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21 documents found
1: Title: miR‑335 promotes stress granule formation to inhibit apoptosis by targeting ROCK2 in acute ischemic stroke.
Authors: Si, Wenwen, et.al. .
Journal: International journal of molecular medicine (Int J Mol Med), Vol. 43 (3): 1452-1466, 2019 .
Snippet: In conclusion, these results demonstrate that miR‑335 promotes SG formation and inhibits apoptosis by reducing ROCK2 expression in acute ischemic stroke, which provides a possible therapeutic target for brain injury.
Affiliation: Department of Anatomy, The Research Center of Basic Integrative Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China. .
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2: Title: A lipodystrophy-causing lamin A mutant alters conformation and epigenetic regulation of the anti-adipogenic MIR335 locus.
Authors: Oldenburg, Anja, et.al. .
Journal: The Journal of cell biology (J Cell Biol), Vol. 216 (9): 2731-2743, 2017 .
Snippet: We show in this study that the lamin A p.R482W hot spot mutation prevents adipogenic gene expression by epigenetically deregulating long-range enhancers of the anti-adipogenic MIR335 microRNA gene in human adipocyte progenitor cells.
Affiliation: Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway. Norwegian Center for Stem Cell Research, Department of Immunology, Oslo University Hospital, Oslo, Norway. Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway philc@medisin.uio.no. .
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3: Title: N-peptide of vMIP-Ⅱ reverses paclitaxel-resistance by regulating miRNA-335 in breast cancer.
Authors: Wang, Yangyang, et.al. .
Journal: International journal of oncology (Int J Oncol), Vol. 51 (3): 918-930, 2017 .
Snippet: Emerging evidence has demonstrated that microRNAs (miRNAs) play important roles in regulation of cell growth, migration and invasion through inhibiting the expression of its target genes.
Affiliation: Clinical Testing and Diagnose Experimental Center, Bengbu Medical College, Bengbu, Anhui 233000, P.R. China. Branch of Tumor of the Center Hospital of Bengbu, Bengbu, Anhui 233000, P.R. China. Research Center for Cancer Precision Medicine, Bengbu Medical College, Bengbu, Anhui 233000, P.R. China. Department of Biochemistry and Molecular Biology, Bengbu Medical College, Bengbu, Anhui 233000, P.R. China. Department of Biotechnology, Bengbu Medical College, Bengbu, Anhui 233000, P.R. China. .
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4: Title: Transcription factor Sox10 regulates oligodendroglial Sox9 levels via microRNAs.
Authors: Reiprich, Simone, et.al. .
Journal: Glia, Vol. 65 (7): 1089-1102, 2017 .
Snippet: We furthermore provide evidence that this coupling involves upregulation of microRNAs miR335 and miR338 as direct transcriptional targets of Sox10.
Affiliation: Institut für Biochemie, Emil-Fischer-Zentrum, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Department of Dermatology, Laboratory of Systems Tumor Immunology, Erlangen University Hospital, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. .
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5: Title: ZNF148 modulates TOP2A expression and cell proliferation via ceRNA regulatory mechanism in colorectal cancer.
Authors: Gao, Xian Hua, et.al. .
Journal: Medicine (Medicine (baltimore)), Vol. 96 (1): e5845, 2017 .
Snippet: ZNF148 mRNA, TOP2A mRNA, miR101, miR144, miR335, and miR365 expression were estimated in 53 fresh frozen CRC tissues by reverse transcription polymerase chain reaction.
Affiliation: aDepartment of Colorectal Surgery, Changhai Hospital, Second Military Medical University bDepartment of Nephrology, Changhai Hospital, Second Military Medical University cDepartment of Epidemiology, Second Military Medical University, Shanghai, China. .
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6: Title: Role of cancer stem cells and microRNA in resistance to chemotherapy in patients with ovarian cancer.
Authors: Markowska, A, et.al. .
Journal: European journal of gynaecological oncology (Eur J Gynaecol Oncol), Vol. 38 (2): 181-183, 2017 .
Snippet: Resistence of ovarian cancer cells to paclitaxel and cisplatin is associated with a reduced expression of miR-30c, miR-130, and miR335, which results in activation of M-CSF, the known factor of resistance to cytostatic drugs.
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7: Title: MicroRNA‑335 inhibits bladder cancer cell growth and migration by targeting mitogen‑activated protein kinase 1.
Authors: Wang, Xiaolin, et.al. .
Journal: Molecular medicine reports (Mol Med Report), Vol. 14 (2): 1765-70, 2016 .
Snippet: The expression of mitogen‑activated protein kinase (MAPK)1 was decreased after overexpression of miR‑335, indicating that MAPK1 may be a target gene of miR‑335.
Affiliation: Department of Urology, Nantong Tumor Hospital, Nantong, Jiangsu 226361, P.R. China. Department of Urology, The First Hospital of Wujiang, Suzhou, Jiangsu 215200, P.R. China. Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China. .
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8: Title: MicroRNA-335 is downregulated in bladder cancer and inhibits cell growth, migration and invasion via targeting ROCK1.
Authors: Wu, Deyao, et.al. .
Journal: Molecular medicine reports (Mol Med Report), Vol. 13 (5): 4379-85, 2016 .
Snippet: Following transfection of miR‑335, MTT, cell migration and invasion, luciferase and western blot assays were conducted in bladder cancer cell lines.
Affiliation: Department of Urology, The Fourth Affiliated Hospital of Nantong Medical College, Yancheng, Jiangsu 224001, P.R. China. Department of Urology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China. .
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9: Title: Tumor-promoting function of single nucleotide polymorphism rs1836724 (C3388T) alters multiple potential legitimate microRNA binding sites at the 3'-untranslated region of ErbB4 in breast cancer.
Authors: Bagheri, Fatemeh, et.al. .
Journal: Molecular medicine reports (Mol Med Report), Vol. 13 (5): 4494-8, 2016 .
Snippet: Bioinformatics analysis identified rs1836724 to be a polymorphism in the seed region of four miRNA binding sites (hsa-miR335-5p, hsa-miR-28-5p, has‑miR‑708‑5p and has‑miR‑665), which may participate in the development of breast cancer.
Affiliation: Biochemistry Division, Department of Biology, Faculty of Science, Payame Noor University of Taft, Yazd 47416‑95447, Iran. Cellular and Molecular Biology Division, Department of Biology, Faculty of Science, University of Isfahan, Isfahan 81746‑73441, Iran. Genetics Division, Department of Biology, Faculty of Science, University of Isfahan, Isfahan 81746‑7344, Iran. Zist Fanavary Novin Institute, Isfahan 14115‑111, Iran. .
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10: Title: MicroRNA-335 and -543 suppress bone metastasis in prostate cancer via targeting endothelial nitric oxide synthase.
Authors: Fu, Qizhong, et.al. .
Journal: International journal of molecular medicine (Int J Mol Med), Vol. 36 (5): 1417-25, 2015 .
Snippet: Using the online target prediction tool, endothelial nitric oxide synthase (eNOS) was found to be a shared target of miR‑335 and ‑543, which was further verified using the luciferase assay.
Affiliation: Department of Urology, Zhongshan Hospital of Dalian University, Dalian, Liaoning 116001, P.R. China. .
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11: Title: Two Different Serum MiRNA Signatures Correlate with the Clinical Outcome and Histological Subtype in Pleural Malignant Mesothelioma Patients.
Authors: Lamberti, Monica, et.al. .
Journal: PloS one, Vol. 10 (8): e0135331, 2015 .
Snippet: In the patients 5 miRNAs were up-regulated (miR101, miR25, miR26b, miR335 and miR433), 2 miRNA were downregulated (miR191, miR223) and two miRNAs were expressed exclusively in patients (miR29a and miR516).
Affiliation: Department of Experimental Medicine, Section of Hygiene, Occupational Medicine and Forensic Medicine, School of Medicine, Second University of Naples, Naples, Italy. Department of Biochemistry, Biophysics and General Pathology, School of Medicine, Second University of Naples, Naples, Italy. Department of Thoracic Surgery, School of Medicine, Second University of Naples, Naples, Italy. Department of Cardiothoracic & Respiratory Sciences, Second University of Naples, Naples, Italy. .
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12: Title: Upregulation of microRNA‑335 and microRNA‑584 contributes to the pathogenesis of severe preeclampsia through downregulation of endothelial nitric oxide synthase.
Authors: Jiang, Feng, et.al. .
Journal: Molecular medicine reports (Mol Med Report), Vol. 12 (4): 5383-90, 2015 .
Snippet: These target endothelial nitric oxide synthase (eNOS), which has been repeatedly reported to be involved in the development of preeclampsia.
Affiliation: Department of Gynecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China. Department of Gastrointestinal Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710033, P.R. China. Department of Urology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710033, P.R. China. Department of Hematology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China. .
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13: Title: Long-term climbing fibre activity induces transcription of microRNAs in cerebellar Purkinje cells.
Authors: Barmack, Neal H, et.al. .
Journal: Philosophical transactions of the Royal Society of London. Series B, Biological sciences (Philos Trans R Soc Lond B Biol Sci), Vol. 369 (1652), 2014 .
Snippet: Knockdown of either 14-3-3-θ or PKC-γ decreased the serine phosphorylation of GABAAγ2, suggesting that 14-3-3-θ and PKC-γ under the control of miR335 homeostatically regulate the phosphorylation and insertion of GABAAγ2 into the Purkinje cell post-synaptic membrane.
Affiliation: Department of Physiology and Pharmacology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA barmackn@ohsu.edu. Department of Physiology and Pharmacology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. .
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14: Title: PAX6, a novel target of miR-335, inhibits cell proliferation and invasion in glioma cells.
Authors: Cheng, Quan, et.al. .
Journal: Molecular medicine reports (Mol Med Report), Vol. 10 (1): 399-404, 2014 .
Snippet: In conclusion, the present study demonstrated that PAX6, as a novel target of miR‑335, has an anti‑oncogenic function in glioma, and thus PAX6 may serve as a therapeutic target for glioma.
Affiliation: Department of Neurosurgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China. Department of Neurosurgery, Brain Hospital of Hunan Province, The Affiliated Hospital of Hunan Traditional Chinese Medicine University, Changsha, Hunan 410007, P.R. China. .
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15: Title: miR-335 promotes mesendodermal lineage segregation and shapes a transcription factor gradient in the endoderm.
Authors: Yang, Dapeng, et.al. .
Journal: Development (Cambridge, England) (Development), Vol. 141 (3): 514-25, 2014 .
Snippet: Here we show that miR-335 fine-tunes TF gradients in the endoderm and promotes mesendodermal lineage segregation.
Affiliation: Institute of Stem Cell Research, Helmholtz Zentrum München, D-85764 Neuherberg, Germany. .
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16: Title: Deregulated MIR335 that targets MAPK1 is implicated in poor outcome of paediatric acute lymphoblastic leukaemia.
Authors: Yan, Junli, et.al. .
Journal: British journal of haematology (Br J Haematol), Vol. 163 (1): 93-103, 2013 .
Snippet: Moreover, we demonstrate that MAPK1 is a novel target of MIR335, and that MEK/ERK inhibitor treatment enhanced prednisolone-induced cell death through the activation of BIM (BCL2L11).
Affiliation: Cancer Science Institute of Singapore, National University of Singapore, Singapore City, Singapore. .
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17: Title: Effect of miR-335 upregulation on the apoptosis and invasion of lung cancer cell A549 and H1299.
Authors: Wang, Huaqi, et.al. .
Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol), Vol. 34 (5): 3101-9, 2013 .
Snippet: The aim of the paper was to study the expression of miR335 in non-small cell lung cancer (NSCLC) and miR335's relation to the metastasis, invasion, and apoptosis in lung cancer cells A549 and H1299.
Affiliation: Department of Respiratory Medicine, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe Road, Zhengzhou, 450052, China. .
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18: Title: Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study.
Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association (Clin Gastroenterol Hepatol), Vol. 11 (6): 681-8.e3, 2013 .
Snippet: We selected a group of 13 miRNAs for validation in an independent cohort of patients; 6 (miR18a, miR19a, miR19b, miR15b, miR29a, and miR335) were confirmed to be significantly up-regulated in patients with CRC, differentiating patients with CRC from controls with area under the receiver operating characteristic curve values ranging from 0.80 (95% confidence interval [CI], 0.71-0.89) to 0.70 (95% CI, 0.59-0.80).
Affiliation: Department of Gastroenterology, Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain. .
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19: Title: [Differential expressions of microRNA between young and senescent endothelial cells].
Authors: Zhang, Jun-bin, et.al. .
Journal: Zhonghua yi xue za zhi, Vol. 92 (31): 2205-9, 2012 .
Snippet: The up-regulation of miR335-3p in old ECs and the up-regulation of miR-135a, miR-96 in the young ECs might contribute to a lower expression of eNOS in senescent ECs.
Affiliation: Department of Vascular & Thyroid Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China. .
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20: Title: [Construction of has-miR-335 lentiviral vector and verification of the target gene of miR-335].
Authors: Yang, Hui, et.al. .
Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao), Vol. 32 (3): 306-11, 2012 .
Snippet: The recombinant PLVTHM-miR335 plasmid was packaged into mature lentivirus by 293FT cells and used to infect SW620 cells.
Affiliation: Department of Pathology, College of Basic Medical Sciences, Key Laboratory of Molecule Tumor Pathology of Guangdong Province, Southern Medical University, Guangzhou 510515, China. yh19820818@sina.com .
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