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8 documents found
1: Title: A Systems View of the Differences between APOE ε4 Carriers and Non-carriers in Alzheimer's Disease.
Authors: Jiang, Shan, et.al. .
Journal: Frontiers in aging neuroscience (Unknown Journal), Vol. 8, 2016 .
Snippet: The module including ISOC1 and ENO3 harbored two conserved promoter motifs in its hub gene cluster that could be regulated by common transcription factors and miRNAs.
Affiliation: Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai China. Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam Hong Kong. .
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2: Title: Abnormal corneal epithelial maintenance in mice heterozygous for the micropinna microphthalmia mutation Mp.
Authors: Douvaras, Panagiotis, et.al. .
Journal: Experimental eye research (Exp Eye Res), Vol. 149, 2016 .
Snippet: It has been shown recently that the Mp mutation involves a chromosome 18 inversion that disrupts the Fbn2 and Isoc1 genes and produces an abnormal, truncated fibrillin-2(MP) protein.
Affiliation: Genes and Development Group, Centre for Integrative Physiology, Clinical Sciences, University of Edinburgh Medical School, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK. Genes and Development Group, Centre for Integrative Physiology, Biomedical Sciences, University of Edinburgh Medical School, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK. Medical and Developmental Genetics Section, MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK. Genes and Development Group, Centre for Integrative Physiology, Clinical Sciences, University of Edinburgh Medical School, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK. Electronic address: John.West@ed.ac.uk. .
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3: Title: Impact of microRNA-130a on the neutrophil proteome.
Journal: BMC immunology (Bmc Immunol), Vol. 16 (1): 70, 2015 .
Snippet: In the 32Dcl3 clone, putative targets were more up-regulated than the remaining quantified proteins following miR-130a inhibition, and three significantly derepressed proteins (NFYC, ISOC1, and CAT) are putative miR-130a targets with good RAIN scores.
Affiliation: The Granulocyte Research Laboratory, Department of Hematology, National University Hospital, University of Copenhagen, 9322, Blegdamsvej 9, DK-2100, Copenhagen Ø, Denmark. corinna.cavan.pedersen@regionh.dk. Disease Systems Biology Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200, Copenhagen N, Denmark. jan.refsgaard@cpr.ku.dk. Department of Autoimmunology & Biomarkers, Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark. ooe@ssi.dk. Disease Systems Biology Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200, Copenhagen N, Denmark. lars.juhl.jensen@cpr.ku.dk. Department of Autoimmunology & Biomarkers, Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark. nhe@ssi.dk. Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, University of Southern Denmark, J.B. Winsløws Vej 19, DK-5000, Odense C, Denmark. nhe@ssi.dk. The Granulocyte Research Laboratory, Department of Hematology, National University Hospital, University of Copenhagen, 9322, Blegdamsvej 9, DK-2100, Copenhagen Ø, Denmark. niels.borregaard@regionh.dk. The Granulocyte Research Laboratory, Department of Hematology, National University Hospital, University of Copenhagen, 9322, Blegdamsvej 9, DK-2100, Copenhagen Ø, Denmark. jack.cowland@regionh.dk. .
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4: Title: Systemic identification of estrogen-regulated genes in breast cancer cells through cap analysis of gene expression mapping.
Authors: Yamaga, Ryonosuke, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 447 (3): 531-6, 2014 .
Snippet: Knockdown experiments of the 15 TC-associated genes demonstrated that the genes such as RAMP3, ISOC1 and GPRC5C potentially regulate the growth or migration of MCF-7 cells.
Affiliation: Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan; Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Anti-Aging Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan. Department of Systems Bioinformatics, Amsterdam Institute for Molecules, Medicines and Systems, VU University Amsterdam, Amsterdam, the Netherlands; RIKEN Omics Science Center, Yokohama, Kanagawa, Japan(1). Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Anti-Aging Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. RIKEN Center for Life Science Technologies, Division of Genomic Technologies, Yokohama, Kanagawa, Japan; RIKEN Omics Science Center, Yokohama, Kanagawa, Japan(1). RIKEN Preventive Medicine and Diagnosis Innovation Program, Wako, Saitama, Japan; RIKEN Omics Science Center, Yokohama, Kanagawa, Japan(1). Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan; Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Anti-Aging Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address: INOUE-GER@h.u-tokyo.ac.jp. .
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5: Title: A trans-acting protein effect causes severe eye malformation in the Mp mouse.
Authors: Rainger, Joe, et.al. .
Journal: PLoS genetics (Plos Genet), Vol. 9 (12): e1003998, 2013 .
Snippet: The Fbn2-Isoc1 fusion gene (Fbn2 (Mp)) predicted protein consists of the N-terminal Fibrillin-2 (amino acids 1-2646, exons 1-62) lacking the C-terminal furin-cleavage site with a short out-of-frame extension encoded by the final exon of Isoc1.
Affiliation: The MRC Human Genetics Unit, MRC Institute of Genetic and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom. Shriners Hospital for Children, Portland, Oregon, United States of America. Biomarker and Drug Analysis Core Facility, Medical Research Institute, School of Medicine, University of Dundee, Dundee, United Kingdom. Molecular Medicine Centre, MRC Institute of Genetic and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom. .
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6: Title: Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses.
Authors: Ahn, Sun-Hee, et.al. .
Journal: PLoS pathogens (Plos Pathog), Vol. 6 (9): e1001088, 2010 .
Snippet: 18 (March3, Cep120, Chmp1b, Dcp2, Dtwd2, Isoc1, Lman1, Spire1, Tnfaip8, and Seh1l) mapped to the two significant QTL regions and were also identified by the expression array selection strategy.
Affiliation: Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA. .
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7: Title: Di-(2 ethylhexyl) phthalate and flutamide alter gene expression in the testis of immature male rats.
Authors: Vo, Thuy T B, et.al. .
Journal: Reproductive biology and endocrinology : RB&E (Reprod Biol Endocrinol), Vol. 7, 2009 .
Snippet: In addition, the expression of a common set of target genes, including CaBP1, Vav2, Plcd1, Lhx1 and Isoc1, was altered following exposure to EDs, suggesting that they may be marker genes to screen for the anti-androgenic or androgenic effects of EDs.
Affiliation: Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, 361-763, Republic of Korea. thuynvdc@yahoo.com .
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8: Title: Microarray study of gene expression in uterine leiomyoma.
Authors: Litovkin, K V, et.al. .
Journal: Experimental oncology (Exp Oncol), Vol. 30 (2): 106-11, 2008 .
Snippet: The first group comprises genes that to our knowledge have not been previously reported as deregulated in fibroids: CLDN1, FGF7 (KGF), HNRPM, ISOC1, MAGEC1 (CT7), MAPK12, RFC, TIE1, TNFRSF21 (DR6).
Affiliation: Institute of Molecular and Cellular Medicine, Odessa State Medical University, Odessa, Ukraine. k.litovkin@rambler.ru .
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