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17 documents found
1: Title: Ancient Haplotypes at the 15q24.2 Microdeletion Region Are Linked to Brain Expression of MAN2C1 and Children's Intelligence.
Authors: Cáceres, Alejandro, et.al. .
Journal: PloS one, Vol. 11 (6): e0157739, 2016 .
Snippet: Our population-based analyses suggest that MAN2C1 may contribute to the verbal difficulties observed in microduplications and to the intellectual disability of microdeletion syndromes, whose characteristic dosage increment and removal may affect different brain areas.
Affiliation: ISGlobal, Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain. Universitat Pompeu Fabra, Barcelona, Spain. Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America. Broad Institute, Cambridge, Massachusetts, United States of America. Division of Endocrinology, Children's Hospital Boston, Boston, Massachusetts, United States of America. Estonian Genome Center, University of Tartu, Tartu, Estonia. School of Pedagogical and Educational Sciences, Erasmus University Rotterdam, Rotterdam, The Netherlands. Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands. Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain. Hospital del Mar Research Institute (IMIM), Barcelona, Spain. Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain. Genomics and Disease Group, Centre for Genomic Regulation (CRG), Barcelona, Spain. Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands. Department of Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands. Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia. Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland. MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland. Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. Rotman Research Institute, University of Toronto, Toronto, Ontario, Canada. Department of Mathematics, Universitat Autònoma de Barcelona, Bellaterra (Barcelona), Spain. .
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2: Title: Accumulation of free oligosaccharides and tissue damage in cytosolic α-mannosidase (Man2c1)-deficient mice.
Authors: Paciotti, Silvia, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 289 (14): 9611-22, 2014 .
Snippet: It has been demonstrated that the inhibition of MAN2C1 expression induces accumulation of Man(8-9)GlcNAc oligosaccharides and apoptosis in vitro.
Affiliation: From the Dipartimento di Scienze Farmaceutiche, University of Perugia, Perugia 06126, Italy. .
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3: Title: Dual functions for cytosolic α-mannosidase (Man2C1): its down-regulation causes mitochondria-dependent apoptosis independently of its α-mannosidase activity.
Authors: Wang, Li, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 288 (17): 11887-96, 2013 .
Snippet: Expression of CHOP (C/EBP homologous protein), a transcription factor critical to endoplasmic reticulum stress-induced apoptosis, was significantly up-regulated in Man2C1 knockdown cells.
Affiliation: Glycometabolome Team, Systems Glycobiology Research Group, RIKEN Max Planck Joint Research Center, RIKEN Global Research Cluster, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. .
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4: Title: α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells.
Authors: He, Lizhi, et.al. .
Journal: Nature communications (Nat Commun), Vol. 2, 2011 .
Snippet: Increases in MAN2C1 were detected only in PTEN-positive prostatic intraepithelial neoplasia and carcinomas, and showed a significant association with PC recurrence only in patients with PTEN-positive PCs.
Affiliation: Division of Nephrology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 4A6. .
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5: Title: Gene expression and methylation signatures of MAN2C1 are associated with PTSD.
Authors: Uddin, Monica, et.al. .
Journal: Disease markers (Dis Markers), Vol. 30 (2-3): 111-21, 2011 .
Snippet: These results indicate that MAN2C1 methylation levels modify cumulative traumatic burden on risk of PTSD, and suggest that both gene expression and epigenetic changes at specific loci are associated with this disorder.
Affiliation: Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, 48109, USA. uddinm@umich.edu .
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6: Title: Calystegine B3 as a specific inhibitor for cytoplasmic alpha-mannosidase, Man2C1.
Authors: Kato, Atsushi, et.al. .
Journal: Journal of biochemistry (J Biochem), Vol. 149 (4): 415-22, 2011 .
Snippet: Cytoplasmic α-mannosidase (Man2C1) has been implicated in non-lysosomal catabolism of free oligosaccharides derived from N-linked glycans accumulated in the cytosol.
Affiliation: Department of Hospital Pharmacy, University of Toyama, Toyama 930-0194, Japan. .
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7: Title: Overexpression of Man2C1 leads to protein underglycosylation and upregulation of endoplasmic reticulum-associated degradation pathway.
Authors: Bernon, Coralie, et.al. .
Journal: Glycobiology, Vol. 21 (3): 363-75, 2011 .
Snippet: The cytosolic mannosidase, Man2C1, plays an essential role in the catabolism of cytosolic free oligomannosides, which are released from the degraded proteins.
Affiliation: Unité de Glycobiologie Structurale et Fonctionnelle, UMR CNRS 8576, IFR 147, Université des Sciences et Technologies de Lille, 59655 Villeneuve d'Ascq Cedex, France. .
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8: Title: Identification of roles for peptide: N-glycanase and endo-beta-N-acetylglucosaminidase (Engase1p) during protein N-glycosylation in human HepG2 cells.
Authors: Chantret, Isabelle, et.al. .
Journal: PloS one, Vol. 5 (7): e11734, 2010 .
Snippet: After sequential trimming by cytosolic endo beta-N-acetylglucosaminidase (ENGase) and Man2c1 mannosidase, cytosolic fOS are transported into lysosomes.
Affiliation: INSERM, U773, Centre de Recherche Bichat Beaujon, Paris, France; Université Paris 7 Denis Diderot, site Bichat, Paris, France. isabelle.chantret@inserm.fr .
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9: Title: hMan2c1 transgene promotes tumor progress in mice.
Authors: Xiang, Z G, et.al. .
Journal: Transgenic research (Transgenic Res), Vol. 19 (1): 67-75, 2010 .
Snippet: Reduced antibody response to BSA was observed in transgenic mice, suggesting that specific antibody response to tumor antigens might be suppressed by hMan2c1 transgene.
Affiliation: Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing 100005, China. .
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10: Title: Inhibition of alpha-mannosidase Man2c1 gene expression suppresses growth of esophageal carcinoma cells through mitotic arrest and apoptosis.
Authors: Tian, Yun, et.al. .
Journal: Cancer science (Cancer Sci), Vol. 99 (12): 2428-34, 2008 .
Snippet: To study the effects of suppressed alpha-mannosidase Man2c1 gene expression on EC9706 human esophageal carcinoma cells, the cells were treated with short interfering RNA.
Affiliation: Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing 100005, China. .
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11: Title: [Effects of human alpha-mannosidase Man2c1 transgene on growth and metastasis of transplanted tumor in mice].
Authors: Jiang, Dong-dong, et.al. .
Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae (Zhongguo Yi Xue Ke Xue Yuan Xue Bao), Vol. 29 (4): 528-32, 2007 .
Snippet: OBJECTIVE: To study the effect of human alpha-mannosidase Man2c1 transgene on tumor growth and metastasis in mice.
Affiliation: Department of Immunology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China. .
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12: Title: Inhibition of malignant activities of nasopharyngeal carcinoma cells with high expression of CD44 by siRNA.
Authors: Shi, Y, et.al. .
Journal: Oncology reports (Oncol Rep), Vol. 18 (2): 397-403, 2007 .
Snippet: Since CD44 was found to be significantly inhibited in the human nasopharyngeal carcinoma cell line CNE-2L2 with profound reduction of malignant activities caused by inhibition of alpha-mannosidase Man2c1 gene expression and CD44 has been observed to be involved in many tumor-supporting functions, we studied the association of CD44 expression with the malignant activities of CNE-2L2 cells.
Affiliation: Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, PR China. .
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13: Title: A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot.
Authors: McDaniel, Amanda H, et.al. .
Journal: Mammalian genome : official journal of the International Mammalian Genome Society (Mamm Genome), Vol. 17 (11): 1078-92, 2006 .
Snippet: Because the causal gene is unknown, we identified and evaluated several candidates within the confidence interval with functional significance to the body fatness phenotype (Il18, Acat1, Cyp19a1, Crabp1, Man2c1, Neil1, Mpi1, Csk, Lsm16, Adpgk, Bbs4, Hexa, Thsd4, Dpp8, Anxa2, and Lipc).
Affiliation: Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA. .
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14: Title: Cloning and expression of mouse cytosolic alpha-mannosidase (Man2c1).
Authors: Costanzi, Egidia, et.al. .
Journal: Biochimica et biophysica acta (Biochim Biophys Acta), Vol. 1760 (10): 1580-6, 2006 .
Snippet: It is known that the neutral/cytosolic alpha-mannosidase (Man2c1) which can cleave alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues, is stimulated by cobalt and is inhibited by furanose analogues swainsonine (SW) and 1,4-dideoxy-1,4-imino-d-mannitol (DIM).
Affiliation: Dipartimento di Medicina Interna, Università degli Studi di Perugia, Via del Giochetto, 06126 Perugia, Italy. .
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15: Title: Man2C1, an alpha-mannosidase, is involved in the trimming of free oligosaccharides in the cytosol.
Authors: Suzuki, Tadashi, et.al. .
Journal: The Biochemical journal (Biochem J), Vol. 400 (1): 33-41, 2006 .
Snippet: The down-regulation of Man2C1 activity by a small interfering RNA drastically changed the amount and structure of oligosaccharides accumulating in the cytosol, demonstrating that Man2C1 indeed is involved in free oligosaccharide processing in the cytosol.
Affiliation: Department of Biochemistry, Osaka University Graduate School of Medicine, Osaka, 565-0871, Japan. tsuzuki@biochem.med.osaka-u.ac.jp .
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16: Title: Fine mapping of the keratoconus with cataract locus on chromosome 15q and candidate gene analysis.
Authors: Dash, Durga Prasad, et.al. .
Journal: Molecular vision (Mol Vis), Vol. 12, 2006 .
Snippet: Positional candidate genes (MORF4L1, KIAA1055, ETFA, AWP1, REC14, KIAA1199, RCN2, FAH, IDH3A, MTHFS, ADAMTS7, MAN2C1, PTPN9, KIAA1024, ARNT2, BCL2A1, ISL2, C15ORF22 (P24B), DNAJA4, FLJ14594, CIB2 (KIP2), C15ORF5, and PSMA4) prioritized on the basis of ocular expression and probable function were screened by PCR-based DNA sequencing methods.
Affiliation: Department of Medical Genetics, Queen's University of Belfast, Royal Victoria Hospital, Belfast, United Kingdom. d.dash@queens-belfast.ac.uk .
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17: Title: Inhibition of the alpha-mannosidase Man2c1 gene expression enhances adhesion of Jurkat cells.
Authors: Qu, Li, et.al. .
Journal: Cell research (Cell Res), Vol. 16 (7): 622-31, 2006 .
Snippet: This paper reports that inhibition of alpha-mannosidase Man2c1 gene expression enhances adhesion of Jurkat T cells.
Affiliation: Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China. .
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