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7 documents found
1: Title: A Comparative Proteomic Analysis of Erinacine A's Inhibition of Gastric Cancer Cell Viability and Invasiveness.
Authors: Kuo, Hsing-Chun, et.al. .
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology (Cell Physiol Biochem), Vol. 43 (1): 195-208, 2017 .
Snippet: Furthermore, the induction of apoptosis and anti-invasion properties by erinacine A could involve the differential expression of the 14-3-3 sigma protein (1433S) and microtubule-associated tumor suppressor candidate 2 (MTUS2), with the activation of the FAK/AKT/p70S6K and PAK1 signaling pathways.
Affiliation: Department of Nursing, Chang Gung University of Science and Technology, Chiayi, Taiwan. Chronic Diseases and Health Promotion Research Center, CGUST, Chiayi, Taiwan. Research Center for Industry of Human Ecology and Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan. Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital Chiayi, Chiayi, Taiwan. Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan. Department of Pathology, Chang Gung Memorial Hospital at Chiayi, Chiayi, Taiwan. Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Department of Hepato-Gastroenterology, Chang Gung Memorial Hospital, Chiayi, Taiwan. Division of Colorectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan. GRAPE KING BIO Ltd, Taoyuan, Taiwan. Chang Gung University College of Medicine, Taoyuan, Taiwan. .
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2: Title: Clinical Relevance and Molecular Phenotypes in Gastric Cancer, of TP53 Mutations and Gene Expressions, in Combination With Other Gene Mutations.
Authors: Park, Sungjin, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 6, 2016 .
Snippet: Here, we identified significant differences in clinical outcomes, as well as in molecular phenotypes, across specific GC tumor subpopulations, when combining TP53 with other signaling networks, including WNT and its related genes NRXN1, CTNNB1, SLITRK5, NCOR2, RYR1, GPR112, MLL3, MTUS2, and MYH6.
Affiliation: New Experimental Therapeutics Branch, National Cancer Center, Goyang-si Gyeonggi-do, 10408, Korea. Department of Biomedical Engineering, Inje University, Gimhae, Gyeongnam, 50834, Korea. Department of Life Sciences, College of BioNano Technology, Gachon University, Seongnam-si, Gyeonggi-do, 13120, Korea. College of Medicine, Gachon University, Incheon, 21936, Korea. Korean Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Korea. Department of Nanobiotechnology and Bioinformatics, University of Science and Technology, Daejeon, 34113, Korea. CrystalGenomics, Inc., Seongnam-si, Gyeonggi-do, 13488, Korea. Digital Information Computing Center, Inje University, Gimhae, Gyeongnam, 50834, Korea. .
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3: Title: The Microtubule Plus End Tracking Protein TIP150 Interacts with Cortactin to Steer Directional Cell Migration.
Authors: Adams, Gregory (Jr), et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 291 (39): 20692-706, 2016 .
Snippet: TIP150 is a newly characterized microtubule plus end tracking protein essential for mitosis and entosis (Ward, T., Wang, M., Liu, X., Wang, Z., Xia, P., Chu, Y., Wang, X., Liu, L., Jiang, K., Yu, H., Yan, M., Wang, J., Hill, D. L., Huang, Y., Zhu, T., and Yao, X. (2013) Regulation of a dynamic interaction between two microtubule-binding proteins, EB1 and TIP150, by the mitotic p300/CBP-associated factor (PCAF) orchestrates kinetochore microtubule plasticity and chromosome stability during mitosis.
Affiliation: From the BUCM-MSM Joint Research Group for Cellular Dynamics, BUCM School of Basic Medical Sciences, and Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, University of Science and Technology of China, Hefei, Anhui 230026, China, the Departments of Physiology and. From the BUCM-MSM Joint Research Group for Cellular Dynamics, BUCM School of Basic Medical Sciences, and Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, University of Science and Technology of China, Hefei, Anhui 230026, China. Medicine and Neurobiology, Morehouse School of Medicine, Atlanta, Georgia 30310. the Comprehensive Cancer Center, University of Alabama, Birmingham, Alabama 35294, and. the Departments of Physiology and the Guangzhou Women and Children's Medical Center, Guangzhou 510623, China heping-2008@163.com. From the BUCM-MSM Joint Research Group for Cellular Dynamics, BUCM School of Basic Medical Sciences, and Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, University of Science and Technology of China, Hefei, Anhui 230026, China, the Departments of Physiology and xing1017@ustc.edu.cn. From the BUCM-MSM Joint Research Group for Cellular Dynamics, BUCM School of Basic Medical Sciences, and Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, University of Science and Technology of China, Hefei, Anhui 230026, China, dingx@bucm.edu.cn. the Departments of Physiology and. .
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4: Title: Sex difference of autosomal alleles in populations of European and African descent.
Authors: Zuo, Lingjun, et.al. .
Journal: Genes & genomics (Conserv Genet), Vol. 37 (12): 1007-1016, 2015 .
Snippet: We found 13 markers that were genome-wide significant (p≤5×10(-8)) between females and males in the meta-analysis of all cohorts of European descent, including rs7740449 at SYNE1, rs7531151 at PLD5, rs697455 at PPP1R12B, rs6745746 at LOC100128413, rs17000079 at PARM1, rs11948070 at PDE4D, rs7801825 at INSIG1, rs9551642 at MTUS2, rs2932174 at TPTE2, rs1961597 at SALL3, rs4117529 at METTL4, rs6021473 at SALL4 and rs6092466 at RAE1, and one marker, i.e., rs10145208 at PCNX, that was genome-wide significant in the meta-analysis of all cohorts of African descent.
Affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA ; VA Connecticut Healthcare System, West Haven Campus, CT, USA. Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA. Provincial Key Laboratory of Translational Cancer Medicine, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, China. Department of EEG & Neuroimaging, Shanghai Mental Health Center, Shanghai, China. Biological Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China. Department of Neurology, Shanghai First People's Hospital, Shanghai Jiao-Tong University, China. Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA ; VA Connecticut Healthcare System, West Haven Campus, CT, USA ; Biological Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China. .
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5: Title: A genome-wide approach to link genotype to clinical outcome by utilizing next generation sequencing and gene chip data of 6,697 breast cancer patients.
Authors: Pongor, Lőrinc, et.al. .
Journal: Genome medicine (Genome Med), Vol. 7 (1): 104, 2015 .
Snippet: RESULTS: According to this approach, the top driver oncogenes having a mutation prevalence over 5 % included AKT1, TRANK1, TRAPPC10, RPGR, COL6A2, RAPGEF4, ATG2B, CNTRL, NAA38, OSBPL10, POTEF, SCLT1, SUN1, VWDE, MTUS2, and PIK3CA, and the top tumor suppressor genes included PHEX, TP53, GGA3, RGS22, PXDNL, ARFGEF1, BRCA2, CHD8, GCC2, and ARMC4.
Affiliation: MTA TTK Lendület Cancer Biomarker Research Group, Research Centre for Natural Sciences, Magyar tudósok körútja 2, Budapest, H-1117, Hungary. 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary. Yale Comprehensive Cancer Center, Yale School of Medicine, New Haven, CT, USA. MTA TTK Lendület Cancer Biomarker Research Group, Research Centre for Natural Sciences, Magyar tudósok körútja 2, Budapest, H-1117, Hungary. gyorffy.balazs@ttk.mta.hu. 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary. gyorffy.balazs@ttk.mta.hu. MTA-SE Pediatrics and Nephrology Research Group, Budapest, Hungary. gyorffy.balazs@ttk.mta.hu. .
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6: Title: Aurora A orchestrates entosis by regulating a dynamic MCAK-TIP150 interaction.
Authors: Xia, Peng, et.al. .
Journal: Journal of molecular cell biology (J Mol Cell Biol), Vol. 6 (3): 240-54, 2014 .
Snippet: To probe if MCAK-TIP150 interaction regulates microtubule plasticity to affect the mechanical properties of cells during entosis, we used an optical trap to measure the mechanical rigidity of live MCF7 cells.
Affiliation: Anhui Key Laboratory of Cellular Dynamics & Chemical Biology, Department of Optics and Optical Engineering, and Hefei National Laboratory for Physical Sciences at Nanoscale, University of Science and Technology of China, Hefei 230027, China. Anhui Key Laboratory of Cellular Dynamics & Chemical Biology, Department of Optics and Optical Engineering, and Hefei National Laboratory for Physical Sciences at Nanoscale, University of Science and Technology of China, Hefei 230027, China Molecular Imaging Center, Atlanta Clinical and Translational Science Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA. Molecular Imaging Center, Atlanta Clinical and Translational Science Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA Harvard Medical School, Boston, MA 02115, USA. Anhui Key Laboratory of Cellular Dynamics & Chemical Biology, Department of Optics and Optical Engineering, and Hefei National Laboratory for Physical Sciences at Nanoscale, University of Science and Technology of China, Hefei 230027, China Guangzhou Institutes of Biomedicine and Health, Guangzhou 510513, China. The 301 Hospital, Beijing 100039, China. Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China. Anhui Key Laboratory of Cellular Dynamics & Chemical Biology, Department of Optics and Optical Engineering, and Hefei National Laboratory for Physical Sciences at Nanoscale, University of Science and Technology of China, Hefei 230027, China Molecular Imaging Center, Atlanta Clinical and Translational Science Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA yaoxb@ustc.edu.cn zhenguo@ustc.edu.cn. Anhui Key Laboratory of Cellular Dynamics & Chemical Biology, Department of Optics and Optical Engineering, and Hefei National Laboratory for Physical Sciences at Nanoscale, University of Science and Technology of China, Hefei 230027, China yaoxb@ustc.edu.cn zhenguo@ustc.edu.cn. .
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7: Title: CAZIP, a novel protein expressed in the developing heart and nervous system.
Authors: Du Puy, Leonie, et.al. .
Journal: Developmental dynamics : an official publication of the American Association of Anatomists (Dev Dyn), Vol. 238 (11): 2903-11, 2009 .
Snippet: Recently, we have performed a whole genome micro-array analysis on human embryonic stem cells differentiating toward cardiomyocytes, which resulted in the identification of novel genes that were highly up-regulated during differentiation.
Affiliation: Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. .
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