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14 documents found
1: Title: Importin-11 overexpression promotes the migration, invasion, and progression of bladder cancer associated with the deregulation of CDKN1A and THBS1.
Authors: Zhao, Junjie, et.al. .
Journal: Urologic oncology (Urol Oncol), 2018 .
Snippet: Using whole transcriptome sequencing, we found that 22 genes (including IPO11) were differentially expressed in IPO11-silenced EJ cells compared with wild-type EJ cells, 4 of which were upregulated, and 18 of which were downregulated.
Affiliation: Department of Urology, Yantai Yuhuangding Hospital, Yantai, China; Department of Urology, Changhai Hospital, The Second Military Medical University, Shanghai, China. Department of Urology, Yantai Yuhuangding Hospital, Yantai, China. Department of Urology, Changhai Hospital, The Second Military Medical University, Shanghai, China. Department of Urology, Changhai Hospital, The Second Military Medical University, Shanghai, China. Electronic address: xuchuanliang@vip.126.com. .
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2: Title: Genetic variants in HSD17B3, SMAD3, and IPO11 impact circulating lipids in response to fenofibrate in individuals with type 2 diabetes.
Authors: Rotroff, Daniel M, et.al. .
Journal: Clinical pharmacology and therapeutics (Clin Pharmacol Ther), 2017 .
Snippet: Associations of variants in SMAD3, IPO11, and HSD17B13, with gene expression changes in mice indicate that TGF-ß and NRF2 signaling pathways may influence fenofibrate effects on dyslipidemia in T2D patients.
Affiliation: Bioinformatics Research Center, North Carolina State University, Raleigh, NC. Dept. of Statistics, North Carolina State University, Raleigh, NC. Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY. Center for Pharmacogenomics and Individualized Therapy, UNC Chapel Hill, Chapel Hill, NC, USA. Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), and CIBERER U759, Center for Biomedical Research on Rare Diseases, Barcelona, Spain. Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain. Center for Pharmaceutical Research and Innovation, University of Kentucky, Lexington, KY. Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY. Irving Institute for Clinical and Translational Research, Columbia University College of Physicians and Surgeons, New York, New York, USA. Joslin Diabetes Center and Harvard Medical School, Boston, MA, USA. Center for Public Health Genomics, University of Virginia, Charlottesville, VA, 22904, USA. Moffitt Cancer Center, 12002 Magnolia Dr., Tampa, FL, USA. Division of Endocrinology, University of North Carolina School of Medicine, Chapel Hill, NC. .
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3: Title: The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein.
Authors: Chen, Muhan, et.al. .
Journal: The Journal of cell biology (J Cell Biol), Vol. 216 (3): 641-656, 2017 .
Snippet: Mechanistically, we find that the E2 ubiquitin-conjugating enzyme and IPO11 cargo, UBE2E1, is a limiting factor for PTEN degradation.
Affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724. Department of Pathology, Neuberger Berman Lung Cancer Research Center, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, NY 10065. Department of Cell and Developmental Biology, Neuberger Berman Lung Cancer Research Center, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, NY 10065. The Watson School of Biological Sciences, Cold Spring Harbor, NY 11724. Free Radical Biology and Aging Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104. Department of Cardiothoracic Surgery, Neuberger Berman Lung Cancer Research Center, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, NY 10065. Department of Pathology, Mount Sinai Medical School, New York, NY 10029. Department of Pathology, University of Michigan, Ann Arbor, MI 48109. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724 trotman@cshl.edu. .
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4: Title: Importin-11 keeps PTEN safe from harm.
Journal: The Journal of cell biology (J Cell Biol), Vol. 216 (3): 539-541, 2017 .
Snippet: This work helps explain the nuclear accumulation of PTEN observed in many healthy tissues and, because Ipo11 mutant mice develop lung tumors, also implicates Importin-11 as a novel tumor suppressor.
Affiliation: Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University, Edinburgh, EH14 4AS, Scotland, UK n.r.leslie@hw.ac.uk. .
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5: Title: Whole-exome sequencing of muscle-invasive bladder cancer identifies recurrent copy number variation in IPO11 and prognostic significance of importin-11 overexpression on poor survival.
Authors: Zhao, Junjie, et.al. .
Journal: Oncotarget, Vol. 7 (46): 75648-75658, 2016 .
Snippet: We performed whole-exome sequencing to analyze superficial tumor tissues (Tsup) and basal tumor tissues (Tbas) from 3 MIBC patients and identified previously unreported copy number variations in IPO11 that warrants further investigation as a molecular target.
Affiliation: Department of Urology, Yantai Yuhuangding Hospital, Yantai 264000, China. Department of Urology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China. Cancer Research Department, BGI-Shenzhen, Yantian District, Shenzhen, Guangdong 518083, China. .
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6: Title: A New Genomewide Association Meta-Analysis of Alcohol Dependence.
Authors: Zuo, Lingjun, et.al. .
Journal: Alcoholism, clinical and experimental research (Alcohol Clin Exp Res), Vol. 39 (8): 1388-95, 2015 .
Snippet: They included 6 at SERINC2 (3.1 × 10(-8) ≤ p ≤ 9.6 × 10(-8) ), 1 at STK40 (p = 1.3 × 10(-7) ), 2 at KIAA0040 (3.3 × 10(-7) ≤ p ≤ 5.2 × 10(-7) ), and 1 at IPO11 (p = 6.9 × 10(-7) ).
Affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut. Biological Psychiatry Research Center , Beijing Huilongguan Hospital, Beijing, China. Menninger Department of Psychiatry and Behavioral Sciences , Baylor College of Medicine, Houston, Texas. Department of Neurology , First People's Hospital, Shanghai Jiaotong University, Shanghai, China. Department of Pharmacology , University of Colorado School of Medicine, Aurora, Colorado. Department of Neurosurgery , Renji Hospital, Shanghai Jiaotong University, Shanghai, China. .
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7: Title: Significant association between rare IPO11-HTR1A variants and attention deficit hyperactivity disorder in Caucasians.
Authors: Zuo, Lingjun, et.al. .
Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics (Am J Med Genet B Neuropsychiatr Genet), Vol. 168 (7): 544-56, 2015 .
Snippet: Cis-eQTL analysis showed that, 29 among the 41 SNPs within or around IPO11 had replicable significant regulatory effects on IPO11 exon expression (1.5 × 10(-17) ≤P < 0.002) in human brain or peripheral blood mononuclear cell tissues.
Affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut. Department of Pharmacology, University of Colorado Denver School of Medicine, Aurora, Colorado. Provincial Key Laboratory of Translational Cancer Medicine, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, China. Biological Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China. Department of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, Tennessee. VA Alcohol Research Center, VA Cnnecticut Healthcare System, West Haven, Connecticut. .
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8: Title: The ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2.
Authors: Plafker, Kendra S, et.al. .
Journal: Molecular biology of the cell (Mol Biol Cell), Vol. 26 (2): 327-38, 2015 .
Snippet: These findings identify a novel pathway of Nrf2 modulation during homeostasis and support a model in which UBE2E3 and Imp-11 promote Nrf2 transcriptional activity by restricting the transcription factor from partitioning to the mitochondria and limiting the repressive activity of nuclear KEAP1.
Affiliation: Free Radical Biology and Aging Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104. Free Radical Biology and Aging Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104 plafkers@omrf.org. .
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9: Title: Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence.
Authors: Zuo, Lingjun, et.al. .
Journal: Alcoholism, clinical and experimental research (Alcohol Clin Exp Res), Vol. 37 (5): 730-9, 2013 .
Snippet: RESULTS: We identified a significant risk region for alcohol and nicotine codependence between IPO11 and HTR1A on chromosome 5q that was reported to be suggestively associated with alcohol dependence previously.
Affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA. lingjun.zuo@yale.edu .
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10: Title: Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1.
Authors: Zhang, Zi Chao, et.al. .
Journal: Molecular biology of the cell (Mol Biol Cell), Vol. 22 (23): 4657-68, 2011 .
Snippet: Karyopherin β2 or transportin recognizes a proline-tyrosine nuclear localization signal (PY-NLS) in the N-terminal tail of NXF1 and imports it into the nucleus.
Affiliation: Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9041, USA. .
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11: Title: [Influence of Tripterygium wilfordii on the expression of spermiogenesis related genes Herc4, Ipo11 and Mrto4 in mice].
Authors: Huang, Di, et.al. .
Journal: Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji (Yi Chuan), Vol. 31 (9): 941-6, 2009 .
Snippet: Genes Herc4, Ipo11, and Mrto4, which are closely associated with spermiogenesis, were expressed irregularly.
Affiliation: Key Laboratory of Liver and Kidney Disease Syndrome of the Ministry of Education, Department of Nephrology, Shanghai Shuguang Hospital/Shanghai University of Traditional Chinese Medicine, Shanghai, China. huangacheng002@163.com .
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12: Title: Ub in charge: regulating E2 enzyme nuclear import.
Authors: Zhang, Xiang-Dong, et.al. .
Journal: Nature cell biology (Nat Cell Biol), Vol. 7 (1): 12-4, 2005 .
No Abstract available.
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13: Title: Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import.
Authors: Plafker, Scott M, et.al. .
Journal: The Journal of cell biology (J Cell Biol), Vol. 167 (4): 649-59, 2004 .
Snippet: The attachment of ubiquitin (Ub) to a substrate proceeds through a multi-enzyme cascade involving an activating enzyme (E1), a conjugating enzyme (E2), and a protein ligase (E3).
Affiliation: Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. scott-plafker@ouhsc.edu .
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14: Title: Synleurin, a novel leucine-rich repeat protein that increases the intensity of pleiotropic cytokine responses.
Authors: Wang, Wei, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Bioph Res Co), Vol. 305 (4): 981-8, 2003 .
Snippet: The LRRs are most homologous to that of chondroadherin, insulin-like growth factor binding proteins, platelet glycoprotein V, slits, and toll-like receptors.
Affiliation: Human Genome Sciences, Inc., 9410 Key West Avenue, Rockville, MD 20850, USA. .
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