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25 documents found
1: Title: Integrated analysis reveals potential long non-coding RNA biomarkers and their potential biological functions for disease free survival in gastric cancer patients.
Authors: Cheng, Canchang, et.al. .
Journal: Cancer cell international (Cancer Cell Int), Vol. 19, 2019 .
Snippet: KDM7A-DT, AP000866.2,
Affiliation: 1Department of Internal Medicine, The Affiliated Chencun Hospital of Shunde Hospital, Southern Medical University, Shunde District, Guangdong China. 2Department of General Surgery, The Affiliated Chencun Hospital of Shunde Hospital, Southern Medical University, Shunde District, Guangdong China. .
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2: Title: Conformational Dynamics Underlies Different Functions of Human KDM7 Histone Demethylases.
Authors: Chaturvedi, Shobhit, et.al. .
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (Chemistry), 2019 .
Snippet: The human KDM7 subfamily histone H3 Nɛ-methyl lysine demethylases PHF8 (KDM7B) and KIAA1718 (KDM7A) have different substrate selectivities and are linked to genetic diseases and cancer.
Affiliation: Michigan Technological University, Chemistry, UNITED STATES. Northumbria University, Applied Sciences, Newcastle upon Tyne, UNITED KINGDOM. University of the West of England Bristol, Applied Sciences, Bristol, UNITED KINGDOM. University of Oxford, Chemistry, UNITED KINGDOM. Michigan Technological University, Chemistry, 1400 Townsend Drive, United States, 49931, Houghton, UNITED STATES. Michigan Technological University, Chemistry, 1400 Townsend Drive, 49931-1295, Houghton, UNITED STATES. .
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3: Title: Histone demethylase KDM7A reciprocally regulates adipogenic and osteogenic differentiation via regulation of C/EBPα and canonical Wnt signalling.
Authors: Yang, Xiaoyue, et.al. .
Journal: Journal of cellular and molecular medicine (J Cell Mol Med), Vol. 23 (3): 2149-2162, 2019 .
Snippet: Mechanism investigations revealed that silencing of Kdm7a down-regulated the expression of the CCAAT/enhancer binding protein α (C/EBPα) and secreted frizzled-related protein 1 (Sfrp1).
Affiliation: NHC Key Lab of Hormones and Development, Tianjin Key Lab of Metabolic Diseases, Metabolic Diseases Hospital & Institute of Endocrinology, Tianjin Medical University, Tianjin, China. Stomatological Hospital, Tianjin Medical University, Tianjin, China. College of Basic Medical Sciences, Tianjin Medical University, Tianjin, China. .
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4: Title: The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction.
Authors: Fellous, Alexandre, et.al. .
Journal: Gene, Vol. 687, 2019 .
Snippet: Twenty-five Kdm orthologues (Jarid2, Jmjd1c, Jmjd4, Jmjd6, Jmjd7, Jmjd8, Kdm1a, Kdm1b, Kdm2a, Kdm2b, Kdm3b, Kdm4a, Kdm4b, Kdm4c, Kdm5a, Kdm5b, Kdm5c, Kdm6a, Kdm6b, Kdm7a, Kdm8, Kdm9, UTY, Phf2 and Phf8) and forty-eight Kmt orthologues (Ezh1, Ezh2, Setd2, Nsd1, Nsd2, Nsd3, Ash1l, Kmt2e, Setd5, Prdm1, Prdm2, Prdm4, Prdm5, Prdm6, Prdm8, Prdm9, Prdm10, Prdm11, Prdm12, Prdm13, Prdm14, Prdm15, Prdm16, Setd3, Setd4, Setd6, Setd1a, Setd1b, Kmt2a, Kmt2b, Kmt2c, Kmt2d, Kmt5a, Kmt5b, Ehmt1, Ehmt2, Suv39h1, Setmar, Setdb1, Setdb2, Smyd1, Smyd2, Smyd3, Smyd4, Smyd5, Setd7, Setd9, Dot1l) were discovered.
Affiliation: Laboratory of Evolutionary and Adaptive Physiology, Institute of Life, Earth and Environment, University of Namur, Rue de Bruxelles 61, B-5000 Namur, Belgium; Coastal Ecology Section, Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung, Wadden Sea Station Sylt, List, Germany. Electronic address: alexandre.fellous@laposte.net. Department of Biological Sciences, University of Alabama, 300 Hackberry Lane, Box 870344, Tuscaloosa, AL 35487, USA. Laboratory of Evolutionary and Adaptive Physiology, Institute of Life, Earth and Environment, University of Namur, Rue de Bruxelles 61, B-5000 Namur, Belgium. .
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5: Title: Inhibition of RNA synthesis during Scriptaid exposure enhances gene reprogramming in SCNT embryos.
Authors: Rissi, Vitor B, et.al. .
Journal: Reproduction (Cambridge, England) (Reproduction), 2018 .
Snippet: However, treatment with Scrip+DRB inhibited early mRNA expression of those genes, as well as several other KDMs (KDM4A, KDM4B, KDM5A, KDM5B, KDM5C and KDM7A) compared to embryos treated with Scrip alone.
Affiliation: V Rissi, Laboratory of Biotechnology and Animal Reproduction, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil. W Glanzner, Department of Animal Science, McGill University, Sainte Anne de Bellevue, H9X 3V9, Canada. M de Macedo, Animal Science, McGill University Faculty of Agriculture and Environment, Sainte Anne de Bellevue, Canada. L Mujica, Laboratory of Biotechnology and Animal Reproduction, Universidade Federal de Santa Maria Centro de Ciencias Rurais, Santa Maria, Brazil. K Campagnolo, Laboratory of Biotechnology and Animal Reproduction - BioRep, Universidade Federal de Santa Maria Centro de Ciencias Rurais, Santa Maria, Brazil. K Gutierrez, Animal Science, McGill University Faculty of Agriculture and Environment, Sainte Anne de Bellevue, Canada. A Bridi, Laboratory of Biotechnology and Animal Reproduction - BioRep, Universidade Federal de Santa Maria Centro de Ciencias Rurais, Santa Maria, Brazil. H Baldassarre, Animal Science, McGill University Faculty of Agriculture and Environment, Sainte Anne de Bellevue, Canada. P Gonçalves, Laboratory of Biotechnology and Animal Reproduction, Federal University of Santa Maria, Santa Maria, 97105-900, Brazil. V Bordignon, Department of Animal Sciences, McGill University, Ste-Anne-de-Bellevue, H9X3V9, Canada. .
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6: Title: Histone demethylase KDM7A controls androgen receptor activity and tumor growth in prostate cancer.
Authors: Lee, Kyoung-Hwa, et.al. .
Journal: International journal of cancer (Int J Cancer), Vol. 143 (11): 2849-2861, 2018 .
Snippet: Here, we found the histone demethylase KDM7A which demethylates histone H3K27 to be overexpressed in enzalutamide resistant castration-resistant prostate cancer cell line C4-2b, and investigated the molecular mechanism whereby androgen receptor activity is regulated by KDM7A.
Affiliation: Department of Urology, Seoul National University Hospital, Seoul, Republic of Korea. Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Department of Urology, Seoul National University College of Medicine, Seoul, Republic of Korea. .
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7: Title: Histone 3 lysine 4, 9 and 27 demethylases expression profile in fertilized and cloned bovine and porcine embryos.
Authors: Glanzner, Werner Giehl, et.al. .
Journal: Biology of reproduction (Biol Reprod), 2018 .
Snippet: Several differences were also observed between SCNT and IVF, which includes a precocious peak in the mRNA expression of KDM1A, KDM3A, KDM4C, KDM5A, KDM5B, KDM5C, KDM6A and KDM7A in bovine SCNT embryos; absence of mRNA peak for KDM4B, KDM4C and KDM6A in porcine SCNT embryos; and early decreasing in KDM5B and KDM5C mRNA in porcine SCNT embryos.
Affiliation: Department of Animal Science, McGill University, Sainte Anne de Bellevue, QC, Canada. Laboratory of Biotechnology and Animal Reproduction - BioRep, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil. .
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8: Title: Discovery of a highly selective cell-active inhibitor of KDM2/7.
Authors: Gerken, Philip, et.al. .
Journal: Angewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl), 2017 .
Snippet: Histone lysine demethylases (KDMs) are of critical importance in the epigenetic regulation of gene expression, yet there are few selective, cell-permeable inhibitors or suitable tool compounds for these enzymes.
Affiliation: University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, OX1 3TA, Oxford, UNITED KINGDOM. .
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9: Title: KDM7A histone demethylase mediates TNF-α-induced ICAM1 protein upregulation by modulating lysosomal activity.
Authors: Choi, Ji-Young, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 478 (3): 1355-62, 2016 .
Snippet: Thus, KDM7A-mediated ICAM1 protein upregulation is likely related to protein stability, not a histone-mediated epigenetic mechanism.
Affiliation: Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, 31116, South Korea. Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, 31116, South Korea; Department of Pharmacology, College of Pharmacy, Dankook University, Cheonan, 31116, South Korea. Electronic address: smahn@dankook.ac.kr. .
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10: Title: Methyltransferase and demethylase profiling studies during brown adipocyte differentiation.
Authors: Son, Min Jeong, et.al. .
Journal: BMB reports (Bmb Rep), Vol. 49 (7): 388-93, 2016 .
Snippet: These results suggest that SUV420H2, a methyltransferase, is involved in brown adipocyte differentiation, and that the methylation of protein lysine is important in brown adipocyte differentiation.
Affiliation: Metabolic Regulation Research Center, KRIBB, Daejeon 34141, Korea. Metabolic Regulation Research Center, KRIBB; Department of Functional Genomics, University of Science and Technology (UST), Daejeon 34141, Korea. .
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11: Title: G9a orchestrates PCL3 and KDM7A to promote histone H3K27 methylation.
Authors: Pan, Mei-Ren, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 5, 2015 .
Snippet: G9a promotes H3K27 methylation of the E-cadherin promoter by upregulating PCL3 to increase PRC2 promoter recruitment and by downregulating the H3K27 demethylase KDM7A to silence E-cadherin gene.
Affiliation: Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 804, Taiwan. National Institute of Cancer Research, National Health Research Institutes, Tainan 704, Taiwan. Division of Hematology/Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan. Institute of Basic Medicine, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan. .
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12: Title: Histone Modifier Genes Alter Conotruncal Heart Phenotypes in 22q11.2 Deletion Syndrome.
Authors: Guo, Tingwei, et.al. .
Journal: American journal of human genetics (Am J Hum Genet), Vol. 97 (6): 869-77, 2015 .
Snippet: Eighteen case subjects (20%) had rdSNVs in four genes (JMJD1C, RREB1, MINA, KDM7A) all involved in demethylation of histones (H3K9, H3K27).
Affiliation: Department of Genetics, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA. Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA. Division of Human Genetics, The Children's Hospital of Philadelphia, and Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Psychiatry and Behavioral Sciences, and Program in Neuroscience, SUNY Upstate Medical University, Syracuse, NY 13210, USA. Department of Genetics, Polish Mother's Memorial Hospital - Research Institute, Łódź 93-338, Poland. Marcus Autism Center, Children's Healthcare of Atlanta, Atlanta, GA 30329, USA. Department of Genetics, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA. Electronic address: bernice.morrow@einstein.yu.edu. .
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13: Title: MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators.
Authors: Nilsson, Emeli M, et.al. .
Journal: Oncotarget, Vol. 6 (34): 35710-25, 2015 .
Snippet: In this study we show that the microRNA hsa-miR-137 (miR137) tumor suppressor regulates expression of an extended network of transcriptional coregulators including KDM1A/LSD1/AOF1, KDM2A/JHDM1A/FBXL11, KDM4A/JMJD2A, KDM5B JARID1B/PLU1, KDM7A/JHDM1D/PHF8, MED1/TRAP220/DRIP205 and NCoA2/SRC2/TIF2.
Affiliation: Faculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, University of Nottingham, Nottingham, United Kingdom. Department of Pharmacology, Weill Cornell Medical College, New York, NY, USA. School of Pharmacy, University of Nottingham, Nottingham, United Kingdom. Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark. Clinical Research Center, Lund University, Malmö, Sweden. .
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14: Title: JHDM1D and HDAC1-3 mRNA expression levels in peripheral blood mononuclear cells of patients with systemic lupus erythematosus.
Authors: Nawrocki, M J, et.al. .
Journal: Zeitschrift für Rheumatologie (Z Rheumatol), Vol. 74 (10): 902-10, 2015 .
Snippet: OBJECTIVE: We studied the histone demethylase JHDM1D and histone deacetylases HDAC1, HDAC2, and HDAC3 transcript levels in peripheral blood mononuclear cells (PBMCs) from patients diagnosed with systemic lupus erythematosus (SLE).
Affiliation: Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, 6 Święcickiego St, 60-781, Poznań, Poland. mjnawrocki@ump.edu.pl. Department of Molecular and Systems Biology, Institute of Bioorganic Chemistry Polish Academy of Sciences, Poznań, Poland. Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, 6 Święcickiego St, 60-781, Poznań, Poland. Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Street, 02-106, Warsaw, Poland. Institute of Rheumatology, Warsaw, Poland. .
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15: Title: Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.
Authors: Suzuki, Takayoshi, et.al. .
Journal: Journal of medicinal chemistry (J Med Chem), Vol. 56 (18): 7222-31, 2013 .
Snippet: Enzyme assays revealed that compound 9 potently inhibits KDM2A, KDM7A, and KDM7B, with IC50s of 6.8, 0.2, and 1.2 μM, respectively.
Affiliation: Graduate School of Medical Science, Kyoto Prefectural University of Medicine , 13 Taishogun Nishitakatsukasa-Cho, Kita-ku, Kyoto 603-8334, Japan. .
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16: Title: OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels.
Authors: Bunt, Jens, et.al. .
Journal: Acta neuropathologica (Acta Neuropathol), Vol. 125 (3): 385-94, 2013 .
Snippet: These tumors show high expression of the homeobox transcription factor OTX2. Silencing of OTX2 in D425 medulloblastoma cells resulted in downregulation of polycomb genes such as EZH2, EED, SUZ12 and RBBP4 and upregulation of H3K27 demethylases KDM6A, KDM6B, JARID2 and KDM7A.
Affiliation: Department of Oncogenomics, Academic Medical Center, Amsterdam, The Netherlands. .
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17: Title: The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.
Authors: Chen, Shuzhen, et.al. .
Journal: Genes & development (Genes Dev), Vol. 26 (12): 1364-75, 2012 .
Snippet: We found that JMJD3 and KIAA1718 collaborate to demethylate trimethylated H3K27 (H3K27me3) on a subset of their target genes, some of which are bivalently marked by H3K4me3 and H3K27me3 and associated with promoter-proximal, paused RNA polymerase II (Pol II) before activation.
Affiliation: Division of Newborn Medicine and Program in Epigenetics, Department of Medicine, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. .
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18: Title: Increased expression of histone demethylase JHDM1D under nutrient starvation suppresses tumor growth via down-regulating angiogenesis.
Authors: Osawa, Tsuyoshi, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), Vol. 108 (51): 20725-9, 2011 .
Snippet: Histone demethylase JHDM1D (also known as KDM7A) modifies the level of methylation in histone and participates in epigenetic gene regulation; however, the role of JHDM1D in tumor progression is unknown.
Affiliation: Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1-5-45 Bunkyo-ku, Yushima, Tokyo 113-8519, Japan. .
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19: Title: Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.
Authors: Xu, Wei, et.al. .
Journal: Cancer cell, Vol. 19 (1): 17-30, 2011 .
Snippet: Hence, tumor-derived IDH1 and IDH2 mutations reduce α-KG and accumulate an α-KG antagonist, 2-HG, leading to genome-wide histone and DNA methylation alterations.
Affiliation: State Key Laboratory of Genetic Engineering, School of Life Sciences, Shanghai Medical School, Fudan University, Shanghai 20032, China. .
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20: Title: The dual histone demethylase KDM7A promotes neural induction in early chick embryos.
Authors: Huang, Chengyang, et.al. .
Journal: Developmental dynamics : an official publication of the American Association of Anatomists (Dev Dyn), Vol. 239 (12): 3350-7, 2010 .
Snippet: Here, we show that an evolutionarily conserved dual histone demethylase KDM7A (KIAA1718) is predominantly expressed in epiblast cells of the primitive streak in early chick embryos.
Affiliation: Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China. .
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