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79 documents found
1: Title: miR-1207-5p regulates the sensitivity of triple-negative breast cancer cells to Taxol treatment via the suppression of LZTS1 expression.
Authors: Hou, Xiaoke, et.al. .
Journal: Oncology letters (Oncol Lett), Vol. 17 (1): 990-998, 2019 .
Snippet: Leucine zipper tumor suppressor gene 1 (LZTS1), which was predicted by TargetScan 6.2 and was supported by the results of a dual luciferase assay, was identified as a target of miR-1207-5p.
Affiliation: Department of Breast Surgery, Yuncheng Central Hospital, Yuncheng, Shanxi 044000, P.R. China. The First Department of Oncology, Linfen Central Hospital, Linfen, Shanxi 041000, P.R. China. Department of Oncology, Linfen People's Hospital, Linfen, Shanxi 041000, P.R. China. .
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2: Title: MiR-214 promotes cell meastasis and inhibites apoptosis of esophageal squamous cell carcinoma via PI3K/AKT/mTOR signaling pathway.
Authors: Guanen, Qiao, et.al. .
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother), Vol. 105, 2018 .
Snippet: In summary, these results suggest that miR-214 serves as tumor promoter to promote proliferation, migration, invasion and inhibit apoptosis of ESCC cells by targeting LZTS1 via PI3K/AKT/mTOR signaling pathway.
Affiliation: Department of Gastroenterology, Handan City First Hospital, Handan, Hebei, 056002, China. Electronic address: qiaoge_yy@sina.com. Department of Thoracic Surgery, Handan City First Hospital, Handan, Hebei, 056002, China. Department of Medical imaging, Handan City First Hospital, Handan, Hebei, 056002, China. Department of infectious disease, Handan City First Hospital, Handan, Hebei, 056002, China. Department of Gastroenterology, Handan City First Hospital, Handan, Hebei, 056002, China. Department of Gynaecology, Handan City First Hospital, Handan, Hebei, 056002, China. Department of Medicine, Handan City First Hospital, Handan, Hebei, 056002, China. .
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3: Title: RNA-seq Reveals Transcriptomic Differences in Inflamed and Noninflamed Intestinal Mucosa of Crohn's Disease Patients Compared with Normal Mucosa of Healthy Controls.
Authors: Hong, Sung Noh, et.al. .
Journal: Inflammatory bowel diseases (Inflamm Bowel Dis), Vol. 23 (7): 1098-1108, 2017 .
Snippet: Among 950 differentially expressed genes, 19 were up- or downregulated (upregulation: ANGPT2, CHN1, CPXM1, CPZ, CXCL1, FCN3, GJC1, HSD11B1, LZTS1, MEOX1, MMP12, PLA1A, SERPINE1, SGIP1, and TRPC4; downregulation: FAM189A1, PDE6A, SLC38A4, and HMGCS2) with statistical significance (p < 0.01 and q < 0.05).
Affiliation: *Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea;†Laboratory of Translational Genomics, Samsung Genome Institute, Samsung Medical Center, Seoul, Korea;‡Department of Internal Medicine, Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea;§Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea;‖Department of Internal Medicine, Yonsei University School of Medicine, Seoul, Korea;¶Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; and**Department of Internal Medicine, Inje University College of Medicine, Seoul, Korea. .
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4: Title: Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking.
Authors: Butkevich, Eugenia, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 6, 2016 .
Snippet: Here, we show that cargoes transported by the Kinesin-1 adapter FEZ1 are enriched for presynaptic components and identify that specific phosphorylation of FEZ1 at its serine 58 regulatory site is mediated by microtubule affinity-regulating kinases (MARK/PAR-1).
Affiliation: Third Institute of Physics-Biophysics, Georg August University Göttingen, 37077, Göttingen, Germany. Paul Flechsig Institute for Brain Research, University of Leipzig, 04103, Leipzig, Germany. Bioanalytical Mass Spectrometry, Max Planck Institute for Biophysical Chemistry, 37077, Göttingen, Germany. Synaptic Systems, 37079, Göttingen, Germany. Effigos AG, 04103, Leipzig, Germany. Bioanalytics, Department of Clinical Chemistry, University Medical Center Göttingen, 37075 Göttingen, Germany. Research Group in Protein Trafficking in Synaptic Development and Function, Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore. Neurobiology/Ageing Programme, Centre for Life Sciences, National University of Singapore. .
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5: Title: Tumor suppressor genes and their underlying interactions in paclitaxel resistance in cancer therapy.
Authors: Xu, Jia-Hui, et.al. .
Journal: Cancer cell international (Unknown Journal), Vol. 16, 2016 .
Snippet: RESULTS: We identified 22 TSGs involved in PTX resistance, including BRCA1, TP53, PTEN, APC, CDKN1A, CDKN2A, HIN-1, RASSF1, YAP, ING4, PLK2, FBW7, BLU, LZTS1, REST, FADD, PDCD4, TGFBI, ING1, Bax, PinX1 and hEx.
Affiliation: Department of Geriatrics, Anhui Provincial Hospital affiliated to Anhui Medical University, 17 Lujiang Road, Hefei, 230001 China ; Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy, Hefei, 230001 China. .
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6: Title: The tumor-suppressor gene LZTS1 suppresses hepatocellular carcinoma proliferation by impairing PI3K/Akt pathway.
Authors: He, Yonghong, et.al. .
Journal: Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie (Biomed Pharmacother), Vol. 76, 2015 .
Snippet: CONCLUSION: LZTS1 could inhibit HCC cell proliferation by impairing PI3K/Akt pathway.
Affiliation: Department of Gastroenterology, Fengcheng Hospital, Shanghai, China. Electronic address: yonghonghe02@126.com. Department of Gastroenterology, Fengcheng Hospital, Shanghai, China. .
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7: Title: Ehlers-Danlos Syndrome, Hypermobility Type, Is Linked to Chromosome 8p22-8p21.1 in an Extended Belgian Family.
Authors: Syx, Delfien, et.al. .
Journal: Disease markers (Dis Markers), Vol. 2015, 2015 .
Snippet: Subsequent whole exome sequencing revealed the presence of a unique missense variant in the LZTS1 gene, located within the candidate region.
Affiliation: Center for Medical Genetics, Ghent University Hospital, 9000 Ghent, Belgium. .
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8: Title: PSD-Zip70 Deficiency Causes Prefrontal Hypofunction Associated with Glutamatergic Synapse Maturation Defects by Dysregulation of Rap2 Activity.
Authors: Mayanagi, Taira, et.al. .
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci), Vol. 35 (42): 14327-40, 2015 .
Snippet: PSD-Zip70 (Lzts1/FEZ1) is a postsynaptic density (PSD) protein predominantly expressed in the frontal cortex, olfactory bulb, striatum, and hippocampus.
Affiliation: Department of Neuroscience, Institute of Biomedical Sciences, School of Medicine, Iwate Medical University, 2-1-1 Yahaba, Shiwa 028-3694, Japan, and. Education and Research Support Center, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi 371-8511, Japan. Department of Neuroscience, Institute of Biomedical Sciences, School of Medicine, Iwate Medical University, 2-1-1 Yahaba, Shiwa 028-3694, Japan, and ksobue@iwate-med.ac.jp. .
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9: Title: [miR-135b promotes the invasion and metastasis of hepatocellular carcinoma cells].
Authors: Zhang, Yanbing, et.al. .
Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi), Vol. 31 (10): 1316-21, 2015 .
Snippet: Western blotting and dual-luciferase report system analysis showed that multiple key components in the Hippo pathway, including large tumor suppressor homolog 2 (LATS2), beta-transducin repeats-containing proteins (β-TrCP), N-myc downstream-regulated gene 2 (NDR2) as well as leucine zipper tumor suppressor gene 1 (LZTS1) were targeted by miR-135b.
Affiliation: Department of Oncology, Tumor Hospital of Shaanxi Province, Medical College, Xi'an Jiaotong University, Xi'an 710061, China. First Affiliated Hospital, Medical College, Xi'an Jiaotong University, Xi'an 710061, China. .
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10: Title: MicroRNA-135b Regulates Leucine Zipper Tumor Suppressor 1 in Cutaneous Squamous Cell Carcinoma.
Authors: Olasz, Edit B, et.al. .
Journal: PloS one, Vol. 10 (5): e0125412, 2015 .
Snippet: In contrast, miR-135b overexpression by synthetic miR-135b mimic induced further down-regulation of LZTS1 mRNA in vitro and increased cancer cell motility and invasiveness.
Affiliation: Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America. Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America. Centre for Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom. Division of Cancer Research, Medical Research Institute, Ninewells Hospital & Medical School, University of Dundee, Dundee, United Kingdom. .
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11: Title: Effects of 5'-azacytidine and alendronate on a hepatocellular carcinoma cell line: a proteomics perspective.
Authors: Ilyas, Amber, et.al. .
Journal: Molecular and cellular biochemistry (Mol Cell Biochem), Vol. 405 (1-2): 53-61, 2015 .
Snippet: Up-regulation of CASP7(Caspase7) and LZTS1 (leucine zipper, putative tumor suppressor 1) and down-regulation of DNMT1(DNA (cytosine-5-)-methyltransferase 1) was noted in treated cells.
Affiliation: National Center for Proteomics, University of Karachi, Karachi, 75270, Pakistan. .
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12: Title: Loss of Leucine Zipper Putative Tumor Suppressor 1 (LZTS1) Expression Contributes to Lymph Node Metastasis of Breast Invasive Micropapillary Carcinoma.
Authors: Wang, Xin-Xin, et.al. .
Journal: Pathology oncology research : POR (Pathol Oncol Res), Vol. 21 (4): 1021-6, 2015 .
Snippet: These data demonstrated that the loss of LZTS1 expression was associated with lymph node metastasis in patients with IMPC, and LZTS1 promoter methylation could be responsible for the loss of LZTS1 expression.
Affiliation: Department of Pathology, Beijing Youan Hospital of Capital Medical University, Beijing, 100069, China. .
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13: Title: The tumor-suppressor gene LZTS1 suppresses colorectal cancer proliferation through inhibition of the AKT-mTOR signaling pathway.
Authors: Zhou, Wei, et.al. .
Journal: Cancer letters (Cancer Lett), Vol. 360 (1): 68-75, 2015 .
Snippet: The Leucine zipper tumor suppressor gene 1 (LZTS1/FEZ1) gene was originally identified as a potential tumor suppressor.
Affiliation: Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, Guangdong, China. Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, Guangdong, China. Electronic address: liaowt2002@gmail.com. Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address: liuside@163.com. .
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14: Title: Genome-wide functional analysis reveals factors needed at the transition steps of induced reprogramming.
Authors: Yang, Chao-Shun, et.al. .
Journal: Cell reports (Cell Rep), Vol. 8 (2): 327-37, 2014 .
Snippet: Among these non-differentially expressed genes, Dmbx1, Hnf4g, Nobox, and Asb4 are important, whereas Nfe2, Cdkn2aip, Msx3, Dbx1, Lzts1, Gtf2i, and Ankrd22 are roadblocks to reprogramming.
Affiliation: Program for RNA Biology, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA; Department of Pediatrics, University of California San Diego School of Medicine, 9500 Gilman Drive, Mail Code 0762, La Jolla, CA 92093, USA. Program for RNA Biology, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Pediatrics, University of California San Diego School of Medicine, 9500 Gilman Drive, Mail Code 0762, La Jolla, CA 92093, USA. Program for RNA Biology, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA; Department of Pediatrics, University of California San Diego School of Medicine, 9500 Gilman Drive, Mail Code 0762, La Jolla, CA 92093, USA. Electronic address: trana@ucsd.edu. .
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15: Title: miR-214 promotes the proliferation and invasion of osteosarcoma cells through direct suppression of LZTS1.
Authors: Xu, Zhengyu, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 449 (2): 190-5, 2014 .
Snippet: Bioinformatics analysis further revealed leucine zipper, putative tumor suppressor 1 (LZTS1) as a potential target of miR-214.
Affiliation: Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. Electronic address: wangtaohappy2010@sohu.com. .
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16: Title: Dendrite development regulated by the schizophrenia-associated gene FEZ1 involves the ubiquitin proteasome system.
Authors: Watanabe, Yasuhito, et.al. .
Journal: Cell reports (Cell Rep), Vol. 7 (2): 552-64, 2014 .
Snippet: We demonstrate that the ubiquitin ligase cell division cycle 20/anaphase-promoting complex (Cdc20/APC) controls dendrite growth by regulating the degradation of FEZ1.
Affiliation: Department of Clinical Neurobiology at the German Cancer Research Center (DKFZ) and the Medical Faculty of Heidelberg University, Heidelberg 69120, Germany. Department of Clinical Neurobiology at the German Cancer Research Center (DKFZ) and the Medical Faculty of Heidelberg University, Heidelberg 69120, Germany. Electronic address: h.monyer@dkfz-heidelberg.de. .
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17: Title: Phase II trial of neoadjuvant weekly nanoparticle albumin-bound paclitaxel, carboplatin, and biweekly bevacizumab therapy in women with clinical stage II or III HER2-negative breast cancer.
Authors: Mrózek, Ewa, et.al. .
Journal: Clinical breast cancer (Clin Breast Cancer), Vol. 14 (4): 228-34, 2014 .
Snippet: BACKGROUND: We hypothesized that adding bevacizumab to neoadjuvant chemotherapy (NCT) with nab-P and carboplatin would increase the rates of pCR in BC patients and that early changes in tumor vascularity imaged by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) would predict pCR.
Affiliation: Division of Medical Oncology, The Ohio State University Medical Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH. Electronic address: ewa.mrozek@osumc.edu. Division of Medical Oncology, The Ohio State University Medical Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH. Department of Molecular Virology, Immunology, and Medical Genetics, College of Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, OH. Division of Imaging Science, Department of Radiology, The Ohio State University, Columbus, OH. .
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18: Title: Targeting CDC25C, PLK1 and CHEK1 to overcome Docetaxel resistance induced by loss of LZTS1 in prostate cancer.
Authors: Nakouzi, Nader Al, et.al. .
Journal: Oncotarget, Vol. 5 (3): 667-78, 2014 .
Snippet: Our findings identify an important role of LZTS1 through its regulation of CDC25C in Docetaxel resistance in prostate cancer and suggest that CDC25C, or the mitotic kinases CHEK1 and PLK1, could be efficient therapeutic targets to overcome Docetaxel resistance.
Affiliation: Prostate Cancer Group, INSERM U981, Gustave Roussy, Villejuif, F-94805, France. .
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19: Title: Cytosine 5-Hydroxymethylation of the LZTS1 Gene Is Reduced in Breast Cancer.
Authors: Wielscher, Matthias, et.al. .
Journal: Translational oncology (Transl Oncol), Vol. 6 (6): 715-21, 2013 .
Snippet: A decrease of 5hmC levels of LZTS1, a classic tumor suppressor gene known to influence metastasis in breast cancer progression, is correlated to down-regulation of LZTS1 mRNA expression in breast cancer and might epigenetically enhance carcinogenesis.
Affiliation: Molecular Diagnostics Unit, Health and Environment Department, Austrian Institute of Technology, Vienna, Austria. Department of Obstetrics and Gynecology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. Department of Surgery, University Hospital Vienna, Vienna, Austria. Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria. .
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20: Title: LZTS1 downregulation confers paclitaxel resistance and is associated with worse prognosis in breast cancer.
Authors: Lovat, Francesca, et.al. .
Journal: Oncotarget, Vol. 5 (4): 970-7, 2014 .
Snippet: The Leucine Zipper Tumor Suppressor 1 (LZTS1) is a tumor suppressor gene, located at chromosome 8p22, which is frequently altered in human cancer.
Affiliation: Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, Columbus, Ohio, USA. .
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