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12 documents found
1: Title: Identification of potential biomarkers related to glioma survival by gene expression profile analysis.
Authors: Hsu, Justin Bo-Kai, et.al. .
Journal: BMC medical genomics (Bmc Med Genomics), Vol. 11 (Suppl 7): 34, 2019 .
Snippet: Moreover, the expressions of ten (CTSZ, EFEMP2, ITGA5, KDELR2, MDK, MICALL2, MAP 2 K3, PLAUR, SERPINE1, and SOCS3) of these genes were significantly higher in GBM than in LGG, and comparing their expression levels to those of the proposed control genes (TBP, IPO8, and SDHA) could have the potential capability to classify patients into high- and low- risk groups, which differ significantly in the overall survival.
Affiliation: Department of Medical Research, Taipei Medical University Hospital, Taipei, 110, Taiwan. Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei, 110, Taiwan. Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, 518172, China. School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, 518172, China. School of Life and Health Science, The Chinese University of Hong Kong, Shenzhen, 518172, China. Research Center of Translational Imaging, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. sandy0932@gmail.com. Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. sandy0932@gmail.com. Department of Medical Imaging and Imaging Research Center, Taipei Medical University Hospital, Taipei Medical University, Taipei, 110, Taiwan. sandy0932@gmail.com. Department of Radiology, Tri-Service General Hospital, Taipei, 114, Taiwan. sandy0932@gmail.com. Department of Radiology, National Defense Medical Center, Taipei, 114, Taiwan. sandy0932@gmail.com. .
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2: Title: A novel MAF missense mutation leads to congenital nuclear cataract by impacting the transactivation of crystallin and noncrystallin genes.
Authors: Si, Nuo, et.al. .
Journal: Gene, Vol. 692, 2019 .
Snippet: Dual luciferase activity assay shows the mutation significantly impair the transcriptional activity of four crystallin genes (CRYAA, CRYBA4, CRYBA1, and CRYGA) and two non-crystallin genes (HMOX1 and KDELR2).
Affiliation: McKusick-Zhang Center for Genetic Medicine, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China. Department of Ophthalmology, Shengjing Hospital, China Medical University, Shenyang, China. Department of Ophthalmology, Shengjing Hospital, China Medical University, Shenyang, China. Electronic address: xiaow@sj-hospital.org. McKusick-Zhang Center for Genetic Medicine, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China. Electronic address: xuezhang@pumc.edu.cn. .
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3: Title: KDELR2 Competes with Measles Virus Envelope Proteins for Cellular Chaperones Reducing Their Chaperone-Mediated Cell Surface Transport.
Authors: Tiwarekar, Vishakha, et.al. .
Journal: Viruses, Vol. 11 (1), 2019 .
Snippet: Our data indicate that KDELR2 competes with MV envelope proteins for binding to calnexin and GRP78/Bip, and that this interaction limits the availability of the chaperones for MV proteins, causing the reduction of virus spread and titers.
Affiliation: Institute for Virology and Immunobiology, University of Würzburg, 97078 Würzburg, Germany. Vishu7yende@gmail.com. Institute for Virology and Immunobiology, University of Würzburg, 97078 Würzburg, Germany. m.fehrholz@monasteriumlab.com. Institute for Virology and Immunobiology, University of Würzburg, 97078 Würzburg, Germany. jss@vim.uni-wuerzburg.de. .
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4: Title: KDEL Receptors Are Differentially Regulated to Maintain the ER Proteome under Calcium Deficiency.
Authors: Trychta, Kathleen A, et.al. .
Journal: Cell reports (Cell Rep), Vol. 25 (7): 1829-1840.e6, 2018 .
Snippet: In addition, we provide evidence that KDELR2 and KDELR3, but not KDELR1, are unfolded protein response (UPR) genes upregulated as an adaptive response to counteract the loss of ERS-containing proteins, suggesting previously unknown isoform-specific functions of the KDEL receptors.
Affiliation: Molecular Mechanisms of Cellular Stress and Inflammation, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA. Molecular Mechanisms of Cellular Stress and Inflammation, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA. Electronic address: bharvey@intra.nida.nih.gov. .
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5: Title: Protein interactions of FAM134B with EB1 and APC/beta-catenin in vitro in colon carcinoma.
Authors: Islam, Farhadul, et.al. .
Journal: Molecular carcinogenesis (Mol Carcinog), 2018 .
Snippet: We have identified 29 novel binding partners, including CAP1, RPS28, FTH1, KDELR2, MAP4, EB1, PSMD6, PPIB/CYPB etc. Subsequent immunoassays confirmed the direct physical interactions of FAM134B with CAP1, EB1, CYPB, and KDELR2 in colon cancer cells.
Affiliation: Cancer Molecular Pathology, School of Medicine, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia. Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi-6205, Bangladesh. Australian Rivers Institute & School of Environment, Griffith University, Gold Coast, Queensland, Australia. School of Medical Science, Griffith University, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia. .
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6: Title: RNA-Sequencing Analyses Demonstrate the Involvement of Canonical Transient Receptor Potential Channels in Rat Tooth Germ Development.
Authors: Yang, Jun, et.al. .
Journal: Frontiers in physiology (Front Physiol), Vol. 8, 2017 .
Snippet: We found that GNAO1, ENO1, EFNB1, CALM1, SIAH2, ATP6V0A1, KDELR2, GTPBP1, POLR2C, SORT1, and members of the canonical transient receptor potential (TRPC) channel family are involved in tooth germ development.
Affiliation: Department of Stomatology, Huashan Hospital, Fudan UniversityShanghai, China. .
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7: Title: ROS1 protein-tyrosine kinase inhibitors in the treatment of ROS1 fusion protein-driven non-small cell lung cancers.
Journal: Pharmacological research (Pharmacol Res), Vol. 121, 2017 .
Snippet: The ROS1 fusion partners include CD74, CCDC6, EZR, FIG, KDELR2, LRIG3, MSN, SDC4, SLC34A2, TMEM106B, TMP3, and TPD52L1.
Affiliation: Blue Ridge Institute for Medical Research, 3754 Brevard Road, Suite 116, Box 19, Horse Shoe, NC 28742-8814, United States. Electronic address: rrj@brimr.org. .
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8: Title: Case of 7p22.1 Microduplication Detected by Whole Genome Microarray (REVEAL) in Workup of Child Diagnosed with Autism.
Authors: Goitia, Veronica, et.al. .
Journal: Case reports in genetics (Case Rep Genet), Vol. 2015, 2015 .
Snippet: This interval included 14 OMIM annotated genes (FBXL18, ACTB, FSCN1, RNF216, OCM, EIF2AK1, AIMP2, PMS2, CYTH3, RAC1, DAGLB, KDELR2, GRID2IP, and ZNF12).
Affiliation: Department of Pediatrics, Driscoll Children's Hospital, Corpus Christi, TX 78411, USA. Department of Medical Genetics, Driscoll Children's Hospital, Corpus Christi, TX 78411, USA. .
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9: Title: A Golgi-based KDELR-dependent signalling pathway controls extracellular matrix degradation.
Authors: Ruggiero, Carmen, et.al. .
Journal: Oncotarget, Vol. 6 (5): 3375-93, 2015 .
Snippet: The KDELR induces Src activation at the invadopodia and leads to phosphorylation of the Src substrates cortactin and ASAP1, which are required for basal and KDELR-stimulated ECM degradation.
Affiliation: Unit of Genomic Approaches to Membrane Traffic, Fondazione Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy. Current address: Institut de Pharmacologie Moléculaire et Cellulaire CNRS and Associated International Laboratory (LIA) NEOGENEX CNRS and University of Nice-Sophia-Antipolis, Valbonne, France. Institute of Protein Biochemistry National Research Council, Naples, Italy. Laboratory of Tumour Cell Invasion, Fondazione Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy. .
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10: Title: Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts.
Authors: Ek, Weronica E, et.al. .
Journal: Gut, Vol. 64 (11): 1774-82, 2015 .
Snippet: RESULTS: One locus at 7p22.1, which includes the genes KDELR2 (KDEL endoplasmic reticulum protein retention receptor 2) and GRID2IP (glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein), showed consistent IBS risk effects in the index GWAS and all replication cohorts and reached p=9.31×10(-6) in a meta-analysis of all datasets.
Affiliation: Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden. Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany. Department of Gastroenterology and Hepatology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia. Faculty of Medical and Human Sciences, Institute of Inflammation and Repair, University of Manchester, Manchester, UK Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA. Laboratory of Biology, School of Medicine, University of Athens, Athens, Greece. Academic Department of Gastroenterology, School of Medicine, University of Athens, Athens, Greece. Molecular Epidemiology Group, German Cancer Research Centre (DKFZ) Heidelberg, Heidelberg, Germany Division of Molecular Biology of Breast Cancer, Department of Gynaecology and Obstetrics, University Women's Clinic, University Heidelberg, Heidelberg, Germany. Gastroenterology Unit, Department of Gastroenterology, University of Pisa, Pisa, Italy. Division of Pharmacology and Chemotherapy, Department of Clinical and Experimental Medicine University of Pisa, Pisa, Italy. Department of Medical and Surgical Sciences, University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy. Department of Medicine, Umeå, University, Umeå, Sweden. Division of Gastroenterology, Institution of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. Department of Clinical Sciences, Skånes University Hospital, Malmoe, Sweden. Department of Internal Medicine & Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden Department of Gastroenterology and Hepatology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden. Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden Stress Research Institute, Stockholm University, Stockholm, Sweden. Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. Translational Research Center for Gastrointestinal Disorders, Leuven University, Leuven, Belgium. Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, Minnesota, USA. .
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11: Title: Visualization of the structures of the hepatitis C virus replication complex.
Authors: Chan, Shih-Ching, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 404 (1): 574-8, 2011 .
Snippet: Knockdown of seven proteins associated with lipid raft (VAPA, COPG, RAB18, COMT, CDC42, DPP4, and KDELR2) of HCV replicon cells reduced the observed number of these particles and suppressed the HCV replication.
Affiliation: Graduate Institute of Molecular and Cellular Biology, Tzu Chi University, Hualien, Taiwan. .
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12: Title: A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1.
Authors: Hsu, V W, et.al. .
Journal: Cell, Vol. 69 (4): 625-35, 1992 .
Snippet: These include the redistribution of the Golgi coat protein, beta-COP, to the cytosol, the loss of the Golgi apparatus as a distinct organelle, the mixing of this organelle with the ER, the addition of complex oligosaccharides to resident ER glycoproteins, and the block of anterograde traffic.
Affiliation: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892. .
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