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4 documents found
1: Title: MicroRNA‑466 inhibits cell proliferation and invasion in osteosarcoma by directly targeting insulin receptor substrate 1.
Authors: Sun, Yongning, .
Journal: Molecular medicine reports (Mol Med Report), 2019 .
Snippet: In the present study, bioinformatics analyses and luciferase assays were employed to show that miR‑466 was able to directly target the 3'‑untranslated region of insulin receptor substrate 1 (IRS1) gene, negatively regulating the mRNA and the protein expression levels of IRS1 in OS cells.
Affiliation: Department of Clinical Laboratory, Ningbo No. 6 Hospital, Ningbo, Zhejiang 315040, P.R. China. Department of Emergency, Ningbo No. 2 Hospital, Ningbo, Zhejiang 315040, P.R. China. Department of Orthopedics, Ningbo No. 6 Hospital, Ningbo, Zhejiang 315040, P.R. China. .
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2: Title: MicroRNA‑466 inhibits the aggressive behaviors of hepatocellular carcinoma by directly targeting metadherin.
Authors: Jia, Chen, .
Journal: Oncology reports (Oncol Rep), Vol. 40 (6): 3890-3898, 2018 .
Snippet: The potential target gene of miR‑466 was predicted using bioinformatic analysis, which was further confirmed by luciferase reporter assay, RT‑qPCR and western blot analysis.
Affiliation: Department of Liver Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China. .
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3: Title: Cardiosome mediated regulation of MMP9 in diabetic heart: role of mir29b and mir455 in exercise.
Authors: Chaturvedi, Pankaj, .
Journal: Journal of cellular and molecular medicine (J Cell Mol Med), Vol. 19 (9): 2153-61, 2015 .
Snippet: We hypothesize that exosomes that are released during exercise contain microRNAs (mir455, mir29b, mir323-5p and mir466) that bind to the 3' region of MMP9 and downregulate its expression, hence mitigating the deleterious downstream effects of MMP9, which causes extracellular matrix remodeling.
Affiliation: Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, KY, USA. .
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4: Title: Prediction and validation of potential pathogenic microRNAs involved in Phytophthora infestans infection.
Authors: Cui, Juanjuan, .
Journal: Molecular biology reports (Mol Biol Rep), Vol. 41 (3): 1879-89, 2014 .
Snippet: The expression quantity of pi-miR466 and pi-miR1918 changed dramatically during incubation of tomato leaves, implying that they are potential pathogenic miRNAs.
Affiliation: School of Life Science and Biotechnology, Dalian University of Technology, Dalian, 116023, China. .
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