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6 documents found
1: Title: The Drosophila junctophilin gene is functionally equivalent to its four mammalian counterparts and is a modifier of a Huntingtin poly-Q expansion and the Notch pathway.
Authors: Calpena, Eduardo, et.al. .
Journal: Disease models & mechanisms (Dis Model Mech), Vol. 11 (1), 2018 .
Snippet: In mammals, this family consists of four members (JPH1-JPH4) that are differentially expressed throughout excitable cells.
Affiliation: Program in Molecular Mechanisms of Disease, Centro de Investigación Príncipe Felipe (CIPF), c/ Eduardo Primo Yúfera no. 3, 46012 Valencia, Spain. Translational Genomics Group, Incliva Health Research Institute, Avda. Menendez Pelayo 4 acc 46010, Valencia, Spain. Department of Genetics and Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de València, c/ Dr Moliner 50, 46100 Burjasot, Spain. UPV-CIPF Joint Unit Disease Mechanisms and Nanomedicine, 46012 Valencia, Spain. Program in Molecular Mechanisms of Disease, Centro de Investigación Príncipe Felipe (CIPF), c/ Eduardo Primo Yúfera no. 3, 46012 Valencia, Spain igalindo@cipf.es. Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, 46022 Valencia, Spain. .
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2: Title: Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells.
Authors: Woo, Jin Seok, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), Vol. 113 (10): 2762-7, 2016 .
Snippet: Silencing or genetic manipulation of JP4 decreased ER Ca(2+) content and SOCE in T cells, impaired activation of the nuclear factor of activated T cells (NFAT) and extracellular signaling-related kinase (ERK) signaling pathways, and diminished expression of activation markers and cytokines.
Affiliation: Department of Physiology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan. Department of Physiology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095; ygwack@mednet.ucla.edu. .
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3: Title: Dysregulated microRNAs and their predicted targets associated with endometrioid endometrial adenocarcinoma in Hong Kong women.
Authors: Chung, Tony K H, et.al. .
Journal: International journal of cancer. Journal international du cancer (Int J Cancer), Vol. 124 (6): 1358-65, 2009 .
Snippet: After transfection of a miR-205 inhibitor, the expression of miR-205 in endometrial cancer cell line RL95-2 cells decreased whereas its predicted target gene, JPH4, showed increased protein expression.
Affiliation: Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong. .
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4: Title: Functional crosstalk between cell-surface and intracellular channels mediated by junctophilins essential for neuronal functions.
Authors: Kakizawa, Sho, et.al. .
Journal: Cerebellum (London, England) (Cerebellum), Vol. 7 (3): 385-91, 2008 .
Snippet: Junctophilins (JPs) contribute to the formation of junctional membrane complexes between the plasma membrane and the endoplasmic/sarcoplasmic reticulum, and provide a structural platform for channel communication during excitation-contraction coupling in muscle cells.
Affiliation: Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. .
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5: Title: Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins.
Authors: Moriguchi, Shigeki, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (P Natl Acad Sci Usa), Vol. 103 (28): 10811-6, 2006 .
Snippet: Junctophilins (JPs) contribute to JMC formation by spanning the sarcoplasmic reticulum membrane and binding with the plasma membrane in muscle cells.
Affiliation: Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Graduate School of Medicine, Tohoku University, Sendai 980, Japan. .
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6: Title: Coexpression of junctophilin type 3 and type 4 in brain.
Authors: Nishi, Miyuki, et.al. .
Journal: Brain research. Molecular brain research (Mol Brain Res), Vol. 118 (1-2): 102-10, 2003 .
Snippet: Recent studies indicated that junctophilins (JPs) contribute to the formation of junctional membrane structures in excitable cells by interacting with the plasma membrane and spanning the endoplasmic/sarcoplasmic reticulum (ER/SR) membrane.
Affiliation: Department of Medical Chemistry, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi 980-8575, Japan. .
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