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1: Title: Whole exome sequencing in 75 high-risk families with validation and replication in independent case-control studies identifies TANGO2, OR5H14, and CHAD as new prostate cancer susceptibility genes.
Authors: Karyadi, Danielle M, .
Journal: Oncotarget, Vol. 8 (1): 1495-1507, 2017 .
Snippet: Our analyses identified three new PCa susceptibility alleles in the TANGO2, OR5H14 and CHAD genes that not only segregate in multiple high-risk families but are also of importance in altering disease risk for men from the general population.
Affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA. .
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