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11 documents found
1: Title: Identification of a Potential Regulatory Variant for Colorectal Cancer Risk Mapping to 3p21.31 in Chinese Population.
Authors: Ke, Juntao, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 6, 2016 .
Snippet: Supported by the analyses of data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), it was suggested that rs1076394 served as an expression Quantitative Trait Loci (eQTL) for gene CCDC12 and NME6, while NME6's expression was obviously higher in CRC tissues.
Affiliation: State Key Laboratory of Environment Health (Incubation), MOE (Ministry of Education) Key Laboratory of Environment &Health, Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. .
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2: Title: Hypermutation of DPYD Deregulates Pyrimidine Metabolism and Promotes Malignant Progression.
Authors: Edwards, Lauren, et.al. .
Journal: Molecular cancer research : MCR (Mol Cancer Res), Vol. 14 (2): 196-206, 2016 .
Snippet: In addition, dihydropyrimidine dehydrogenase (DPYD) and other important pyrimidine-related genes: DPYS, AK9, CAD, CANT1, ENTPD1, NME6, NT5C1A, POLE, POLQ, POLR3B, PRIM2, REV3L, and UPP2 are significantly enriched in somatic mutations relative to the background mutation rate.
Affiliation: Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, Merced, California. Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, Merced, California. filipp@ucmerced.edu. .
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3: Title: Purine metabolism gene deregulation in Parkinson's disease.
Authors: Garcia-Esparcia, Paula, et.al. .
Journal: Neuropathology and applied neurobiology (Neuropathol Appl Neurobiol), Vol. 41 (7): 926-40, 2015 .
Snippet: METHODS: Analysis of mRNA using real-time quantitative PCR of 22 genes involved in purine metabolism in the substantia nigra, putamen and cerebral cortex area 8 in PD at different stages of disease progression, and localization of selected purine metabolism-related enzymes with immunohistochemistry. RESULTS: Reduced expression of adenylate kinase 2 (AKA2), AK3, AK4, adenine phosphoribosyltransferase, ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), ENTPD3, nonmetastatic cells 3, nucleoside-diphosphatese kinase 3 (NME1), NME7 and purine nucleoside phosphorylase 1 (PNP1) mRNA in the substantia nigra at stages 3-6; up-regulation of ADA mRNA in the frontal cortex area 8 at stages 3-4 and of AK1, AK5, NME4, NME5, NME6, 5'-nucleotidase (NT5E), PNP1 and prune homolog Drosophila at stages 5-6.
Affiliation: Institute of Neuropathology, Bellvitge University Hospital-Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain. Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), Institute Carlos III, Ministry of Health, Barcelona, Spain. University of Barcelona, Barcelona, Spain. .
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4: Title: Regulation of Sec16 levels and dynamics links proliferation and secretion.
Authors: Tillmann, Kerstin D, et.al. .
Journal: Journal of cell science (J Cell Sci), Vol. 128 (4): 670-82, 2015 .
Snippet: Surprisingly, we find that Sec16A is a short-lived protein that is regulated by growth factors in a manner dependent on Egr family transcription factors.
Affiliation: Biotechnology Institute Thurgau (BITg) at the University of Konstanz, Unterseestrasse 47, CH-8280 Kreuzlingen, Switzerland University of Konstanz, Universitätsstrasse 10, Konstanz 78464, Germany. Biotechnology Institute Thurgau (BITg) at the University of Konstanz, Unterseestrasse 47, CH-8280 Kreuzlingen, Switzerland. Experimental Physics I, University of Bayreuth, Bayreuth 95440, Germany. Blavatnik School of Computer Science, Tel Aviv University, Tel-Aviv 69978, Israel. Experimental Physics I, University of Bayreuth, Bayreuth 95440, Germany matthias.weiss@uni-bayreuth.de hesso.farhan@uni-konstanz.de. Biotechnology Institute Thurgau (BITg) at the University of Konstanz, Unterseestrasse 47, CH-8280 Kreuzlingen, Switzerland University of Konstanz, Universitätsstrasse 10, Konstanz 78464, Germany matthias.weiss@uni-bayreuth.de hesso.farhan@uni-konstanz.de. .
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5: Title: Acute L-glutamine deprivation affects the expression of TP53-related protein genes in U87 glioma cells.
Authors: Minchenko, D O, et.al. .
Journal: Fiziolohichnyĭ zhurnal (Kiev, Ukraine : 1994) (Unknown Journal), Vol. 60 (4): 11-21, 2014 .
Snippet: We have studied the effect of acute L-glutamine deprivation on the expression oftumor protein 53 (TP53)-related genes such as TOPORS (topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase), TP53BPI (TP53 bindingprotein 1), TP53TG1 (TP53 inducible gene 1), SESN1 (p53 regulatedPA26 nuclear protein), NME6 (NME/NM23 nucleoside diphosphate kinase 6), and ZMAT3 (zinc finger Matrin-type 3) in glioma cells with ERN1 knockdown.
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6: Title: Gene expression and thiopurine metabolite profiling in inflammatory bowel disease - novel clues to drug targets and disease mechanisms?
Authors: Haglund, Sofie, et.al. .
Journal: PloS one, Vol. 8 (2): e56989, 2013 .
Snippet: The expression levels of four genes identified by microarray screening (PLCB2, HVCN1, CTSS, and DEF8) and one purine/thiopurine related gene (NME6) correlated significantly with the clinical activity of Crohn's disease.
Affiliation: Division of Medical Diagnostics, Laboratory Medicine, Ryhov County Hospital, Jönköping, Sweden. sofie.haglund@lj.se .
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7: Title: A shRNA functional screen reveals Nme6 and Nme7 are crucial for embryonic stem cell renewal.
Authors: Wang, Chia-Hui, et.al. .
Journal: Stem cells (Dayton, Ohio) (Stem Cells), Vol. 30 (10): 2199-211, 2012 .
Snippet: We demonstrate that Nme6 and Nme7 are important for the regulation of Oct4, Nanog, Klf4, c-Myc, telomerase, Dnmt3B, Sox2, and ERas expression.
Affiliation: Genomics Research Center, Academia Sinica, Taipei, Taiwan. .
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8: Title: Characterization of Nme6-like gene/protein from marine sponge Suberites domuncula.
Authors: Perina, Drago, et.al. .
Journal: Naunyn-Schmiedeberg's archives of pharmacology (Naunyn Schmiedebergs Arch Pharmacol), Vol. 384 (4-5): 451-60, 2011 .
Snippet: Our results show that the sponge Nme6 compared to human Nme6 does not possess NDPK activity, does not localize in mitochondria at least in human cells although it has a putative mitochondrial signal sequence, lacks two recent introns that comprise miRNAs and have different transcriptional binding sites in the promoter region.
Affiliation: Laboratory of Molecular Genetics, Division of Molecular Biology, Ruđer Bošković Institute, Bijenička cesta 54, P.P. 180, 10002, Zagreb, Croatia. .
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9: Title: The NME gene family in zebrafish oogenesis and early development.
Authors: Desvignes, T, et.al. .
Journal: Naunyn-Schmiedeberg's archives of pharmacology (Naunyn Schmiedebergs Arch Pharmacol), Vol. 384 (4-5): 439-49, 2011 .
Snippet: Here, we show that nme2b1, nme3, nme4, and nme6 are highly expressed in the ovary and present in the zebrafish oocyte throughout oogenesis.
Affiliation: INRA, UR1037 SCRIBE, Campus de Beaulieu, 35042, Rennes, France. .
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10: Title: Nme protein family evolutionary history, a vertebrate perspective.
Authors: Desvignes, Thomas, et.al. .
Journal: BMC evolutionary biology (Bmc Evol Biol), Vol. 9, 2009 .
Snippet: Nme1, Nme2, Nme3, and Nme4 belong to Group I while vertebrate Nme5, Nme6, Nme7, Nme8, and Nme9 belong to Group II.
Affiliation: INRA, UR1037 SCRIBE, IFR140, Ouest-Genopole, F-35000 Rennes, France. thomas.desvignes@rennes.inra.fr .
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11: Title: NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3.
Authors: Mehus, J G, et.al. .
Journal: Human genetics (Hum Genet), Vol. 104 (6): 454-9, 1999 .
Snippet: The 1.3-kb transcript of NME6 is expressed at a moderately low level in many human tissues, and is most abundant in kidney, prostate, ovary, intestine, and spleen.
Affiliation: Department of Biochemistry and Molecular Biology, University of North Dakota School of Medicine and Health Sciences, Grand Forks 58202, USA. .
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