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11 documents found
1: Title: Critical steps for computational inference of the 3'-end of novel alleles of immunoglobulin heavy chain variable genes - illustrated by an allele of IGHV3-7.
Authors: Thörnqvist, Linnea, et.al. .
Journal: Molecular immunology (Mol Immunol), Vol. 103, 2018 .
Snippet: Importantly, the presence of the novel allele, but not the standard IGHV3-7*02 sequence, in the genotype was strongly supported by the actual sequences that were assigned to the allele.
Affiliation: Dept. of Immunotechnology, Lund University, Lund, Sweden. Dept. of Immunotechnology, Lund University, Lund, Sweden. Electronic address: mats.ohlin@immun.lth.se. .
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2: Title: VDJ Gene Usage of B Cell Receptors in Peripheral Blood of ABO-incompatible Kidney Transplantation Patients.
Authors: Jeon, H J, et.al. .
Journal: Transplantation proceedings (Transplant Proc), Vol. 50 (4): 1056-1062, 2018 .
Snippet: According to individual gene segments, IGHV3-7, IGHV3-15, IGHV4-59, IGKV3-11, IGLV1-44, IGLV2-14, IGLV4-69, and IGLV7-46 were more frequently used in the ABOcS group than other groups, and IGKV3-7 was more frequently used in the ABOiR group than other groups.
Affiliation: Department of Internal Medicine, Hallym University College of Medicine, Seoul, Republic of Korea. Transplantation Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Division of Clinical Bioinformatics, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea. Transplantation Center, Seoul National University Hospital, Seoul, Republic of Korea. Transplantation Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea; Transplantation Center, Seoul National University Hospital, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. Transplantation Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea; Transplantation Center, Seoul National University Hospital, Seoul, Republic of Korea; Department of Surgery, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address: jcyjs@dreamwiz.com. .
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3: Title: The functional 3'-end of immunoglobulin heavy chain variable (IGHV) genes.
Authors: Thörnqvist, Linnea, et.al. .
Journal: Molecular immunology (Mol Immunol), Vol. 96, 2018 .
Snippet: In addition, we also present data that indicate the existence of a common so far un-recognized allelic variant of IGHV3-7 that carries an A318G difference in relation to IGHV3-7*02.
Affiliation: Department of Immunotechnology, Lund University, Lund, Sweden. Department of Immunotechnology, Lund University, Lund, Sweden. Electronic address: mats.ohlin@immun.lth.se. .
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4: Title: Proteomic analysis of influenza haemagglutinin-specific antibodies following vaccination reveals convergent immunoglobulin variable region signatures.
Authors: Adamson, Penelope J, et.al. .
Journal: Vaccine, Vol. 35 (42): 5576-5580, 2017 .
Snippet: Analysis of the anti-haemagglutinin serum antibody proteome from six H1N1pdm09 influenza A vaccinated subjects demonstrated restricted IgG1 heavy chain species encoded by IGHV5-51 and IGHV3-7 gene families in 2 subjects and either IGHV5-51 or IGHV3-7 in 4 individuals.
Affiliation: Department of Microbiology and Infectious Diseases, Flinders University and SA Pathology, Flinders Medical Centre, Bedford Park, SA 5042, Australia. Electronic address: penelope.adamson@sa.gov.au. Department of Immunology, Flinders University and SA Pathology, Flinders Medical Centre, Bedford Park, SA 5042, Australia. Electronic address: dralkindi@squ.edu.om. Department of Immunology, Flinders University and SA Pathology, Flinders Medical Centre, Bedford Park, SA 5042, Australia. Electronic address: jing.wang@flinders.edu.au. Flinders Proteomic Facility, Flinders University, Flinders Medical Centre, Bedford Park, SA 5042, Australia. Electronic address: Alexander.Colella@sa.gov.au. Flinders Proteomic Facility, Flinders University, Flinders Medical Centre, Bedford Park, SA 5042, Australia. Electronic address: tim.chataway@flinders.edu.au. Department of Endocrinology, Flinders University and Vaxine Pty Ltd., Flinders Medical Centre, Bedford Park, SA 5042, Australia. Electronic address: nikolai.petrovsky@flinders.edu.au. Department of Immunology, Flinders University and SA Pathology, Flinders Medical Centre, Bedford Park, SA 5042, Australia. Electronic address: t.gordon@flinders.edu.au. Department of Microbiology and Infectious Diseases, Flinders University and SA Pathology, Flinders Medical Centre, Bedford Park, SA 5042, Australia. Electronic address: d.gordon@flinders.edu.au. .
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5: Title: Distinct molecular genetics of chronic lymphocytic leukemia in Taiwan: clinical and pathogenetic implications.
Authors: Wu, Shang-Ju, et.al. .
Journal: Haematologica, Vol. 102 (6): 1085-1090, 2017 .
Snippet: The IgHV gene repertoire was biased and distinct from that observed in the West with the most common IgHV genes being IgHV3-23, IgHV3-7, and IgHV3-48 In terms of IgHV gene mutational status, 63.8% of patients carried mutated rearrangements, whereas 22.4% of patients were assigned to stereotyped subsets (6.9% to major subsets and 15.5% to minor ones).
Affiliation: Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Tai-Cheng Stem Cell Therapy Center, National Taiwan University, Taipei, Taiwan. Strategic Research Program on CLL and B-cell Neoplasia Unit, Division of Experimental Oncology, Vita-Salute San Raffaele University and IRCCS San Raffaele Scientific Institute, Milan, Italy. Department of Clinical Laboratory Science and Medical Technology, College of Medicine, National Taiwan University, Taipei, Taiwan. Graduate Institution of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan. Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan hftien@ntu.edu.tw ghia.paolo@hsr.it. Strategic Research Program on CLL and B-cell Neoplasia Unit, Division of Experimental Oncology, Vita-Salute San Raffaele University and IRCCS San Raffaele Scientific Institute, Milan, Italy hftien@ntu.edu.tw ghia.paolo@hsr.it. .
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6: Title: Immunoglobulin gene rearrangements in Chinese and Italian patients with chronic lymphocytic leukemia.
Authors: Marinelli, Marilisa, et.al. .
Journal: Oncotarget, Vol. 7 (15): 20520-31, 2016 .
Snippet: Chinese patients showed a higher proportion of mutated IGHV and a more frequent usage of IGHV3-7, IGHV3-74, IGHV4-39 and IGHV4-59 genes.
Affiliation: Department of Cellular Biotechnologies and Hematology, "Sapienza" University, Rome, Italy. Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China. Department of Lymphoma & Myeloma Institute of Hematology, CAMS & PUMC, Tianjin, China. Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong. GIMEMA Data Center, GIMEMA Foundation, Rome, Italy. .
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7: Title: Serum SmD autoantibody proteomes are clonally restricted and share variable-region peptides.
Authors: Al Kindi, Mahmood A, et.al. .
Journal: Journal of autoimmunity (J Autoimmun), Vol. 57, 2015 .
Snippet: SmD autoantibody proteomes from all six patients with SLE expressed IgG1 kappa restricted clonotypes specified by IGHV3-7 and IGHV1-69 H-chains and IGKV3-20 and IGKV2-28 L-chains, with shared and individual V-region amino acid replacement mutations.
Affiliation: Department of Immunology, Flinders Medical Centre and Flinders University, SA Pathology, Bedford Park, 5042 South Australia, Australia. Flinders Proteomic Facility, Flinders University, Australia. Department of Immunology, Flinders Medical Centre and Flinders University, SA Pathology, Bedford Park, 5042 South Australia, Australia. Electronic address: t.gordon@flinders.edu.au. .
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8: Title: Clues to pathogenesis of Waldenström macroglobulinemia and immunoglobulin M monoclonal gammopathy of undetermined significance provided by analysis of immunoglobulin heavy chain gene rearrangement and clustering of B-cell receptors.
Authors: Varettoni, Marzia, et.al. .
Journal: Leukemia & lymphoma (Leuk Lymphoma), Vol. 54 (11): 2485-9, 2013 .
Snippet: At the gene level, in WM/IgM-MGUS there was an over-representation of IGHV3-23 (24% vs. 12%, p = 0.0003), IGHV3-64 (3% vs. < 1%, p = 0.003), IGHV3-7 (12% vs. 4%, p = 0.0001) and IGHV3-74 (9% vs. 2%, p < 0.0001), while IGHV4-39 was never used (0 vs. 5%, p = 0.03).
Affiliation: Department of Hematology-Oncology, Fondazione IRCCS Policlinico San Matteo , Pavia , Italy. .
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9: Title: A novel chronic lymphocytic leukemia subset expressing mutated IGHV3-7-encoded rheumatoid factor B-cell receptors that are functionally proficient.
Authors: Hoogeboom, R, et.al. .
Journal: Leukemia, Vol. 27 (3): 738-40, 2013 .
No Abstract available.
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10: Title: Immunoglobulin heavy chain variable region gene usage and mutational status of the leukemic B cells in Iranian patients with chronic lymphocytic leukemia.
Journal: Cancer science (Cancer Sci), Vol. 100 (12): 2346-53, 2009 .
Snippet: Of the IGHV genes, IGHV3-7 was significantly over-represented in non-progressive compared to progressive CLL patients (P = 0.036), whereas IGHV1-69 and IGHV1-2 were expressed at a higher frequency in unmutated compared to mutated CLL patients (P < 0.03).
Affiliation: Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. .
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11: Title: [Detection of IgVH mutation status in patients with chronic lymphocytic leukemia by multiplex PCR].
Authors: Zheng, Wen-Juan, et.al. .
Journal: Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology (Zhongguo Shi Yan Xue Ye Xue Za Zhi), Vol. 14 (6): 1101-4, 2006 .
Snippet: The results showed that 5 patients had mutated IgVH, and IgVHs were IGHV3-11*03, IGHV3-9*01, IGHV3-23*01, IGHV4-59*01, IGHV4-34*02, respectively; whereas 4 others had unmutated IgVH, these IgVHs were IGHV3-53*01, IGHV3-23*03, IGHV3-33*05 and IGHV3-7*01.
Affiliation: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province People Hospital, Nanjing 210029, China. .
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