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59 documents found
1: Title: miR-126 Suppresses Invasion and Migration of Malignant Glioma by Targeting Mature T Cell Proliferation 1 (MTCP1).
Authors: Han, Liangbo, et.al. .
Journal: Medical science monitor : international medical journal of experimental and clinical research (Med Sci Monit), Vol. 24, 2018 .
Snippet: After 6 weeks, the tumor volume in the miR-126 inhibitor group was significantly increased, while that in the MTCP1 siRNA group was significantly decreased.
Affiliation: Department of Neurosurgery, Weifang Yidu Central Hospital, Weifang, Shandong, China (mainland). Department of Radiotherapy, Weifang Yidu Central Hospital, Weifang, Shandong, China (mainland). Department of Neurosurgery, Weifang People's Hospital, Weifang, Shandong, China (mainland). .
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2: Title: Genes encoding members of the JAK-STAT pathway or epigenetic regulators are recurrently mutated in T-cell prolymphocytic leukaemia.
Authors: López, Cristina, et.al. .
Journal: British journal of haematology (Br J Haematol), Vol. 173 (2): 265-73, 2016 .
Snippet: The primary genetic alteration in T-PLL are the inv(14)(q11q32)/t(14;14)(q11;q32) leading to TRD/TRA-TCL1A fusion, or the t(X;14)(q28;q11) associated with TRD/TRA-MTCP1 fusion.
Affiliation: Institute for Human Genetics, Christian-Albrechts-University Kiel & University Hospital Schleswig Holstein, Kiel, Germany. Department of Paediatrics, Christian-Albrechts-University Kiel & University Hospital Schleswig Holstein, Kiel, Germany. Cell Networks, Bioquant, University of Heidelberg, Heidelberg, Germany. Department of Haematology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. Faculty of Medicine, Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Essen, Germany. Second Department of Medicine, University Hospital of Schleswig-Holstein, Kiel, Germany. Department of Haematology, Hospital Clínic, Institut d'Investigaciones Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain. Haematopathology Unit, Hospital Clínic, Institut d'Investigaciones Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain. Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester, UK. German Cancer Consortium (DKTK), Heidelberg, Germany. .
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3: Title: Brazilian Red Propolis Attenuates Inflammatory Signaling Cascade in LPS-Activated Macrophages.
Authors: Bueno-Silva, Bruno, et.al. .
Journal: PloS one, Vol. 10 (12): e0144954, 2015 .
Snippet: BRP significantly reduced the up-regulation promoted by LPS of transcription of genes in inflammatory signaling (Pdk1, Pak1, Nfkb1, Mtcp1, Gsk3b, Fos and Elk1) and of Il1β and Il1f9 (fold-change rate > 5), which were further confirmed by the inhibition of NF-κB and MAPK signaling pathways.
Affiliation: Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil. College of Agriculture "Luiz de Queiroz" (ESALQ/USP), Piracicaba, SP, Brazil. Piracicaba Dental School, University of Campinas-UNICAMP, Department of Physiologic Sciences, Piracicaba, SP, Brazil. .
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4: Title: Impairment of PI3K/AKT and WNT/β-catenin pathways in bone marrow mesenchymal stem cells isolated from patients with myelodysplastic syndromes.
Authors: Falconi, Giulia, et.al. .
Journal: Experimental hematology (Exp Hematol), Vol. 44 (1): 75-83.e1-4, 2016 .
Snippet: Statistically significant downregulation of GSK3β, SOS1, RASA1, and MTCP1 gene expression was observed in BM-MSCs isolated from patients with de novo MDS, as compared with controls.
Affiliation: Institute of Hematology, Università Cattolica del Sacro Cuore, Rome, Italy. Department of Biomedicine and Prevention, Università Tor Vergata, Rome, Italy. Institute of Hematology, Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address: fdalo@rm.unicatt.it. .
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5: Title: Genetic characterization of T-PLL reveals two major biologic subgroups and JAK3 mutations as prognostic marker.
Authors: Stengel, Anna, et.al. .
Journal: Genes, chromosomes & cancer (Genes Chromosomes Cancer), Vol. 55 (1): 82-94, 2016 .
Snippet: Two distinct genetic subgroups of T-PLL were identified: A large subset (86% of patients) showed abnormalities involving the TCRA/D locus activating the proto-oncogenes TCL1 or MTCP1, while the second group was characterized by a high frequency of TP53 mutations (4/7 cases).
Affiliation: MLL Munich Leukemia Laboratory, Max-Lebsche-Platz 31, Munich, 81377, Germany. MLL2 S.R.O., KCD4, Kolbenova 609/40, 190 00 Praha 9, Czech Republic. .
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6: Title: Moyamoya disease and syndromes: from genetics to clinical management.
Authors: Guey, Stéphanie, et.al. .
Journal: The application of clinical genetics (Appl Clin Genet), Vol. 8, 2015 .
Snippet: Characteristics of genetic moyamoya syndromes are presented, with a focus on recently reported mutations in BRCC3/MTCP1 and GUCY1A3 genes.
Affiliation: Inserm UMR-S1161, Université Paris 7 Denis Diderot, Sorbonne Paris Cité, Paris, France ; Service de Neurologie, Centre de Référence des maladies Vasculaires Rares du Cerveau et de l'OEil (CERVCO), Groupe Hospitalier Saint-Louis Lariboisière-Fernand Widal, Assistance Publique-Hôpitaux de Paris, Paris, France. Inserm UMR-S1161, Université Paris 7 Denis Diderot, Sorbonne Paris Cité, Paris, France ; AP-HP, Groupe hospitalier Lariboisière-Saint-Louis, Service de génétique neurovasculaire, Paris, France. Pediatric Neurology Department, French Center for Pediatric Stroke, University Hospital Necker-Enfants Malades, AP-HP Assistance publique-Hôpitaux de Paris, Paris, France. .
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7: Title: Recurrent mutation of JAK3 in T-cell prolymphocytic leukemia.
Authors: Bergmann, Anke K, et.al. .
Journal: Genes, chromosomes & cancer (Genes Chromosomes Cancer), Vol. 53 (4): 309-16, 2014 .
Snippet: T-cell prolymphocytic leukemia (T-PLL) is an aggressive post-thymic T-cell malignancy characterized by the recurrent inv(14)(q11q32)/t(14;14)(q11;q32) or t(X;14)(q28;q11) leading to activation of either the TCL1 or MTCP1 gene, respectively.
Affiliation: Institute for Human Genetics, Christian-Albrechts-University Kiel and University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany; Department of Pediatrics, Christian-Albrechts-University Kiel and University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany. .
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8: Title: An efficient null model for conformational fluctuations in proteins.
Authors: Harder, Tim, et.al. .
Journal: Structure (London, England : 1993) (Structure), Vol. 20 (6): 1028-39, 2012 .
Snippet: TYPHON is a probabilistic method to explore the conformational space of proteins under the guidance of a sophisticated probabilistic model of local structure and a given set of restraints that represent nonlocal interactions, such as hydrogen bonds or disulfide bridges.
Affiliation: The Bioinformatics Section, Department of Biology, University of Copenhagen, 2200 Copenhagen, Denmark. .
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9: Title: Loss of BRCC3 deubiquitinating enzyme leads to abnormal angiogenesis and is associated with syndromic moyamoya.
Authors: Miskinyte, Snaigune, et.al. .
Journal: American journal of human genetics (Am J Hum Genet), Vol. 88 (6): 718-28, 2011 .
Snippet: We show that this syndromic moyamoya is caused by Xq28 deletions removing MTCP1/MTCP1NB and BRCC3.
Affiliation: INSERM UMR-S-740; Université Paris, 7 Denis Diderot, 10 Avenue de Verdun, 75010 Paris, France. .
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10: Title: Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation setting.
Journal: Blood, Vol. 115 (1): 107-21, 2010 .
Snippet: This effect was not attributable to a proapoptotic effect of the drug but to the down-regulation of genes involved in T-cell cycle progression and activation such as CCNG2, MTCP1, CD58, and ADK and up-regulation of genes that induce cell-growth arrest, such as DCUN1D2, U2AF2, GADD45B, or p53.
Affiliation: Hospital Clínico Universitario de Salamanca y Centro de Investigación del Cáncer (CIC/CSIC), Salamanca, Spain. .
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11: Title: Haploinsufficiency of CDKN1B contributes to leukemogenesis in T-cell prolymphocytic leukemia.
Authors: Le Toriellec, Emilie, et.al. .
Journal: Blood, Vol. 111 (4): 2321-8, 2008 .
Snippet: T-cell prolymphocytic leukemia (T-PLL) is consistently associated with inactivation of the ATM gene and chromosomal re-arrangements leading to an overexpression of MTCP1/TCL1 oncoproteins.
Affiliation: Institut Curie, Centre de Recherche, Paris. .
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12: Title: The TCL1 oncoprotein inhibits activation-induced cell death by impairing PKCtheta and ERK pathways.
Authors: Despouy, Gilles, et.al. .
Journal: Blood, Vol. 110 (13): 4406-16, 2007 .
Snippet: The TCL1/MTCP1 oncogenes were identified on the basis of their involvement in T-cell prolymphocytic leukemia (T-PLL).
Affiliation: Institut Curie, Centre de Recherche, Paris, France. .
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13: Title: Unraveling protein dynamics through fast spectral density mapping.
Authors: Ropars, Virginie, et.al. .
Journal: Journal of biomolecular NMR (J Biomol Nmr), Vol. 37 (3): 159-77, 2007 .
Snippet: Applied to the dynamics analysis of the protein p13( MTCP1) at three different NMR fields, this approach allowed us to divide by nearly a factor of two the total measuring time, without altering further results obtained by the "model free" analysis of the resulting spectral densities.
Affiliation: Centre de Biochimie Structurale, UMR UM1/5048 CNRS/554 INSERM, 29 rue de Navacelles, 34090, Montpellier Cedex, France. .
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14: Title: The MTCP1 oncogene modifies T-cell homeostasis before leukemogenesis in transgenic mice.
Authors: Joiner, M, et.al. .
Journal: Leukemia, Vol. 21 (2): 362-6, 2007 .
No Abstract available.
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15: Title: Frataxin deficiency alters heme pathway transcripts and decreases mitochondrial heme metabolites in mammalian cells.
Authors: Schoenfeld, Robert A, et.al. .
Journal: Human molecular genetics (Hum Mol Genet), Vol. 14 (24): 3787-99, 2005 .
Snippet: Combining all mouse and human microarray data for frataxin-deficient cells and tissues, the most consistently decreased transcripts were mitochondrial coproporphyrinogen oxidase (CPOX) of the heme pathway and mature T-cell proliferation 1, a homolog of yeast COX23, which is thought to function as a mitochondrial metallochaperone.
Affiliation: Department of Molecular Biosciences, University of California, Davis 95616, USA. .
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16: Title: Structural basis for the co-activation of protein kinase B by T-cell leukemia-1 (TCL1) family proto-oncoproteins.
Authors: Auguin, Daniel, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 279 (34): 35890-902, 2004 .
Snippet: p14(TCL1)/p13(MTCP1) co-activate protein kinase B (PKB, also named Akt) by binding to its pleckstrin homology (PH) domain, suggesting that p14(TCL1)/p13(MTCP1) induce T-cell leukemia by promoting anti-apoptotic signals via PKB (2, 3).
Affiliation: Centre de Biochimie Structurale, UMR 5048 CNRS/UM1-UMR 554 INSERM/UM1, Faculté de Pharmacie, BP14491, 15 Avenue Charles Flahault, 34093 Montpellier Cedex 5, France. .
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17: Title: Solution structure and backbone dynamics of the pleckstrin homology domain of the human protein kinase B (PKB/Akt). Interaction with inositol phosphates.
Authors: Auguin, Daniel, et.al. .
Journal: Journal of biomolecular NMR (J Biomol Nmr), Vol. 28 (2): 137-55, 2004 .
Snippet: Thus, it has been shown that induction of PKB activity is augmented by the TCL1/MTCP1 oncoproteins through a physical association requiring the PKB PH domain.
Affiliation: Centre de Biochimie Structurale, UMR 5048 CNRS/UM1 - UMR 554 INSERM/UM1, Faculté de Pharmacie, BP14491, 15 Avenue Charles Flahault, 34093 Montpellier Cedex 5, France. .
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18: Title: Highly fluctuating protein structures revealed by variable-pressure nuclear magnetic resonance.
Journal: Biochemistry (Biochemistry-us), Vol. 42 (37): 10875-85, 2003 .
Snippet: A number of rare conformers are detected under pressure for a variety of proteins such as the Ras-binding domain of RalGDS, beta-lactoglobulin, dihydrofolate reductase, ubiquitin, apomyoglobin, p13(MTCP1), and prion, which disclose a rich world of protein structure between basically folded and globally unfolded states.
Affiliation: Department of Biotechnological Science, School of Biology-Oriented Science and Technology, Kinki University, Wakayama 649-6493, Japan. akasaka8@spring8.or.jp .
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19: Title: Crystal structures of Tcl1 family oncoproteins and their conserved surface features.
Authors: Petock, John M, et.al. .
Journal: TheScientificWorldJournal (Scientificworldjournal), Vol. 2, 2002 .
Snippet: The tertiary structures of mouse Tcl1, human Tcl1, and Mtcp1 are very similar.
Affiliation: Department of Biology, Georgia State University, Atlanta, GA, USA. biojmp@langate.gsu.edu .
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20: Title: Helix motion in protein C12A-p8(MTCP1): comparison of molecular dynamics simulations and multifield NMR relaxation data.
Authors: Barthe, Philippe, et.al. .
Journal: Journal of computational chemistry (J Comput Chem), Vol. 23 (16): 1577-86, 2002 .
Snippet: To get atomic scale description of the possible motions involved, a 12-ns molecular dynamics simulation of the C12A-p8(MTCP1) mutated protein and 10 400-ps simulations were performed in explicit water at 298 K. Analyses of the essential dynamics subspace and of the time-evolution of secondary structures indicate large displacements and internal motions of the third helix.
Affiliation: Centre de Biochimie Structurale, UMR CNRS 5048/INSERM U554/Université Montpellier I, 15, avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France. .
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