refine search
Authors
Locations
Journals
Publication Dates
Find concepts in Knowledge Base
Explore current query
documentsstatisticstop authorclipboard
54 documents found
1: Title: Paip2 is localized to active promoters and loaded onto nascent mRNA in Drosophila.
Authors: Kachaev, Zaur M, et.al. .
Journal: Cell cycle (Georgetown, Tex.) (Cell Cycle), 2018 .
Snippet: Paip2 (Poly(A)-binding protein - interacting protein 2) is a conserved metazoan-specific protein that has been implicated in regulating the translation and stability of mRNAs.
Affiliation: a Institute of Gene Biology, Russian Academy of Sciences , 34/5 Vavilov St., Moscow , 119334 Russia. d V.I. Orekhovich Research Institute of Biomedical Chemistry , 10, Pogodinskaya St., Moscow , 119832 Russia. b Department of Molecular Biology , Princeton University , Princeton , NJ 08540 , USA. c I.M. Sechenov First Moscow State Medical University , 8, bldg. 2 Trubetskaya St., Moscow , 119048 Russia. .
Related Products: order online
2: Title: In silico analysis of single-cell RNA sequencing data from 3 and 7 days old mouse spermatogonial stem cells to identify their differentially expressed genes and transcriptional regulators.
Authors: Sisakhtnezhad, Sajjad .
Journal: Journal of cellular biochemistry (J Cell Biochem), 2018 .
Snippet: It also found that DAZL, FKBP6, PAIP2, DDX4, H3F3B, TEX15, XRN2, MAEL, and SOD1 are important factors with the higher gene expression pattern, which may be pivotal for mSSCs fate and function during development of germ cells.
Affiliation: Faculty of Science, Department of Biology, Razi University, Kermanshah, Iran. .
Related Products: order online
3: Title: Kinetics of Endogenous CaMKII Required for Synaptic Plasticity Revealed by Optogenetic Kinase Inhibitor.
Authors: Murakoshi, Hideji, et.al. .
Journal: Neuron, Vol. 94 (1): 37-47.e5, 2017 .
Snippet: The photoactivation of paAIP2 in neurons for 1-2 min during the induction of LTP and structural LTP (sLTP) of dendritic spines inhibited these forms of plasticity in hippocampal slices of rodents.
Affiliation: Supportive Center for Brain Research, National Institute for Physiological Sciences, Okazaki, Aichi 444-8585, Japan; Department of Physiological Sciences, Graduate University for Advanced Studies, Okazaki, Aichi 444-8585, Japan; Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: murakosh@nips.ac.jp. Max Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA. Supportive Center for Brain Research, National Institute for Physiological Sciences, Okazaki, Aichi 444-8585, Japan. Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA; Max Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA. Electronic address: ryohei.yasuda@mpfi.org. .
Related Products: order online
4: Title: Mini Review: Circular RNAs as Potential Clinical Biomarkers for Disorders in the Central Nervous System.
Authors: Lu, Dan, et.al. .
Journal: Frontiers in genetics (Unknown Journal), Vol. 7, 2016 .
Snippet: For example, ciRS-7 was found to be a natural microRNAs sponge for miRNA-7 and regulate Parkinson's disease/Alzheimer's disease-related genes; circPAIP2 is an intron-retaining circRNA which upregulates memory-related parental genes PAIP2 to affect memory development through PABP reactivation.
Affiliation: Department of Neurology and Stroke Center, The First Affiliated Hospital, Jinan University Guangzhou Guangdong, China. .
Related Products: order online
5: Title: A Specialized Mechanism of Translation Mediated by FXR1a-Associated MicroRNP in Cellular Quiescence.
Authors: Bukhari, Syed I A, et.al. .
Journal: Molecular cell (Mol Cell), Vol. 61 (5): 760-73, 2016 .
Snippet: Activation requires shortened/no poly(A)-tail targets; polyadenylated mRNAs are partially activated upon PAIP2 overexpression, which interferes with poly(A)-bound PABP, precluding PABP-enhanced microRNA-mediated inhibition and canonical translation.
Affiliation: Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Department of Biochemistry, Goodman Cancer Research Center, McGill University, Montreal, QC H3A 1A3, Canada. Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: vasudevan.shobha@mgh.harvard.edu. .
Related Products: order online
6: Title: ROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expression.
Authors: Yoshikawa, Takeshi, et.al. .
Journal: Nucleic acids research (Nucleic Acids Res), Vol. 43 (15): 7577-89, 2015 .
Snippet: The regulation of miRNA function by ROCK inhibitors is mediated, at least in part, by poly(A)-binding protein-interacting protein 2 (PAIP2), which enhances poly(A)-shortening of miRNA-targeted mRNAs and leads to global upregulation of miRNA function.
Affiliation: Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan. State Key Laboratory of Cellular Stress Biology and School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China. Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan Japan Science and Technology Agency, PRESTO, Kawaguchi, Saitama 332-0012, Japan otsukamo-tky@umin.ac.jp. Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA. Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, TX, USA. State Key Laboratory of Cellular Stress Biology and School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China otsukamo-tky@umin.ac.jp. .
Related Products: order online
7: Title: Functions of MiRNA-128 on the regulation of head and neck squamous cell carcinoma growth and apoptosis.
Authors: Hauser, Belinda, et.al. .
Journal: PloS one, Vol. 10 (3): e0116321, 2015 .
Snippet: miRNA-128 was able to bind with the 3'-untranslated regions of BMI-1, BAG-2, BAX, H3f3b, and Paip2 mRNAs, resulting in significant reduction of the targeted protein levels.
Affiliation: Department of Genetics and Human Genetics, Howard University, Washington, DC, United States of America. Department of Oral Pathology, Howard University, Washington DC, United States of America. Zhejiang Cancer Research Institute, Hangzhou, China. Department of Otolaryngology-Head and Neck Surgery, Howard University, Washington, DC, United States of America. Department of Radiology, Howard University, Washington DC, United States of America; Cancer Center, Howard University, Washington, District of Columbia, United States of America. Departments of Otolaryngology-Head and Neck Surgery, and Head & Neck Research Division, Johns Hopkins University, Baltimore, Maryland, United states of America. Department of Genetics and Human Genetics, Howard University, Washington, DC, United States of America; Department of Oral Pathology, Howard University, Washington DC, United States of America; Cancer Center, Howard University, Washington, District of Columbia, United States of America. .
Related Products: order online
8: Title: Poly(A) binding protein 1 enhances cap-independent translation initiation of neurovirulence factor from avian herpesvirus.
Journal: PloS one, Vol. 9 (12): e114466, 2014 .
Snippet: RNA interference and reverse genetic mutagenesis results show that a subset of virally encoded-microRNAs (miRNAs) targets the inhibitor of PABP1, known as paip2, and therefore plays an indirect role in PABP1 recruitment strategy by increasing the available pool of active PABP1.
Affiliation: The Pirbright Institute, Ash Road, Pirbright, Woking, Surrey, United Kingdom. The Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, United Kingdom. .
Related Products: order online
9: Title: Proteasome modulates positive and negative translational regulators in long-term synaptic plasticity.
Authors: Dong, Chenghai, et.al. .
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci), Vol. 34 (9): 3171-82, 2014 .
Snippet: Furthermore, inhibition of the proteasome causes a buildup of translational repressors, such as polyadenylate-binding protein interacting protein 2 (Paip2) and eukaryotic initiation factor 4E-binding protein 2 (4E-BP2), during late stages of L-LTP contributing to the blockade of L-LTP maintenance.
Affiliation: Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, North Carolina 27157. .
Related Products: order online
10: Title: Recurrent genomic alterations in sequential progressive leukoplakia and oral cancer: drivers of oral tumorigenesis?
Authors: Cervigne, Nilva K, et.al. .
Journal: Human molecular genetics (Hum Mol Genet), Vol. 23 (10): 2618-28, 2014 .
Snippet: Amplified genes mapping within recurrent CNAs (KHDRBS1, PARP1, RAB1A, HBEGF, PAIP2, BTBD7) were selected for validation, by quantitative real-time PCR, in an independent set of 32 progressive leukoplakia, 32 OSSCs and 21 non-progressive leukoplakia samples.
Affiliation: Division of Applied Molecular Oncology, Ontario Cancer Institute. .
Related Products: order online
11: Title: Poly(A) RNA and Paip2 act as allosteric regulators of poly(A)-binding protein.
Authors: Lee, Seung Hwan, et.al. .
Journal: Nucleic acids research (Nucleic Acids Res), Vol. 42 (4): 2697-707, 2014 .
Snippet: When bound to the 3' poly(A) tail of mRNA, poly(A)-binding protein (PABP) modulates mRNA translation and stability through its association with various proteins.
Affiliation: School of Interdisciplinary Bioscience & Bioengineering, Pohang University of Science & Technology (POSTECH), Pohang 790-784, Korea, Department of Physics, Pohang University of Science & Technology (POSTECH), Pohang 790-784, Korea, Department of Life Sciences, Pohang University of Science & Technology (POSTECH), Pohang 790-784, Korea and Division of Integrative Biosciences & Biotechnology, Pohang University of Science & Technology (POSTECH), Pohang 790-784, Korea. .
Related Products: order online
12: Title: A new role for the cellular PABP repressor Paip2 as an innate restriction factor capable of limiting productive cytomegalovirus replication.
Authors: McKinney, Caleb, et.al. .
Journal: Genes & development (Genes Dev), Vol. 27 (16): 1809-20, 2013 .
Snippet: Paradoxically, while PABP accumulation promotes human cytomegalovirus (HCMV) protein synthesis, we show that this is accompanied by an analogous increase in the abundance of Paip2 and EDD1, an E3 ubiquitin ligase that destabilizes Paip2.
Affiliation: Department of Microbiology, New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA. .
Related Products: order online
13: Title: Control of synaptic plasticity and memory via suppression of poly(A)-binding protein.
Authors: Khoutorsky, Arkady, et.al. .
Journal: Neuron, Vol. 78 (2): 298-311, 2013 .
Snippet: Here, we report that the translational repressor poly(A)-binding protein (PABP)-interacting protein 2A (PAIP2A), an inhibitor of PABP, is rapidly proteolyzed by calpains in stimulated neurons and following training for contextual memory.
Affiliation: Department of Biochemistry and Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montréal, QC H3A 1A3, Canada. .
Related Products: order online
14: Title: Identification and analysis of expressed genes using a cDNA library from rat thymus during regeneration following cyclophosphamide-induced T cell depletion.
Authors: Yoon, Tae-Deuk, et.al. .
Journal: International journal of molecular medicine (Int J Mol Med), Vol. 31 (3): 731-9, 2013 .
Snippet: Based on the data of RT-PCR analysis, the expression of TLP, E2IG2, pincher, Paip2, TGF-β1, 4-1BB and laminin α3 genes was increased during thymus regeneration.
Affiliation: Department of Anatomy, Pusan National University, School of Medicine, Yangsan, Gyeongsangnam-do 626-870, Republic of Korea. .
Related Products: order online
15: Title: Poly(A) binding protein C1 is essential for efficient L1 retrotransposition and affects L1 RNP formation.
Authors: Dai, Lixin, et.al. .
Journal: Molecular and cellular biology (Mol Cell Biol), Vol. 32 (21): 4323-36, 2012 .
Snippet: Knockdown of the PABPC1 inhibitor PAIP2 increased L1 retrotransposition up to 2-fold.
Affiliation: High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. .
Related Products: order online
16: Title: PABP interacting protein 2A (PAIP2A) regulates specific key proteins during spermiogenesis in the mouse.
Authors: Delbes, Geraldine, et.al. .
Journal: Biology of reproduction (Biol Reprod), Vol. 86 (3): 95, 2012 .
Snippet: We confirmed the significantly different expression levels of three proteins, EIF4G1, AKAP4, and HK1, by Western blot analysis.
Affiliation: Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada. .
Related Products: order online
17: Title: Suppression of cellular transformation by poly (A) binding protein interacting protein 2 (Paip2).
Journal: PloS one, Vol. 6 (9): e25116, 2011 .
Snippet: Poly (A) binding protein interacting protein 2 (Paip2) inhibits efficient initiation of translation by impairing formation of the necessary closed loop of mRNA.
Affiliation: Department of Microbiology & Immunology, Columbia University College of Physicians & Surgeons, New York, New York, United States of America. amy.abrosenfeld@gmail.com .
Related Products: order online
18: Title: Functional interactions between mRNA turnover and surveillance and the ubiquitin proteasome system.
Journal: Wiley interdisciplinary reviews. RNA (Wires Rna), Vol. 1 (2): 240-52, 2010 Sep-Oct .
Snippet: A number of proteins involved in mRNA translation are regulated in part by proteasome-mediated decay, including the initiation factors eIF4G, eIF4E, and eIF3a, and the poly(A)-binding protein (PABP) interacting protein, Paip2.
Affiliation: Veterans Administration Medical Center Research, White River Junction, VT 05009, USA. seth.brooks@dartmouth.edu .
Related Products: order online
19: Title: Spermatids do it differently! Paip2a-the essential regulator of spermiogenesis?
Authors: McLaughlin, Eileen A, et.al. .
Journal: Asian journal of andrology (Asian J Androl), Vol. 13 (1): 122-4, 2011 .
No Abstract available.
Affiliation: ARC Centre of Excellence in Biotechnology and Development, Callaghan, NSW 2308, Australia. Eileen.McLaughlin@newcastle.edu.au .
Related Products: order online
20: Title: The poly(A)-binding protein partner Paip2a controls translation during late spermiogenesis in mice.
Authors: Yanagiya, Akiko, et.al. .
Journal: The Journal of clinical investigation (J Clin Invest), Vol. 120 (9): 3389-400, 2010 .
Snippet: To investigate the role of Paip2 in spermiogenesis, we generated mice with knockout of either Paip2a or Paip2b and double-KO (DKO) mice lacking both Paip2a and Paip2b.
Affiliation: Department of Biochemistry and Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada. .
Related Products: order online
Page 1 2 3 
Documents per page: 20 | 50 | 100