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24 documents found
1: Title: Prognostic genes of hepatocellular carcinoma based on gene coexpression network analysis.
Authors: Xu, Baojin, et.al. .
Journal: Journal of cellular biochemistry (J Cell Biochem), 2019 .
Snippet: These hub genes were subsequently validated by a new data set GSE76427 and KM Plotter Online Tool, and the results indicated that 10 genes (FBXO43, ARHGEF39, MXD3, VIPR1, DNASE1L3, PHLDA1, CSRNP1, ADR2B, C1RL, and CDC37L1) could act as prognosis and progression biomarkers of HCC.
Affiliation: Department of General Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, China. Department of Pathology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, China. .
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2: Title: SHP2 is required for BCR-ABL1-induced hematologic neoplasia.
Authors: Gu, S, et.al. .
Journal: Leukemia, 2017 .
Snippet: Our results suggest that SHP2, via SFKs and ERK, represses MXD3/4 to facilitate a MYC-dependent proliferation program in BCR-ABL1-transformed pre-B cells.Leukemia accepted article preview online, 14 August 2017.
Affiliation: Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. Princess Margaret Cancer Center, Toronto, ON, Canada. Department of Orthopaedics, Brown University Alpert Medical School, Providence, RI, USA. Chao Family Comprehensive Cancer Center, Division of Hematology/Oncology, University of California, Irvine, Irvine, CA, USA. .
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3: Title: Novel targeted therapy for neuroblastoma: silencing the MXD3 gene using siRNA.
Authors: Duong, Connie, et.al. .
Journal: Pediatric research (Pediatr Res), Vol. 82 (3): 527-535, 2017 .
Snippet: We developed nanocomplexes using siRNA and superparamagnetic iron oxide nanoparticles to target MXD3 in neuroblastoma cell lines in vitro as a single-agent therapeutic and in combination with doxorubicin, vincristine, cisplatin, or maphosphamide-common drugs used in current neuroblastoma treatment.ResultsMXD3 was highly expressed in neuroblastoma cell lines and in patient tumors that had high-risk features.
Affiliation: Department of Pediatrics, University of California, Davis, California. Department of Pharmacology, University of California, Davis, California. Department of Public Health Sciences, University of California, Davis, California. Stem Cell Program and Institute for Regenerative Cures, University of California, Davis, California. Department of Biological &Agricultural Engineering, University of California, Davis, California. .
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4: Title: Novel Targeted Therapy for Precursor B Cell Acute Lymphoblastic Leukemia: anti-CD22 Antibody-MXD3 Antisense Oligonucleotide Conjugate.
Authors: Satake, Noriko, et.al. .
Journal: Molecular medicine (Cambridge, Mass.) (Mol Med), Vol. 22, 2016 .
Snippet: Our compound uses an ASO that specifically targets the transcription factor MAX dimerization protein 3 (MXD3), which was previously identified to be critical for precursor B cell (preB) acute lymphoblastic leukemia (ALL) cell survival.
Affiliation: Department of Pediatrics. Stem Cell Program. Isis Pharmaceuticals. Department of Public Health Sciences. Departments of Food Science & Technology and Biological & Agricultural Engineering. Department of Internal Medicine, University of California, Davis. .
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5: Title: Activation of NF-κB and AP-1 Mediates Hyperproliferation by Inducing β-Catenin and c-Myc in Helicobacter pylori-Infected Gastric Epithelial Cells.
Authors: Byun, Eunyoung, et.al. .
Journal: Yonsei medical journal (Yonsei Med J), Vol. 57 (3): 647-51, 2016 .
Snippet: RESULTS: H. pylori induced activation of NF-κB and AP-1, cell proliferation, and expression of oncogenes (β-catenein, c-myc) in AGS cells, which was inhibited by transfection of MAD3 and TAM67.
Affiliation: Department of Food and Nutrition, Brain Korea 21 PLUS Project, College of Human Ecology, Yonsei University, Seoul, Korea. Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea. kim626@yonsei.ac.kr. .
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6: Title: Histological Stratification of Thick and Thin Plaque Psoriasis Explores Molecular Phenotypes with Clinical Implications.
Authors: Kim, Jaehwan, et.al. .
Journal: PloS one, Vol. 10 (7): e0132454, 2015 .
Snippet: In this study, we sought to stratify psoriasis patients by histological measurements of epidermal thickness, and to compare their molecular characterizations by gene expression, serum cytokines, and response to biologics.
Affiliation: Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, United States of America. Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, United States of America; Harvard University, Cambridge, Massachusetts, United States of America. Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, United States of America; School of Medicine, Stony Brook University, Stony Brook, New York, United States of America. Immunology & Biomarkers, Janssen Research & Development, Radnor, Pennsylvania, United States of America. The Center for Clinical and Translational Science, The Rockefeller University, New York, New York, United States of America. The Center for Clinical and Translational Science, The Rockefeller University, New York, New York, United States of America; Icahn School of Medicine at Mount Sinai, New York, New York, United States of America. .
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7: Title: Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells.
Authors: Barisone, Gustavo A, et.al. .
Journal: Blood cells, molecules & diseases (Blood Cells Mol Dis), Vol. 54 (4): 329-35, 2015 .
Snippet: Here, we demonstrate that MXD3 is highly enriched in human precursor B acute lymphoblastic leukemia (preB ALL) samples compared to mobilized peripheral blood mononuclear cells, bone marrow, or hematopoietic stem cells from healthy donors.
Affiliation: Department of Pharmacology, UC Davis School of Medicine, Davis, CA, USA. Department of Pediatrics, Hematology/Oncology Section, UC Davis School of Medicine, Sacramento, CA, USA; Stem Cell Program and Institute of Regenerative Cures, UC Davis School of Medicine, Sacramento, CA, USA. Department of Pediatrics, Hematology/Oncology Section, UC Davis School of Medicine, Sacramento, CA, USA. Department of Biochemistry and Molecular Medicine, UC Davis School of Medicine, Sacramento, CA, USA. Stem Cell Program and Institute of Regenerative Cures, UC Davis School of Medicine, Sacramento, CA, USA. Department of Pharmacology, UC Davis School of Medicine, Davis, CA, USA. Electronic address: ediaz@ucdavis.edu. .
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8: Title: Targeted therapy with MXD3 siRNA, anti-CD22 antibody and nanoparticles for precursor B-cell acute lymphoblastic leukaemia.
Authors: Satake, Noriko, et.al. .
Journal: British journal of haematology (Br J Haematol), Vol. 167 (4): 487-99, 2014 .
Snippet: We demonstrated that the MXD3 siRNA-αCD22 Ab-SPIO NP complexes entered leukaemia cells and knocked down MXD3, leading the cells to undergo apoptosis and resulting in decreased live cell counts in the cell line Reh and in primary preB ALL samples in vitro.
Affiliation: Department of Pediatrics, University of California Davis, Sacramento, CA, USA; Stem Cell Program and Institute for Regenerative Cures, University of California Davis, Sacramento, CA, USA. .
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9: Title: MXD3 regulation of DAOY cell proliferation dictated by time course of activation.
Authors: Ngo, Tin, et.al. .
Journal: BMC cell biology (Bmc Cell Biol), Vol. 15, 2014 .
Snippet: Finally, with microarray expression profiling and gene ontology analysis we identify several major pathways enriched in response to acute (immune response, apoptosis, cell cycle) versus persistent (cell adhesion) MXD3 activation.
Affiliation: Department of Pharmacology, UC Davis School of Medicine, 451 Health Sciences Drive, 3503 GBSF, Davis, CA 95616, USA. ediaz@ucdavis.edu. .
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10: Title: Downregulation of Max dimerization protein 3 is involved in decreased visceral adipose tissue by inhibiting adipocyte differentiation in zebrafish and mice.
Authors: Shimada, Y, et.al. .
Journal: International journal of obesity (2005) (Int J Obes (lond)), Vol. 38 (8): 1053-60, 2014 .
Snippet: We then intraperitoneally injected morpholino antisense oligonucleotides (MO-mxd3) to knockdown mxd3 gene expression in DIO-zebrafish and measured several parameters, which reflected human obesity and associated metabolic diseases.
Affiliation: 1] Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Mie, Japan [2] Department of Systems Pharmacology, Mie University Graduate School of Medicine, Mie, Japan [3] Mie University Medical Zebrafish Research Center, Mie, Japan [4] Department of Bioinformatics, Mie University Life Science Research Center, Mie, Japan [5] Department of Omics Medicine, Mie University Industrial Technology Innovation, Mie, Japan. Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Mie, Japan. 1] Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Mie, Japan [2] Department of Systems Pharmacology, Mie University Graduate School of Medicine, Mie, Japan. .
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11: Title: Hairless and the polyamine putrescine form a negative regulatory loop in the epidermis.
Authors: Luke, Courtney T, et.al. .
Journal: Experimental dermatology (Exp Dermatol), Vol. 22 (10): 644-9, 2013 .
Snippet: We also show that the regulation of ODC by HR is dependent on the MYC superfamily of proteins, in particular MYC, MXI1 and MXD3.
Affiliation: Department of Dermatology, Columbia University, College of Physicians & Surgeons, New York, NY, USA. .
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12: Title: Matrix metalloprotease 9 promotes liver recovery from ischemia and reperfusion injury.
Authors: Feng, Min, et.al. .
Journal: The Journal of surgical research (J Surg Res), Vol. 180 (1): 156-61, 2013 .
Snippet: Serum alanine aminotransferase and hepatic cytokines (tumor necrosis factor alpha, interleukin [IL]-1β, IL-10, and transforming growth factor beta [TGF-β]) levels were analyzed after IRI.
Affiliation: Department of General Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China. .
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13: Title: Role of MXD3 in proliferation of DAOY human medulloblastoma cells.
Authors: Barisone, Gustavo A, et.al. .
Journal: PloS one, Vol. 7 (7): e38508, 2012 .
Snippet: MXD3, a basic helix-look-helix zipper transcription factor of the MAD family, has been reported to be upregulated during postnatal cerebellar development and to promote GNP proliferation and MYCN expression.
Affiliation: Department of Pharmacology, University of California Davis School of Medicine, Davis, California, United States of America. .
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14: Title: Bub1 and BubR1: at the interface between chromosome attachment and the spindle checkpoint.
Journal: Molecular and cellular biology (Mol Cell Biol), Vol. 31 (15): 3085-93, 2011 .
Snippet: The spindle checkpoint ensures genome fidelity by temporarily halting chromosome segregation and the ensuing mitotic exit until the last kinetochore is productively attached to the mitotic spindle.
Affiliation: Reproduction, Perinatal Health, and Infant Health, CHUL-CRCHUQ, 2705 Blvd. Laurier, RC-9800, Québec G1V 4G2, Canada. sabine.elowe@crchuq.ulaval.ca .
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15: Title: Histone deacetylase activity is necessary for left-right patterning during vertebrate development.
Authors: Carneiro, Katia, et.al. .
Journal: BMC developmental biology (Bmc Dev Biol), Vol. 11, 2011 .
Snippet: While Mad3 overexpression led to an absence of Nr1 transcription and randomized the LR axis, a mutant form of Mad3 lacking 5HT binding sites was not able to induce heterotaxia, showing that Mad3's biological activity is dependent on 5HT binding.
Affiliation: Department of Biology Center for Regenerative and Developmental Biology Tufts University, Medford, MA 02155 USA. .
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16: Title: Mutual regulation between the spindle checkpoint and APC/C.
Authors: Kim, Soonjoung, et.al. .
Journal: Seminars in cell & developmental biology (Semin Cell Dev Biol), Vol. 22 (6): 551-8, 2011 .
Snippet: In response to sister chromatids not properly captured by spindle microtubules, the spindle checkpoint interferes with the functions of Cdc20, the mitotic activator of the anaphase-promoting complex or cyclosome (APC/C), thereby blocking APC/C-mediated degradation of securin and cyclin B to delay anaphase onset.
Affiliation: Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States. .
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17: Title: Mad3 negatively regulates B cell differentiation in the spleen by inducing Id2 expression.
Authors: Gore, Yael, et.al. .
Journal: Molecular biology of the cell (Mol Biol Cell), Vol. 21 (11): 1864-71, 2010 .
Snippet: Results demonstrate that high expression levels of Mad3 in immature B cells induce Id2 expression, which inhibits transcription of genes essential for B cell differentiation.
Affiliation: Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel. .
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18: Title: Gene expression profiles following exposure to a developmental neurotoxicant, Aroclor 1254: pathway analysis for possible mode(s) of action.
Authors: Royland, Joyce E, et.al. .
Journal: Toxicology and applied pharmacology (Toxicol Appl Pharmacol), Vol. 231 (2): 179-96, 2008 .
Snippet: Functional analysis suggests that pathways related to calcium homeostasis (Gng3, Ryr2, Trdn, Cacna1a), intracellular signaling (Camk2d, Stk17b, Pacsin2, Ryr2, Trio, Fert2, Ptk2b), axonal guidance (Lum, Mxd3, Akap11, Gucy1b3), aryl hydrocarbon receptor signaling (Nfia, Col1a2), and transcripts involved in cell proliferation (Gspt2, Cdkn1c, Ptk2b) and differentiation (Ifitm31, Hpca, Zfp260, Igsf4a, Hes5) leading to the development of nervous system were significantly altered by Aroclor 1254 exposure.
Affiliation: Cellular and Molecular Toxicology Branch, Neurotoxicology Division, NHEERL, ORD, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. .
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19: Title: From cerebellar proliferation to tumorigenesis: new insights into the role of Mad3.
Authors: Barisone, Gustavo A, et.al. .
Journal: Cell cycle (Georgetown, Tex.) (Cell Cycle), Vol. 7 (4): 423-7, 2008 .
Snippet: Here, we discuss our recent work in the context of candidate Mad3-interacting proteins and Mad3 expression in human brain tumors that together suggest interesting insights into the role of Mad3 in cellular proliferation and tumorigenesis.
Affiliation: Department of Pharmacology, UC Davis School of Medicine, Davis, California 95616, USA. .
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20: Title: A novel role of the Mad family member Mad3 in cerebellar granule neuron precursor proliferation.
Authors: Yun, Jun-Soo, et.al. .
Journal: Molecular and cellular biology (Mol Cell Biol), Vol. 27 (23): 8178-89, 2007 .
Snippet: Surprisingly, basic-domain-dependent DNA binding of Mad3 is not required, suggesting that Mad3 interacts with other DNA binding proteins to repress transcription.
Affiliation: Department of Pharmacology, UC Davis School of Medicine, Davis, CA 95616, USA. .
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