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128 documents found
1: Title: Prognostic significance of MEOX2 in gliomas.
Authors: Tachon, Gaelle, et.al. .
Journal: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc (Mod Pathol), 2019 .
Snippet: We then evaluated the prognostic significance of MEOX2 protein expression on 112 glioma clinical samples including; 56 IDH1 wildtype glioblastomas, 7 IDH1 wild-type lower grade gliomas, 49 IDH1 mutated lower grade gliomas.
Affiliation: Inserm U1084, Laboratoire de Neurosciences Expérimentales et Cliniques, Poitiers, F-86073, France. Université de Poitiers, F-86073, Poitiers, France. CHU de Poitiers, Laboratoire de Cancérologie Biologique, Poitiers, F-86022, France. CHU de Poitiers, Service d'Anatomo-Cytopathologie, Poitiers, F-86021, France. CHU de Poitiers, Service de Neurochirurgie, Poitiers, F-86021, France. Inserm U1084, Laboratoire de Neurosciences Expérimentales et Cliniques, Poitiers, F-86073, France. pierre-olivier.guichet@chu-poitiers.fr. Université de Poitiers, F-86073, Poitiers, France. pierre-olivier.guichet@chu-poitiers.fr. CHU de Poitiers, Laboratoire de Cancérologie Biologique, Poitiers, F-86022, France. pierre-olivier.guichet@chu-poitiers.fr. Inserm U1084, Laboratoire de Neurosciences Expérimentales et Cliniques, Poitiers, F-86073, France. lucie.karayan-tapon@chu-poitiers.fr. Université de Poitiers, F-86073, Poitiers, France. lucie.karayan-tapon@chu-poitiers.fr. CHU de Poitiers, Laboratoire de Cancérologie Biologique, Poitiers, F-86022, France. lucie.karayan-tapon@chu-poitiers.fr. .
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2: Title: Generation of induced pluripotent stem cell line (ZZUi0013-A) from a 65-year-old patient with a novel MEOX2 gene mutation in Alzheimer's disease.
Authors: Wang, Yanlin, et.al. .
Journal: Stem cell research (Stem Cell Res), Vol. 34, 2019 .
Snippet: MEOX2 mutation has been reported as a potential cause of familial Alzheimer's disease.
Affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address: xuyuming@zzu.edu.cn. Center for Stem Cell and Regenerative Medicine, Department of Basic Medical Sciences, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China; Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang 310058, China. Electronic address: zhgene@gmail.com. .
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3: Title: RING finger protein 10 attenuates vascular restenosis by inhibiting vascular smooth muscle cell hyperproliferation in vivo and vitro.
Authors: Li, Siyu, et.al. .
Journal: IUBMB life, 2018 .
Snippet: In vivo and in vitro, we found that overexpression of RNF10 significantly affected neointima formation and VSMC proliferation, and displayed further inhibitory activity by promoting mesenchyme homeobox 2 (Meox2) and suppressing activating protein 1 (AP-1).
Affiliation: Department of Cardiology, First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China. Department of Neurosurgery, Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China. Department of Cardiology, Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China. .
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4: Title: Gene network variation and alternative paths to convergent evolution in turtles.
Authors: Cordero, Gerardo A, et.al. .
Journal: Evolution & development (Evol Dev), Vol. 20 (5): 172-185, 2018 .
Snippet: Notably, mesenchyme homeobox 2 (MEOX2) and HOXA3-5 were central hubs driving the activity of 2,806 genes in a candidate network for scapula segmentation, albeit in only one species.
Affiliation: Department of Ecology, Evolution, and Organismal Biology, Iowa State University, Ames, Iowa. Program in Bioinformatics and Computational Biology, Iowa State University, Ames, Iowa. .
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5: Title: Xenopus SOX5 enhances myogenic transcription indirectly through transrepression.
Authors: Della Gaspera, Bruno, et.al. .
Journal: Developmental biology (Dev Biol), Vol. 442 (2): 262-275, 2018 .
Snippet: Meox2 which is a dermomyotome marker, represses myogenic transcription in Myod-induced myogenic transcription assay and in Nodal5-induced mesoderm from animal cap assay.
Affiliation: UMR INSERM 1124, Université Paris Descartes, Faculté des sciences biomédicales et fondamentales, 45 rue des Saints-Pères, F-75270 Paris Cedex 06, France. Electronic address: bruno.della-gaspera@parisdescartes.fr. Paris-Saclay Institute of Neuroscience, CNRS, Univ Paris Sud, Université Paris-Saclay, Orsay 91405, France. UMR INSERM 1124, Université Paris Descartes, Faculté des sciences biomédicales et fondamentales, 45 rue des Saints-Pères, F-75270 Paris Cedex 06, France. UMR INSERM 1124, Université Paris Descartes, Faculté des sciences biomédicales et fondamentales, 45 rue des Saints-Pères, F-75270 Paris Cedex 06, France. Electronic address: christophe.chanoine@parisdescartes.fr. .
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6: Title: Over-expression of MEOX2 promotes apoptosis through inhibiting PI3K/Akt pathway in laryngeal cancer cells.
Authors: Tian, L, et.al. .
Journal: Neoplasma, 2018 .
Snippet: Over-expression of MEOX2 inhibited cell viability and promoted apoptosis of TU212 cells, via increasing the expression levels of Caspase-3, and decreasing levels of C-Myc, XIAP, PI3K p110α, PI3K p110β, PI3K class III and p-Akt.
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7: Title: Comprehensive analysis of differential expression profiles of mRNAs and lncRNAs and identification of a 14-lncRNA prognostic signature for patients with colon adenocarcinoma.
Authors: Xing, Yanwei, et.al. .
Journal: Oncology reports (Oncol Rep), 2018 .
Snippet: MDFI and MEOX2 were the PPI network hubs.
Affiliation: Department of Colorectal Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China. Department of General Surgery, China-Japan Friendship Hospital of Jilin University, Changchun, Jilin 130033, P.R. China. .
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8: Title: Hypoxia-Preconditioned Human Umbilical Vein Endothelial Cells Protect Against Neurovascular Damage After Hypoxic Ischemia in Neonatal Brain.
Authors: Lee, Yi-Chao, et.al. .
Journal: Molecular neurobiology (Mol Neurobiol), 2018 .
Snippet: After hypoxia, 12 genes (ADAMTS1, EFNA1, HIF1A, LOX, MEOX2, SELE, VEGFA, VEGFC, CX3CL1, HMMR, SDC, and SERPINE) associated with migration and/or angiogenesis were regulated in HUVECs.
Affiliation: Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan. Center for Neurotrauma and Neuroregeneration, Taipei Medical University, Taipei, Taiwan. Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan. Department of Pediatrics Chang Gung University College of Medicine, Taoyuan, Taiwan. Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Department of Pediatrics, College of Medicine, Taipei Medical University, Taipei City, Taiwan. huangped@tmu.edu.tw. Department of Pediatrics, Wan-Fang Hospital, Taipei Medical University, Taipei, Taiwan. huangped@tmu.edu.tw. Department of Pediatrics, National Cheng Kung University Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan. huangped@tmu.edu.tw. .
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9: Title: Cardiac Endothelial Cell Transcriptome.
Authors: Lother, Achim, et.al. .
Journal: Arteriosclerosis, thrombosis, and vascular biology (Arterioscler Thromb Vasc Biol), 2018 .
Snippet: For example, we found the Meox2/Tcf15, Fabp4, and Cd36 signaling cascade higher expressed in cardiac ECs which is a key regulator of fatty acid uptake and involved in the development of atherosclerosis.
Affiliation: From the Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine (A.L., S.B., L.D., L.H.), Heart Center Freiburg University, Department of Cardiology and Angiology I, Faculty of Medicine (A.L., M.M., C.B.), and BIOSS Centre for Biological Signaling Studies (L.H.), University of Freiburg, Germany. achim.lother@universitaets-herzzentrum.de. From the Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine (A.L., S.B., L.D., L.H.), Heart Center Freiburg University, Department of Cardiology and Angiology I, Faculty of Medicine (A.L., M.M., C.B.), and BIOSS Centre for Biological Signaling Studies (L.H.), University of Freiburg, Germany. .
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10: Title: Regulation of mesenchymal signaling in palatal mucosa differentiation.
Authors: Neupane, Sanjiv, et.al. .
Journal: Histochemistry and cell biology (Histochem Cell Biol), 2017 .
Snippet: Genome-wide screening analysis using laser micro-dissection to collect spatiotemporal specific molecules between anterior and posterior palate suggested Meox2 in the posterior mesenchymal tissue to be a candidate regulator controlling epithelial differentiation.
Affiliation: Department of Biochemistry, School of Dentistry, Kyungpook National University, 2177 Dalgubeol-daero, Jung-gu, Daegu, 41940, South Korea. Institute for Hard Tissue and Bio-tooth Regeneration, Kyungpook National University, Daegu, South Korea. Department of Oral Medicine, School of Dentistry, Kyungpook National University, Daegu, South Korea. Department of Oral and Maxillofacial Radiology, School of Dentistry, Kyungpook National University, Daegu, South Korea. School of Life Science and Biotechnology, Kyungpook National University, Daegu, South Korea. Department of Ophthalmology, School of Medicine, Dongsan Medical Center, Keimyung University, Daegu, South Korea. Department of Dental Hygiene, Gachon University, Incheon, South Korea. Institute for Hard Tissue and Bio-tooth Regeneration, Kyungpook National University, Daegu, South Korea. undine75@gmail.com. Department of Biochemistry, School of Dentistry, Kyungpook National University, 2177 Dalgubeol-daero, Jung-gu, Daegu, 41940, South Korea. jykim91@knu.ac.kr. Institute for Hard Tissue and Bio-tooth Regeneration, Kyungpook National University, Daegu, South Korea. jykim91@knu.ac.kr. .
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11: Title: Association of MEOX2 polymorphism with nonsyndromic cleft palate only in a Vietnamese population.
Authors: Tran, Duy L, et.al. .
Journal: Congenital anomalies (Congenit Anom (kyoto)), 2017 .
Snippet: To evaluate the association between the single nucleotide polymorphism (SNP) rs227493 in the MEOX2 gene and nonsyndromic cleft palate only, this research was conducted as a case-control study by comparing a nonsyndromic cleft palate only group with an independent, healthy, and unaffected control group who were both examined by specialists.
Affiliation: Division of Research and Treatment for Oral Maxillofacial Congenital Anomalies, Aichi Gakuin University, Nagoya, Japan. Nguyen Dinh Chieu General Hopsital, Ben Tre, Vietnam. Cleft Lip and Palate Center, Aichi Gakuin Dental Hospital, Nagoya, Japan. Division of Speech, Hearing, and Language, Aichi Gakuin Dental Hospital, Nagoya, Japan. Odonto and Maxillofacial Hospital, Ho Chi Minh, Vietnam. .
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12: Title: Dual effects of hyperglycemia on endothelial cells and cardiomyocytes to enhance coronary LPL activity.
Authors: Chiu, Amy Pei-Ling, et.al. .
Journal: American journal of physiology. Heart and circulatory physiology (Am J Physiol Heart Circ Physiol), 2017 .
Snippet: In the EC, TGFβ signaling promotes mesodermal homeobox 2 (Meox2) translocation to the nucleus that increases the expression of GPIHBP1, which facilitates movement of LPL to the vascular lumen.
Affiliation: The University of British Columbia. Technion. University of British Columbia rodrigue@interchange.ubc.ca. .
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13: Title: Epigenomic study identifies a novel mesenchyme homeobox2-GLI1 transcription axis involved in cancer drug resistance, overall survival and therapy prognosis in lung cancer patients.
Authors: Armas-López, Leonel, et.al. .
Journal: Oncotarget, Vol. 8 (40): 67056-67081, 2017 .
Snippet: Several homeobox-related gene (HOX) transcription factors such as mesenchyme HOX-2 (MEOX2) have previously been associated with cancer drug resistance, malignant progression and/or clinical prognostic responses in lung cancer patients; however, the mechanisms involved in these responses have yet to be elucidated.
Affiliation: National University Autonomous of México (UNAM), Facultad de Estudios Superiores (FES) Iztacala, Biomedicine Research Unit (UBIMED), Lung Diseases And Cancer Epigenomics Laboratory, Mexico State, Mexico. Instituto Mexicano del Seguro Social (IMSS), Centro Medico Nacional (CMN) Siglo XXI, Unidad de Investigación Médica en Enfermedades Oncológicas (UIMEO), Molecular Oncology Laboratory, Mexico City, Mexico. National Cancer Institute (INCAN), Thoracic Oncology Clinic, Mexico City, Mexico. National Institute of Respiratory Diseases (INER) "Ismael Cosío Villegas", Mexico City, Mexico. Harvard Medical School, Harvard School of Public Health, Department of Environmental Health, Boston, Massachusetts, USA. .
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14: Title: Molecular mechanisms underlying gliomas and glioblastoma pathogenesis revealed by bioinformatics analysis of microarray data.
Authors: Vastrad, Basavaraj, et.al. .
Journal: Medical oncology (Northwood, London, England) (Med Oncol), Vol. 34 (11): 182, 2017 .
Snippet: The significant enriched pathway (PI3K-Akt) for up-regulated genes such as COL4A1, COL4A2, EGFR, FGFR1, LAPR6, MYC, PDGFA, SPP1 were selected as well as significant GO term (ear development) for up-regulated genes such as CELSR1, CHRNA9, DDR1, FGFR1, GLI2, LGR5, SOX2, TSHR were selected, while the significant enriched pathway (amebiasis) for down-regulated gene such as COL3A1, COL5A2, LAMA2 were selected as well as significant GO term (RNA polymerase II core promoter proximal region sequence-specific binding (5) such as MEIS2, MEOX2, NR2E1, PITX2, TFAP2B, ZFPM2 were selected.
Affiliation: Department of Pharmaceutics, SET'S College of Pharmacy, Dharwad, Karnataka, 580002, India. basavarajmv@gmail.com. Department of Computer Science, Karnatak University, Dharwad, Karnataka, India. Radiant Research Services Private Limited, Bangalore, Karnataka, India. Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India. .
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15: Title: Vascular senescence and ageing: a role for the MEOX proteins in promoting endothelial dysfunction.
Authors: Northcott, Josette M, et.al. .
Journal: Canadian journal of physiology and pharmacology (Can J Physiol Pharmacol), Vol. 95 (10): 1067-1077, 2017 .
Snippet: Herein, we show that, in ECs, the MEOX homeodomain transcription factors decrease the expression of genes involved in angiogenesis, repress eNOS expression at the mRNA and protein levels, and increase the expression of p53.
Affiliation: a Institute of Cardiovascular Sciences, St. Boniface Albrechtsen Research Centre, Winnipeg, MB R2H 2A6, Canada. b Department of Biochemistry and Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, Canada. c Department of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, Canada. .
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16: Title: Generation of an immortalized mouse embryonic palatal mesenchyme cell line.
Authors: Fantauzzo, Katherine A, et.al. .
Journal: PloS one, Vol. 12 (6): e0179078, 2017 .
Snippet: In recent decades, the use of model systems such as genetically-modified mice, mouse palatal organ cultures and primary mouse embryonic palatal mesenchyme (MEPM) cultures has provided significant insight into the molecular and cellular defects underlying cleft palate.
Affiliation: Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America. Department of Craniofacial Biology, School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America. .
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17: Title: Role of microRNA-130a in the pathogeneses of obstructive sleep apnea hypopnea syndrome-associated pulmonary hypertension by targeting the GAX gene.
Authors: An, Zhe, et.al. .
Journal: Medicine (Medicine (baltimore)), Vol. 96 (20): e6746, 2017 .
Snippet: Compared with the control, mimic-NC, and inhibitor-NC groups, the relative expressions of miR-130a in the miR-130a mimic group were enhanced, whereas the expression of miR-130a in the miR-130a inhibitor group was reduced.
Affiliation: aDepartment of Cardiology, China-Japan Union Hospital of Jilin University bDepartment of Breast Surgery, The Second Hospital of Jilin University cDepartment of Molecular Biology, College of Basic Medical Sciences, Jilin University dDepartment of Respiratory Medicine, the Second Hospital of Jilin University eDepartment of Ophthalmology, The Second Hospital of Jilin University, Changchun, Jilin, P.R. China. .
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18: Title: The long noncoding RNA SPRIGHTLY acts as an intranuclear organizing hub for pre-mRNA molecules.
Authors: Lee, Bongyong, et.al. .
Journal: Science advances (Sci Adv), Vol. 3 (5): e1602505, 2017 .
Snippet: This lncRNA interacts with the intronic regions of six pre-mRNAs: SOX5, SMYD3, SND1, MEOX2, DCTN6, and RASAL2, all of which have cancer-related functions.
Affiliation: Sanford Burnham Prebys Medical Discovery Institute, 6400 Sanger Road, Orlando, FL 32827, USA. Department of Computer Science, University of Central Florida, Orlando, FL 32816, USA. Medical and Biological Laboratories, Nagoya 460-0008, Japan. Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, NJ 07103, USA. Keck Graduate Institute, 535 Watson Drive, Claremont, CA 91711, USA. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. .
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19: Title: Gestational Exposure to Sidestream (Secondhand) Cigarette Smoke Promotes Transgenerational Epigenetic Transmission of Exacerbated Allergic Asthma and Bronchopulmonary Dysplasia.
Authors: Singh, Shashi P, et.al. .
Journal: Journal of immunology (Baltimore, Md. : 1950) (J Immunol), Vol. 198 (10): 3815-3822, 2017 .
Snippet: We reported that gestational exposure to sidestream cigarette smoke (SS), or secondhand smoke, promoted nicotinic acetylcholine receptor-dependent exacerbation of AA and BPD in mice.
Affiliation: Lovelace Respiratory Research Institute, Albuquerque, NM 87108. Florida International University, Miami, FL 33199. University of Southern Alabama, Mobile, AL 36688. Pulmonary and Critical Care Medicine, University of New Mexico Medical Center, Albuquerque, NM 87131. Department of Pediatrics, University of New Mexico Medical Center, Albuquerque, NM 87131; and. Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205. Lovelace Respiratory Research Institute, Albuquerque, NM 87108; msopori@lrri.org. .
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20: Title: Gax suppresses chemerin/CMKLR1-induced preadipocyte biofunctions through the inhibition of Akt/mTOR and ERK signaling pathways.
Authors: Jiang, Yunqi, et.al. .
Journal: Journal of cellular physiology (J Cell Physiol), Vol. 233 (1): 572-586, 2018 .
Snippet: MTT, flow cytometry, Western blotting, and imunohisto(cyto)-chemistry analyses showed that chemerin enhanced the expression of FABP4 and VEGF, activated Akt/mTOR and ERK pathways, increased the cell percent of S phase, decreased the percent of G0-G1 phase and apoptotic cells, and augmented neovascular density in fat pads.
Affiliation: Department of Cardiology, The Second Hospital of Shandong University, Jinan, Shandong, China. College of Pharmacy, Shandong University, Jinan, Shandong, China. Central Laboratory, The Qilu Hospital of Shandong University, Jinan, Shandong, China. .
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