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23 documents found
1: Title: 3' RNA Uridylation in Epitranscriptomics, Gene Regulation, and Disease.
Authors: Menezes, Miriam R, et.al. .
Journal: Frontiers in molecular biosciences (Front Mol Biosci), Vol. 5, 2018 .
Snippet: We also introduce recent changes to the HUGO-approved gene names for multiple terminal nucleotidyl transferases that affects in part TUTase nomenclature (TUT1/TENT1, TENT2/PAPD4/GLD2, TUT4/ZCCHC11/TENT3A, TUT7/ZCCHC6/TENT3B, TENT4A/PAPD7, TENT4B/PAPD5, TENT5A/FAM46A, TENT5B/FAM46B, TENT5C/FAM46C, TENT5D/FAM46D, MTPAP/TENT6/PAPD1).
Affiliation: Department of Neurosurgery, University of Texas Health Science Center at Houston, Houston, TX, United States. .
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2: Title: An effective and efficient method of transfecting primary human chondrocytes in suspension.
Journal: Analytical biochemistry (Anal Biochem), Vol. 526, 2017 .
Snippet: Chondrocyte cultures were digested using Pronase and Collagenase and transfected in suspension.
Affiliation: Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH 44272, United States. Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH 44272, United States. Electronic address: thaqqi@neomed.edu. .
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3: Title: Hepatitis C Virus Core Protein Promotes miR-122 Destabilization by Inhibiting GLD-2.
Authors: Kim, Geon-Woo, et.al. .
Journal: PLoS pathogens (Plos Pathog), Vol. 12 (7): e1005714, 2016 .
Snippet: The liver-specific microRNA miR-122, which has essential roles in liver development and metabolism, is a key proviral factor for hepatitis C virus (HCV).
Affiliation: Department of Biotechnology, Yonsei University, Seoul, Korea. Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea. .
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4: Title: Nucleotide specificity of the human terminal nucleotidyltransferase Gld2 (TUT2).
Authors: Chung, Christina Z, et.al. .
Journal: RNA (New York, N.Y.) (Rna), Vol. 22 (8): 1239-49, 2016 .
Snippet: A phylogeny of the PAP/TUTase superfamily suggests that uridylyltransferases, which are derived from distinct adenylyltransferase ancestors, arose multiple times during evolution via insertion of an active site histidine.
Affiliation: Department of Biochemistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada. .
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5: Title: The STAR protein QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs.
Authors: Yamagishi, Ryota, et.al. .
Journal: Nucleic acids research (Nucleic Acids Res), Vol. 44 (6): 2475-90, 2016 .
Snippet: An anti-mitogenic signal that induces cell cycle arrest at G1 phase elicits polyadenylation and translation of p27(kip1)mRNA via QKI and PAPD4.
Affiliation: Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan. Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan hoshino@phar.nagoya-cu.ac.jp. .
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6: Title: Pilocarpine-induced seizures trigger differential regulation of microRNA-stability related genes in rat hippocampal neurons.
Authors: Kinjo, Erika R, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 6, 2016 .
Snippet: SE simultaneously upregulated XRN2 and downregulated PAPD4 gene expression in the hippocampus, two genes related to miRNA degradation and stability, respectively.
Affiliation: Núcleo de Cognição e Sistemas Complexos, Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, São Bernardo do Campo, SP, Brazil. Departamento de Fisiologia e Biofísica, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil. Programa de Neuroengenharia, Instituto Internacional de Neurociências Edmond e Lily Safra, ISD, Macaíba, RN, Brazil. Laboratório de Neurociências, LIM 01, Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil. .
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7: Title: Identification of factors involved in target RNA-directed microRNA degradation.
Authors: Haas, Gabrielle, et.al. .
Journal: Nucleic acids research (Nucleic Acids Res), Vol. 44 (6): 2873-87, 2016 .
Snippet: We show that this protein interacts with Argonaute 2 and functionally validate its role in target-directed miRNA degradation both by artificial targets and in the context of mouse cytomegalovirus infection.
Affiliation: Architecture and Reactivity of RNA, Institut de biologie moléculaire et cellulaire du CNRS, Université de Strasbourg, 15 rue René Descartes, 67084 Strasbourg, France. Architecture and Reactivity of RNA, Institut de biologie moléculaire et cellulaire du CNRS, Université de Strasbourg, 15 rue René Descartes, 67084 Strasbourg, France s.pfeffer@ibmc-cnrs.unistra.fr. .
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8: Title: Unraveling the Rat Intestine, Spleen and Liver Genome-Wide Transcriptome after the Oral Administration of Lavender Oil by a Two-Color Dye-Swap DNA Microarray Approach.
Authors: Kubo, Hiroko, et.al. .
Journal: PloS one, Vol. 10 (7): e0129951, 2015 .
Snippet: Further IPA analysis in particular unraveled the presence of novel genes, such as Papd4, Or8k5, Gprc5b, Taar5, Trpc6, Pld2 and Onecut3 (up-regulated top molecules) and Tnf, Slc45a4, Slc25a23 and Samt4 (down-regulated top molecules), to be influenced by LO treatment in the small intestine, spleen and liver, respectively.
Affiliation: Department of Anatomy I, Showa University School of Medicine, Shinagawa, Tokyo, Japan; Oriental Aromatherapy College, Katsushika, Tokyo, Japan. Department of Anatomy I, Showa University School of Medicine, Shinagawa, Tokyo, Japan; Global Research Center for Innovative Life Science, Peptide Drug Innovation, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo, Japan; Laboratory of Exercise Biochemistry and Neuroendocrinology, Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan. Department of Anatomy I, Showa University School of Medicine, Shinagawa, Tokyo, Japan. Department of Anatomy I, Showa University School of Medicine, Shinagawa, Tokyo, Japan; Department of Physiology, Saitama Medical University, Iruma-gun, Saitama, Japan. Department of Anatomy I, Showa University School of Medicine, Shinagawa, Tokyo, Japan; Global Research Center for Innovative Life Science, Peptide Drug Innovation, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo, Japan; Organization for Educational Initiatives, University of Tsukuba, Tsukuba, Ibaraki, Japan; Faculty of Health and Sport Sciences & Tsukuba International Academy for Sport Studies (TIAS), University of Tsukuba, Tsukuba, Ibaraki, Japan. Department of Anatomy I, Showa University School of Medicine, Shinagawa, Tokyo, Japan; Global Research Center for Innovative Life Science, Peptide Drug Innovation, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo, Japan. .
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9: Title: TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms.
Authors: Kim, Boseon, et.al. .
Journal: The EMBO journal (Embo J), Vol. 34 (13): 1801-15, 2015 .
Snippet: We find that the overhang of a pre-miRNA is the key structural element that is recognized by TUT7 and its paralogues, TUT4 (ZCCHC11) and TUT2 (GLD2/PAPD4).
Affiliation: Center for RNA Research, Institute for Basic Science, Seoul, Korea School of Biological Sciences, Seoul National University, Seoul, Korea. Kavli Institute of NanoScience, Department of BioNanoScience, Delft University of Technology, Delft, The Netherlands. Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. Kavli Institute of NanoScience, Department of BioNanoScience, Delft University of Technology, Delft, The Netherlands c.joo@tudelft.nl narrykim@snu.ac.kr. Center for RNA Research, Institute for Basic Science, Seoul, Korea School of Biological Sciences, Seoul National University, Seoul, Korea c.joo@tudelft.nl narrykim@snu.ac.kr. .
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10: Title: HBx down-regulated Gld2 plays a critical role in HBV-related dysregulation of miR-122.
Authors: Peng, Feng, et.al. .
Journal: PloS one, Vol. 9 (3): e92998, 2014 .
Snippet: As revealed by qRT-PCR and western blotting analyses, both miR-122 and Gld2 levels were reduced in hepatic cell lines with expression of HBV or HBx but not other proteins of HBV, and over-expression of Gld2 could abolish the effect of HBV and HBx on the miR-122 level.
Affiliation: Department of Infectious Diseases, Second Xiangya Hospital of Central South University, Changsha, Hunan, China. .
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11: Title: A possible new mechanism for the control of miRNA expression in neurons.
Authors: Kinjo, Erika Reime, et.al. .
Journal: Experimental neurology (Exp Neurol), Vol. 248, 2013 .
Snippet: Combining bioinformatics and real-time PCR, we demonstrated that XRN2 and PAPD4 expression is regulated by the uncorrelated action of transcription factors, resulting in distinct gene expression profiles during development.
Affiliation: Núcleo de Cognição e Sistemas Complexos, Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, 09210-580 Santo André, SP, Brazil. .
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12: Title: Developmental and functional expression of miRNA-stability related genes in the nervous system.
Authors: de Sousa, Érica, et.al. .
Journal: PloS one, Vol. 8 (5): e56908, 2013 .
Snippet: Indeed, XRN2 and PAPD4 were observed mainly after neuronal differentiation, since low expression was also observed in astrocytes, endothelial and microglial cells.
Affiliation: Núcleo de Cognição e Sistemas Complexos, Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, Santo André, SP, Brasil. .
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13: Title: Translational control of cell growth and malignancy by the CPEBs.
Authors: D'Ambrogio, Andrea, et.al. .
Journal: Nature reviews. Cancer (Nat Rev Cancer), Vol. 13 (4): 283-90, 2013 .
Snippet: Several CPEB-regulated mRNAs govern cell cycle progression, regulate senescence, establish cell polarity, and promote tumorigenesis and metastasis.
Affiliation: The Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA. .
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14: Title: Common variant in FUT2 gene is associated with levels of vitamin B(12) in Indian population.
Authors: Tanwar, Vinay Singh, et.al. .
Journal: Gene, Vol. 515 (1): 224-8, 2013 .
Snippet: Thus, our study reveals that vegetarian diet along with polymorphism in the FUT2 gene may contribute significantly to the high prevalence of vitamin B(12) deficiency in India.
Affiliation: Genomics and Molecular Medicine, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi-110007, India. vinay.singh@igib.in .
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15: Title: Specific miRNA stabilization by Gld2-catalyzed monoadenylation.
Authors: D'Ambrogio, Andrea, et.al. .
Journal: Cell reports (Cell Rep), Vol. 2 (6): 1537-45, 2012 .
Snippet: These results establish a mechanism of miRNA stability and resulting posttranscriptional gene regulation.
Affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. .
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16: Title: mRNAs containing the histone 3' stem-loop are degraded primarily by decapping mediated by oligouridylation of the 3' end.
Authors: Su, Wei, et.al. .
Journal: RNA (New York, N.Y.) (Rna), Vol. 19 (1): 1-16, 2013 .
Snippet: We introduced firefly luciferase reporter mRNAs containing the histone 3' UTR SL (Luc-SL) and either a normal or hDcp2-resistant cap into S-phase HeLa cells.
Affiliation: Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130-3932, USA. .
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17: Title: Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs.
Authors: Heo, Inha, et.al. .
Journal: Cell, Vol. 151 (3): 521-32, 2012 .
Snippet: We identify TUT7/ZCCHC6, TUT4/ZCCHC11, and TUT2/PAPD4/GLD2 as the terminal uridylyl transferases responsible for pre-miRNA mono-uridylation.
Affiliation: Institute for Basic Science, Seoul National University, Seoul 151-742, Korea. .
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18: Title: Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.
Authors: Udagawa, Tsuyoshi, et.al. .
Journal: Molecular cell (Mol Cell), Vol. 47 (2): 253-66, 2012 .
Snippet: Synaptic stimulation induces phosphorylation of CPEB, PARN expulsion from the ribonucleoprotein complex, and polyadenylation in dendrites.
Affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. .
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19: Title: Involvement of hGLD-2 in cytoplasmic polyadenylation of human p53 mRNA.
Authors: Glahder, Jacob A, et.al. .
Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica (Apmis), Vol. 119 (11): 769-75, 2011 .
Snippet: Herein, we report the down regulation of a luciferase reporter fused to the p53 3'-UTR, when human CPE-binding protein 1 (hCPEB1) is overexpressed.
Affiliation: Department of Cellular and Molecular Medicine, Panum Institute, University of Copenhagen, Denmark. .
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20: Title: Yeast two-hybrid screening of proteins interacting with plasmin receptor subunit: C-terminal fragment of annexin A2.
Authors: Li, Qun, et.al. .
Journal: Acta pharmacologica Sinica (Acta Pharmacol Sin), Vol. 32 (11): 1411-8, 2011 .
Snippet: Sequence analysis and a database search revealed that 15 of these positive clones matched eight different proteins (SNX17, ProCathepsin S, RPS2, ZBTB4, OGDH, CCDC32, PAPD4, and actin which was already known to interact with annexin A2).
Affiliation: Joint Laboratory of Vascular Biology, Ruijin Hospital, Health Science Center, Shanghai, China. liqun@sibs.ac.cn .
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