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2 documents found
1: Title: The Integrator Complex Prevents Dedifferentiation of Intermediate Neural Progenitors back into Neural Stem Cells.
Authors: Zhang, Yingjie, et.al. .
Journal: Cell reports (Cell Rep), Vol. 27 (4): 987-996.e3, 2019 .
Snippet: INP-specific knockdown of intS8, intS1, and intS2 resulted in the formation of excess type II neuroblasts, indicating that Integrator prevents INP dedifferentiation.
Affiliation: Neuroscience & Behavioral Disorders Programme, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore. Genome Institute of Singapore, 60 Biopolis Street, Genome, Singapore 138672, Singapore. Neuroscience & Behavioral Disorders Programme, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore. Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore. Genome Institute of Singapore, 60 Biopolis Street, Genome, Singapore 138672, Singapore; Cancer & Stem Cell Biology Program, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore; Cellular and Molecular Research, National Cancer Centre, Singapore 169610, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore 119074, Singapore. Neuroscience & Behavioral Disorders Programme, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore; Temasek Life Sciences Laboratory and Department of Biological Sciences, 1 Research Link, National University of Singapore, Singapore 117604, Singapore. Genome Institute of Singapore, 60 Biopolis Street, Genome, Singapore 138672, Singapore; Department of Computer Science, National University of Singapore, Singapore. Neuroscience & Behavioral Disorders Programme, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. Electronic address: hongyan.wang@duke-nus.edu.sg. .
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2: Title: Genetic alterations and their clinical implications in gastric cancer peritoneal carcinomatosis revealed by whole-exome sequencing of malignant ascites.
Authors: Lim, Byungho, et.al. .
Journal: Oncotarget, Vol. 7 (7): 8055-66, 2016 .
Snippet: Comparative analysis revealed several candidate mutations for GC peritoneal carcinomatosis: recurrent mutations in COL4A6, INTS2, and PTPN13; mutations in druggable genes including TEP1, PRKCD, BRAF, ERBB4, PIK3CA, HDAC9, FYN, FASN, BIRC2, FLT3, ROCK1, CD22, and PIK3C2B; and mutations in metastasis-associated genes including TNFSF12, L1CAM, DIAPH3, ROCK1, TGFBR1, MYO9B, NR4A1, and RHOA.
Affiliation: Genome Structure Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea. Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea. Song-Dang Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Korea. Epigenomics Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea. Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea. Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. Department of Functional Genomics, University of Science and Technology, Daejeon, Korea. .
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