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17 documents found
1: Title: Circulating Microparticle Proteins Obtained in the Late First Trimester Predict Spontaneous Preterm Birth at Less than 35 Weeks Gestation: A Panel Validation with Specific Characterization by Parity.
Authors: McElrath, Thomas F, et.al. .
Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol), 2019 .
Snippet: RESULTS: For delivery ≤35 weeks, the ROC (receiver operating characteristic) curve for a panel of CMP proteins (F13A, FBLN1, IC1, ITIH2 and LCAT) revealed an associated area under the receiver operating characteristic curve (AUC) of 0.74 (95% CI: 0.63-0.81).
Affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA. Electronic address: tmcelrath@bwh.harvard.edu. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA. Division of Maternal-Fetal Medicine, Magee-Women's Research Institute, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA. NX Prenatal Inc. Louisville, KY. Global Pregnancy Collaboration, Magee-Women's Research Institute, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA. Center for Biomarker Discovery and Translation, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD. NX Prenatal Inc. Louisville, KY; Division of Oncology, Department of Internal Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX. .
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2: Title: IRF2BP2-deficient microglia block the anxiolytic effect of enhanced postnatal care.
Authors: Hari, Aswin, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7 (1): 9836, 2017 .
Snippet: Proteoglycan 4 (Prg4), prostaglandin D2 synthase (Ptgds) and extracellular matrix protease inhibitor Itih2 were suppressed by EPC in WT but elevated in KO mice.
Affiliation: Ottawa Hospital Research Institute, Ottawa, Canada. University of Ottawa Heart Institute, Ottawa, Canada. Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Canada. Medicine, University of Ottawa, Ottawa, Canada. University of Ottawa, Center for Infection, Immunity and Inflammation (CI3), Ottawa, Canada. Ottawa Hospital Research Institute, Ottawa, Canada. hchen@uottawa.ca. University of Ottawa, Brain and Mind Institute, Ottawa, Canada. hchen@uottawa.ca. Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada. hchen@uottawa.ca. Medicine, University of Ottawa, Ottawa, Canada. hchen@uottawa.ca. Canadian Partnership for Stroke Recovery, Ottawa, Canada. hchen@uottawa.ca. University of Ottawa, Center for Infection, Immunity and Inflammation (CI3), Ottawa, Canada. hchen@uottawa.ca. .
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3: Title: Obese dogs with and without obesity-related metabolic dysfunction - a proteomic approach.
Authors: Tvarijonaviciute, Asta, et.al. .
Journal: BMC veterinary research (Bmc Vet Res), Vol. 12, 2016 .
Snippet: In obese dogs with ORMD, the relative amounts of ten proteins (albumin, apoliprotein A-I, C2, C3, C5, C4BPA, A2M, Uncharacterised protein (Fragment) OS = Canis familiaris, fibrinogen, and ITIH2) were increased and two proteins (IGJ and glutathione peroxidase) were decreased, compared with obese dogs without ORMD.
Affiliation: Departament de Medicina i Cirugia Animals, Universitat Autónoma de Barcelona, 08193, Barcelona, Spain. asta@um.es. Interdisciplinary Laboratory of Clinical Pathology, Iterlab-UMU, Campus of Excellence Mare Nostrum, University of Murcia, Murcia, Spain. asta@um.es. Interdisciplinary Laboratory of Clinical Pathology, Iterlab-UMU, Campus of Excellence Mare Nostrum, University of Murcia, Murcia, Spain. Unidad de Proteómica, Hospital Clínico Universitario Virgen de la Arrixaca (HCUVA), IMIB-Arrixaca, 30120, Murcia, Spain. Internal Diseases Clinic, Faculty of Veterinary Medicine, University of Zagreb, 10000, Zagreb, Croatia. Department of Obesity and Endocrinology, University of Liverpool, Leahurst Campus, Chester High Road, Neston, Wirral, CH64 7TE, UK. Royal Canin Research Center, B.P.4-650 Avenue de la Petite Camargue, 30470, Aimargues, France. The WALTHAM Centre for Pet Nutrition, Freeby Lane, Waltham-on-the-Wolds, Melton Mowbray, LE14 4RT, UK. Departament de Medicina i Cirugia Animals, Universitat Autónoma de Barcelona, 08193, Barcelona, Spain. .
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4: Title: Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer.
Authors: Chen, Wei-Ching, et.al. .
Journal: PloS one, Vol. 11 (5): e0155660, 2016 .
Snippet: ACSL4 was coexpressed with SERPIN2, HNRNPCL1, ITIH2, PROCR, LRRFIP1.
Affiliation: Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C. Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C. Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C. Center for Infectious Diseases and Signaling Research, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C. .
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5: Title: Development of Diagnostic Biomarkers for Detecting Diabetic Retinopathy at Early Stages Using Quantitative Proteomics.
Authors: Jin, Jonghwa, et.al. .
Journal: Journal of diabetes research (J Diabetes Res), Vol. 2016, 2016 .
Snippet: Although further validation with a larger sample size is needed, the 4-protein marker panel (APO4, C7, CLU, and ITIH2) could represent a useful multibiomarker model for detecting the early stages of DR.
Affiliation: Department of Biomedical Sciences, Seoul National University College of Medicine, 28 Yongon-Dong, Seoul 110-799, Republic of Korea ; Department of Biomedical Engineering, Seoul National University College of Medicine, 28 Yongon-Dong, Seoul 110-799, Republic of Korea. Department of Biomedical Sciences, Seoul National University College of Medicine, 28 Yongon-Dong, Seoul 110-799, Republic of Korea. Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Republic of Korea. Department of Biostatistics, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, 20 Borame-ro 5-gil, Dongjak-gu, Seoul 156-707, Republic of Korea. Department of Ophthalmology, Seoul National University College of Medicine, 28 Yongon-Dong, Seoul 110-799, Republic of Korea. Department of Statistics, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-747, Republic of Korea. .
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6: Title: Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis.
Authors: Yeo, Sujung, et.al. .
Journal: Genetics and molecular biology (Genet Mol Biol), Vol. 38 (1): 115-27, 2015 .
Snippet: Gene array analysis revealed that 22 (10 annotated genes: Cdh1, Itih2, Mpzl2, Rdh9, Serping1, Slc6a13, Slc6a20a, Slc6a4, Tph2, and Ucma) probes that were up-regulated in MPTP animals relative to controls were exclusively down-regulated by acupuncture stimulation.
Affiliation: Research Group of Pain and Neuroscience, WHO Collaborating Center for Traditional Medicine, East-West Medical Research Institute, Kyung Hee University, Seoul, Republic of Korea . ; Department of Basic Korean Medical Science, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea . Department of Basic Korean Medical Science, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea . Department of Basic Korean Medical Science, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea . ; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, USA . .
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7: Title: Genome-wide association study of genetic predictors of overall survival for non-small cell lung cancer in never smokers.
Authors: Wu, Xifeng, et.al. .
Journal: Cancer research (Cancer Res), Vol. 73 (13): 4028-38, 2013 .
Snippet: An additional six variants (rs4237904, rs7976914, rs4970833, rs954785, rs485411, and rs10906104) were validated through eQTL analysis that identified significant correlations with expression levels of six genes (LEMD3, TMBIM, ATXN7L2, SHE, ITIH2, and NUDT5, respectively) in normal lung tissue.
Affiliation: Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. xwu@mdanderson.org .
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8: Title: Hyaluronan and hyaluronan binding proteins are normal components of mouse pancreatic islets and are differentially expressed by islet endocrine cell types.
Authors: Hull, Rebecca L, et.al. .
Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society (J Histochem Cytochem), Vol. 60 (10): 749-60, 2012 .
Snippet: We investigated whether hyaluronan, a common ECM component that may mediate inflammatory events, and molecules that bind hyaluronan such as versican, tumor necrosis factor-stimulated gene 6 (TSG-6), and components of inter-α-trypsin inhibitor (IαI), heavy chains 1 and 2 (ITIH1/ITIH2), and bikunin, are normally produced in the pancreatic islet.
Affiliation: Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA. rhull@u.washington.edu .
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9: Title: Functional analysis of expressed sequence tags from the liver and brain of Korean Jindo dogs.
Authors: Kim, Jae Young, et.al. .
Journal: BMB reports (Bmb Rep), Vol. 44 (4): 238-43, 2011 .
Snippet: Using PolyPhen, a program that predicts changes in protein structure and potential effects on protein function caused by amino acid substitutions, three of the non-synonymous SNPs were predicted to result in changes in protein function for proteins expressed by three different genes (TUSC3, ITIH2, and NAT2).
Affiliation: Department of Systems Immunology, College of Biomedical Science, Kangwon National University, Chuncheon, Gangwon 200-701, Korea. .
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10: Title: Endometrial gene expression of acute phase extracellular matrix components following estrogen disruption of pregnancy in pigs.
Authors: Ashworth, Morgan D, et.al. .
Journal: Animal reproduction science (Anim Reprod Sci), Vol. 122 (3-4): 215-21, 2010 .
Snippet: The present study demonstrates that while the pig endometrium expresses key components of ECM only ITIH2 gene expression was altered by E-treatment.
Affiliation: Department of Animal Science, Oklahoma State University, Stillwater, OK 74078, USA. morgan.ashworth@Yale.edu .
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11: Title: Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors: a systematic expression analysis.
Authors: Hamm, Alexander, et.al. .
Journal: BMC cancer, Vol. 8, 2008 .
Snippet: We found a strong correlation (p < 0.001) between ITIH2 expression and estrogen receptor (ER) expression indicating that ER may be involved in the regulation of this ECM molecule.
Affiliation: Institute of Pathology, University Hospital of RWTH Aachen, Aachen, Germany. alexander.hamm@rwth-aachen.de .
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12: Title: Proteomic analysis of human vitreous fluid by fluorescence-based difference gel electrophoresis (DIGE): a new strategy for identifying potential candidates in the pathogenesis of proliferative diabetic retinopathy.
Authors: García-Ramírez, M, et.al. .
Journal: Diabetologia, Vol. 50 (6): 1294-303, 2007 .
Snippet: RESULTS: Eight proteins were highly produced in PDR patients in comparison with non-diabetic subjects: zinc-alpha(2)-glycoprotein (ZAG), apolipoprotein (apo) A1, apoH, fibrinogen A, and the complement factors C3, C4b, C9 and factor B). We found three proteins that were underproduced in PDR subjects: pigment epithelial derived factor (PEDF), interstitial retinol-binding protein (IRBP) and inter-alpha-trypsin inhibitor heavy chain (ITIH2).
Affiliation: Diabetes Research Unit, Endocrinology Division, Vall d'Hebron University Hospital Research Institute, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain. .
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13: Title: Expression of inter-alpha-trypsin inhibitor heavy chains in endometrium of cyclic and pregnant gilts.
Authors: Geisert, R D, et.al. .
Journal: Reproduction (Cambridge, England) (Reproduction), Vol. 126 (5): 621-7, 2003 .
Snippet: Gene expression of ITIH1, ITIH2, ITIH3 and ITIH4 was detected in the endometrium of cyclic and pregnant gilts; however, gene expression of ITIH was not altered throughout the oestrous cycle or early pregnancy.
Affiliation: Department of Animal Science, Oklahoma Agriculture Experiment Station, Oklahoma State University, Stillwater, OK 74078, USA. geisert@okstate.edu .
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14: Title: Comparative mapping of a region on chromosome 10 containing QTL for reproduction in swine.
Authors: Nonneman, D J, et.al. .
Journal: Animal genetics (Anim Genet), Vol. 34 (1): 42-6, 2003 .
Snippet: Six genes from human chromosome 10p (AKR1C2, PRKCQ, ITIH2, ATP5C1, PIP5K2A and GAD2) were mapped in the MARC swine mapping population.
Affiliation: USDA, ARS, US Meat Animal Research Center, Spur 18D, Clay Center, NB, USA. .
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15: Title: Localization of the fourth locus (GLC1E) for adult-onset primary open-angle glaucoma to the 10p15-p14 region.
Authors: Sarfarazi, M, et.al. .
Journal: American journal of human genetics (Am J Hum Genet), Vol. 62 (3): 641-52, 1998 .
Snippet: A partial list of genes that positionally are considered as candidates includes NET1, PRKCT, ITIH2, IL2RA, IL15RA, IT1H2, hGATA3, the mRNA for open reading frame KIAA0019, and the gene for D123 protein.
Affiliation: Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030-1110, USA. msarfara@cortex.uchc.edu .
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16: Title: An hypervariable polymorphism detected in the human inter-alpha-trypsin inhibitor heavy chain gene ITIH2.
Authors: Léveillard, T, et.al. .
Journal: Nucleic acids research (Nucleic Acids Res), Vol. 18 (5): 1319, 1990 .
No Abstract available.
Affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), Faculté de Médecine-Pharmacie de Rouen, St Etienne Rouvray, France. .
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17: Title: Two RFLPs in human inter-alpha-trypsin inhibitor heavy chain gene ITIH2 on chromosome 10.
Authors: Léveillard, T, et.al. .
Journal: Nucleic acids research (Nucleic Acids Res), Vol. 17 (13): 5418, 1989 .
No Abstract available.
Affiliation: Institut National de la Santé et de la Recherche Médicale, INSERM Unité 295, Faculté de Médecine-Pharmacie de Rouen, St. Etienne, Rouvray, France. .
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