of Internal Medicine, Saint Louis University, Saint Louis, Missouri, USA. bulmasov@slu.edu .
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15: Title: Effects of the absence of procollagen C-endopeptidase enhancer-2 on myocardial collagen accumulation in chronic pressure overload.
Authors: Baicu, Catalin F, et.al. .
Journal: American journal of physiology. Heart and circulatory physiology (Am J Physiol Heart Circ Physiol), Vol. 303 (2): H234-40, 2012 .
Snippet: Hence, PCOLCE2 is required for efficient procollagen processing and deposition of fibrillar collagen in the PO myocardium.
Affiliation: Gazes Cardiac Research Institute, Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA. .
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16: Title: Cubbing in proapolipoprotein maturation.
Authors: Getz, Godfrey S, et.al. .
Journal: Journal of lipid research (J Lipid Res), Vol. 52 (11): 1861-4, 2011 .
No Abstract available.
Affiliation: Department of Pathology, The University of Chicago, Chicago, IL 60637, USA. g-getz@uchicago.edu .
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17: Title: Disruption of the murine procollagen C-proteinase enhancer 2 gene causes accumulation of pro-apoA-I and increased HDL levels.
Authors: Francone, Omar L, et.al. .
Journal: Journal of lipid research (J Lipid Res), Vol. 52 (11): 1974-83, 2011 .
Snippet: Recent studies revealed an unexpected role for this protein in the proteolytic processing of pro-apolipoprotein (apo) A-I by enhancing the cleavage of the hexapeptide extension present at the N-terminus of apoA-I.
Affiliation: Department of Cardiovascular and Metabolic Diseases, Global Research and Development, Pfizer, Inc., Groton, CT, USA. omarfrancone@gmail.com .
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18: Title: Maturation of apolipoprotein A-I: unrecognized health benefit or a forgotten rudiment?
Journal: Journal of lipid research (J Lipid Res), Vol. 50 (7): 1257-8, 2009 .
No Abstract available.
Affiliation: Baker IDI Heart and Diabetes Institute, Melbourne, Australia. Dmitri.Sviridov@Bakeridi.edu.au .
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19: Title: Regulation of apoAI processing by procollagen C-proteinase enhancer-2 and bone morphogenetic protein-1.
Authors: Zhu, Jian, et.al. .
Journal: Journal of lipid research (J Lipid Res), Vol. 50 (7): 1330-9, 2009 .
Snippet: Data indicate that PCPE2 accelerates the proteolytic processing of pro-apolipoprotein (apo) AI by enhancing the cleavage of the hexapeptide extension present at the N terminus of apoAI.
Affiliation: Pfizer Global Research and Development, Department of Cardiovascular and Metabolic Diseases, Groton, CT 06340, USA. .
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20: Title: The Foxn1-dependent transcripts PCOLCE2 and mPPP1R16B are not required for normal thymopoiesis.
Authors: Heinzel, Kornelia, et.al. .
Journal: European journal of immunology (Eur J Immunol), Vol. 37 (9): 2562-71, 2007 .
Snippet: In order to study the functional role of this gene in TEC differentiation, we have genetically inactivated PCOLCE2 and the gene encoding phosphatase 1 regulatory inhibitory subunit 16B (mPPP1R16B), another transcript lacking in Foxn1-deficient TEC.
Affiliation: The Max-Planck-Institute of Immunobiology, Department of Developmental Immunology, Freiburg, Germany. .
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