refine search
Authors
Locations
Journals
Publication Dates
Find concepts in Knowledge Base
Explore current query
documentsstatisticstop authorclipboard
11 documents found
1: Title: Founder Mutations for Early Onset Melanoma as Revealed by Whole Exome Sequencing Suggests That This is Not Associated with the Increasing Incidence of Melanoma in Poland.
Authors: Dębniak, Tadeusz, et.al. .
Journal: Cancer research and treatment : official journal of Korean Cancer Association (Cancer Res Treat), 2018 .
Snippet: Purpose: Germline mutations within melanoma susceptibility genes are present only in minority of melanoma patients and it is expected that additional genes will be discovered with next generation sequence technology and whole-exome sequencing.
Affiliation: Department of Genetics and Pathomorphology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, Szczecin, Poland. School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle and the Hunter Medical Research Institute, Newcastle, Australia. MS Research Group, Hunter Medical Research Institute, University of Newcastle, New Lambton, Australia. West Pomeranian Oncology Center, Szczecin, Poland. Department of Skin Diseases and Venerology PUM, Siedlecka, Police, Poland. I Department of Oncological and General Surgery, Greater Poland Cancer Center, Garbary Poznań, Poland. .
Related Products: order online
2: Title: Genetic determinants of adiponectin regulation revealed by pregnancy.
Authors: Hivert, Marie-France, et.al. .
Journal: Obesity (Silver Spring, Md.) (Obesity (silver Spring)), Vol. 25 (5): 935-944, 2017 .
Snippet: RESULTS: In the combined meta-analysis, the maternal T allele of rs900400 located on chr3q25 (near LEKR1/CCNL1) was associated with lower maternal adiponectin (β ± standard error [SE] = -0.18 ± 0.03 standard deviation [SD] of adiponectin per risk allele; P = 1.5 ×10(-8) ; N = 2,004; multivariable adjusted models).
Affiliation: Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, Massachusetts, USA. Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, USA. Department of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada. Department of Preventive Medicine, Division of Biostatistics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Department of Mathematics, Université de Sherbrooke, Sherbrooke, Quebec, Canada. Department of Biochemistry, Université de Sherbrooke, Sherbrooke, Quebec, Canada. Department of Medicine, Université de Montréal, ECOGENE-21 and Lipid Clinic, Chicoutimi, Quebec, Canada. Department of Preventive Medicine, Division of Epidemiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Department of Biostatistics and Bioinformatics, Duke Institute for Genome Sciences and Policy, Durham, North Carolina, USA. Department of Internal Medicine, Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada. Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada. Department of Twin Research, King's College London, London, UK. Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. .
Related Products: order online
3: Title: Association between LEKR1-CCNL1 and IGSF21-KLHDC7A gene polymorphisms and diabetic retinopathy of type 2 diabetes mellitus in the Chinese Han population.
Authors: Lin, Xiaohui, et.al. .
Journal: The journal of gene medicine (J Gene Med), Vol. 18 (10): 282-287, 2016 .
Snippet: We found significant differences in cystatin-C concentrations with LEKR1-CCNL1 rs13064954 and NOS3 rs3918227 of different genotypes.
Affiliation: Department of Ophthalmology, The Inner Mongolia Autonomous Region People's Hospital, Hohhot, China. Xiaoh_lin@163.com. Department of Hand and Microsurgery II, the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China. Department of Ophthalmology, The Inner Mongolia Autonomous Region People's Hospital, Hohhot, China. .
Related Products: order online
4: Title: Genome-wide DNA methylation study in human placenta identifies novel loci associated with maternal smoking during pregnancy.
Authors: Morales, Eva, et.al. .
Journal: International journal of epidemiology (Int J Epidemiol), Vol. 45 (5): 1644-1655, 2016 .
Snippet: We validated and replicated differential methylation at three top-ranking loci: cg27402634 located between LINC00086 and LEKR1, a gene previously related to birthweight in genome-wide association studies; cg20340720 (WBP1L); and cg25585967 and cg12294026 (TRIO).
Affiliation: IMIB-Arrixaca Biomedical Research Institute, Virgen de la Arrixaca University Hospital, 30120 Murcia, Spain, embarto@hotmail.com. CIBER Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain. Centre for Research in Environmental Epidemiology (CREAL), 08003 Barcelona, Catalonia, Spain. Genomics and Disease Group, Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, 08003 Barcelona, Catalonia, Spain. Universitat Pompeu Fabra (UPF), 08003 Barcelona, Catalonia, Spain. Department of Epidemiology, Geisel School of Medicine at Dartmouth College, Lebanon, NH 03756, USA. EPIGET-Epidemiology, Epigenetics and Toxicology Lab-Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milano, Italy. Instituto de Investigación Biosanitaria (ibs.GRANADA), University of Granada, San Cecilio University Hospital, 18012 Granada, Spain. FISABIO-Universitat de València-Universitat Jaume I Joint Research Unit of Epidemiology and Environmental Health, 46020 Valencia, Spain. Molecular Epidemiology of Cancer Unit, University Institute of Oncology, University of Oviedo, 33003 Oviedo, Spain. Subdirección de Salud Pública y Adicciones de Gipuzkoa, 20010 Donostia/San Sebastián, Spain. Instituto de Investigación Sanitaria BIODONOSTIA, 20014 Donostia/San Sebastián, Spain and. Faculty of Pharmacy, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, Spain. .
Related Products: order online
5: Title: Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk.
Authors: Permuth, Jennifer B, et.al. .
Journal: Human molecular genetics (Hum Mol Genet), Vol. 25 (16): 3600-3612, 2016 .
Snippet: One of the most significant signals (Pall histologies = 1.01 × 10 (-)  (13);Pserous = 3.54 × 10 (-)  (14)) occurred at 3q25.31 for rs62273959, a missense variant mapping to the LEKR1 gene that is in LD (r(2 )=( )0.90) with a previously identified 'best hit' (rs7651446) mapping to an intron of TIPARP.
Affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA. Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK. Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, USA. Department of Epidemiology, Director of Genetic Epidemiology Research Institute, UCI School of Medicine, University of California Irvine, Irvine, CA, USA. Cancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA. Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver BC, Canada. Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada. Department of Obstetrics and Gynecology, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA. Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Queensland, Australia. Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA. Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts, USA. Department of Laboratory of Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland. Social and Scientific Systems, Inc, Durham, NC, USA. Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NY, USA. Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA. Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Ovarian Cancer Center of Excellence, Womens Cancer Research Program, Magee- Womens Research Institute & University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA. Department of Biostatistics, University of Kansas Medical Center, Kansas City, KS, USA. Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA. Women's Cancer, Institute for Women's Health, University College London, London, UK. Cancer Prevention and Control, Samuel Oshin Comprehensive Cancer Institute, Cedars- Sinai Medical Center, Los Angeles, CA, USA. Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark and Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark. Department of Statistical Science, Duke University, Durham, NC, USA. Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark. Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California. Department of Public Health Sciences, Medical University of South Carolina College of Medicine, Charleston, SC, USA. Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Program in Genetic Epidemiology and Statistical Genetics, Harvard TH Chan School of Public Health, Boston, MA, USA. Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada. Department of Cancer Epidemiology and Prevention, The Maria Sklodowska-Curie Memorial Cancer Center, Warsaw, Poland. Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan. Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA. Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA. Department of Gynecologic Oncology, Aichi Cancer Center Central Hospital, Nagoya, Aichi, Japan. The University of Texas School of Public Health, Houston, TX, USA. Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York,NY, USA. Department of Epidemology,University of Michigan School of Public Health, Ann Arbor, MI, USA. Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA. Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA. Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Department of Epidemiology, University of Washington, Seattle, WA, USA. Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA. Vanderbilt University School of Medicine, Nashville, TN, USA. Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK. Cancer Research Malaysia, Subang Jaya, Malaysia. University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia. Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD, USA. Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA. Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA. Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia. Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA. Department of Epidemiology, University of California Irvine, Irvine, CA, USA. Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA. Cancer Control and Population Sciences, Duke Cancer Institute, Durham, NC, USA. Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA, Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk. .
Related Products: order online
6: Title: Genetic variants in LEKR1 and GALNT10 modulate sex-difference in carotid intima-media thickness: a genome-wide interaction study.
Authors: Dong, Chuanhui, et.al. .
Journal: Atherosclerosis, Vol. 240 (2): 462-7, 2015 .
Snippet: For rs7616559 within LEKR1, men had greater cIMT than women in G allele carriers (beta ± SE: 0.044 ± 0.007, P = 4.2E-09 in AG carriers; beta ± SE: 0.064 ± 0.007, P = 6.2E-05 in GG carriers).
Affiliation: Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Systems Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy; IRCCS San Raffaele Pisana, Rome, Italy. John T. McDonald Department of Human Genetics, John P Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; John T. McDonald Department of Human Genetics, John P Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Epidemiology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Epidemiology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Electronic address: trundek@med.miami.edu. .
Related Products: order online
7: Title: The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study.
Authors: Urbanek, Margrit, et.al. .
Journal: Human molecular genetics (Hum Mol Genet), Vol. 22 (17): 3583-96, 2013 .
Snippet: Strong evidence for association was observed with measures of newborn adiposity (sum of skinfolds model 3 Z-score 7.356, P = 1.90×10⁻¹³, and to a lesser degree fat mass and birth weight) and a region on Chr3q25.31 mapping between CCNL and LEKR1.
Affiliation: Division on Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA. m-urbanek@northwestern.edu .
Related Products: order online
8: Title: The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge.
Authors: Andersson, Ehm A, et.al. .
Journal: PloS one, Vol. 6 (11): e27096, 2011 .
Snippet: BACKGROUND AND AIM: The first genome-wide association study on birth weight was recently published and the most significant associated birth weight lowering variant was the rs900400 C-allele located near LEKR1 and CCNL1.
Affiliation: Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. .
Related Products: order online
9: Title: Replication of a genome-wide association study of birth weight in preterm neonates.
Authors: Ryckman, Kelli K, et.al. .
Journal: The Journal of pediatrics (J Pediatr), Vol. 160 (1): 19-24.e4, 2012 .
Snippet: RESULTS: Each additional C allele of rs900400 (LEKR1/CCNL1) in infants was marginally associated with a 0.069 SD lower birth weight (95% CI, -0.159 to 0.022; P = .068).
Affiliation: Department of Pediatrics, University of Iowa, Iowa City, IA, USA. .
Related Products: order online
10: Title: Variants near CCNL1/LEKR1 and in ADCY5 and fetal growth characteristics in different trimesters.
Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab), Vol. 96 (5): E810-5, 2011 .
Snippet: CONTEXT: A recent genome-wide association study identified variants near CCNL1/LEKR1 (rs900400) and in ADCY5 (rs9883204) to be associated with birth weight.
Affiliation: The Generation R Study Group and Department of Epidemiology, Erasmus Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. .
Related Products: order online
11: Title: Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.
Authors: Freathy, Rachel M, et.al. .
Journal: Nature genetics (Nat Genet), Vol. 42 (5): 430-5, 2010 .
Snippet: rs900400 near LEKR1 and CCNL1 (P = 2 x 10(-35)) and rs9883204 in ADCY5 (P = 7 x 10(-15)) were robustly associated with birth weight.
Affiliation: Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK. .
Related Products: order online
Documents per page: 20 | 50 | 100