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19 documents found
1: Title: Differential miRNA expression profile and proteome in plasma exosomes from patients with paroxysmal nocturnal hemoglobinuria.
Authors: Teruel-Montoya, Raúl, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 9 (1): 3611, 2019 .
Snippet: We found differential expression of miRNAs miR-148b-3p, miR-423-3p, miR29b-3p, miR15b-5p, let-7e-5p, miR126-3p, miR-125b-5p and miR-376c-3p as well as hemoglobin, haptoglobin, protein S and C4-binding protein in healthy controls vs PNH patients.
Affiliation: Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Arrixaca, Murcia, Spain. raulteruelmontoya@hotmail.com. Grupo de Investigación CB15/00055, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. raulteruelmontoya@hotmail.com. Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Arrixaca, Murcia, Spain. Servicio de Metabolómica, CEBAS-CSIC, 30100, Campus de Espinardo, Murcia, Spain. Laboratory of Food & Health, Group of Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, 30100, Campus de Espinardo, Murcia, Spain. Grupo de Investigación CB15/00055, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Arrixaca, Murcia, Spain. immlgi@um.es. Grupo de Investigación CB15/00055, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. immlgi@um.es. .
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2: Title: Biomarkers associated with response to regorafenib in patients with hepatocellular carcinoma.
Authors: Teufel, Michael, et.al. .
Journal: Gastroenterology, 2019 .
Snippet: We identified 9 plasma miRNAs (MIR30A, MIR122, MIR125B, MIR200A, MIR374B, MIR15B, MIR107, MIR320, and MIR645) whose levels significantly associated with overall survival time with regorafenib (adjusted P≤.05).
Affiliation: Bayer HealthCare Pharmaceuticals, Whippany, NJ, USA. Electronic address: michael.teufel@bayer.com. Bayer AG, Berlin, Germany. Bayer HealthCare Pharmaceuticals, Whippany, NJ, USA. David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. BCLC Group, Liver Unit, Hospital Clinic, University of Barcelona, IDIBAPS, CIBEREHD, Barcelona, Spain; Liver Cancer Program, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. BCLC Group, Liver Unit, Hospital Clinic, University of Barcelona, IDIBAPS, CIBEREHD, Barcelona, Spain. .
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3: Title: Urinary concentrations of phenols and phthalate metabolites reflect extracellular vesicle microRNA expression in follicular fluid.
Authors: Martinez, Rosie M, et.al. .
Journal: Environment international (Environ Int), Vol. 123, 2019 .
Snippet: Hsa-miR-125b, hsa-miR-106b, hsa-miR-374a, and hsa-miR15b was associated with mono(2-ethylhexyl) phthalate concentrations, hsa-let-7c with concentrations mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP), mono-2-ethyl-5-oxohexyl phthalate (MEOHP), mono-2-ethyl-5-carboxypentyl phthalate (MECPP), and the sum of metabolites of di(2-ethylhexyl) phthalate, hsa-miR-24 with mono-n-butyl phthalate concentrations, hsa-miR-19a with cyclohexane-1,2-dicarboxylic acid monohydroxy isononyl ester (MHiNCH), and hsa-miR-375 with ethyl paraben concentrations.
Affiliation: Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Laboratory of Precision Environmental Biosciences, Department of Environmental Health Sciences, Columbia Mailman School of Public Health, NY, New York 10032, USA. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Department of Obstetrics and Gynecology, Sheba Medical Center, Ramat-Gan 52561 and, Sackler School of Medicine, Tel-Aviv University, Israel. EPIGET - Epidemiology, Epigenetics and Toxicology Lab, Department of Clinical Sciences and Community Health, University of Milan, 20122 Milano, Italy. Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Laboratory of Precision Environmental Biosciences, Department of Environmental Health Sciences, Columbia Mailman School of Public Health, NY, New York 10032, USA. Department of Obstetrics and Gynecology, Sheba Medical Center, Ramat-Gan 52561 and, Sackler School of Medicine, Tel-Aviv University, Israel. Electronic address: Ronit.Machtinger@sheba.health.gov.il. .
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4: Title: Effects of the antagomiRs 15b and 200b on the altered healing pattern of diabetic mice.
Authors: Pizzino, Gabriele, et.al. .
Journal: British journal of pharmacology (Br J Pharmacol), 2017 .
Snippet: In diabetic wounds, the microRNAs, miR15b and miR200b, which respectively inhibit VEGF and VEGF-R2 mRNAs, are up-regulated, further affecting the impaired angiogenesis.
Affiliation: Department of Clinical and Experimental Medicine, Section of Pharmacology, Medical School, University of Messina, Messina, Italy. Department of Human Pathology, University of Messina, Messina, Italy. Department of Biomedical Sciences, Dentistry and Morphological and Functional Images, University of Messina, Messina, Italy. .
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5: Title: Overexpression of miR-15b-5p promotes gastric cancer metastasis by regulating PAQR3.
Authors: Zhao, Chengcheng, et.al. .
Journal: Oncology reports (Oncol Rep), Vol. 38 (1): 352-358, 2017 .
Snippet: Moreover, progestin and adipoQ receptor family member 3 (PAQR3) was found to be a direct target of miR-15b-5p and re-expression of PAQR3 in miR-15b-5p-overexpressing GC cells partly attenuated the proliferation, migration and invasion.
Affiliation: Central Laboratory, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China. Department of Oncology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China. .
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6: Title: MicroRNA-15b promotes proliferation and invasion of non‑small cell lung carcinoma cells by directly targeting TIMP2.
Authors: Wang, Haowen, et.al. .
Journal: Oncology reports (Oncol Rep), Vol. 37 (6): 3305-3312, 2017 .
Snippet: Moreover, the effect of miR-15b on A549 and LTEP-a-2 cell viability, cell cycle, migration and invasion was further evaluated.
Affiliation: Department of Chemoradiotherapy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China. Department of Pharmacy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China. .
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7: Title: Significance of Serum MicroRNAs in the Auxiliary Diagnosis of Non-Small Cell Lung Cancer.
Authors: Shi, Guang-Li, et.al. .
Journal: Clinical laboratory (Clin Lab), Vol. 63 (1): 133-140, 2017 .
Snippet: CONCLUSIONS: Serum miRNAs have potential as NSCLC-screening tumor markers, and serum miR-22 and miR15b might be used as reference indexes for the early diagnosis of NSCLC in the future.
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8: Title: Identification of miRNAs as Potential Biomarkers in Cerebrospinal Fluid from Amyotrophic Lateral Sclerosis Patients.
Authors: Benigni, Michele, et.al. .
Journal: Neuromolecular medicine (Neuromolecular Med), Vol. 18 (4): 551-560, 2016 .
Snippet: The receiver operator characteristic (ROC) curve analyses revealed the highest diagnostic accuracy for the upregulated miR181a-5p and the downregulated miR21-5p and miR15b-5p.
Affiliation: Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy. Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy. claudia.ricci@unisi.it. Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. .
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9: Title: Decreased Expression of Plasma MicroRNA in Patients with Methamphetamine (MA) Use Disorder.
Authors: Zhao, Yan, et.al. .
Journal: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology (J Neuroimmune Pharmacol), Vol. 11 (3): 542-8, 2016 .
Snippet: We found that the expression of miR181a, miR15b, miR- let-7e, miR- let-7d in plasma were decreased compared to normal controls.
Affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wanping Rd., Shanghai, 200030, People's Republic of China. Mental Health Institute of the Second Xiangya Hospital, Central South University, 139 Renmin (M) Rd, Changsha, Hunan, 410011, People's Republic of China. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wanping Rd., Shanghai, 200030, People's Republic of China. yushuny@yahoo.com. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wanping Rd., Shanghai, 200030, People's Republic of China. drminzhao@gmail.com. .
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10: Title: MicroRNA-15b suppresses the growth and invasion of glioma cells through targeted inhibition of cripto-1 expression.
Authors: Sun, Guan, et.al. .
Journal: Molecular medicine reports (Mol Med Report), Vol. 13 (6): 4897-903, 2016 .
Snippet: Fluorescent quantitative PCR confirmed that miR‑15b expression was significantly downregulated in glioma tissue while cripto‑1 expression was significantly increased.
Affiliation: Department of Neurosurgery, Fourth Affiliated Hospital of Nantong University, First Hospital of Yancheng, Yancheng, Jiangsu 224001, P.R. China. Department of Surgical Oncology, Eighty‑First Hospital of People's Liberation Army, Nanjing, Jiangsu 210002, P.R. China. Department of Neurosurgery, The First People's Hospital of Kunshan Affiliated with Jiangsu University, Suzhou, Jiangsu 215300, P.R. China. Department of Neurosurgery, Jiangning Hospital Affiliated with Nanjing Medical University, Nanjing, Jiangsu 211100, P.R. China. .
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11: Title: miR-15b and miR-21 as Circulating Biomarkers for Diagnosis of Glioma.
Authors: Ivo D'Urso, Pietro, et.al. .
Journal: Current genomics (Curr Genomics), Vol. 16 (5): 304-11, 2015 .
Snippet: Furthermore, combined expression analyses of miR15b and miR-21 distinguished between patients with and without glioma (90% sensitivity and 100% specificity).
Affiliation: Department of Neurosurgery, King's College Hospital, London, UK; Department of Biological and Environmental Sciences and Technologies (DISTEBA), Salento University, Lecce 73100, Italy; Neurosurgery Operative Unit, "V. Fazzi" Hospital 73100 Lecce, Italy; Institute of Sciences of Food Productions, National Research Council, ISPA-CNR, Via Lecce-Monteroni, 73100 Lecce, Italy. .
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12: Title: miR-15b promotes epithelial-mesenchymal transition by inhibiting SMURF2 in pancreatic cancer.
Authors: Zhang, Wen-Long, et.al. .
Journal: International journal of oncology (Int J Oncol), Vol. 47 (3): 1043-53, 2015 .
Snippet: We report here that silencing SMURF2 (SMAD specific E3 ubiquitin protein ligase 2) promoted EMT in HPDE6c7 normal pancreas cells and overexpression of SMURF2 inhibited TGF-β-mediated EMT in the cells.
Affiliation: Department of General Surgery, The Second Artillery General Hospital of PLA, Beijing 100088, P.R. China. Department of Pathology, The Second Artillery General Hospital of PLA, Beijing 100088, P.R. China. Department of Hepatobiliary Surgery, The Second Artillery General Hospital of PLA, Beijing 100088, P.R. China. .
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13: Title: Mangiferin regulates proliferation and apoptosis in glioma cells by induction of microRNA-15b and inhibition of MMP-9 expression.
Authors: Xiao, Jinsong, et.al. .
Journal: Oncology reports (Oncol Rep), Vol. 33 (6): 2815-20, 2015 .
Snippet: MMP-9 agonist, miR-15b mimics and anti-miR-15b mimics were added to the U87 glioma cells for elucidating the mechanisms involved in the curative effects of mangiferin.
Affiliation: Division of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China. .
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14: Title: Analysis of serum miRNA profiles of myasthenia gravis patients.
Authors: Nogales-Gadea, Gisela, et.al. .
Journal: PloS one, Vol. 9 (3): e91927, 2014 .
Snippet: MiR15b, miR122, miR-140-3p, miR185, miR192, miR20b and miR-885-5p were in lower levels in MG patients than in controls.
Affiliation: Neuromuscular Diseases Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain; CIBER de enfermedades neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain. Department of Statistics, University of Barcelona, Barcelona, Spain. .
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15: Title: Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study.
Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association (Clin Gastroenterol Hepatol), Vol. 11 (6): 681-8.e3, 2013 .
Snippet: We selected a group of 13 miRNAs for validation in an independent cohort of patients; 6 (miR18a, miR19a, miR19b, miR15b, miR29a, and miR335) were confirmed to be significantly up-regulated in patients with CRC, differentiating patients with CRC from controls with area under the receiver operating characteristic curve values ranging from 0.80 (95% confidence interval [CI], 0.71-0.89) to 0.70 (95% CI, 0.59-0.80).
Affiliation: Department of Gastroenterology, Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain. .
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16: Title: Cycling exercise affects the expression of apoptosis-associated microRNAs after spinal cord injury in rats.
Authors: Liu, Gang, et.al. .
Journal: Experimental neurology (Exp Neurol), Vol. 226 (1): 200-6, 2010 .
Snippet: We show that SCI results in increased expression of miR Let-7a and miR16 while exercise leads to elevated levels of miR21 and decreased levels of miR15b.
Affiliation: Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA. .
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17: Title: Morphine treatment of human monocyte-derived macrophages induces differential miRNA and protein expression: impact on inflammation and oxidative stress in the central nervous system.
Authors: Dave, Rajnish S, et.al. .
Journal: Journal of cellular biochemistry (J Cell Biochem), Vol. 110 (4): 834-45, 2010 .
Snippet: Computational analysis predicted fibroblast growth factor-2 (FGF-2) as the strongest target gene for hsa-miR15b.
Affiliation: Center for Neurovirology, Department of Neuroscience, Temple University, MERB 774A, 3500 North Broad Street, Philadelphia, Pennsylvania 19140, USA. rsdave@temple.edu .
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18: Title: STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease.
Authors: Li, Geqiang, et.al. .
Journal: Blood, Vol. 115 (7): 1416-24, 2010 .
Snippet: However, only STAT5a could effectively induce bcl-2 mRNA and reciprocally suppress miR15b/16 leading to maintained bcl-2 protein levels.
Affiliation: Department of Medicine, Division of Hematology/Oncology, Case Western Reserve University, Cleveland, OH 44106-7284, USA. .
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19: Title: Glucocorticoid-regulated microRNAs and mirtrons in acute lymphoblastic leukemia.
Authors: Rainer, J, et.al. .
Journal: Leukemia, Vol. 23 (4): 746-52, 2009 .
Snippet: In an in vitro model, overexpression of miR15b ~ 16 mimics increased and silencing by miR15b ~ 16 inhibitors decreased GC sensitivity.
Affiliation: Tyrolean Cancer Research Institute, Innsbruck, Austria. .
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