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1: Title: Genetic Polymorphisms in the Long Noncoding RNA MIR2052HG Offer a Pharmacogenomic Basis for the Response of Breast Cancer Patients to Aromatase Inhibitor Therapy.
Authors: Ingle, James N, et.al. .
Journal: Cancer research (Cancer Res), Vol. 76 (23): 7012-7023, 2016 .
Snippet: Functional genomic studies in lymphoblastoid cell lines and ERα-positive breast cancer cell lines showed that expression from MIR2052HG and the ESR1 gene encoding estrogen receptor-α (ERα) was induced by estrogen and AI in a SNP-dependent manner.
Affiliation: Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota. ingle.james@mayo.edu. Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota. Baylor Breast Center, Houston, Texas. Massachusetts General Hospital Cancer Center, Harvard University, Boston, Massachusetts. Canadian Cancer Trials Group, Kingston, Ontario, Canada. RIKEN Center for Integrative Medical Science, Yokohama, Japan. University of Tokyo, Tokyo, Japan. Johns Hopkins School of Medicine, Baltimore, Maryland. Sunnybrook Odette Regional Cancer Centre, University of Toronto, Toronto, Ontario, Canada. Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota. Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota. .
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