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33 documents found
1: Title: Transcriptomic effects of metformin in skeletal muscle arteries of obese insulin-resistant rats.
Authors: Padilla, Jaume, et.al. .
Journal: Experimental biology and medicine (Maywood, N.J.) (Exp Biol Med (maywood)), Vol. 242 (6): 617-624, 2017 .
Snippet: We also found that two genes were differentially expressed in aortic endothelial cells (LETMD1 and HMGCS2, both downregulated), one gene in the gastrocnemius feed artery (BLNK, downregulated), and no genes in the soleus and diaphragm feed arteries and white gastrocnemius 2a arterioles.
Affiliation: 1 Nutrition and Exercise Physiology, University of Missouri, Columbia, MO 65211, USA. 2 Child Health, University of Missouri, Columbia, MO 65211, USA. 3 Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, USA. 4 Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA. 5 Department of Cell Biology and Physiology, Edward Via College of Osteopathic Medicine, Auburn, AL 36832, USA. 6 School of Kinesiology, Auburn University, Auburn, AL 36849, USA. 7 Research Service-Harry S Truman Memorial VA Medical Center, Columbia, MO 65211, USA. 8 Medicine-Division of Gastroenterology and Hepatology, University of Missouri, Columbia, MO 65211, USA. 9 MU Informatics Institute, University of Missouri, Columbia, MO 65211, USA. 10 Health Management and Informatics, University of Missouri, Columbia, MO 65211, USA. 11 Statistics, University of Missouri, Columbia, MO 65211, USA. 12 Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA. 13 Kinesiology, University of Georgia, Athens, GA 30602, USA. .
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2: Title: Targeting HCCR expression resensitizes gastric cancer cells to chemotherapy via down-regulating the activation of STAT3.
Authors: Zhang, Jun-Ling, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 6, 2016 .
Snippet: Western blot and luciferase reporter assays showed that the activation of STAT3 upregulated HCCR expression in a positive feedback loop model.
Affiliation: Department of General Surgery, Peking University First Hospital, Beijing 100034, P. R. China. Department of Thoracic Surgery, Peking University First Hospital, Beijing 100034, P. R. China. Department of Hematology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, P. R. China. .
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3: Title: Calcitriol Inhibits Cervical Cancer Cell Proliferation Through Downregulation of HCCR1 Expression.
Authors: Wang, Guoqing, et.al. .
Journal: Oncology research (Oncol Res), Vol. 22 (5): 301-9, 2015 .
Snippet: The mRNA and protein expression levels of human cervical cancer oncogene (HCCR-1) and p21 were determined by RT-PCR and Western blot, respectively.
Affiliation: Department of Oncology, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi, China. .
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4: Title: Up-regulation of human cervical cancer proto-oncogene contributes to hepatitis B virus-induced malignant transformation of hepatocyte by down-regulating E-cadherin.
Authors: Li, Junfeng, et.al. .
Journal: Oncotarget, Vol. 6 (30): 29196-208, 2015 .
Snippet: We also found that overexpression of HCCR in hepatocytes promoted cell proliferation, migration, and invasion and reduced cell adhesion.
Affiliation: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China. Laboratory of Viral Immunology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, USA. Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College, Fudan University, Shanghai, China. Department of Biological Sciences, The University of Texas at El Paso, El Paso, TX, USA. .
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5: Title: The nuclear splicing factor RNA binding motif 5 promotes caspase activation in human neuronal cells, and increases after traumatic brain injury in mice.
Authors: Jackson, Travis C, et.al. .
Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (J Cereb Blood Flow Metab), Vol. 35 (4): 655-66, 2015 .
Snippet: Finally, we confirm that RBM5/10 regulate protein expression of several target genes including caspase-2, cellular FLICE-like inhibitory protein (c-FLIP), LETM1 Domain-Containing Protein 1 (LETMD1), and amyloid precursor-like protein 2 (APLP2) in neuronal cells.
Affiliation: Department of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Pharmaceutical Sciences Department, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania, USA. Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. .
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6: Title: Quantitative detection of the human cervical cancer oncogene for monitoring the minimal residual disease in acute leukemia.
Authors: Qiao, Shu-Kai, et.al. .
Journal: Experimental biology and medicine (Maywood, N.J.) (Exp Biol Med (maywood)), Vol. 240 (1): 128-34, 2015 .
Snippet: Besides white blood cell count, we did not find any significant correlation between HCCR expression and clinical characteristics, such as age, sex, CD34 antigen expression, and response to chemotherapy.
Affiliation: Department of Hematology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China saidesa@163.com. Department of Hematology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China. .
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7: Title: Silencing HCCR2 expression inhibits the proliferation of leukemia cells by inducing apoptosis and promoting cell cycle arrest.
Authors: Qiao, Shu-Kai, et.al. .
Journal: International journal of molecular medicine (Int J Mol Med), Vol. 32 (6): 1373-9, 2013 .
Snippet: Silencing HCCR2 expression significantly suppressed cell proliferation, induced G1 cell cycle arrest and promoted the apoptosis of K562 cells.
Affiliation: Department of Hematology, Peking University First Hospital, Beijing 100034, P.R. China. .
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8: Title: HCCRBP-3 induces tumorigenesis through direct interaction with HCCR-1 in human cancers.
Authors: Ha, Seon Ah, et.al. .
Journal: Molecular carcinogenesis (Mol Carcinog), Vol. 53 (1): 30-7, 2014 .
Snippet: In support of this, p21 promoter activities containing p53 responsive elements were inhibited by HCCRBP-3 in a dose-dependent manner.
Affiliation: Molecular Genetic Laboratory, College of Medicine, The Catholic University of Korea, Seoul, Korea. .
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9: Title: Clinical implication of elevated human cervical cancer oncogene-1 expression in esophageal squamous cell carcinoma.
Authors: Liu, Ying, et.al. .
Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society (J Histochem Cytochem), Vol. 60 (7): 512-20, 2012 .
Snippet: Here, the authors investigated HCCR-1 level in esophageal squamous cell carcinoma (ESCC) tissues and assessed the correlation between HCCR-1 level and prognosis of the patients with ESCC.
Affiliation: Department of Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China. .
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10: Title: Combined analysis of AFP and HCCR-1 as an useful serological marker for small hepatocellular carcinoma: a prospective cohort study.
Authors: Zhang, Guoxin, et.al. .
Journal: Disease markers (Dis Markers), Vol. 32 (4): 265-71, 2012 .
Snippet: Many cases (54%) for AFP-negative HCC were positive for HCCR-1 and vice versa.
Affiliation: Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China. .
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11: Title: [Preparation and characterization of monoclonal antibody against HCCR protein].
Authors: Liu, Bao-cai, et.al. .
Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi), Vol. 27 (10): 1094-7, 2011 .
Snippet: The results of immunofluorescence indicated that HCCR proteins mainly localized on the plasma membrane and cytoplasm of HepG2 cells.
Affiliation: Institute of Radiation Medicine Academy of Military Medical Science, Beijing, China. liubaocai221@126.com .
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12: Title: Simultaneous measurements of serum AFP, GPC-3 and HCCR for diagnosing hepatocellular carcinoma.
Authors: Qiao, Shi-Shi, et.al. .
Journal: Hepato-gastroenterology (Hepato-gastroenterol), Vol. 58 (110-111): 1718-24, 2011 Sep-Oct .
Snippet: Simultaneously detecting three markers can significantly increases the sensitivity to 80.2%, much higher than AFP alone.
Affiliation: Department of Hepatobiliary Surgery, Peking University People's Hospital, Beijing, China. .
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13: Title: Silencing of the HCCR2 gene induces apoptosis and suppresses the aggressive phenotype of hepatocellular carcinoma cells in culture.
Authors: Guo, Jun, et.al. .
Journal: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract (J Gastrointest Surg), Vol. 15 (10): 1807-13, 2011 .
Snippet: METHODS: Changes of HepG2 cells stably transfected by an HCCR-2 RNA interference vector were detected by real-time PCR, MTT staining, plate colony formation, flow cytometry, and cell migration experiments.
Affiliation: Department of Gastroenterology, The Third Military Medical University, Chongqing, China. .
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14: Title: Clinical utility of alpha fetoprotein and HCCR-1, alone or in combination, in patients with chronic hepatitis, liver cirrhosis and hepatocellular carcinoma.
Authors: Jirun, Peng, et.al. .
Journal: Disease markers (Dis Markers), Vol. 30 (6): 307-15, 2011 .
Snippet: We conducted a prospective study in 120 normal and 524 liver disease patients to evaluate the significance of simultaneous measurement of 2 tumor markers (AFP and HCCR-1) in the diagnosis of HCC through the cohort study in Korea and China.
Affiliation: Department of Surgery, Peking University People's Hospital, Beijing, P. R. China. .
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15: Title: Protein-coding and microRNA biomarkers of recurrence of prostate cancer following radical prostatectomy.
Authors: Long, Qi, et.al. .
Journal: The American journal of pathology (Am J Pathol), Vol. 179 (1): 46-54, 2011 .
Snippet: We identified a panel of 10 protein-coding genes and two miRNA genes (RAD23B, FBP1, TNFRSF1A, CCNG2, NOTCH3, ETV1, BID, SIM2, LETMD1, ANXA1, miR-519d, and miR-647) that could be used to separate patients with and without biochemical recurrence (P < 0.001), as well as for the subset of 42 Gleason score 7 patients (P < 0.001).
Affiliation: Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USA. .
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16: Title: Immortalized cells and one oncogene in malignant transformation: old insights on new explanation.
Authors: Kavsan, Vadym M, et.al. .
Journal: BMC cell biology (Bmc Cell Biol), Vol. 12, 2011 .
Snippet: However, when a cell line gains the ability to undergo continuous cell division, the cells are not normal any more, they are immortalized cells.
Affiliation: Department of Biosynthesis of Nucleic Acids, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kyiv, Ukraine. kavsan@imbg.org.ua .
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17: Title: [HCCR-2 enhances the division and proliferation of SMMC 7721 via PI3K/Akt pathway].
Authors: Yang, Yan-mei, et.al. .
Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (Zhonghua Gan Zang Bing Za Zhi), Vol. 18 (11): 837-41, 2010 .
Snippet: CONCLUSIONS: EGF upregulated HCCR-2 protein expression in SMMC 7721 cell line via PI3K/Akt pathway.
Affiliation: Department of Gastroenterology, the Second Affiliated Hospital of Nantong University, Nantong 226001, China. .
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18: Title: Transdifferentiation-inducing HCCR-1 oncogene.
Authors: Ha, Seon-Ah, et.al. .
Journal: BMC cell biology (Bmc Cell Biol), Vol. 11, 2010 .
Snippet: The stem cell factor receptor CD117/c-Kit was induced in this transdifferentiated (EMT) sarcoma tissues.
Affiliation: Molecular Genetic Laboratory, Catholic Medical Research Institute, The Catholic University of Korea, Seoul, Korea. .
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19: Title: Epidermal growth factor induces HCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pancreatic cancer cells.
Authors: Xu, Zekuan, et.al. .
Journal: BMC cancer, Vol. 10, 2010 .
Snippet: The specific inhibitor of PI3K and mTOR was used to see if PI3K/mTOR signal transduction was involved in the induction of HCCR gene expression.
Affiliation: Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. .
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20: Title: Novel components of an active mitochondrial K(+)/H(+) exchange.
Authors: Zotova, Ludmila, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 285 (19): 14399-414, 2010 .
Snippet: A LETM1 human homologue, HCCR-1/LETMD1, described as an oncogene, partially suppresses the yeast triple mutant phenotype.
Affiliation: Department of Microbiology, Max F. Perutz Laboratories, Vienna University, A-1030 Vienna, Austria. .
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