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34 documents found
1: Title: Single-cell gene expression of the bovine blastocyst.
Journal: Reproduction (Cambridge, England) (Reproduction), Vol. 154 (5): 627-644, 2017 .
Snippet: Among the genes upregulated in epiblast were AJAP1, DNMT3A, FGF4, H2AFZ, KDM2B, NANOG, POU5F1, SAV1 and SLIT2 Genes overexpressed in hypoblast included ALPL, FGFR2, FN1, GATA6, GJA1, HDAC1, MBNL3, PDGFRA and SOX17, while genes overexpressed in all four TE populations were ACTA2, CDX2, CYP11A1, GATA2, GATA3, IFNT, KRT8, RAC1 and SFN The subpopulations of TE varied among each other for multiple genes including the prototypical TE marker IFNT.
Affiliation: Department of Animal SciencesD. H. Barron Reproductive and Perinatal Biology Research Program and Genetics Institute, University of Florida, Gainesville, Florida, USA. Gene Expression and Genotyping CoreInterdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida, USA. Department of Animal SciencesD. H. Barron Reproductive and Perinatal Biology Research Program and Genetics Institute, University of Florida, Gainesville, Florida, USA pjhansen@ufl.edu. .
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2: Title: Disrupted prenatal RNA processing and myogenesis in congenital myotonic dystrophy.
Authors: Thomas, James D, et.al. .
Journal: Genes & development (Genes Dev), Vol. 31 (11): 1122-1133, 2017 .
Snippet: To test this possibility and the contribution of MBNLs to CDM pathogenesis, we generated mouse Mbnl double (Mbnl1; Mbnl2) and triple (Mbnl1; Mbnl2; Mbnl3) muscle-specific knockout models that recapitulate the congenital myopathy, gene expression, and spliceopathy defects characteristic of CDM.
Affiliation: Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, College of Medicine, University of Florida, Gainesville, Florida 32610, USA. Department of Neuromuscular Research, National Center of Neurology and Psychiatry, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan. Department of Neurology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan. .
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3: Title: The MBNL3 splicing factor promotes hepatocellular carcinoma by increasing PXN expression through the alternative splicing of lncRNA-PXN-AS1.
Authors: Yuan, Ji-Hang, et.al. .
Journal: Nature cell biology (Nat Cell Biol), Vol. 19 (7): 820-832, 2017 .
Snippet: Transcriptomic analysis revealed that MBNL3 induces lncRNA-PXN-AS1 exon 4 inclusion.
Affiliation: Department of Medical Genetics, Second Military Medical University, Shanghai 200433, China. The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200433, China. .
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4: Title: Pseudouridine Modification Inhibits Muscleblind-like 1 (MBNL1) Binding to CCUG Repeats and Minimally Structured RNA through Reduced RNA Flexibility.
Authors: deLorimier, Elaine, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 292 (10): 4350-4357, 2017 .
Snippet: These CCUG repeats bind and sequester a family of RNA-binding proteins known as Muscleblind-like 1, 2, and 3 (MBNL1, MBNL2, and MBNL3), and sequestration plays a significant role in pathogenicity.
Affiliation: From the Institute of Molecular Biology, Department of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon 97403 and. the Center for NeuroGenetics, Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida 32610-3010. From the Institute of Molecular Biology, Department of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon 97403 and aberglund@ufl.edu. .
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5: Title: Featured Article: Transcriptional landscape analysis identifies differently expressed genes involved in follicle-stimulating hormone induced postmenopausal osteoporosis.
Authors: Maasalu, Katre, et.al. .
Journal: Experimental biology and medicine (Maywood, N.J.) (Exp Biol Med (maywood)), Vol. 242 (2): 203-213, 2017 .
Snippet: Further statistical analysis identified a potential osteoporosis mRNA biomarker pattern consisting of six genes: CACNA1G, ALG13, SBK1, GGT7, MBNL3, and RIOK3.
Affiliation: 1 Department of Traumatology and Orthopedics, University of Tartu, Tartu 51014, Estonia. 2 Clinic of Traumatology and Orthopedics, Tartu University Hospital, Tartu 51014, Estonia. 3 Department of Pathophysiology, University of Tartu, Tartu 50411, Estonia. .
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6: Title: Mechanistic determinants of MBNL activity.
Authors: Sznajder, Łukasz J, et.al. .
Journal: Nucleic acids research (Nucleic Acids Res), Vol. 44 (21): 10326-10342, 2016 .
Snippet: When coexpressed in the same cells, MBNL1, MBNL2 and MBNL3 bind the same RNA motifs with different affinities.
Affiliation: Department of Gene Expression, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Umultowska 89, 61-614 Poznań, Poland lukasz.j.sznajder@gmail.com. Department of Molecular and Cellular Biology, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Umultowska 89, 61-614 Poznań, Poland. Department of Gene Expression, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Umultowska 89, 61-614 Poznań, Poland. Department of Bioinformatics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Umultowska 89, 61-614 Poznań, Poland. Department of Gene Expression, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Umultowska 89, 61-614 Poznań, Poland ksobczak@amu.edu.pl. .
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7: Title: Muscleblind-like 3 deficit results in a spectrum of age-associated pathologies observed in myotonic dystrophy.
Authors: Choi, Jongkyu, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 6, 2016 .
Snippet: Retention of embryonic splice isoforms in adult organs, a prominent defect in DM1, is not observed in multiple RNAs including the Insulin Receptor (Insr), Cardiac Troponin T (Tnnt2), Lim Domain Binding 3 (Ldb3) RNAs in Mbnl3(ΔE2) mice.
Affiliation: Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA. USC Eye Institute, Los Angeles, CA 90033, USA. Department of Ophthalmology, Faculty of Medicine, Zagazig University, Zagazig, Egypt. Department of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1751, USA. Department of Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA. .
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8: Title: MiR674 inhibits the neuraminidase-stimulated immune response on dendritic cells via down-regulated Mbnl3.
Authors: Lin, Jian, et.al. .
Journal: Oncotarget, Vol. 7 (31): 48978-48994, 2016 .
Snippet: Furthermore, we predicted and demonstrated that Pgm2l1, Aldh18a1, Camk1d, and Mbnl3 were the target genes of miR-674.
Affiliation: Life Science College, Nanjing Agricultural University, Weigang, Nanjing, Jiangsu, PR China. College of Veterinary Medicine, Nanjing Agricultural University, Weigang, Jiangsu, PR China. .
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9: Title: miR-30-5p Regulates Muscle Differentiation and Alternative Splicing of Muscle-Related Genes by Targeting MBNL.
Authors: Zhang, Bo-Wen, et.al. .
Journal: International journal of molecular sciences (Int J Mol Sci), Vol. 17 (2), 2016 .
Snippet: Our results confirmed that miR-30a-5p and miR-30e-5p repress the expression of MBNL1, MBNL2 and MBNL3, whereas miR-30b-5p inhibits MBNL1 and MBNL2 expression.
Affiliation: Shaanxi Key Laboratory of Agricultural Molecular Biology, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China. zhangbowen361@163.com. Shaanxi Key Laboratory of Agricultural Molecular Biology, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China. caihanfang.cool@163.com. Shaanxi Key Laboratory of Agricultural Molecular Biology, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China. weixuefeng.happy@163.com. Shaanxi Key Laboratory of Agricultural Molecular Biology, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China. jiajieking@126.com. Shaanxi Key Laboratory of Agricultural Molecular Biology, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China. lan342@126.com. Shaanxi Key Laboratory of Agricultural Molecular Biology, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China. leichuzhao1118@126.com. Department of Animal Husbandry, Bureau of Biyang County of Henan province, Biyang 463700, Henan, China. FengPengLin10@163.com. Department of Animal Husbandry, Bureau of Biyang County of Henan province, Biyang 463700, Henan, China. Xing-LeiQi@163.com. Shaanxi Key Laboratory of Agricultural Molecular Biology, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China. mplath-zoology@gmx.de. Shaanxi Key Laboratory of Agricultural Molecular Biology, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China. chenhong1212@263.net. .
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10: Title: Reversion to an embryonic alternative splicing program enhances leukemia stem cell self-renewal.
Authors: Holm, Frida, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), Vol. 112 (50): 15444-9, 2015 .
Snippet: In this study, RNA sequencing, splice isoform-specific quantitative RT-PCR, lentiviral transduction, and in vivo humanized mouse model studies demonstrated that malignant reprogramming of progenitors into self-renewing blast crisis chronic myeloid leukemia stem cells (BC LSCs) was partially driven by decreased MBNL3.
Affiliation: Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0820; Institute of Genomic Medicine, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, V5Z 1L3, Canada; Division of Hematology, Princess Margaret Hospital, Toronto, Ontario, M5G 2M9, Canada; Roche Innovation Center Penzberg, Oncology Division, Roche Pharmaceutical Research and Early Development, 82377 Penzberg, Germany. Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0820; cjamieson@ucsd.edu. .
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11: Title: Muscleblind-Like 1 and Muscleblind-Like 3 Depletion Synergistically Enhances Myotonia by Altering Clc-1 RNA Translation.
Authors: Choi, Jongkyu, et.al. .
Journal: EBioMedicine, Vol. 2 (9): 1034-47, 2015 .
Snippet: Thus binding of Mbnl1 and Mbnl3 to Clc-1 mRNA engaged with ribosomes can facilitate an increase in the local concentration of Hsp70 and eEF1A to assist Clc-1 translation.
Affiliation: Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA. Department of Rehabilitation Science and Program in Neuroscience, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY 14214, USA. Department of Physiology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA. Department of Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA. .
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12: Title: Transcriptome-wide landscape of pre-mRNA alternative splicing associated with metastatic colonization.
Authors: Lu, Zhi-xiang, et.al. .
Journal: Molecular cancer research : MCR (Mol Cancer Res), Vol. 13 (2): 305-18, 2015 .
Snippet: These include splicing factors known to be differentially regulated in epithelial-mesenchymal transition (ESRP1, ESRP2, and RBFOX2), a cellular process critical for cancer metastasis, as well as novel findings (NOVA1 and MBNL3).
Affiliation: Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, California. Department of Molecular Physiology and Biophysics, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa. Department of Pathology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa. Department of Molecular Physiology and Biophysics, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa. Department of Pathology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa. yxing@ucla.edu Michael-henry@uiowa.edu. Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, California. yxing@ucla.edu Michael-henry@uiowa.edu. .
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13: Title: Loss of MBNL leads to disruption of developmentally regulated alternative polyadenylation in RNA-mediated disease.
Authors: Batra, Ranjan, et.al. .
Journal: Molecular cell (Mol Cell), Vol. 56 (2): 311-22, 2014 .
Snippet: Although MBNL1 and MBNL2 bind to nascent transcripts to regulate alternative splicing during muscle and brain development, another major binding site for the MBNL protein family is the 3' untranslated region of target RNAs.
Affiliation: Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine, Gainesville, FL 32610, USA. Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA. Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA; Department of Gene Expression, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Umultowska 89, 61-614 Poznan, Poland. Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA. Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine, Gainesville, FL 32610, USA. Electronic address: mswanson@ufl.edu. .
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14: Title: Development of a Drosophila melanogaster spliceosensor system for in vivo high-throughput screening in myotonic dystrophy type 1.
Authors: García-Alcover, Irma, et.al. .
Journal: Disease models & mechanisms (Dis Model Mech), Vol. 7 (11): 1297-306, 2014 .
Snippet: These events are triggered by an RNA gain-of-function and resultant deregulation of specific RNA-binding factors, such as the nuclear sequestration of muscleblind-like family factors (MBNL1-MBNL3).
Affiliation: Valentia BioPharma, Scientific Park of the University of Valencia, Paterna, Valencia 46980, Spain. Department of Genetics, University of Valencia, Burjassot, Valencia 46010, Spain. Valentia BioPharma, Scientific Park of the University of Valencia, Paterna, Valencia 46980, Spain. Department of Genetics, University of Valencia, Burjassot, Valencia 46010, Spain. INCLIVA Health Research Institute, Valencia 46010, Spain. Valentia BioPharma, Scientific Park of the University of Valencia, Paterna, Valencia 46980, Spain. a.lopez@valentiabiopharma.com. Valentia BioPharma, Scientific Park of the University of Valencia, Paterna, Valencia 46980, Spain. Department of Genetics, University of Valencia, Burjassot, Valencia 46010, Spain. INCLIVA Health Research Institute, Valencia 46010, Spain. .
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15: Title: Neurotransmitter map of the asymmetric dorsal habenular nuclei of zebrafish.
Authors: deCarvalho, Tagide N, et.al. .
Journal: Genesis (New York, N.Y. : 2000) (Genesis), Vol. 52 (6): 636-55, 2014 .
Snippet: The goal of our study was to generate a comprehensive map of the zebrafish dorsal habenular nuclei, by delineating the relationship between gene expression domains, comparing the extent of left-right asymmetry at larval and adult stages, and identifying potentially functional subnuclear regions as defined by neurotransmitter phenotype.
Affiliation: Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland. .
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16: Title: Progressive impairment of muscle regeneration in muscleblind-like 3 isoform knockout mice.
Authors: Poulos, Michael G, et.al. .
Journal: Human molecular genetics (Hum Mol Genet), Vol. 22 (17): 3547-58, 2013 .
Snippet: Here, we report that mouse Mbnl3, which encodes protein isoforms that differ in the number of tandem zinc-finger RNA-binding motifs and subcellular localization, is expressed primarily during embryonic development but also transiently during injury-induced adult skeletal muscle regeneration.
Affiliation: Department of Molecular Genetics and Microbiology, Genetics Institute and the Center for NeuroGenetics, University of Florida, College of Medicine, Gainesville, FL 32610, USA. .
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17: Title: RNA steady-state defects in myotonic dystrophy are linked to nuclear exclusion of SHARP.
Authors: Dansithong, Warunee, et.al. .
Journal: EMBO reports (Embo Rep), Vol. 12 (7): 735-42, 2011 .
Snippet: Changes to the levels of a panel of RNAs involved in muscle development and function that are downregulated in DM1 are due to aberrant localization of the transcription factor SHARP (SMART/HDAC1-associated repressor protein).
Affiliation: Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, 2250 Alcazar Street, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA. .
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18: Title: Monoclonal antibodies against Muscleblind-like 3, a protein with punctate nuclear localization.
Authors: Lee, Kyung-Soon, et.al. .
Journal: Hybridoma (2005) (Hybridoma (larchmt)), Vol. 30 (2): 181-8, 2011 .
Snippet: Muscleblind-like 3 (MBNL3) belongs to a family of RNA binding proteins that regulate alternative splicing.
Affiliation: Department of Pharmacology, University of Washington, Seattle, Washington, USA. .
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19: Title: Zebrafish deficient for Muscleblind-like 2 exhibit features of myotonic dystrophy.
Authors: Machuca-Tzili, Laura E, et.al. .
Journal: Disease models & mechanisms (Dis Model Mech), Vol. 4 (3): 381-92, 2011 .
Snippet: Previous studies have shown that the mutant mRNAs containing the transcribed CUG or CCUG repeats are retained within the nuclei of cells from individuals with DM, where they bind and sequester the muscleblind-like proteins MBNL1, MBNL2 and MBNL3.
Affiliation: Institute of Genetics, University of Nottingham, Queen's Medical Centre, Nottingham, NG7 2UH, UK. .
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20: Title: Identification of MBNL1 and MBNL3 domains required for splicing activation and repression.
Authors: Grammatikakis, Ioannis, et.al. .
Journal: Nucleic acids research (Nucleic Acids Res), Vol. 39 (7): 2769-80, 2011 .
Snippet: MBNL1 and MBNL3 contain core regulatory regions for both activation and repression located within an 80-amino-acid segment located downstream of the N-terminal zinc-finger pair.
Affiliation: Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA. .
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